Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability

Genes and Development

Volumn 14, Issue 19, 2000, Pages 2501-2514

  Sears, Rosalie ^a   Nuckolls, Faison ^a   Haura, Eric ^a   Taya, Yoichi ^b   Tamai, Katsuyuki ^c   Nevins, Joseph R ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^c Cyclex   (Japan)

Author keywords

ERK; GSK 3; Myc; Ras; Ser 62; Stability; Thr 58

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE; MYC PROTEIN; RAS PROTEIN; SERINE; THREONINE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL FUNCTION; CELL GROWTH; CELL PROLIFERATION; EMBRYO; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; RAT; REGULATORY MECHANISM;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACID SEQUENCE; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; GLYCOGEN SYNTHASE KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR SEQUENCE DATA; PEPTIDE MAPPING; PHOSPHOPEPTIDES; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-MYC; RAS PROTEINS; SERINE;

EID: 0034306997     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.836800     Document Type: Article

References (63)

1. Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas
2. Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates
3. Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene
4. Degradation of nuclear oncoproteins by the ubiquitin system in vitro
5. Mutations in the coding region of c-MYC in AIDS-associated and other aggressive lymphomas
6. The myc oncogene: Its role in transformation and differentiation
7. Constitutive c-myc oncogene expression blocks mouse erythroleukaemia cell differentiation but not commitment
8. The small GTP-binding proteins Racl and Cdc42 regulate the activity of the JNK/SAPK signaling pathway
9. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
10. A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice
11. 1/S regulatory genes
12. Distinct roles for E2F proteins in cell growth control and apoptosis
13. Synergistic phosphorylation and activation of ATP-Mg-dependent phosphoprotein phosphatase by F A/GSK-3 and casein kinase II (PC0.7)
14. Glycogen synthase kinase-3b regulates cyclin D1 proteolysis and subcellular localization
15. Role of glycogen synthase kinase 3b as a negative regulator of dorsoventral axis formation in Xenopus embryos
16. A synthetic inhibitor of the mitogen-activated protein kinase cascade
17. Induction of apoptosis in fibroblasts by c-myc protein
18. Reversible tumorigenesis by MYC in hematiopoietic lineages
19. Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin
20. Myc Boxes, which are conserved in myc family proteins, are signals for protein degradation via the proteasome
21. Two MAD tails: What the recent knockouts of Madl and Mxil tell us about the MYC/MAX/MAD network
22. c-myc proteolysis by the ubiquitin-proteasome pathway: Stabilization of c-Myc in Burkitt's lymphoma cells
23. Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway
24. Proteins encoded by the human c-myc oncogene: Differential expression in neoplastic cells
25. c-myc oncogene protein synthesis is independent of the cell cycle in human and avian cells
26. Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos
27. Phosphorylation sites mapping in the N-terminal domain of c-Myc modulate its transforming potential
28. Eliminating all obstacles: Regulated proteolysis in the eukaryotic cell cycle
29. Rapid cytoplasmic turnover of c-myc mRNA: Requirement of the 3' untranslated sequences
30. Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB
31. Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor
32. How proteolysis drives the cell cycle
33. The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2
34. Rac andn Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65(PAK) and the JNK/SAPK MAP kinase cascade
35. Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOG MAPK pathway
36. Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F
37. New light on Myc and Myb. Part I. Myc
38. The basic region/helix-loop-helix/leucine zipper domain of Myc proto-oncoproteins: Function and regulation
39. Hierarchical phosphorylation at N-terminal transformation-sensitive sites in c-Myc protein is regulated by mitogens and in mitosis
40. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs
41. Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases
42. MYC oncogenes and human neoplastic disease
43. Functional analysis of E2F
44. Quail embryo fibroblasts transformed by four v-myc isolates show enhanced proliferation but are non-tumorigenic
45. Sequence curiosity in v-myc oncogenes
46. Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein
47. Reversible activation of c-Myc in skin: Induction of a complex neoplastic phenotype by a single oncogenic lesion
48. Site-specific modulation of c-Myc cotransformation by residues phosphorylated in vivo
49. The human proto-oncogene N-myc encodes nuclear proteins that bind DNA
50. New Myc-interacting proteins: A second Myc network emerges
51. Destruction of Myc by ubiquitin-mediated proteolysis: Cancer-associated and transforming mutations stabilize Myc
52. Identification of positively and negatively acting elements regulating expression of the E2F2 gene in response to cell growth signals
53. Ras enhances Myc protein stability
54. The MAPK signaling cascade
55. Signal transduction within the nucleus by mitogen-activated protein kinase
56. DNA damage induced phosphorylation of p53 alleviates inhibition by MDM2
57. Functional analysis of Burkitt's lymphoma mutant c-Myc proteins
58. Control of c-myc regulation in normal and neoplastic cells
59. Enhanced translation and increased turnover of c-myc proteins occur during differentiation of murine erythroleukemia cells
60. Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase
61. Phosphopeptide mapping and phosphoamino acid analysis by electrophoresis and chromatography on thin-layer cellulose plates
62. Multiple Ras functions can contribute to mammalian cell transformation
63. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis