Structure of a Fbw7-Skp1-Cyclin E Complex: Multisite-Phosphorylated Substrate Recognition by SCF Ubiquitin Ligases

Molecular Cell

Volumn 26, Issue 1, 2007, Pages 131-143

  Hao, Bing ^a   Oehlmann, Stephanie ^a   Sowa, Mathew E ^b   Harper, J Wade ^b   Pavletich, Nikola P ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

CELLCYCLE

Indexed keywords

CYCLIN E; F BOX PROTEIN; HYBRID PROTEIN; PROTEIN; PROTEIN FBW7; PROTEIN SIC1; S PHASE KINASE ASSOCIATED PROTEIN; S PHASE KINASE ASSOCIATED PROTEIN 1; SERINE; THREONINE; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; COMPLEX FORMATION; CONTROLLED STUDY; DIMERIZATION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; UBIQUITINATION;

AMINO ACID SEQUENCE; BINDING SITES; CELL CYCLE PROTEINS; CELL LINE; CYCLIN E; DIMERIZATION; F-BOX PROTEINS; HUMANS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; PHOSPHOPEPTIDES; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; S-PHASE KINASE-ASSOCIATED PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SERINE; SKP CULLIN F-BOX PROTEIN LIGASES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THREONINE; TRANSFECTION; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 34047249627     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2007.02.022     Document Type: Article

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