The utility F-box for protein destruction

Cellular and Molecular Life Sciences

Volumn 65, Issue 13, 2008, Pages 1977-2000

  Ho, M S ^a   Ou, C ^a   Chan, Y R ^a   Chien, C T ^a   Pi, H ^b  

^a INSTITUTE OF MOLECULAR BIOLOGY   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

26S proteasome; F box; Protein degradation; SCF; Ubiquitination

Indexed keywords

ANAPLASTIC LYMPHOMA KINASE; AUXIN; CARRIER PROTEINS AND BINDING PROTEINS; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN E; DNA BINDING PROTEIN; F BOX PROTEIN; GLUTAMATE RECEPTOR 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIGASE; MYC PROTEIN; PARKIN; PHYTOHORMONE; PROTEIN BETA TRCP; PROTEIN COI1; PROTEIN CULLIN 1; PROTEIN EBF; PROTEIN EIN3; PROTEIN FBW7; PROTEIN FSN 1; PROTEIN JAZ; PROTEIN LIN 23; PROTEIN P53; PROTEIN SEL 10; PROTEIN SLY1; PROTEIN TIR1; S PHASE KINASE ASSOCIATED PROTEIN 2; SONIC HEDGEHOG PROTEIN; UBIQUITIN PROTEIN LIGASE E3; WNT PROTEIN;

APOPTOSIS; CAENORHABDITIS ELEGANS; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CIRCADIAN RHYTHM; COMPLEX FORMATION; CRYSTAL STRUCTURE; DIMERIZATION; DROSOPHILA; GENOMIC INSTABILITY; HOST RESISTANCE; HUMAN; MORPHOGENESIS; NERVE CELL; NONHUMAN; PLANT ROOT; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; PROTEIN TARGETING; REVIEW; SIGNAL TRANSDUCTION; SYNAPSE; UBIQUITINATION;

ANIMALS; ARABIDOPSIS; CAENORHABDITIS ELEGANS; CELL CYCLE; CIRCADIAN RHYTHM; DIMERIZATION; DROSOPHILA MELANOGASTER; F-BOX PROTEINS; GENOMIC INSTABILITY; HOST-PATHOGEN INTERACTIONS; MODELS, BIOLOGICAL; MULTIPROTEIN COMPLEXES; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; SKP CULLIN F-BOX PROTEIN LIGASES; SYNAPSES; UBIQUITINATION;

EID: 46449129104     PISSN: 1420682X     EISSN: 15691632     Source Type: Journal    
DOI: 10.1007/s00018-008-7592-6     Document Type: Review

References (212)

1. Kumar A. and Paietta J. V. (1995) The sulfur controller-2 negative regulatory gene of Neurospora crassa encodes a protein with beta-transducin repeats. Proc. Natl. Acad. Sci. USA 92, 3343-3347.
2. Bai C., Sen P., Hofmann K., Ma L., Goebl M., Harper J. W. & Elledge S. J. (1996) SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell 86, 263-274.
3. Durfee T., Becherer K., Chen P. L., Yeh S. H., Yang Y., Kilburn A. E., Lee W. H. & Elledge S. J. (1993) The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. Genes Dev. 7, 555-569.
4. Harper J. W., Adami G. R., Wei N., Keyomarsi K. & Elledge S. J. (1993) The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75, 805-816.
5. Cenciarelli C., Chiaur D. S., Guardavaccaro D., Parks W., Vidal M. & Pagano M. (1999) Identification of a family of human F-box proteins. Curr. Biol. 9, 1177-1179.
6. Ho M. S., Tsai P. I. & Chien C. T. (2006) F-box proteins: the key to protein degradation. J. Biomed. Sci. 13, 181-191.
7. Kipreos E. T. & Pagano M. (2000) The F-box protein family. Genome Biol. 1, REVIEWS3002.
8. Winston J. T., Koepp D. M., Zhu C., Elledge S. J. & Harper J. W. (1999) A family of mammalian F-box proteins. Curr. Biol. 9, 1180-1182.
9. Patton E. E., Willems A. R. & Tyers M. (1998) Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the Fbox hypothesis. Trends Genet. 14, 236-243.
10. Skowyra D., Craig K. L., Tyers M., Elledge S. J. & Harper J. W. (1997) F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91, 209-219.
11. Enkhbayar P., Kamiya M., Osaki M., Matsumoto T. & Matsushima N. (2004) Structural principles of leucine-rich repeat (LRR) proteins. Proteins 54, 394-403.
12. Kobe B. & Kajava A. V. (2001) The leucine-rich repeat as a protein recognition motif. Curr. Opin. Struct. Biol. 11, 725-732.
13. Smith T. F., Gaitatzes C., Saxena K. & Neer E. J. (1999) The WD repeat: a common architecture for diverse functions. Trends Biochem. Sci. 24, 181-185.
14. Cardozo T. & Pagano M. (2004) The SCF ubiquitin ligase: insights into amolecular machine. Nat. Rev. Mol. Cell. Biol. 5, 739-751.
15. Orlicky S., Tang X., Willems A., Tyers M. & Sicheri F. (2003) Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase. Cell 112, 243-256.
16. Zheng N., Schulman B. A., Song L., Miller J. J., Jeffrey P. D., Wang P., Chu C., Koepp D. M., Elledge S. J., Pagano M., Conaway R. C., Conaway J. W., Harper J. W. & Pavletich N. P. (2002) Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature 416, 703-709.
17. Spencer E., Jiang J. & Chen Z. J. (1999) Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/ beta-TrCP. Genes Dev. 13, 284-294.
18. Winston J. T., Strack P., Beer-Romero P., Chu C. Y., Elledge S. J. & Harper J. W. (1999) The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro. Genes Dev. 13, 270-283.
19. Yaron A., Hatzubai A., Davis M., Lavon I., Amit S., Manning A. M., Andersen J. S., Mann M., Mercurio F. & Ben-Neriah Y. (1998) Identification of the receptor component of the IkappaBalpha-ubiquitin ligase. Nature 396, 590-594.
20. Hao B., Oehlmann S., Sowa M. E., Harper J. W. & Pavletich N. P. (2007) Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases. Mol. Cell 26, 131-143.
