An SCF-like ubiquitin ligase complex that controls presynaptic differentiation

Nature

Volumn 430, Issue 6997, 2004, Pages 345-350

  Liao, Edward H ^a   Hung, Wesley ^a   Abrams, Benjamin ^b   Zhen, Mel ^a  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENES; NEUROLOGY;

EPHRINS; GENE ENCODING; SUBCELLULAR STRUCTURES;

PROTEINS;

ANAPLASTIC LYMPHOMA KINASE; EPHRIN; F BOX PROTEIN; PROTEIN FSN 1; PROTEIN TYROSINE KINASE; S PHASE KINASE ASSOCIATED PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; WNT PROTEIN;

BIOLOGY;

ANIMAL CELL; ARTICLE; CAENORHABDITIS ELEGANS; CELL DIFFERENTIATION; CELL STRUCTURE; CONTROLLED STUDY; NERVE CELL; NERVE ENDING; NONHUMAN; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; SYNAPSE;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL DIFFERENTIATION; F-BOX PROTEINS; GENE EXPRESSION REGULATION; GUANINE NUCLEOTIDE EXCHANGE FACTORS; MACROMOLECULAR SUBSTANCES; MUTATION; NEURONS; ORGAN SPECIFICITY; PROTEIN BINDING; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; SKP CULLIN F-BOX PROTEIN LIGASES; SUBSTRATE SPECIFICITY; SYNAPSES;

ANIMALIA; CAENORHABDITIS; CAENORHABDITIS ELEGANS; INVERTEBRATA;

EID: 3142708002     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02647     Document Type: Article

References (30)

1. Sanes, J. R. & Lichtman, J. W. Development of the vertebrate neuromuscular junction. Annu. Rev. Neurosci. 22, 389-442 (1999).
2. Packard, M., Mathew, D. & Budnik, V. Wnts and TGF beta in synaptogenesis: old friends signaling at new places. Nature Rev. Neurosci. 4, 113-120 (2003).
3. Scheiffele, P. Cell-cell signaling during synapse formation in the CNS. Annu. Rev. Neurosci. 26, 485-508 (2003).
4. Skowyra, D. et al. Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1. Science 284, 662-665 (1999).
5. Tyers, M. & Jorgensen, P. Proteolysis and the cell cycle: with this RING I do thee destroy. Curr. Opin. Genet. Dev. 10, 54-64 (2000).
6. Deshaies, R. J. SCF and Cullin/Ring H2-based ubiquitin ligases. Dev. Biol. 15, 435-467 (1999).
7. Ko, H. W., Jiang, J. & Edery, I. Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime. Nature 420, 673-678 (2002).
8. Schaefer, A. M., Hadwinger, G. D. & Nonet, M. L. rpm-1, a conserved neuronal gene that regulates targeting and synaptogenesis in C. elegans. Neuron 26, 345-356 (2000).
9. Zhen, M., Huang, X., Bamber, B. & Jin, Y. Regulation of presynaptic terminal organization by C. elegans RPM-1, a putative guanine nucleotide exchanger with a RING-H2 finger domain. Neuron 26, 331-343 (2000).
10. Morris, S. W. et al. ALK, the chromosome 2 gene locus altered by the t(2:5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK). Oncogene 14, 2175-2188 (1997).
11. Jin, Y. Synaptogenesis: insights from worm and fly. Curr. Opin. Neurobiol. 12, 71-79 (2002).
12. Broadie, K. S. & Richmond, R. E. Establishing and sculpting the synapse in Drosophila and C. elegans. Curr. Opin. Neurobiol. 12, 491-498 (2002).
13. Sone, M. et al. Synaptic development is controlled in the periactive zones of Drosophila synapses. Development 127, 4157-4168 (2000).
14. Wan, H. I. et al. Highwire regulates synaptic growth in Drosophila. Neuron 26, 313-329 (2000).
15. McCabe, B. D. et al. Highwire regulates presynaptic BMP signaling essential for synaptic growth. Neuron 41, 891-905 (2004).
16. Guo, Q., Xie, J., Dang, C. V., Liu, E. T. & Bishop, J. M. Identification of a large Myc-binding protein that contains RCC1-like repeats. Proc. Natl Acad. Sci. USA 95, 9172-9177 (1998).
17. Pickart, C. M. Mechanisms underlying ubiquitination. Annu. Rev. Biochem. 70, 503-533 (2001).
18. DiAntonio, A. et al. Ubitiquitination-dependent mechanisms regulate synaptic growth and function. Nature 412, 449-452 (2001).
19. Zhen, M. & Jin, Y. The liprin protein SYD-2 regulates the differentiation of presynaptic termini in C. elegans. Nature 401, 371-375 (1999).
20. Nonet, M. L. Visualization of synaptic specializations in live C. elegans with synaptic vesicle protein-GFP fusions. J. Neurosci. Methods 89, 33-40 (1999).
21. Wang, D., Li, Z., Messing, E. M. & Wu, G. Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM. J. Biol. Chem. 277, 36216-36222 (2002).
22. Nayak, S. et al. The Caenorhabditis elegans Skp1-related gene family: diverse functions in cell proliferation, morphogenesis, and meiosis. Curr. Biol. 12, 277-287 (2002).
23. Yamanaka, A. et al. Multiple Skp1-related proteins in Caenorhabditis elegans: diverse patterns of interaction with Cullins and F-box proteins. Curr. Biol. 12, 267-275 (2002).
24. Iwahara, T. et al. Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system. Oncogene 14, 439-449 (1997).
25. Lee, H. H., Norris, A., Weiss, J. B. & Frash, M. Jelly belly protein activates the receptor tyrosine kinase Alk to specify visceral muscle pioneers. Nature 425, 507-512 (2003).
26. Englund, C. et al. Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion. Nature 425, 512-516 (2003).
27. Speese, S. D., Trotta, N., Rodesch, C. K., Aravamudan, B. & Broadie, K. The ubiquitin proteasome system acutely regulates presynaptic protein turnover and synaptic efficacy. Curr. Biol. 13, 899-910 (2003).
28. Hedge, A. N. & DiAntonio, A. Ubiquitin and the synapse. Nature Rev. Neurosci. 3, 854-861 (2002).
29. Colledge, M. et al. Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression. Neuron 40, 595-607 (2003).
30. Pak, D. T. & Sheng, M. Targeted protein degradation and synapse remodeling by an inducible protein kinase. Science 302, 1368-1373 (2003).