메뉴 건너뛰기




Volumn 386, Issue 6627, 1997, Pages 804-810

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; BREAST CANCER; CELL PROLIFERATION; CELL SURVIVAL; DNA REPAIR; GENE MUTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOSENSITIVITY; TUMOR SUPPRESSOR GENE;

EID: 0030933762     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/386804a0     Document Type: Article
Times cited : (952)

References (46)
  • 1
    • 0028006563 scopus 로고
    • Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13
    • Wooster, R. et al. Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13. Nature 265, 2088-2090 (1994).
    • (1994) Nature , vol.265 , pp. 2088-2090
    • Wooster, R.1
  • 2
    • 0026935108 scopus 로고
    • Allele losses in the region 17q12-21 in familial breast and ovarian cancer involve the wild type chromosome
    • Smith, S. A., Easton, D. G., Evans, D. G. R. & Ponder, B. A. J. Allele losses in the region 17q12-21 in familial breast and ovarian cancer involve the wild type chromosome. Nature Genet. 2, 128-131 (1992).
    • (1992) Nature Genet. , vol.2 , pp. 128-131
    • Smith, S.A.1    Easton, D.G.2    Evans, D.G.R.3    Ponder, B.A.J.4
  • 3
    • 0027433563 scopus 로고
    • Genetic linkage analysis in the familial breast and ovarian cancer: Results from 214 families
    • Easton, D. F., Bishop, D. T., Ford, D., Crockford, G. P. & the breast cancer linkage consortium Genetic linkage analysis in the familial breast and ovarian cancer: Results from 214 families. Am. J. Hum. Genet. 52, 678-701 (1993).
    • (1993) Am. J. Hum. Genet. , vol.52 , pp. 678-701
    • Easton, D.F.1    Bishop, D.T.2    Ford, D.3    Crockford, G.P.4
  • 4
    • 0031012305 scopus 로고    scopus 로고
    • Variations of risks of breast and ovarian cancer associated with different germline mutations of the BRCA2 gene
    • Gayther, S. A. et al. Variations of risks of breast and ovarian cancer associated with different germline mutations of the BRCA2 gene. Nature Genet. 15, 103-105 (1997).
    • (1997) Nature Genet. , vol.15 , pp. 103-105
    • Gayther, S.A.1
  • 5
    • 0006713602 scopus 로고
    • Identification of the breast cancer susceptibility gene BRCA2
    • Wooster, R. et al. Identification of the breast cancer susceptibility gene BRCA2. Nature 378, 789-792 (1995).
    • (1995) Nature , vol.378 , pp. 789-792
    • Wooster, R.1
  • 6
    • 13344269668 scopus 로고    scopus 로고
    • The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds
    • Tavtigian, S. V. et al. The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds. Nature Genet. 12, 333-337 (1996).
    • (1996) Nature Genet. , vol.12 , pp. 333-337
    • Tavtigian, S.V.1
  • 7
    • 0030139524 scopus 로고    scopus 로고
    • BRCA2 germline mutations in male breast cancer cases and breast cancer families
    • Couch, F. J. et al. BRCA2 germline mutations in male breast cancer cases and breast cancer families. Nature Genet. 13, 123-125 (1996).
    • (1996) Nature Genet. , vol.13 , pp. 123-125
    • Couch, F.J.1
  • 8
    • 0030138354 scopus 로고    scopus 로고
    • Recurrent BRCA2617delT mutations in Ashkenazi Jewish women affected by breast cancer
    • Neuhausen, S. et al. Recurrent BRCA2617delT mutations in Ashkenazi Jewish women affected by breast cancer. Nature Genet. 13, 126-128 (1996).
    • (1996) Nature Genet. , vol.13 , pp. 126-128
    • Neuhausen, S.1
  • 9
    • 0030137718 scopus 로고    scopus 로고
    • Mutation analysis of the BRCA2 gene in 49 site specific breast cancer families
    • Phelan, C. M. et al. Mutation analysis of the BRCA2 gene in 49 site specific breast cancer families. Nature Genet. 13, 120-122 (1996).
    • (1996) Nature Genet. , vol.13 , pp. 120-122
    • Phelan, C.M.1
  • 10
    • 0030140026 scopus 로고    scopus 로고
    • A single BRCA2 mutation in male and female breast cancer families from Iceland with varied cancer phenotypes
    • Thorlacius, S. et al. A single BRCA2 mutation in male and female breast cancer families from Iceland with varied cancer phenotypes. Nature Genet. 13, 117-119 (1996).