21. Koepp D. M., Schaefer L. K., Ye X., Keyomarsi K., Chu C., Harper J. W. & Elledge S. J. (2001) Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase. Science 294, 173-177.
22. Nash P., Tang X., Orlicky S., Chen Q., Gertler F. B., Mendenhall M. D., Sicheri F., Pawson T. & Tyers M. (2001) Multisite phosphorylation of a CDKinhibitor sets a threshold for the onset of DNA replication. Nature 414, 514-521.
23. Suzuki H., Chiba T., Suzuki T., Fujita T., Ikenoue T., Omata M., Furuichi K., Shikama H. & Tanaka K. (2000) Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination. J. Biol. Chem. 275, 2877-2884.
24. Moberg K. H., Bell D. W., Wahrer D. C., Haber D. A. & Hariharan I. K. (2001) Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines. Nature 413, 311-316.
25. Spruck C. H., Strohmaier H., Sangfelt O., Muller H. M., Hubalek M., Muller-Holzner E., Marth C., Widschwendter M. & Reed S. I. (2002) hCDC4 gene mutations in endometrial cancer. Cancer Res. 62, 4535-4539.
26. Strohmaier H., Spruck C. H., Kaiser P., Won K. A., Sangfelt O. & Reed S. I. (2001) Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line. Nature 413, 316-322.
27. Welcker M. & Clurman B. E. (2007) Fbw7/hCDC4 dimerization regulates its substrate interactions. Cell Div. 2, 7.
28. Chew E. H., Poobalasingam T., Hawkey C. J. & Hagen T. (2007) Characterization of cullin-based E3 ubiquitin ligases in intact mammalian cells - evidence for cullin dimerization. Cell Signal 19, 1071-1080.
29. Kominami K., Ochotorena I. & Toda T. (1998) Two F-box/ WD-repeat proteins Pop1 and Pop2 form hetero- and homocomplexes together with cullin-1 in the fission yeast SCF (Skp1-Cullin-1-F-box) ubiquitin ligase. Genes Cells 3, 721-735.
30. Seibert V., Prohl C., Schoultz I., Rhee E., Lopez R., Abderazzaq K., Zhou C. &Wolf D. A. (2002) Combinatorial diversity of fission yeast SCF ubiquitin ligases by homo- and heterooligomeric assemblies of the F-box proteins Pop1p and Pop2p. BMC Biochem. 3, 22.
31. Wolf D. A., McKeon F. & Jackson P. K. (1999) Budding yeast Cdc6p induces re-replication in fission yeast by inhibition of SCF(Pop)-mediated proteolysis. Mol. Gen. Genet. 262, 473-480.
32. Cope G. A. & Deshaies R. J. (2003) COP9 signalosome: a multifunctional regulator of SCF and other cullin-based ubiquitin ligases. Cell 114, 663-671.
33. Lyapina S. A., Correll C. C., Kipreos E. T. & Deshaies R. J. (1998) Human CUL1 forms an evolutionarily conserved ubiquitin ligase complex (SCF) with SKP1 and an F-box protein. Proc. Natl. Acad. Sci. USA 95, 7451-7456.
34. Wu J. T., Chan Y. R. & Chien C. T. (2006) Protection of cullin-RING E3 ligases by CSN-UBP12. Trends Cell Biol. 16, 362-369.
35. Bornstein G., Ganoth D. & Hershko A. (2006) Regulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrate. Proc. Natl. Acad. Sci. USA 103, 11515-11520.
36. Liu J., Furukawa M., Matsumoto T. & Xiong Y. (2002) NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases. Mol. Cell 10, 1511-1518.
37. Zheng J., Yang X., Harrell J. M., Ryzhikov S., Shim E. H., Lykke-Andersen K., Wei N., Sun H., Kobayashi R. & Zhang H. (2002)CAND1binds to unneddylated CUL1and regulates the formation of SCF ubiquitin E3 ligase complex. Mol. Cell 10, 1519-1526.
38. Abida W. M., Nikolaev A., Zhao W., Zhang W. & Gu W. (2007) FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity. J. Biol. Chem. 282, 1797-1804.
39. Galan J. M. & Peter M. (1999) Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism. Proc. Natl. Acad. Sci. USA 96, 9124-9129.
40. Zhou P. & Howley P. M. (1998) Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligases. Mol. Cell 2, 571-580.
41. Mathias N., Johnson S., Byers B. & Goebl M. (1999) The abundance of cell cycle regulatory protein Cdc4p is controlled by interactions between its F box and Skp1p. Mol. Cell. Biol 19, 1759-1767.
42. Wirbelauer C., Sutterluty H., Blondel M., Gstaiger M., Peter M., Reymond F. & Krek W. (2000) The F-box protein Skp2 is a ubiquitylation target of a Cul1-based core ubiquitin ligase complex: evidence for a role of Cul1 in the suppression of Skp2 expression in quiescent fibroblasts. EMBO J. 19, 5362-5375.
43. Li Y., Gazdoiu S., Pan Z. Q. & Fuchs S. Y. (2004) Stability of homologue of Slimb F-box protein is regulated by availability of its substrate. J. Biol. Chem. 279, 11074-11080.
44. Cope G. A. & Deshaies R. J. (2006) Targeted silencing of Jab1/ Csn5 in human cells downregulates SCF activity through reduction of F-box protein levels. BMC Biochem. 7, 1.
45. Wee S., Geyer R. K., Toda T. & Wolf D. A. (2005) CSN facilitates Cullin-RING ubiquitin ligase function by counter-acting autocatalytic adapter instability. Nat. Cell Biol. 7, 387-391.
46. Hermand D. (2006) F-box proteins: more than baits for the SCF? Cell Div. 1, 30.
47. Durr M., Escobar-Henriques M., Merz S., Geimer S., Langer T. & Westermann B. (2006) Nonredundant roles of mitochondria-associated F-box proteins Mfb1 and Mdm30 in maintenance of mitochondrial morphology in yeast. Mol. Biol. Cell 17, 3745-3755.
48. Kitagawa K., Skowyra D., Elledge S. J., Harper J. W. & Hieter P. (1999) SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex. Mol. Cell 4, 21-33.
49. Kim J., Kim J. H., Lee S. H., Kim D. H., Kang H. Y., Bae S. H., Pan Z. Q. & Seo Y. S. (2002) The novel human DNA helicase hFBH1 is an F-box protein. J. Biol. Chem. 277, 24530-24537.
