The F-box protein family

Genome Biology

Volumn 1, Issue 5, 2000, Pages XIX-XX

  Kipreos, Edward T ^a   Pagano, Michèle ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE SYNTHASE; UBIQUITIN PROTEIN LIGASE;

ANIMAL; GENE EXPRESSION REGULATION; GENETICS; GENOME; HUMAN; METABOLISM; MOLECULAR EVOLUTION; PHOSPHORYLATION; REVIEW;

ANIMALS; EVOLUTION, MOLECULAR; GENE EXPRESSION REGULATION; GENOME; HUMANS; PEPTIDE SYNTHASES; PHOSPHORYLATION; SKP CULLIN F-BOX PROTEIN LIGASES;

EID: 0034568688     PISSN: 14656906     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (41)

1. Kumar A, Paietta JV: The sulfur controller-2 negative regulatory gene of Neurosporo croisa encodes a protein with betatransducin repeats. Proc NatlAcad Sei USA I99S, 92:3343-3347. The first description of the protein region that became known as the F box
2. Bai C, Sen P, Hofmann K, Ma U Goebl M, Harper JW. Elledge SJ: SKPI connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell 1996, 86:263-274. This work was the first to recognize the F-box as a widespread protein motif, and demonstrated that the F-box bound to the Skp I protein.
3. Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidai M, Pagano M: Identification of a family of human F-box proteins. Curr 6/0/1999.9:1177-1179. This paper extended the number of known F-box proteins in humans and demonstrated that F-box proteins without WD or LRR motifs can bind to SCF components in vivo.
4. Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW: A family of mammalian F-box proteins. Currβ/o/1999, 9:1180-1182. Extended the number of known F-box proteins in humans and mice.
5. Clifford R, Lee M-H, Nayak S. Ohmachi M, Giorgini F, Schedl T: FOG-2, a novel F-box containing protein, associates with the GLD-I RNA binding protein to direct male sex determination in the C. e/egans hermaphrodite germline. Deve/opment 2000, in press. Demonstrates that the F-box protein FOG-2 functions in a protein complex with the RNA binding protein GLD-I to repress tro-2 mRNA translation.
6. ISREC ProfileScan Server [http://www.isrec.isb-sib.ch/sofcware/PFSCAN_form.htmlJ. This site can be used to search both the Pfam and Prosite databases for F-box motifs.
7. Skowyra D, Craig KL, Tyers M, Elledge SJ, Harper JW: F-Box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 1997, 91:209-219. In this seminal paper and the following one, the authors reconstituted active SCF E3 complexes with purified components thereby demonstrating the biochemical action of the complex and the subunit interaction.
8. Feldman RMR, Correll CC, Kaplan KB, Deshaies RJ: A complex of Cdc4p, Skplp, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Siclp. Cell 1997, 91:221-230. See [7J.
9. Tyers M, Jorgensen P: Proteolysis and the cell cycle: with this RING I do thee destroy. Curr Opin Genet Dev 2000, 10:54-64. Provides an overview of SCF and APC complexes.
10. 2-based ubiquitin ligases. Annu Rev Cell Dev Biol 1999, 15:435-467. A detailed review of SCF ubiquitin-ligase complexes.
11. Craig KL, Tyers M: The F-box: a new motif for ubiquitin dependent proteolysis in cell cycle regulation and signal transduction. Prog β/ophys Mol Biol 1999, 72:299-328. A second detailed review of SCF ubiquitin-ligase complexes.
12. Hershko A, Ciechanover A: The ubiquitin system. Annu Rev Biochem 1998, 67:425-479. A detailed review of the ubiquitin proteolytic pathway.
13. Russell ID, Grancell AS, Sorger PK: The unstable F-box protein p58-Ctf!3 forms the structural core of the CBF3 kinetochore complex.J Cell Biol 1999, 145:933-950. This work provides evidence that the F-box motif of Ctf 13 is required for binding Skp I and that the CBF3 complex assembles around Ctf 13.