    • (1996) Nature Genet. , vol.13 , pp. 117-119
    • Thorlacius, S.1
  • 11
    • 0031105010 scopus 로고    scopus 로고
    • Murine Brca2: Sequence, map position and expression pattern
    • Sharan, S. K. & Bradley, A. Murine Brca2: Sequence, map position and expression pattern. Genomics 40, 234-241 (1997).
    • (1997) Genomics , vol.40 , pp. 234-241
    • Sharan, S.K.1    Bradley, A.2
  • 12
    • 0029822055 scopus 로고    scopus 로고
    • Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells
    • Rajan, J. V., Wang, M., Marquis, S. T. & Chodosh, L. A. Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells. Proc. Natl Acad. Sci. USA 93, 13078-13083 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 13078-13083
    • Rajan, J.V.1    Wang, M.2    Marquis, S.T.3    Chodosh, L.A.4
  • 13
    • 0031472370 scopus 로고    scopus 로고
    • Association of BRCA1 with Rad51 in mitotic and meiotic cells
    • Scully, R. et al. Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 88, 265-275 (1997).
    • (1997) Cell , vol.88 , pp. 265-275
    • Scully, R.1
  • 14
    • 0029947714 scopus 로고    scopus 로고
    • Double strand break repair in the absence of RAD51 in yeast: A possible role of break-induced DNA replication
    • Malkova, A., Ivanov, E. L. & Harber, J. E. Double strand break repair in the absence of RAD51 in yeast: a possible role of break-induced DNA replication. Proc. Natl Acad. Sci. USA 93, 7131-7136 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 7131-7136
    • Malkova, A.1    Ivanov, E.L.2    Harber, J.E.3
  • 15
    • 0027325816 scopus 로고
    • Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and RecA
    • Shinohara, A. et al. Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and RecA. Nature Genet. 4, 239-243 (1993).
    • (1993) Nature Genet. , vol.4 , pp. 239-243
    • Shinohara, A.1
  • 16
    • 0026751113 scopus 로고
    • Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein
    • Shinohara, A., Ogawa, H. & Ogawa, T. Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein. Cell 69, 457-470 (1992).
    • (1992) Cell , vol.69 , pp. 457-470
    • Shinohara, A.1    Ogawa, H.2    Ogawa, T.3
  • 17
    • 0029909565 scopus 로고    scopus 로고
    • A mutaiton in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53
    • Lim, D.-S. & Hasty, P. A mutaiton in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53. Mol. Cell Biol. 16, 7133-7143 (1996).
    • (1996) Mol. Cell Biol. , vol.16 , pp. 7133-7143
    • Lim, D.-S.1    Hasty, P.2
  • 18
    • 0029112483 scopus 로고
    • DNA strand exchange mediated by a Rad51-ssDNA nucleoprotein filament with polarity opposite to that of RecA
    • Sung, P. & Robberson, D. L. DNA strand exchange mediated by a Rad51-ssDNA nucleoprotein filament with polarity opposite to that of RecA. Cell 82, 453-461 (1995).
    • (1995) Cell , vol.82 , pp. 453-461
    • Sung, P.1    Robberson, D.L.2
  • 19
    • 0026095558 scopus 로고
    • Helical interactions in homologous pairing and strand exchange driven by RecA protein
    • Raddling, C. M. Helical interactions in homologous pairing and strand exchange driven by RecA protein. J. Biol. Chem. 266, 5355-5358 (1991).
    • (1991) J. Biol. Chem. , vol.266 , pp. 5355-5358
    • Raddling, C.M.1
  • 20
    • 0030584084 scopus 로고    scopus 로고
    • Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro
    • Baumann, P., Benson, F. E. & West, S. C. Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro. Cell 87, 757-766 (1996).
    • (1996) Cell , vol.87 , pp. 757-766
    • Baumann, P.1    Benson, F.E.2    West, S.C.3
  • 21
    • 0028600050 scopus 로고
    • RecA homologs Dmc1 and rad51 interact to form multiple nuclear complexes prior to meiotic chromosome synapsis
    • Bishop, D. K. RecA homologs Dmc1 and rad51 interact to form multiple nuclear complexes prior to meiotic chromosome synapsis. Cell 79, 1081-1092 (1994).