50. Kim J. H., Kim J., Kim D. H., Ryu G. H., Bae S. H. & Seo Y. S. (2004) SCFhFBH1 can act as helicase and E3 ubiquitin ligase. Nucleic Acids Res. 32, 2287-2297.
51. Harrison C., Katayama S., Dhut S., Chen D., Jones N., Bahler J. & Toda T. (2005) SCF(Pof1)-ubiquitin and its target Zip1 transcription factor mediate cadmium response in fission yeast. EMBO J. 24, 599-610.
52. Tafforeau L., Le Blastier S., Bamps S., Dewez M., Vandenhaute J. & Hermand D. (2006) Repression of ergosterol level during oxidative stress by fission yeast F-box protein Pof14 independently of SCF. EMBO J. 25, 4547-4556.
53. Collins G. A. & Tansey W. P. (2006) The proteasome: a utility tool for transcription? Curr. Opin. Genet. Dev. 16, 197-202.
54. Muratani M. & Tansey W. P. (2003) How the ubiquitin-proteasome system controls transcription. Nat. Rev. Mol. Cell. Biol. 4, 192-201.
55. Muratani M., Kung C., Shokat K. M. & Tansey W. P. (2005) The F box protein Dsg1/Mdm30 is a transcriptional coactivator that stimulates Gal4 turnover and cotranscriptional mRNA processing. Cell 120, 887-899.
56. Carrano A. C., Eytan E., Hershko A. & Pagano M. (1999) SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat. Cell Biol. 1, 193-199.
57. Pagano M., Tam S. W., Theodoras A. M., Beer-Romero P., Del Sal G., Chau V., Yew P. R., Draetta G. F. & Rolfe M. (1995) Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science 269, 682-685.
58. Sutterluty H., Chatelain E., Marti A., Wirbelauer C., Senften M., Muller U. & Krek W. (1999) p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells. Nat. Cell Biol. 1, 207-214.
59. Tsvetkov L. M., Yeh K. H., Lee S. J., Sun H. & Zhang H. (1999) p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27. Curr. Biol. 9, 661-664.
60. Montagnoli A., Fiore F., Eytan E., Carrano A. C., Draetta G. F., Hershko A. & Pagano M. (1999) Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation. Genes Dev. 13, 1181-1189.
61. Vlach J., Hennecke S. & Amati B. (1997) Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27. EMBO J. 16, 5334-5344.
62. Nakayama K., Nagahama H., Minamishima Y. A., Matsumoto M., Nakamichi I., Kitagawa K., Shirane M., Tsunematsu R., Tsukiyama T., Ishida N., Kitagawa M., Nakayama K. & Hatakeyama S. (2000) Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. EMBO J. 19, 2069-2081.
63. Nakayama K., Nagahama H., Minamishima Y. A., Miyake S., Ishida N., Hatakeyama S., Kitagawa M., Iemura S., Natsume T. & Nakayama K. I. (2004) Skp2-mediated degradation of p27 regulates progression into mitosis. Dev. Cell 6, 661-672.
64. Reichert M., Saur D., Hamacher R., Schmid R. M. & Schneider G. (2007) Phosphoinositide-3-kinase signaling controls S-phase kinase-associated protein 2 transcription via E2F1 in pancreatic ductal adenocarcinoma cells. Cancer Res. 67, 4149-4156.
65. Zhang L. & Wang C. (2006) F-box protein Skp2: a novel transcriptional target of E2F. Oncogene 25, 2615-2627.
66. Wang W., Ungermannova D., Jin J., Harper J. W. & Liu X. (2004) Negative regulation of SCFSkp2 ubiquitin ligase by TGF-beta signaling. Oncogene 23, 1064-1075.
67. Ganoth D., Bornstein G., Ko T. K., Larsen B., Tyers M., Pagano M. & Hershko A. (2001) The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27. Nat. Cell Biol. 3, 321-324.
68. Bashir T., Dorrello N. V., Amador V., Guardavaccaro D. & Pagano M. (2004) Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase. Nature 428, 190-193.
69. Wei W., Ayad N. G., Wan Y., Zhang G. J., Kirschner M. W. & Kaelin W. G., Jr. (2004) Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex. Nature 428, 194-198.
70. Kim S. Y., Herbst A., Tworkowski K. A., Salghetti S. E. & Tansey W. P. (2003) Skp2 regulates Myc protein stability and activity. Mol. Cell 11, 1177-1188.
71. von der Lehr N., Johansson S., Wu S., Bahram F., Castell A., Cetinkaya C., Hydbring P., Weidung I., Nakayama K., Nakayama K. I., Soderberg O., Kerppola T. K. & Larsson L. G. (2003) The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription. Mol. Cell 11, 1189-1200.
72. Welcker M., Orian A., Jin J., Grim J. E., Harper J. W., Eisenman R. N. & Clurman B. E. (2004) The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Proc. Natl. Acad. Sci. USA 101, 9085-9090.
73. Yada M., Hatakeyama S., Kamura T., Nishiyama M., Tsunematsu R., Imaki H., Ishida N., Okumura F., Nakayama K. & Nakayama K. I. (2004) Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. EMBO J. 23, 2116-2125.
74. Sears R., Nuckolls F., Haura E., Taya Y., Tamai K. & Nevins J. R. (2000) Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev. 14, 2501-2514.
75. Bahram F., von der Lehr N., Cetinkaya C. & Larsson L. G. (2000) c-Myc hot spot mutations in lymphomas result in inefficient ubiquitination and decreased proteasome-mediated turnover. Blood 95, 2104-2110.
76. Reed S. I. (2003) Ratchets and clocks: the cell cycle, ubiquitylation and protein turnover. Nat. Rev. Mol. Cell. Biol. 4, 855-864.
77. Winston J. T., Chu C. & Harper J. W. (1999) Culprits in the degradation of cyclin E apprehended. Genes Dev. 13, 2751-2757.
78. Singer J. D., Gurian-West M., Clurman B. & Roberts J. M. (1999) Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells. Genes Dev. 13, 2375-2387.
