Two F-box/WD-repeat proteins Pop1 and Pop2 form hetero- and homo- complexes together with cullin-1 in the fission yeast SCF (Skp1-Cullin-1-F- box) ubiquitin ligase

Genes to Cells

Volumn 3, Issue 11, 1998, Pages 721-735

  Kominami, Kin Ichiro ^a,b   Ochotorena, Itziar ^a   Toda, Takashi ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; LIGASE; PROTEASOME; UBIQUITIN;

ANIMAL CELL; ARTICLE; CELL CYCLE S PHASE; COMPLEX FORMATION; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME REGULATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; GENE DELETION; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

AMINO ACID SEQUENCE; CELL CYCLE PROTEINS; CULLIN PROTEINS; CYCLIN-DEPENDENT KINASES; ENZYME INHIBITORS; FUNGAL PROTEINS; GENOME, FUNGAL; MOLECULAR SEQUENCE DATA; MUTATION; OXIDATIVE STRESS; PEPTIDE SYNTHASES; PHENOTYPE; RIBONUCLEASES; RIBONUCLEOPROTEINS; S PHASE; SACCHAROMYCES CEREVISIAE PROTEINS; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SKP CULLIN F-BOX PROTEIN LIGASES; TRANSCRIPTION FACTORS;

ANIMALIA; SCHIZOSACCHAROMYCES POMBE;

EID: 0032440674     PISSN: 13569597     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2443.1998.00225.x     Document Type: Article

References (67)

