JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS

Science

Volumn 312, Issue 5781, 2006, Pages 1809-1812

  Koh, Kyunghee ^a   Zheng, Xiangzhong ^a   Sehgal, Amita ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; GENES; MICROORGANISMS; PHASE SHIFT; PROTEINS; SENSITIVITY ANALYSIS;

CIRCADIAN PHOTORECEPTOR CRYPTOCHROME (CRY); DROSOPHILA CIRCADIAN CLOCK; LIGHT-DEPENDENT DEGRADATION; PHOTIC ENTRAINMENT;

BIODIVERSITY;

CRYPTOCHROME; F BOX PROTEIN; LEUCINE; PROTEASOME; PROTEIN; PROTEIN TIMELESS; UNCLASSIFIED DRUG;

CIRCADIAN RHYTHM; FLY; GENE EXPRESSION; HUMAN BEHAVIOR; LIGHT; LUMINESCENCE DATING; PROTEIN;

ARTICLE; CELL CULTURE; CIRCADIAN RHYTHM; DROSOPHILA; GENE; JETLAG GENE; LIGHT DARK CYCLE; MUTANT; NONHUMAN; PHOTORECEPTOR; PHOTOSTIMULATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CELLS, CULTURED; CIRCADIAN RHYTHM; DROSOPHILA; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EYE PROTEINS; F-BOX PROTEINS; FEMALE; LIGHT; MALE; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, G-PROTEIN-COUPLED; TRANSGENES; UBIQUITIN;

EID: 33745503975     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1124951     Document Type: Article

References (26)

1. P. E. Hardin, Curr. Biol. 15, R714 (2005).
2. S. Panda, J. B. Hogenesch, S. A. Kay, Novartis Found. Symp. 253, 73 (2003).
3. L. J. Ashmore, A. Sehgal, J. Biol. Rhythms 18, 206 (2003).
4. A. Busza, M. Emery-Le, M. Rosbash, P. Emery, Science 304, 1503 (2004).
5. S. Dissel et al., Nat. Neurosci. 7, 834 (2004).
6. M. F. Ceriani et al., Science 285, 553 (1999).
7. N. Naidoo, W. Song, M. Hunter-Ensor, A. Sehgal, Science 285, 1737 (1999).
8. F. J. Lin, W. Song, E. Meyer-Bernstein, N. Naidoo, A. Sehgal, Mol. Cell. Biol. 21, 7287 (2001).
9. Z. Yang, M. Emerson, H. S. Su, A. Sehgal, Neuron 21, 215 (1998).
10. V. Suri, Z. Qian, J. C. Hall, M. Rosbash, Neuron 21, 225 (1998).
11. R. Stanewsky et al., Cell 95, 681 (1998).
12. T. Cardozo, M. Pagano, Nat. Rev. Mol. Cell Biol. 5, 739 (2004).
13. M. F. Ceriani et al., J. Neurosci. 22, 9305 (2002).
14. R. Stanewsky, C. F. Jamison, J. D. Plautz, S. A. Kay, J. C. Hall, EMBO J. 16, 5006 (1997).
15. M. Ivanchenko, R. Stanewsky, J. M. Giebultowics, J. Biol. Rhythms 16, 205 (2001).
16. B. Collins, E. O. Mazzoni, R. Stanewsky, J. Blau, Curr. Biol. 16, 441 (2006).
17. Although light-induced TIM ubiquitination, but not degradation, was previously observed without cotransfected JET (7, 8), we did not detect significant ubiquitination under these conditions. This discrepancy may arise from procedural differences (e.g., use of S2R+ cells instead of 52 cells, or the fact that we did not apply heat to induce expression of hemagglutinin-tagged ubiquitin).
18. J. C. Hendricks, A. Sehgal, Sleep 27, 334 (2004).
19. S. A. Tischkau, J. W. Mitchell, S. H. Tyan, G. F. Buchanan, M. U. Gillette, J. Biol. Chem. 278, 718 (2003).
20. Z. Travnickova-Bendova, N. Cermakian, S. M. Reppert, P. Sassone-Corsi, Proc. Natl. Acad. Sci. U.S.A. 99, 7728 (2002).
21. A. Sancar, Chem. Rev. 103, 2203 (2003).
22. H. O. Yang et al., Cell 103, 815 (2000).
23. P. Mas, W. Y. Kim, D. E. Somers, S. A. Kay, Nature 426, 567 (2003).
24. B. Grima et al., Nature 420, 178 (2002).
25. H. W. Ko, J. Jiang, I. Edery, Nature 420, 673 (2002).
26. We thank P. Emery for the cry-Gal4 strain, J. Nambu for the GST-SkpA construct the Bloomington Stock Center for fly strains; J. Evans, Z. Yue, and D. Chen for technical assistance; S. Sathyanarayanan for help with cell culture experiments; Y. Fang for the plZ-MYC-cry construct; K. Ho, N. Naidoo, and Q. Yuan for comments on the manuscript and other members of the lab for discussions. Supported by NIH grant N5048471 (AS.). A.S. is an Investigator of the Howard Hughes Medical Institute.