79. Yeh K. H., Kondo T., Zheng J., Tsvetkov L. M., Blair J. & Zhang H. (2001) The F-box protein SKP2 binds to the phosphorylated threonine 380 in cyclin E and regulates ubiquitin-dependent degradation of cyclin E. Biochem. Biophys. Res. Commun. 281, 884-890.
80. Reed S. I. (2006) Cooperation between different Cdc4/Fbw7 isoforms may be associated with 2-step inactivation of SCF(Cdc4) targets. Cell Cycle 5, 1923-1924.
81. van Drogen F., Sangfelt O., Malyukova A., Matskova L., Yeh E., Means A. R. & Reed S. I. (2006) Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms. Mol. Cell 23, 37-48.
82. Welcker M., Orian A., Grim J. E., Eisenman R. N. & Clurman B. E. (2004) A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size. Curr. Biol. 14, 1852-1857.
83. Guardavaccaro D., Kudo Y., Boulaire J., Barchi M., Busino L., Donzelli M., Margottin-Goguet F., Jackson P. K., Yamasaki L. & Pagano M. (2003) Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo. Dev. Cell 4, 799-812.
84. Nakayama K., Hatakeyama S., Maruyama S., Kikuchi A., Onoe K., Good R. A. & Nakayama K. I. (2003) Impaired degradation of inhibitory subunit of NF-kappa B (I kappa B) and beta-catenin as a result of targeted disruption of the beta-TrCP1 gene. Proc. Natl. Acad. Sci. USA 100, 8752-8757.
85. Reimann J. D., Freed E., Hsu J. Y., Kramer E. R., Peters J. M. & Jackson P. K. (2001) Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Cell 105, 645-655.
86. Reimann J. D., Gardner B. E., Margottin-Goguet F. & Jackson P. K. (2001) Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins. Genes Dev. 15, 3278-3285.
87. Hansen D. V., Loktev A. V., Ban K. H. & Jackson P. K. (2004) Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1. Mol. Biol. Cell 15, 5623-5634.
88. Margottin-Goguet F., Hsu J. Y., Loktev A., Hsieh H. M., Reimann J. D. & Jackson P. K. (2003) Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase. Dev. Cell 4, 813-826.
89. Moshe Y., Boulaire J., Pagano M. & Hershko A. (2004) Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/ cyclosome. Proc. Natl. Acad. Sci. USA 101, 7937-7942.
90. Ayad N. G., Rankin S., Murakami M., Jebanathirajah J., Gygi S. & Kirschner M. W. (2003) Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC. Cell 113, 101-113.
91. Watanabe N., Arai H., Nishihara Y., Taniguchi M., Watanabe N., Hunter T. & Osada H. (2004) M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP. Proc. Natl. Acad. Sci. USA 101, 4419-4424.
92. Busino L., Donzelli M., Chiesa M., Guardavaccaro D., Ganoth D., Dorrello N. V., Hershko A., Pagano M. & Draetta G. F. (2003) Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. Nature 426, 87-91.
93. Jin J., Shirogane T., Xu L., Nalepa G., Qin J., Elledge S. J. & Harper J. W. (2003) SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. Genes Dev. 17, 3062-3074.
94. DiAntonio A., Haghighi A. P., Portman S. L., Lee J. D., Amaranto A. M. & Goodman C. S. (2001) Ubiquitination-dependent mechanisms regulate synaptic growth and function. Nature 412, 449-452.
95. DiAntonio A. & Hicke L. (2004) Ubiquitin-dependent regulation of the synapse. Annu. Rev. Neurosci. 27, 223-246.
96. Hegde A. N. & DiAntonio A. (2002) Ubiquitin and the synapse. Nat. Rev. Neurosci. 3, 854-861.
97. Patrick G. N. (2006) Synapse formation and plasticity: recent insights from the perspective of the ubiquitin proteasome system. Curr. Opin. Neurobiol. 16, 90-94.
98. Liao E. H., Hung W., Abrams B. & Zhen M. (2004) An SCF-like ubiquitin ligase complex that controls presynaptic differentiation. Nature 430, 345-350.
99. Schaefer A. M., Hadwiger G. D. & Nonet M. L. (2000) rpm-1, a conserved neuronal gene that regulates targeting and synaptogenesis in C. elegans. Neuron 26, 345-356.
100. Zhen M., Huang X., Bamber B. & Jin Y. (2000) Regulation of presynaptic terminal organization by C. elegans RPM-1, a putative guanine nucleotide exchanger with a RING-H2 finger domain. Neuron 26, 331-343.
101. Kipreos E. T., Gohel S. P. & Hedgecock E. M. (2000) The C. elegans F-box/WD-repeat protein LIN-23 functions to limit cell division during development. Development 127, 5071-5082.
102. Mehta N., Loria P. M. & Hobert O. (2004) Agenetic screen for neurite outgrowth mutants in Caenorhabditis elegans reveals a new function for the F-box ubiquitin ligase component LIN-23. Genetics 166, 1253-1267.
103. Tanaka H., Yamashita T., Asada M., Mizutani S., Yoshikawa H. & Tohyama M. (2002) Cytoplasmic p21(Cip1/WAF1) regulates neurite remodeling by inhibiting Rho-kinase activity. J. Cell Biol. 158, 321-329.
104. Dreier L., Burbea M. & Kaplan J. M. (2005) LIN-23-mediated degradation of beta-catenin regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of C. elegans. Neuron 46, 51-64.
105. Burbea M., Dreier L., Dittman J. S., Grunwald M. E. & Kaplan J. M. (2002) Ubiquitin and AP180 regulate the abundance of GLR-1 glutamate receptors at postsynaptic elements in C. elegans. Neuron 35, 107-120.
106. Juo P. & Kaplan J. M. (2004) The anaphase-promoting complex regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of C. elegans. Curr. Biol. 14, 2057-2062.
107. Ding M., Chao D., Wang G. & Shen K. (2007) Spatial regulation of an E3 ubiquitin ligase directs selective synapse elimination. Science 317, 947-951.
108. Shen K. & Bargmann C. I. (2003) The immunoglobulin superfamily protein SYG-1 determines the location of specific synapses in C. elegans. Cell 112, 619-630.
109. Shen K., Fetter R. D. & Bargmann C. I. (2004) Synaptic specificity is generated by the synaptic guidepost protein SYG-2 and its receptor, SYG-1. Cell 116, 869-881.