1. Al-Khodairy, F., Enoch, T., Hagan, I.M. & Carr, A.M. (1995) The Schizosaccharomyces pombe hus5 gene encodes a ubiquitin conjugating enzyme required for normal mitosis. J. Cell Sci. 108, 475-486.
2. + gene as a new selectable marker for molecular genetic study. Curr. Genet. 24, 491-495.
3. Bähler, J., Wu, J., Longtine, M.S., et al. (1998) Heterologous modules for efficient and versatile PCR-based gene targeting in Schizosaccharomyces pombe. Yeast 14, 943-951.
4. Bai, C., Sen, P., Hofmann, K., et al. (1996) SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell 86, 263-274.
5. rum1 CDK inhibitor. EMBO J. 17, 482-497.
6. Connelly, C. & Hieter, P. (1996) Budding yeast SKP1 encodes an evolutionary conserved kinetochore protein required for cell cycle progression. Cell 86, 275-285.
7. Drury, L.S., Perkins, G. & Diffley, J.F.X. (1997) The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast. EMBO J. 16, 5966-5976.
8. Egel, R. & Egel-Mitani, M. (1974) Premeiotic DNA synthesis in fission yeast. Exp. Cell Res. 107, 127-134.
9. Enoch, T., Carr, A.M. & Nurse, P. (1992) Fission yeast genes involved in coupling mitosis to completion of DNA replication. Genes Dev. 6, 2035-2046.
10. Feldman, R.M.R., Correll, C.C., Kaplan, K.B. & Deshaies, R.J. (1997) A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell 91, 221-230.
11. Goebl, M. & Yanagida, M. (1991) The TPR snap helix: a novel protein repeat motif from mitosis to transcription. Trends Biochem. Sci. 16, 173-177.
12. Goebl, M.G., Yochem, J., Jentsch, S., McGrath, J.P., Varshavsky A. & Byers, B. (1988) The yeast cell cycle gene CDC34 encodes a ubiquitin-conjugating enzyme. Science 241, 1331-1335.
13. Grimm, C., Kohli, J., Murray, J. & Maundrell, K. (1988) Genetic engineering of Schizosaccharomyces pombe: a system for gene disruption and replacement using the ura4 gene as a selectable marker. Mol. Gen. Genet. 215, 81-86.
14. Henchoz, S., Chi, Y., Catarin, B., Herskowitz, I., Deshaies, R.J. & Peter, M. (1997) Phosphorylation- and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1p in budding yeast. Genes Dev. 11, 3046-3060.
15. Hershko, A. (1997) Roles of ubiquitin-mediated proteolysis in cell cycle control. Curr. Opin. Cell Biol. 9, 788-799.
16. Hershko, A. & Ciechanover, A. (1992) The ubiquitin system for protein degradation. Annu. Rev. Biochem. 61, 761-807.
17. Hershko, A., Ganoth, D., Sudakin, V., et al. (1994) Components of a system that ligates cyclin to ubiquitin and their regulation by protein kinase cdc2. J. Biol. Chem. 269, 4940-4946.
18. Hirano, T., Kobayashi, R. & Hirano, M. (1997) Condensins, chromosome condensation protein complexes containing XCAP-C, XCAP-E and a Xenopus homolog of the Drosophila Barren protein. Cell 89, 511-521.
19. Hirano, T., Mitchison, T.J. & Swedlow, J.R. (1995) The SMC family: from chromosome condensation to dosage compensation. Curr. Opin. Cell Biol. 7, 329-336.
20. Hochstrasser, M. (1996) Ubiquitin-dependent protein degradation. Annu. Rev. Genet. 30, 405-439.
21. Hubbard, E.J.A., Wu, G., Kitajewski, J. & Greenwald, I. (1997) sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins. Genes Dev. 11, 3182-3193.
22. Huibregtse, J.M., Scheffner, M., Beaudenon, S. & Howley, P.M. (1995) A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. Proc. Natl. Acad. Sci. USA 92, 2563-2567.
23. Ingram, G.C., Doyle, S., Carpenter, R., Schultz, E.A., Simon, R. & Coen, E.S. (1997) Dual role for fimbriata in regulating floral homeotic genes and cell division in Antirrhinum. EMBO J. 16, 6521-6534.
24. Irniger, S., Piatti, S., Michaelis, C. & Nasmyth, K. (1995) Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast. Cell 81, 269-277.
25. cdc18 by CDK phosphorylation. Genes Dev. 11, 2767-2779.
26. + targets cyclin-dependent kinase-phosphorylated Cdc18 and Rum1 proteins for degradation and stops unwanted diploidization in fission yeast. Proc. Natl. Acad. Sci. USA 95, 8159-8164.
27. Jiang, J. & Struhl, G. (1998) Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40- repeat protein Slimb. Nature 391, 493-496.
28. Johnson, E.S. & Blobel, G. (1997) Ubc9p is the conjugating enzyme for the ubiquitin-like protein Smt3p. J. Biol. Chem. 272, 26799.
29. Kaplan, K.B., Hyman, A.A. & Soeger, P.K. (1997) Regulating the yeast kinetochore by ubiquitin-dependent degradation and Skp1p-mediated phosphorylation. Cell 91, 491-500.
30. King, R.W., Peters, J.-M., Tugendreich, S.T., Rolfe, M., Hieter, P. & Kirschner, M.W. (1995) A 20S complex containing CDC27 and CDC16 catalyzes the mitotic-specific conjugation of ubiquitin to cyclin B. Cell 81, 279-288.
31. Kipreos, E., Lander, L.E., Wing, J.P., He, W.W. & Hedgecock, E.M. (1996) cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. Cell 85, 829-839.
32. Kominami, K. & Toda, T. (1997) Fission yeast WD-repeat protein Pop1 regulates genome ploidy through ubiquitin-proteasome-mediated degradation of the CDK inhibitor Rum1 and the S-phase initiator Cdc18. Genes Dev. 11, 1548-1560.
33. Koshland, D. & Strunnikov, A. (1996) Mitotic chromosome condensation. Annu. Rev. Cell Dev. Biol, 12, 305-333.
34. 1-arrest upon nitrogen starvation and is an inhibitor of septum formation. J. Cell Sci. 108, 895-905.