    • (1994) Cell , vol.79 , pp. 1081-1092
    • Bishop, D.K.1
  • 22
    • 0028886603 scopus 로고
    • Role of two RecA homologs in promoting meiotic chromosome synapsis
    • Rockmill, B., Sym, M., Schertham, H. & Roeder, G. S. Role of two RecA homologs in promoting meiotic chromosome synapsis. Genes Dev. 9, 2684-2695 (1995).
    • (1995) Genes Dev. , vol.9 , pp. 2684-2695
    • Rockmill, B.1    Sym, M.2    Schertham, H.3    Roeder, G.S.4
  • 24
    • 0017739051 scopus 로고
    • Gastrulation in the mouse: Growth and regionalization of the epiblast
    • Snow, M. L. H. Gastrulation in the mouse: Growth and regionalization of the epiblast. J. Embryol. Exp. Morph. 42, 293-303 (1977).
    • (1977) J. Embryol. Exp. Morph. , vol.42 , pp. 293-303
    • Snow, M.L.H.1
  • 25
    • 0027209231 scopus 로고
    • Onset of gastrulation, morphogenesis and somitogenesis in mouse embryos displaying compensatory growth
    • Power, M.-A. & Tam, P. P. L. Onset of gastrulation, morphogenesis and somitogenesis in mouse embryos displaying compensatory growth. Anat. Embryol. 187, 493-504 (1993).
    • (1993) Anat. Embryol. , vol.187 , pp. 493-504
    • Power, M.-A.1    Tam, P.P.L.2
  • 26
    • 0028105106 scopus 로고
    • Homotypic and heterotypic protein associations control Rad51 function in double-strand break repair
    • Donovan, J. W., Milne, C. T. & Weaver, T. D. Homotypic and heterotypic protein associations control Rad51 function in double-strand break repair. Genes Dev. 8, 2552-2562 (1994).
    • (1994) Genes Dev. , vol.8 , pp. 2552-2562
    • Donovan, J.W.1    Milne, C.T.2    Weaver, T.D.3
  • 27
    • 15844371372 scopus 로고    scopus 로고
    • The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse
    • Hakem, R. et al. The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell 85, 1009-1023 (1996).
    • (1996) Cell , vol.85 , pp. 1009-1023
    • Hakem, R.1
  • 28
    • 0029784528 scopus 로고    scopus 로고
    • Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development
    • Liu, C. Y., Flesken-Nikitin, A., Li, S., Zeng, Y. & Lee W.-H. Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development. Genes Dev. 10, 1835-1843 (1996).
    • (1996) Genes Dev. , vol.10 , pp. 1835-1843
    • Liu, C.Y.1    Flesken-Nikitin, A.2    Li, S.3    Zeng, Y.4    Lee, W.-H.5
  • 29
    • 0025832422 scopus 로고
    • Allelotype of human breast carcinoma: A second major site for loss of heterozygosity is on chromosome 6q
    • Devilee, P. et al. Allelotype of human breast carcinoma: a second major site for loss of heterozygosity is on chromosome 6q. Oncogene 6, 1705-1711 (1991).
    • (1991) Oncogene , vol.6 , pp. 1705-1711
    • Devilee, P.1
  • 30
    • 9244225624 scopus 로고    scopus 로고
    • Evidence for a novel tumor suppressor gene on chromosome 15 associated with progression to a metastic stage in breast cancer
    • Wick, W. et al. Evidence for a novel tumor suppressor gene on chromosome 15 associated with progression to a metastic stage in breast cancer. Oncogene 12, 973-978 (1996).
    • (1996) Oncogene , vol.12 , pp. 973-978
    • Wick, W.1
  • 31
    • 0028797399 scopus 로고
    • The cellular response to DNA damage
    • Carr, A. M. & Hoekstra, M. F. The cellular response to DNA damage. Trends Cell Biol. 5, 32-40 (1995).
    • (1995) Trends Cell Biol. , vol.5 , pp. 32-40
    • Carr, A.M.1    Hoekstra, M.F.2
  • 32
    • 0027182741 scopus 로고
    • WT-1 is required for early kidney development
    • Kreidberg, J. A. et al. WT-1 is required for early kidney development. Cell 74, 679-791 (1993).
    • (1993) Cell , vol.74 , pp. 679-791
    • Kreidberg, J.A.1
  • 33
    • 0028174064 scopus 로고
    • Heterozygous Rb-1 delta20/+ mice are predisposed to tumors of the pituitary gland with nearly complete penetrance
    • Hu, N. et al. Heterozygous Rb-1 delta20/+ mice are predisposed to tumors of the pituitary gland with nearly complete penetrance. Oncogene 9, 1021-1027 (1994).
