Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

Nature

Volumn 428, Issue 6979, 2004, Pages 194-198

  Wei, Wenyi ^a   Ayad, Nagi G ^b   Wan, Yong ^b   Zhang, Guo Jun ^a   Kirschner, Marc W ^b   Kaelin Jr , William G ^a,c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEXATION; DEGRADATION; ENZYMES; SEPARATION;

ANAPHASE-PROMOTING COMPLEXES (APC); CELL CYCLES;

CELLS;

ANAPHASE PROMOTING COMPLEX; CULLIN; CYCLIN B; CYCLIN DEPENDENT KINASE INHIBITOR; F BOX PROTEIN; PROTEIN; PROTEIN P27; S PHASE KINASE ASSOCIATED PROTEIN; S PHASE KINASE ASSOCIATED PROTEIN 1; S PHASE KINASE ASSOCIATED PROTEIN 2; SECURIN; UBIQUITIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; UVOMORULIN;

BIOLOGY;

ANAPHASE; ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CHROMATID; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; METAPHASE; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN TARGETING; UBIQUITINATION;

AMINO ACID MOTIFS; ANIMALS; CELL EXTRACTS; FLOW CYTOMETRY; G1 PHASE; HELA CELLS; HUMANS; MUTATION; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; RNA INTERFERENCE; S-PHASE KINASE-ASSOCIATED PROTEINS; SKP CULLIN F-BOX PROTEIN LIGASES; UBIQUITIN; UBIQUITIN-PROTEIN LIGASE COMPLEXES; XENOPUS LAEVIS;

EID: 1642399624     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02381     Document Type: Article

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