110. Imai Y., Soda M. & Takahashi R. (2000) Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity. J. Biol. Chem. 275, 35661-35664.
111. Shimura H., Hattori N., Kubo S., Mizuno Y., Asakawa S., Minoshima S., Shimizu N., Iwai K., Chiba T., Tanaka K. & Suzuki T. (2000) Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat. Genet. 25, 302-305.
112. Zhang Y., Gao J., Chung K. K., Huang H., Dawson V. L. & Dawson T. M. (2000) Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1. Proc. Natl. Acad. Sci. USA 97, 13354-13359.
113. Staropoli J. F., McDermott C., Martinat C., Schulman B., Demireva E.&Abeliovich A. (2003) Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity. Neuron 37, 735-749.
114. Jiang J. & Struhl G. (1998) Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb. Nature 391, 493-496.
115. Baeuerle P. A. & Baltimore D. (1996) NF-kappa B: ten years after. Cell 87, 13-20.
116. Baldwin A. S., Jr. (1996) The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu. Rev. Immunol. 14, 649-683.
117. Maniatis T. (1999) Aubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedgehog signaling pathways. Genes Dev. 13, 505-510.
118. Moberg K. H., Mukherjee A., Veraksa A., Artavanis-Tsakonas S. & Hariharan I. K. (2004) The Drosophila F box protein archipelago regulates dMyc protein levels in vivo. Curr. Biol. 14, 965-974.
119. Mortimer N. T. & Moberg K. H. (2007) The Drosophila F-box protein Archipelago controls levels of the Trachealess transcription factor in the embryonic tracheal system. Dev. Biol. 312, 560-571.
120. Ruegger M., Dewey E., Gray W. M., Hobbie L., Turner J. & Estelle M. (1998) The TIR1 protein of Arabidopsis functions in auxin response and is related to human SKP2 and yeast grr1p. Genes Dev. 12, 198-207.
121. Gray W. M., del Pozo J. C., Walker L., Hobbie L., Risseeuw E., Banks T., Crosby W. L., Yang M., Ma H. & Estelle M. (1999) Identification of an SCF ubiquitin-ligase complex required for auxin response in Arabidopsis thaliana. Genes Dev. 13, 1678-1691.
122. Quint M. & Gray W. M. (2006) Auxin signaling. Curr. Opin. Plant Biol. 9, 448-453.
123. Ramos J. A., Zenser N., Leyser O. & Callis J. (2001) Rapid degradation of auxin/indoleacetic acid proteins requires conserved amino acids of domain II and is proteasome dependent. Plant Cell 13, 2349-2360.
124. Dharmasiri N., Dharmasiri S., Jones A. M. & Estelle M. (2003) Auxin action in a cell-free system. Curr. Biol. 13, 1418-1422.
125. Yang X., Lee S., So J. H., Dharmasiri S., Dharmasiri N., Ge L., Jensen C., Hangarter R., Hobbie L. & Estelle M. (2004) The IAA1 protein is encoded by AXR5 and is a substrate of SCF(TIR1). Plant J. 40, 772-782.
126. Dharmasiri N., Dharmasiri S. & Estelle M. (2005) The F-box protein TIR1 is an auxin receptor. Nature 435, 441-445.
127. Kepinski S. & Leyser O. (2005) The Arabidopsis F-box protein TIR1 is an auxin receptor. Nature 435, 446-451.
128. Tan X., Calderon-Villalobos L. I., Sharon M., Zheng C., Robinson C. V., Estelle M. & Zheng N. (2007) Mechanism of auxin perception by the TIR1 ubiquitin ligase. Nature 446, 640-645.
129. Dharmasiri N., Dharmasiri S., Weijers D., Lechner E., Yamada M., Hobbie L., Ehrismann J. S., Jurgens G. & Estelle M. (2005) Plant development is regulated by a family of auxin receptor F box proteins. Dev. Cell 9, 109-119.
130. Walsh T. A., Neal R., Merlo A. O., Honma M., Hicks G. R., Wolff K., Matsumura W. & Davies J. P. (2006) Mutations in an auxin receptor homolog AFB5 and in SGT1b confer resistance to synthetic picolinate auxins and not to 2,4-dichlorophenoxyacetic acid or indole-3-acetic acid in Arabidopsis. Plant Physiol. 142, 542-552.
131. Xu L., Liu F., Lechner E., Genschik P., Crosby W. L., Ma H., Peng W., Huang D. & Xie D. (2002) The SCF(COI1) ubiquitin-ligase complexes are required for jasmonate response in Arabidopsis. Plant Cell 14, 1919-1935.
132. Xie D. X., Feys B. F., James S., Nieto-Rostro M. & Turner J. G. (1998) COI1: an Arabidopsis gene required for jasmonate-regulated defense and fertility. Science 280, 1091-1094.
133. Chini A., Fonseca S., Fernandez G., Adie B., Chico J. M., Lorenzo O., Garcia-Casado G., Lopez-Vidriero I., Lozano F. M., Ponce M. R., Micol J. L. & Solano R. (2007) The JAZ family of repressors is the missing link in jasmonate signalling. Nature 448, 666-671.
134. Thines B., Katsir L., Melotto M., Niu Y., Mandaokar A., Liu G., Nomura K., He S. Y., Howe G. A. & Browse J. (2007) JAZ repressor proteins are targets of the SCF(COI1) complex during jasmonate signalling. Nature 448, 661-665.
135. Fleet C. M. & Sun T. P. (2005) ADELLAcate balance: the role of gibberellin in plant morphogenesis. Curr. Opin. Plant Biol. 8, 77-85.
136. McGinnis K. M., Thomas S. G., Soule J. D., Strader L. C., Zale J. M., Sun T. P. & Steber C. M. (2003) The Arabidopsis SLEEPY1 gene encodes a putative F-box subunit of an SCF E3 ubiquitin ligase. Plant Cell 15, 1120-1130.
137. Dill A., Thomas S. G., Hu J., Steber C. M. & Sun T. P. (2004) The Arabidopsis F-box protein SLEEPY1 targets gibberellin signaling repressors for gibberellin-induced degradation. Plant Cell 16, 1392-1405.
