Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

EMBO Journal

Volumn 23, Issue 10, 2004, Pages 2116-2125

  Yada, Masayoshi ^a,b   Hatakeyama, Shigetsugu ^a,b   Kamura, Takumi ^a,b   Nishiyama, Masaaki ^a,b   Tsunematsu, Ryosuke ^a,b   Imaki, Hiroyuki ^a,b   Ishida, Noriko ^b,c   Okumura, Fumihiko ^a,b   Nakayama, Keiko ^b,c   Nakayama, Keiichi I ^a,b  

^a KYUSHU UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

c Myc; Fbw7; SCF complex; Skp2; Ubiquitin ligase

Indexed keywords

F BOX PROTEIN; MUTANT PROTEIN; MYC PROTEIN; PROTEIN FBW7; RNA; S PHASE KINASE ASSOCIATED PROTEIN 2; SERINE; THREONINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; RNA INTERFERENCE; STEM CELL; UBIQUITINATION; WILD TYPE;

ANIMALS; CELL CYCLE PROTEINS; CELLS, CULTURED; CYCLIN E; F-BOX PROTEINS; HUMANS; LIGASES; MICE; MICE, KNOCKOUT; PEPTIDES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-MYC; RECOMBINANT PROTEINS; RNA INTERFERENCE; S-PHASE KINASE-ASSOCIATED PROTEINS; SERINE; STEM CELLS; THREONINE; TRANS-ACTIVATION (GENETICS); UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 2942614705     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600217     Document Type: Article

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