14. Kaplan KB, Hyman AA, Sorger PK: Regulating the yeast kinetochore by ubiquitin-dependent degradation and Skplp-mediated phosphorylation. Cell 1997, 91:491-500. Describes Skp I binding to the kinetochore protein Ctf 13 and promoting the activating-phosphorylation of Ctf 13.
15. Doheny KF, Sorger PK, Hyman AA, Tugendreich S, Spencer F, Mieter P: Identification of essential components of the S. cerevfs/ae kinetochore. Cell 1993, 73:761-774. This paper describes the Ctf 13 loss-of-function phenotype.
16. Shilatifard A: Factors regulating the transcriptional elongation activity of RNA polymerase \\.FASEBJ 1998, 12:1437-1446. A review of RNA polymerase II transcriptional elongation factors, including the F-box protein Elongin A.
17. Aso T, Haque D, Barstead RJ, Conaway RC, Conaway JW: The inducible elongin A elongation activation domain: structure, function and interaction with the elongin BC complex. EA160 7I996, 15:5557-5566. This work and [ 18] found that the smallest human or yeast [ 18] Elongin A region sufficient for binding Elongin C contained the F-box motif.
18. Koth CM, Botuyan MV, Moreland RJ, Jansma DB, Conaway JW, Conaway RC, Chazin WJ, Friesen JD, Arrowsmith CH, Edwards AM: Elongin from Socchoromyces cerev/s/oe. ] Biol Chem 2000, 275:11174-11180. See [17J.
19. Jan E, Motzny CK, Graves LE, Goodwin EB: The STAR protein, GLD-I, is a translational regulator of sexual identity in Caenorhabditis elegans. EMBO] 1999, 18:258-269. Shows that GLD-I translationally represses tra-2 by binding the tra-2 3' UTR.
20. Kong M, Barnes EA, Ollendorff V, Donoghue DJ: Cyclin F regulates the nuclear localization of cyclin BI through a cyclincyclin interaction. EMBO] 2000, 19:1378-1388. Demonstrates that cyclin F binds cyclin B through a cyclin box-CRS interaction.
21. Zhou P, Howley PM: Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligases. Mot Cell 1998, 2:571-580. This study represents the first demonstration that F-box proteins are unstable proteins.
22. Galan JM, Peter M: Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism. Proc Natl Acad Sei USA 1999, 96:9124-9129. This paper shows that ubiquitination of the F-box protein Cdc4 and Grrl requires all the core components of the SCF and an intact F box.
23. Rouillon A, Barbey R, Patton EE, Tyers M, Thomas D: Feedbackregulated degradation of the transcriptional activator Met4 is triggered by the SCF(Met30) complex. £MβO J 2000, 19:282-294. Demonstrates that Met30 can be degraded in an F-box-independent manner.
24. Zhang H, Kobayashi R, Galaktionov K, Beach D: p!9-Skpl and p45-Skp2 are essential elements of the cyclin A-CDK2 S phase kinase. Cell 1995, 82:915-925. Describes the cloning of Skp I and Skp2 as cydin-A-interacting proteins.
25. Carrano AC, Eytan E, Hershko A, Pagano M: SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol 1999, 1:193-199.
26. This work and [39, 40] demonstrate that the SCF ?2 complex targets the degradation of p27l°P| in vitro and in vivo.
27. Yam CH, Ng RW, Siu WY, Lau AW, Poon RY: Regulation of cyclin A-Cdk2 by SCF component Skpl and F-box protein Skp2. Mol Cell Biol 1999, 19:635-645. Identifies the phosphorylation site in Skp2 targeted by cyclin A.
28. Spiegelman VS, Slaga TJ, Pagano M, Minamoto T, Ronai Z, Fuchs SY: Wnt/beta-catenin signaling induces the expression and activity of betaTrCP ubiquitin ligase receptor. Mol Cell 2000, 5:877-882. Shows that β-catenin induces a stabilization of β-Trcp mRNA. suggesting that a negative feedback loop regulation may control the β-catenin pathway.