138. Sasaki A., Itoh H., Gomi K., Ueguchi-Tanaka M., Ishiyama K., Kobayashi M., Jeong D. H., An G., Kitano H., Ashikari M. & Matsuoka M. (2003) Accumulation of phosphorylated repressor for gibberellin signaling in an F-box mutant. Science 299, 1896-1898.
139. Strader L. C., Ritchie S., Soule J. D., McGinnis K. M. & Steber C. M. (2004) Recessive-interfering mutations in the gibberellin signaling gene SLEEPY1 are rescued by overexpression of its homologue, SNEEZY. Proc. Natl. Acad. Sci. USA 101, 12771-12776.
140. Fu X., Richards D. E., Fleck B., Xie D., Burton N. & Harberd N. P. (2004) The Arabidopsis mutant sleepy1gar2-1 protein promotes plant growth by increasing the affinity of the SCFSLY1 E3 ubiquitin ligase for DELLA protein substrates. Plant Cell 16, 1406-1418.
141. Schwager K. M., Calderon-Villalobos L. I., Dohmann E. M., Willige B. C., Knierer S., Nill C. & Schwechheimer C. (2007) Characterization of the VIER F-BOX PROTEINE genes from Arabidopsis reveals their importance for plant growth and development. Plant Cell 19, 1163-1178.
142. Griffiths J., Murase K., Rieu I., Zentella R., Zhang Z. L., Powers S. J., Gong F., Phillips A. L., Hedden P., Sun T. P. & Thomas S. G. (2006) Genetic characterization and functional analysis of the GID1 gibberellin receptors in Arabidopsis. Plant Cell 18, 3399-3414.
143. Ueguchi-Tanaka M., Ashikari M., Nakajima M., Itoh H., Katoh E., Kobayashi M., Chow T. Y., Hsing Y. I., Kitano H., Yamaguchi I. & Matsuoka M. (2005) GIBBERELLIN INSENSITIVE DWARF1 encodes a soluble receptor for gibberellin. Nature 437, 693-698.
144. Willige B. C., Ghosh S., Nill C., Zourelidou M., Dohmann E. M., Maier A. & Schwechheimer C. (2007) The DELLA domain of GA INSENSITIVE mediates the interaction with the GA INSENSITIVE DWARF1A gibberellin receptor of Arabidopsis. Plant Cell 19, 1209-1220.
145. Gagne J. M., Smalle J., Gingerich D. J., Walker J. M., Yoo S. D., Yanagisawa S. & Vierstra R. D. (2004) Arabidopsis EIN3-binding F-box 1 and 2 form ubiquitin-protein ligases that repress ethylene action and promote growth by directing EIN3 degradation. Proc. Natl. Acad. Sci. USA 101, 6803-6808.
146. Guo H. & Ecker J. R. (2003) Plant responses to ethylene gas are mediated by SCF(EBF1/EBF2)-dependent proteolysis of EIN3 transcription factor. Cell 115, 667-677.
147. Potuschak T., Lechner E., Parmentier Y., Yanagisawa S., Grava S., Koncz C. & Genschik P. (2003) EIN3-dependent regulation of plant ethylene hormone signaling by two Arabidopsis F box proteins: EBF1 and EBF2. Cell 115, 679-689.
148. Binder B. M., Walker J. M., Gagne J. M., Emborg T. J., Hemmann G., Bleecker A. B. & Vierstra R. D. (2007) The Arabidopsis EIN3 binding F-Box proteins EBF1 and EBF2 have distinct but overlapping roles in ethylene signaling. Plant Cell 19, 509-523.
149. Olmedo G., Guo H., Gregory B. D., Nourizadeh S. D., Aguilar-Henonin L., Li H., An F., Guzman P. & Ecker J. R. (2006) ETHYLENE-INSENSITIVE5 encodes a 5′ → 3′ exoribonuclease required for regulation of the EIN3-targeting F-box proteins EBF1/2. Proc. Natl. Acad. Sci. USA 103, 13286-13293.
150. Potuschak T., Vansiri A., Binder B. M., Lechner E., Vierstra R. D. & Genschik P. (2006) The exoribonuclease XRN4 is a component of the ethylene response pathway in Arabidopsis. Plant Cell 18, 3047-3057.
151. Ingram G. C., Doyle S., Carpenter R., Schultz E. A., Simon R. &Coen E. S. (1997) Dual role for fimbriata in regulating floral homeotic genes and cell division in Antirrhinum. EMBO J. 16, 6521-6534.
152. Samach A., Klenz J. E., Kohalmi S. E., Risseeuw E., Haughn G. W. & Crosby W. L. (1999) The UNUSUAL FLORAL ORGANS gene of Arabidopsis thaliana is an F-box protein required for normal patterning and growth in the floral meristem. Plant J. 20, 433-445.
153. Ni W., Xie D., Hobbie L., Feng B., Zhao D., Akkara J. & Ma H. (2004) Regulation of flower development in Arabidopsis by SCF complexes. Plant Physiol. 134, 1574-1585.
154. Stirnberg P., Furner I. J. & Ottoline Leyser H. M. (2007) MAX2 participates in an SCF complex which acts locally at the node to suppress shoot branching. Plant J. 50, 80-94.
155. Stirnberg P., van De Sande K. & Leyser H. M. (2002) MAX1 and MAX2 control shoot lateral branching in Arabidopsis. Development 129, 1131-1141.
156. Coates J. C., Laplaze L. & Haseloff J. (2006) Armadillo-related proteins promote lateral root development in Arabidopsis. Proc. Natl. Acad. Sci. USA 103, 1621-1626.
157. Dong L., Wang L., Zhang Y., Zhang Y., Deng X. & Xue Y. (2006) An auxin-inducible F-box protein CEGENDUO negatively regulates auxin-mediated lateral root formation in Arabidopsis. Plant Mol. Biol. 60, 599-615.
158. Takayama S.&Isogai A. (2005) Self-incompatibility in plants. Annu. Rev. Plant. Biol. 56, 467-489.
159. Qiao H., Wang F., Zhao L., Zhou J., Lai Z., Zhang Y., Robbins T. P. & Xue Y. (2004) The F-box protein AhSLF-S2 controls the pollen function of S-RNase-based self-incompatibility. Plant Cell 16, 2307-2322.
