Breast and Ovarian Cancer Risks Due to Inherited Mutations in BRCA1 and BRCA2

Science

Volumn 302, Issue 5645, 2003, Pages 643-646

  King, Mary Claire ^a   Marks, Joan H ^b   Mandell, Jessica B ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b SARAH LAWRENCE COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENES; HEALTH RISKS; MUTAGENESIS; TUMORS;

MOLECULAR ANALYSIS;

BIOMEDICAL ENGINEERING;

CANCER; MUTATION;

ADULT; AGED; ARTICLE; BRCA2 GENE; BREAST CANCER; CANCER RISK; CONTROLLED STUDY; EXERCISE; FAMILY HISTORY; FEMALE; GENE MUTATION; GENETIC ANALYSIS; HETEROZYGOTE; HUMAN; INHERITANCE; JEW; MAJOR CLINICAL STUDY; OBESITY; ONCOGENE; ONSET AGE; OVARY CANCER; PENETRANCE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

AGE OF ONSET; ALLELES; BREAST NEOPLASMS; COHORT STUDIES; EXERCISE; FAMILY; FATHERS; FEMALE; GENES, BRCA1; GENES, BRCA2; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HETEROZYGOTE; HUMANS; INCIDENCE; JEWS; LIFE STYLE; MALE; MUTATION; OBESITY; OVARIAN NEOPLASMS; PENETRANCE; RISK; RISK ASSESSMENT; TIME FACTORS;

EID: 0142178215     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1088759     Document Type: Article

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29. This project was supported by the Breast Cancer. Research Foundation and by the Department of Defense Breast Cancer Research Program (project 17-98-18257). We especially thank E. Lauder for ongoing support. The authors are grateful to the more than 100 graduate students of the Human Genetics Program at Sarah Lawrence College who were instrumental in bringing this project to fruition.