    • (1994) Oncogene , vol.9 , pp. 1021-1027
    • Hu, N.1
  • 34
    • 0027756014 scopus 로고
    • Association of the APC tumor suppressor protein with catenins
    • Su, L.-K., Vogelstein, B. & Kinzler, K. W. Association of the APC tumor suppressor protein with catenins. Science 262, 1734-1737 (1993).
    • (1993) Science , vol.262 , pp. 1734-1737
    • Su, L.-K.1    Vogelstein, B.2    Kinzler, K.W.3
  • 35
    • 0028978672 scopus 로고
    • High susceptibility to ultraviolet-induced carcinogenesis in mice lacking XPC
    • Sands, A. T., Abuin, A., Sanchez, A., Conti, C. J. & Bradley, A. High susceptibility to ultraviolet-induced carcinogenesis in mice lacking XPC. Nature 377, 162-165 (1995).
    • (1995) Nature , vol.377 , pp. 162-165
    • Sands, A.T.1    Abuin, A.2    Sanchez, A.3    Conti, C.J.4    Bradley, A.5
  • 36
    • 0029083409 scopus 로고
    • Increased susceptibility to ultraviolet B and carcinogenesis of mice lacking the DNA excision repair gene XPA
    • de Vries, A. et al. Increased susceptibility to ultraviolet B and carcinogenesis of mice lacking the DNA excision repair gene XPA. Nature 377, 169-173 (1995).
    • (1995) Nature , vol.377 , pp. 169-173
    • De Vries, A.1
  • 37
    • 0026561121 scopus 로고
    • Mice deficient for p53 are normal but susceptible to spontaneous tumours
    • Donehower, L. A. et al. Mice deficient for p53 are normal but susceptible to spontaneous tumours. Nature 356, 215-221 (1992).
    • (1992) Nature , vol.356 , pp. 215-221
    • Donehower, L.A.1
  • 38
    • 0026621796 scopus 로고
    • α-Inhibin is a tumour-suppressor gene with agonadal specificity in mice
    • Matzuk, M. M., Finegold, M. J., Su, J.-G. J., Hsueh, A. J. W. & Bradley, A. α-Inhibin is a tumour-suppressor gene with agonadal specificity in mice. Nature 360, 313-319 (1992).
    • (1992) Nature , vol.360 , pp. 313-319
    • Matzuk, M.M.1    Finegold, M.J.2    Su, J.-G.J.3    Hsueh, A.J.W.4    Bradley, A.5
  • 41
    • 0025950213 scopus 로고
    • wis mutant embryos
    • wis mutant embryos. Development 120, 913-917 (1991).
    • (1991) Development , vol.120 , pp. 913-917
    • Herrmann, B.G.1
  • 42
    • 0027251721 scopus 로고
    • The retinoblastoma protein associates with the protein phsophatase type 1 catalytic subunit
    • Durfee, T. et al. The retinoblastoma protein associates with the protein phsophatase type 1 catalytic subunit. Genes Dev. 7, 555-569 (1993).
    • (1993) Genes Dev. , vol.7 , pp. 555-569
    • Durfee, T.1
  • 43
    • 0028263738 scopus 로고
    • Construction of an improved host strain for two hydbrid screening
    • Feilotter, H. E., Hannon, G. J., Ruddell, C. J. & Beach, D. Construction of an improved host strain for two hydbrid screening. Nucleic Acids. Res. 22, 1502-1503 (1994).
    • (1994) Nucleic Acids. Res. , vol.22 , pp. 1502-1503
    • Feilotter, H.E.1    Hannon, G.J.2    Ruddell, C.J.3    Beach, D.4
  • 45
    • 0020645052 scopus 로고
    • Yeast promoters and lacZ fusions designed to study expression of cloned genes in yeast
    • Guarente, L. Yeast promoters and lacZ fusions designed to study expression of cloned genes in yeast. Meth. Enzymol. 101, 181-191 (1983).
    • (1983) Meth. Enzymol. , vol.101 , pp. 181-191
    • Guarente, L.1
  • 46
    • 0003785155 scopus 로고
    • Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
    • Miller, J. H. in Experiments in Molecular Genetics 352-355 (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1972).
    • (1972) Experiments in Molecular Genetics , pp. 352-355
    • Miller, J.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.