35. Kumar, A. & Paietta, J.V. (1998) An additional role for the F-box motif: Gene regulation within the Neurospora crassa sulfur control network. Proc. Natl. Acad. Sci. USA 95, 2417-2422.
36. SKP2: evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway. EMBO J. 17, 368-383.
37. Lonergan, K.M., Iliopoulos, O., Ohh, M., et al. (1998) Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2. Mol. Cell. Biol. 18, 732-741.
38. Lyapina, S.A., Correll, C.C., Kipreos, E.T. & Deshaies, R.J. (1998) Human CUL1 forms an evolutionarily conserved ubiquitin ligase complex (SCF) with SKP1 and an F-box protein. Proc. Natl. Acad. Sci. USA 95, 7451-7456.
39. Maekawa, H., Kitamura, K. & Shimoda, C. (1998) The Ste16 WD-repeat protein regulates cell-cycle progression under starvation through the Rum1 protein in Schizosaccharomyces pombe. Curr. Genet. 33, 29-37.
40. Margottin, F., Bour, S.P., Durand, H., et al. (1998) A novel human WD protein, h-SSTrCP, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif. Mol. Cell 1, 565-574.
41. Mathias, N., Johnson, S.L., Winey M., et al. (1996) Cdc53 acts in concert with Cdc4 and Cdc34p to control the G1-to-S phase transition and identifies a conserved family of proteins. Mol. Cell. Biol. 16, 6634-6643.
42. Maundrell, K. (1990) nmt1 of fission yeast. J. Biol. Chem. 265, 10857-10864.
43. Moreno, S., Klar, A. & Nurse, P. (1991) Molecular genetic analyses of fission yeast Schizosaccharomyces pombe. Meth. Enzymol. 194, 773-782.
44. Natorff, R., Piotrowska, M. & Paszewski, A. (1998) The Aspergillus nidulans sulphur regulatory gene sconB encodes a protein with WD40 repeats and an F-box. Mol. Gen. Genet. 257, 255-263.
45. Neer, E.J., Schmidt, C.J., Nambudripad, R. & Smith, T.F. (1994) The ancient regulatory-protein family of WD-repeat proteins. Nature 371, 297-300.
46. Pagano, M., Tam, S.W., Theodoras, A.M., et al. (1995) Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science 269, 682-685.
47. Patton, E.E., Willems, A.R., Sa, D., et al. (1998a) Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box protein complexes that regulate cell division and methionine biosynthesis in yeast. Genes Dev. 12, 692-705.
48. Patton, E.E., Willems, A.R. & Tyers, M. (1998b) Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis. Trends Genet. 14, 236-243.
49. Pause, A., Lee, S., Lonergan, K.M. & Klausner, R.D. (1998) The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal. Proc. Natl. Acad. Sci. USA 95, 993-998.
50. Pause, A., Lee, S., Worrell, R.A., et al. (1997) The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. Proc. Natl. Acad. Sci. 94, 2156-2161.
51. + encodes a protein kinase related to mammalian glycogen synthase kinase 3 and complements a cdc14 cytokinesis mutant. Mol. Cell. Biol. 16, 179-191.
52. Pringle, J.R. & Hartwell, L.H. (1981) The molecular biology of the yeast Saccharomyces cerevisiae. Life cycle and inheritance. In: The Saccharomyces Cerevisiae Cell Cyde, pp. 97-142. Cold Spring Harbor, NY: Cold Spring, Harbor Laboratory Press.
53. Rothstein, R.J. (1983) One-step gene disruption in yeast. Meth. Enzymol. 101, 202-211.
54. Ruegger, M., Dewey, E., Gray, W.M., Hobbie, L., Turner, J. & Estelle, M. (1998) The TIR1 protein of A rabidopsis functions in auxin response and is related to human SKP2 and yeast Grr1p. Genes Dev. 12, 198-207.
55. Sambrook, J., Fritsch, E.F. & Maniatis, T. (1989) Molecular Cloning: a Laboratory Manual, 2nd edn. Cold Spring Harbor, NY: Cold Spring, Harbor Laboratory Press.
56. Schwarz, S.E., Matuschewski, K., Liakopoulos, D., Scheffner, M. & Jentsch, S. (1998) The ubiquitin-like proteins SMT3 and SUMO-1 are conjugated by the UBC9, E2 enzyme. Proc. Natl. Acad. Sci. USA 95, 560-564.
57. SIC1 controls the G1 to S transition in S. cerevisiae. Cell 79, 233-244.
58. Skowyra, D., Craig, K.L., Tyers, M., Elledge, S.J. & Harper, J.W. (1997) F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91, 209-219.
59. Sudakin, V., Ganoth, D., Dahan, A., et al. (1995) The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis. Mol. Biol. Cell 6, 185-198.
60. Sutani, T. & Yanagida, M. (1997) DNA renaturation activity of the SMC complex implicated in chromosome condensation. Nature 388, 798-801.
61. Thomas, D., Kuras, L., Barbey, R., Cherest, H., Blaiseau, P.-L. & Surdin-Kerjan, Y. (1995) Met30p, a yeast transcriptional inhibitor that responds to S-adenosylmethionine, is an essential protein with WD40 repeats. Mol. Cell Biol. 15, 6526-6234.
62. Varshavsky, A. (1996) The N-end rule: functions, mysteries, uses. Proc. Natl. Acad. Sci. USA 93, 12142-12149.
63. 1 Cdk required for its degradation and entry into S phase. Science 278, 455-460.
64. Willems, A.R., Lanker, S., Patton, E.E., et al. (1996) Cdc53 targets phosphorylated G1 cyclins for degradation by the ubiquitin proteolytic pathway. Cell 86, 453-463.
65. Yen, P.R. & Kirschner, M.K. (1997) Proteolysis and DNA replication: the CDC34 requirement in the Xenopus egg cell cycle. Science 277, 1672-1676.
66. Yu, H., Peters, J., King, R.W., Page, A.M., Hieter, P. & Kirschner, M.W. (1998) Identification of a cullin homology region in a subunit of the anaphase-promoting complex. Science 279, 1219-1222.
67. Skp2 are essential elements of the cyclin A-CDK2 S phase kinase. Cell 82, 915-925.