29. Li FN, Johnston M: Grrl of Socchoromyces cerevisiae is connected to the ubiquitin proteolysis machinery through Skpl: coupling glucose sensing to gene expression and the cell cycle. EMBOJ 1997, 16:5629-5638. This work demonstrates that the ability of Grrl to bind the SCF component Skpl is upregulated in cells grown in the presence of glucose.
30. European Bioinformatics Institute Proteome Analysis [http://www.ebi.ac.uk/proteome/index.htmlj The Interfro project catalogs proteomes by analyzing protein motifs. Links from this page can produce lists of all of the cataloged F-box proteins in an organism, with accompanying figures of the motifs in each protein.
31. Pfam entry: F-box [http://pfam.wustl.edu/cgi-bin/getdesc?name=FboxJ. This page provides links to the alignments used to generate the Pfam Fbox search algorithm.
32. GenBank [http://www.ncbi.nlm.nih.gov/Genbank/GenBankOverview. html] Database of DMA and protein sequences.
33. Samach A, Klenz JE, Kohalmi SE, Risseeuw E, Haughn WV, Crosby WL The UNUSUAL FLORAL ORGANS gene of Arabidopsh thaliana is an F-box protein required for normal patterning and growth in the floral meristem. Plant] 1999, 20:433-445. Demonstrates that the F-box protein UFO, which functions in flower development, interacts with Skp I -related proteins.
34. Ingram GC, Doyle S, Carpenter R, Schultz EA, Simon R, Coen ES: Dual role for fimbriata in regulating floral homeotic genes and cell division in Antirrhinum. EMBOJ 1997. 16:6521-6534. Demonstrates that the F-box protein FIM. an ortholog of UFO, interacts with Skp I -related proteins.
35. Kipreos ET, Gohel SP, Hedgecock EM: The C. elegant F-box/WDrepeat protein LIN-23 functions to limit cell division during development. Development 2000, 127:5071-5082. Shows that the F-box protein LIN-23 functions cell autonomously to limit cell division in C etegans.
36. Wojcik EJ, Glover DM, Hays TS: The SCF ubiquitin ligase protein Slimb regulates centrosome duplication in Drosophi/o. Curr Biol 2000, 10:1131 -1134. Found that mutants of the s/imb gene, encoding an F-box protein, have centrosome overduplication.
37. Kaiser P, Flick K, Wittenberg C, Reed SI: Regulation of transcription by ubiquitination without proteolysis: Cdc34/SCF(Met30)-mediated inactivation of the transcription factor Met4. Cell 2000, 102:303-314. Demonstrates that SCFMet30-mediated ubiqutination of Met4 inhibits Met4 transcriptional activity but does not lead to Met4 degradation.
38. Meimoun A, Holtzman T, Weissman Z, McBride HJ, Stillman DJ, Fink GR, Kornitzer D: Degradation of the transcription factor Gcn4 requires the kinase Pho85 and the SCF(CDC4) ubiquitin-ligase complex. Mol Biol Cell 2000, I 1:915-927. This paper demonstrates that the transcription factor Gcn4 is targeted for degradation by SCF04.
39. Nakayama K, Nagahama H, Minamishima YA, Matsumoto M, Nakamichi I, Kitagawa K, Shirane M, Tsunematsu R, Tsukiyama T, Ishida N, et al.: Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kipl), polyploidy and centrosome overduplication. EMBOJ 2000, 19:2069-2081. Demonstration that mice lacking the F-box protein Skp2 are viable but in certain tissues have an accumulation of cyclin E and p271GP| as well as centrosome overduplication.
40. Sutterluty H, Châtelain E, Marti A, Wirbelauer C, Senften M, Muller U, Krek W: p45SKP2 promotes p27Kipl degradation and induces S phase in quiescent cells. Nat Cell Biol 1999, 1:207-214. See [25J.
41. Tsvetkov LM, Yeh KH, Lee SJ, Sun H. Zhang H: p27(Kip I) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thrl87 in p27. Curr Biol 1999.9:661-664. See [25].