160. Sijacic P., Wang X., Skirpan A. L., Wang Y., Dowd P. E., McCubbin A. G., Huang S. & Kao T. H. (2004) Identification of the pollen determinant of S-RNase-mediated self-incompatibility. Nature 429, 302-305.
161. Huang J., Zhao L., Yang Q. & Xue Y. (2006) AhSSK1, a novel SKP1-like protein that interacts with the S-locus F-box protein SLF. Plant J. 46, 780-793.
162. Hua Z. & Kao T. H. (2006) Identification and characterization of components of a putative petunia S-locus F-box-containing E3 ligase complex involved in S-RNase-based self-incompatibility. Plant Cell 18, 2531-2553.
163. Qiao H., Wang H., Zhao L., Zhou J., Huang J., Zhang Y. & X ue Y. (2004) The F-box protein AhSLF-S2 physically interacts with S-RNases that may be inhibited by the ubiquitin/26S proteasome pathway of protein degradation during compatible pollination in Antirrhinum. Plant Cell 16, 582-595.
164. Sonneveld T., Tobutt K. R., Vaughan S. P. & Robbins T. P. (2005) Loss of pollen-S function in two self-compatible selections of Prunus avium is associated with deletion/ mutation of an S haplotype-specific F-box gene. Plant Cell 17, 37-51.
165. Ushijima K., Yamane H., Watari A., Kakehi E., Ikeda K., Hauck N. R., Iezzoni A. F. & Tao R. (2004) The S haplotype-specific F-box protein gene, SFB, is defective in self-compatible haplotypes of Prunus avium and P. mume. Plant J. 39, 573-586.
166. Dieterle M., Zhou Y. C., Schafer E., Funk M. & Kretsch T. (2001) EID1, an F-box protein involved in phytochrome Aspecific light signaling. Genes Dev. 15, 939-944.
167. Marrocco K., Zhou Y., Bury E., Dieterle M., Funk M., Genschik P., Krenz M., Stolpe T. & Kretsch T. (2006) Functional analysis of EID1, an F-box protein involved in phytochrome A-dependent light signal transduction. Plant J. 45, 423-438.
168. Harmon F. G. & Kay S. A. (2003) The F box protein AFR is a positive regulator of phytochrome A-mediated light signaling. Curr. Biol. 13, 2091-2096.
169. Somers D. E., Schultz T. F., Milnamow M. & Kay S. A. (2000) ZEITLUPE encodes a novel clock-associated PAS protein from Arabidopsis. Cell 101, 319-329.
170. Han L., Mason M., Risseeuw E. P., Crosby W. L. & Somers D. E. (2004) Formation of an SCF(ZTL) complex is required for proper regulation of circadian timing. Plant J. 40, 291-301.
171. Calhoun E. S., Jones J. B., Ashfaq R., Adsay V., Baker S. J., Valentine V., Hempen P. M., Hilgers W., Yeo C. J., Hruban R. H. & Kern S. E. (2003) BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets. Am. J. Pathol. 163, 1255-1260.
172. Kiba T., Henriques R., Sakakibara H. & Chua N. H. (2007) Targeted degradation of PSEUDO-RESPONSE REGULATOR5 by a SCFZTL complex regulates clock function and photomorphogenesis in Arabidopsis thaliana. Plant Cell.
173. Imaizumi T., Tran H. G., Swartz T. E., Briggs W. R. & Kay S. A. (2003) FKF1 is essential for photoperiodic-specific light signalling in Arabidopsis. Nature 426, 302-306.
174. Kim W. Y., Fujiwara S., Suh S. S., Kim J., Kim Y., Han L., David K., Putterill J., Nam H. G. & Somers D. E. (2007) ZEITLUPE is a circadian photoreceptor stabilized by GIGANTEA in blue light. Nature 449, 356-360.
175. Fowler S., Lee K., Onouchi H., Samach A., Richardson K., Morris B., Coupland G. & Putterill J. (1999) GIGANTEA: a circadian clock-controlled gene that regulates photoperiodic flowering in Arabidopsis and encodes a protein with several possible membrane-spanning domains. EMBO J. 18, 4679-4688.
176. Park D. H., Somers D. E., Kim Y. S., Choy Y. H., Lim H. K., Soh M. S., Kim H. J., Kay S. A. & Nam H. G. (1999) Control of circadian rhythms and photoperiodic flowering by the Arabidopsis GIGANTEA gene. Science 285, 1579-1582.
177. Yanovsky M. J. & Kay S. A. (2003) Living by the calendar: how plants know when to flower. Nat. Rev. Mol. Cell. Biol. 4, 265-275.
178. Imaizumi T., Schultz T. F., Harmon F. G., Ho L. A. & Kay S. A. (2005) FKF1 F-box protein mediates cyclic degradation of a repressor of CONSTANS in Arabidopsis. Science 309, 293-297.
179. Schultz T. F., Kiyosue T., Yanovsky M., Wada M. & Kay S. A. (2001) A role for LKP2 in the circadian clock of Arabidopsis. Plant Cell 13, 2659-2670.
180. Sawa M., Nusinow D. A., Kay S. A. & Imaizumi T. (2007) FKF1 and GIGANTEA complex formation is required for day-length measurement in Arabidopsis. Science 318, 261-265.
181. Ko C. H. & Takahashi J. S. (2006) Molecular components of the mammalian circadian clock. Hum. Mol. Genet. 15 Spec No. 2, R271-277.
182. Reppert S. M. & Weaver D. R. (2001) Molecular analysis of mammalian circadian rhythms. Annu. Rev. Physiol. 63, 647-676.
183. Wang G. K. & Sehgal A. (2002) Signaling components that drive circadian rhythms. Curr. Opin. Neurobiol. 12, 331-338.
184. Grima B., Lamouroux A., Chelot E., Papin C., Limbourg-Bouchon B. & Rouyer F. (2002) The F-box protein slimb controls the levels of clock proteins period and timeless. Nature 420, 178-182.
185. Jia J., Zhang L., Zhang Q., Tong C., Wang B., Hou F., Amanai K. & Jiang J. (2005) Phosphorylation by double-time/CK-Iepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing. Dev. Cell 9, 819-830.
186. Ko H. W., Jiang J. & Edery I. (2002) Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime. Nature 420, 673-678.
187. Shirogane T., Jin J., Ang X. L. & Harper J. W. (2005) SCF-beta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein. J. Biol. Chem. 280, 26863-26872.
