In search of the tumour-suppressor functions of BRCA1 and BRCA2

Nature

Volumn 408, Issue 6811, 2000, Pages 429-432

  Scully, R ^a   Livingston, D M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; DNA; DNA POLYMERASE; GENE PRODUCT;

ANIMAL CELL; ARTICLE; BREAST CANCER; CANCER SUSCEPTIBILITY; CELL CYCLE; CHROMATIN; DNA SYNTHESIS; FEMALE GENITAL TRACT CANCER; GENE MUTATION; GENETIC PREDISPOSITION; GENETIC RECOMBINATION; GYNECOLOGIC CANCER; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

BRCA1 PROTEIN; BRCA2 PROTEIN; CHROMATIN; DNA; DNA-DIRECTED DNA POLYMERASE; FEMALE; GENES, BRCA1; GENES, TUMOR SUPPRESSOR; HUMANS; NEOPLASM PROTEINS; NEOPLASMS; OVARIAN NEOPLASMS; RECOMBINATION, GENETIC; S PHASE; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

ANIMALIA;

EID: 0034707053     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35044000     Document Type: Article

References (42)

1. Insights into the functions of BRCA1 and BRCA2
2. Association of BRCA1 with Rad51 in mitotic and meiotic cells
3. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2
4. Stable interaction between the products of the BRCA1 and BRCA2 tumoursuppressor genes in mitotic and meiotic cells
5. Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage
6. Identification of a RING protein that can interact in vivo with the BRCA1 gene product
7. The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes
8. Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks
9. Role of the tumor suppressor gene Brca1 in genetic stability and mammary gland tumor formation
10. The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse
11. Involvement of Brca2 in DNA repair
12. Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death
13. Genetic analysis of BRCA1 function in a defined tumor cell line
14. Brca1 controls homology-directed DNA repair
15. BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a brca1 transgene
16. DNA polymerase stalling, sister chromatid recombination and the BRCA genes
17. Recombination of parent and daughter strand DNA after UV-irradiation in mammalian cells
18. Initiation of genetic recombination and recombination-dependent replication
19. Analysis of DNA replication forks encountering a pyrimidine dimer in the template to the leading strand
20. ATR disruption leads to chromosomal fragmentation and early embryonic lethality
21. ATM: A mediator of multiple responses to genotoxic stress
22. hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
23. BRCA1 required for transcription-coupled repair of oxidative DNA damage
24. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures
25. Transcriptional activation by BRCA1
26. Evidence for a transcriptional activation function of BRCA1 C-terminal region
27. Transcriptional activation functions in BRCA2
28. The functions of breast cancer susceptibility gene I (BRCA1) product and its associated proteins
29. BRCA1 is associated with a human SWI/SNF-related complex: Linking chromatin remodeling to breast cancer
30. Diverse and dynamic functions of the Sir silencing complex
31. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
32. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination
33. An entire functional mammary gland may comprise the progeny from a single cell
34. Malignant breast tumors among atomic bomb survivors, Hiroshima and Nagasaki, 1950-74
35. Second cancers following pediatric Hodgkin's disease
36. Cancer-susceptibility genes. Gatekeepers and caretakers
37. The role of estrogen in mammary carcinogenesis
38. Nuclear organization and gene expression: Homologous pairing and long-range interactions
39. Intergenic transcription and transinduction of the human beta-globin locus
40. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
41. Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress
42. BRCA1 and BRCA2 are necessary for the transcription-coupled repair of the oxidative 8-oxoguanine lesion in human cells