188. Ashmore L. J. & Sehgal A. (2003) A fly's eye view of circadian entrainment. J. Biol. Rhythms 18, 206-216.
189. Lin F. J., Song W., Meyer-Bernstein E., Naidoo N. & Sehgal A. (2001) Photic signaling by cryptochrome in the Drosophila circadian system. Mol. Cell. Biol 21, 7287-7294.
190. Naidoo N., Song W., Hunter-Ensor M. & Sehgal A. (1999) A role for the proteasome in the light response of the timeless clock protein. Science 285, 1737-1741.
191. Martinek S., Inonog S., Manoukian A. S. & Young M. W. (2001) A role for the segment polarity gene shaggy/GSK-3 in the Drosophila circadian clock. Cell 105, 769-779.
192. Koh K., Zheng X. & Sehgal A. (2006) JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS. Science 312, 1809-1812.
193. VanGelder R. N. (2006) Timeless genes and jetlag. Proc. Natl. Acad. Sci. USA 103, 17583-17584.
194. Busino L., Bassermann F., Maiolica A., Lee C., Nolan P. M., Godinho S. I., Draetta G. F. & Pagano M. (2007) SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. Science 316, 900-904.
195. Godinho S. I., Maywood E. S., Shaw L., Tucci V., Barnard A. R., Busino L., Pagano M., Kendall R., Quwailid M. M., Romero M. R., O'Neill J., Chesham J. E., Brooker D., Lalanne Z., Hastings M. H. & Nolan P. M. (2007) The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period. Science 316, 897-900.
196. Siepka S. M., Yoo S. H., Park J., Song W., Kumar V., Hu Y., Lee C. & Takahashi J. S. (2007) Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression. Cell 129, 1011-1023.
197. Coadou G., Gharbi-Benarous J., Megy S., Bertho G., Evrard-Todeschi N., Segeral E., Benarous R. & Girault J. P. (2003) NMR studies of the phosphorylation motif of the HIV-1 protein Vpu bound to the F-box protein beta-TrCP. Biochemistry 42, 14741-14751.
198. Estrabaud E., Le Rouzic E., Lopez-Verges S., Morel M., Belaidouni N., Benarous R., Transy C., Berlioz-Torrent C. & Margottin-Goguet F. (2007) Regulated degradation of the HIV-1 Vpu protein through a betaTrCP-independent pathway limits the release of viral particles. PLoS Pathog. 3, e104.
199. Margottin F., Bour S. P., Durand H., Selig L., Benichou S., Richard V., Thomas D., Strebel K. & Benarous R. (1998) A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif. Mol. Cell 1, 565-574.
200. Welcker M. & Clurman B. E. (2005) The SV40 large Tantigen contains a decoy phosphodegron that mediates its interactions with Fbw7/hCdc4. J. Biol. Chem. 280, 7654-7658.
201. Voinnet O. (2005) Induction and suppression of RNA silencing: insights from viral infections. Nat. Rev. Genet. 6, 206-220.
202. Pazhouhandeh M., Dieterle M., Marrocco K., Lechner E., Berry B., Brault V., Hemmer O., Kretsch T., Richards K. E., Genschik P. & Ziegler-Graff V. (2006) F-box-like domain in the polerovirus protein P0 is required for silencing suppressor function. Proc. Natl. Acad. Sci. USA 103, 1994-1999.
203. Baumberger N., Tsai C. H., Lie M., Havecker E. & Baulcombe D. C. (2007) The polerovirus silencing suppressor P0 targets ARGONAUTE proteins for degradation. Curr. Biol. 17, 1609-1614.
204. Bortolamiol D., Pazhouhandeh M., Marrocco K., Genschik P. & Ziegler-Graff V. (2007) The polerovirus F box protein P0 targets ARGONAUTE1 to suppress RNA Silencing. Curr. Biol. 17, 1615-1621.
205. Schrammeijer B., Risseeuw E., Pansegrau W., Regensburg-Tuink T. J., Crosby W. L. & Hooykaas P. J. (2001) Interaction of the virulence protein VirF of Agrobacterium tumefaciens with plant homologs of the yeast Skp1 protein. Curr. Biol. 11, 258-262.
206. Tzfira T., Vaidya M. & Citovsky V. (2004) Involvement of targeted proteolysis in plant genetic transformation by Agrobacterium. Nature 431, 87-92.
207. Yoshida Y., Chiba T., Tokunaga F., Kawasaki H., Iwai K., Suzuki T., Ito Y., Matsuoka K., Yoshida M., Tanaka K. & Tai T. (2002) E3 ubiquitin ligase that recognizes sugar chains. Nature 418, 438-442.
208. Kato A., Rouach N., Nicoll R. A. & Bredt D. S. (2005) Activity-dependent NMDA receptor degradation mediated by retrotranslocation and ubiquitination. Proc. Natl. Acad. Sci. USA 102, 5600-5605.
209. Yoshida Y., Murakami A., Iwai K. & Tanaka K. (2007) A neural-specific F-box protein Fbs1 functions as a chaperone suppressing glycoprotein aggregation. J. Biol. Chem. 282, 7137-7144.
210. Nelson R. F., Glenn K. A., Zhang Y., Wen H., Knutson T., Gouvion C. M., Robinson B. K., Zhou Z., Yang B., Smith R. J. & Paulson H. L. (2007) Selective cochlear degeneration in mice lacking the F-box protein, Fbx2, a glycoprotein-specific ubiquitin ligase subunit. J. Neurosci. 27, 5163-5171.
211. Mizushima T., Hirao T., Yoshida Y., Lee S. J., Chiba T., Iwai K., Yamaguchi Y., Kato K., Tsukihara T. & Tanaka K. (2004) Structural basis of sugar-recognizing ubiquitin ligase. Nat. Struct. Mol. Biol. 11, 365-370.
212. Mizushima T., Yoshida Y., Kumanomidou T., Hasegawa Y., Suzuki A., Yamane T. & Tanaka K. (2007) Structural basis for the selection of glycosylated substrates by SCF(Fbs1) ubiquitin ligase. Proc. Natl. Acad. Sci. USA 104, 5777-5781.