Spatial regulation of an E3 ubiquitin ligase directs selective synapse elimination

Science

Volumn 317, Issue 5840, 2007, Pages 947-951

  Ding, Mei ^a   Chao, Dan ^a   Wang, George ^a   Shen, Kang ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; F BOX PROTEIN; IMMUNOGLOBULIN; PROTEIN; PROTEIN SEL 10; PROTEIN SKP 1; PROTEIN SYG 1; S PHASE KINASE ASSOCIATED PROTEIN; S PHASE KINASE ASSOCIATED PROTEIN 1; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

DEVELOPMENTAL BIOLOGY; ENZYME ACTIVITY; HERMAPHRODITE; INHIBITOR; MOLECULAR ANALYSIS; NEMATODE; NERVOUS SYSTEM; PROTEIN;

ARTICLE; CAENORHABDITIS ELEGANS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME REGULATION; MOLECULAR DYNAMICS; MOTONEURON; NONHUMAN; PRIMARY SYNAPSE REGION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RNA INTERFERENCE; SECONDARY SYNAPSE REGION; SPATIAL REGULATION; SYNAPTIC INHIBITION; SYNAPTOGENESIS;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL CYCLE PROTEINS; IMMUNOGLOBULINS; MODELS, NEUROLOGICAL; MOTOR NEURONS; MUTATION; NERVE TISSUE PROTEINS; OVIPOSITION; PROMOTER REGIONS (GENETICS); PROTEASOME ENDOPEPTIDASE COMPLEX; R-SNARE PROTEINS; RECOMBINANT FUSION PROTEINS; RNA INTERFERENCE; SKP CULLIN F-BOX PROTEIN LIGASES; SYNAPSES; TWO-HYBRID SYSTEM TECHNIQUES;

CAENORHABDITIS ELEGANS;

EID: 34548044548     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1145727     Document Type: Article

References (28)

1. J. W. Lichtman, H. Colman, Neuron 25, 269 (2000).
2. W. Lin et al., Neuron 46, 569 (2005).
3. T. Misgeld, T. T. Kummer, J. W. Lichtman, J. R. Sanes, Proc. Natl. Acad. Sci. U.S.A. 102, 11088 (2005).
4. K. Shen, C. I. Bargmann, Cell 112, 619 (2003).
5. G. Fischer von Mollard et al., Proc. Natl. Acad. Sci. U.S.A. 87, 1988 (1990).
6. M. Zhen, Y. Jin, Nature 401, 371 (1999).
7. K. Shen, R. D. Fetter, C. I. Bargmann, Cell 116, 869 (2004).
8. T. Cardozo, M. Pagano, Nat. Rev. Mol. Cell Biol. 5, 739 (2004).
9. K. I. Nakayama, K. Nakayama, Nat. Rev. Cancer 6, 369 (2006).
10. A. DiAntonio et al., Nature 412, 449 (2001).
11. M. D. Ehlers, Nat. Neurosci. 6, 231 (2003).
12. R. J. Watts, E. D. Hoopfer, L. Luo, Neuron 38, 871 (2003).
13. M. Zhen, X. Huang, B. Bamber, Y. Jin, Neuron 26, 331 (2000).
14. A. M. Schaefer, G. D. Hadwiger, M. L. Nonet, Neuron 26, 345 (2000).
15. L. Dreier, M. Burbea, J. M. Kaplan, Neuron 46, 51 (2005).
16. E. H. Liao, W. Hung, B. Abrams, M. Zhen, Nature 430, 345 (2004).
17. S. Jager, H. T. Schwartz, H. R. Horvitz, B. Conradt, Proc. Natl. Acad. Sci. U.S.A. 101, 12549 (2004).
18. E. J. Hubbard, G. Wu, J. Kitajewski, I. Greenwald, Genes Dev. 11, 3182 (1997).
19. D. H. Lee, A. L. Goldberg, Trends Cell Biol. 8, 397 (1998).
20. R. J. Deshaies, Annu. Rev. Cell Dev. Biol. 15, 435 (1999).
21. C. L. Waites, A. M. Craig, C. C. Garner, Annu. Rev. Neurosci. 28, 251 (2005).
22. S. D. Speese, N. Trotta, C. K. Rodesch, B. Aravamudan, K. Broadie, Curr. Biol. 13, 899 (2003).
23. A. N. Hegde, A. DiAntonio, Nat. Rev. Neurosci. 3, 854 (2002).
24. M. Colledge et al., Neuron 40, 595 (2003).
25. P. Juo, J. M. Kaplan, Curr. Biol. 14, 2057 (2004).
26. A. DiAntonio, L. Hicke, Annu. Rev. Neurosci. 27, 223 (2004).
27. B. Bingol, E. M. Schuman, Nature 441, 1144 (2006).
28. We thank CGC, Japanese NBPR, Y. Kohara, M. Nonet, and J. Audhya for reagents. Supported by NIH grant 1R01NS048392 (K.S.), the McKnight endowment fund (K.S.), the W. M. Keck Foundation (K.S.), and the Searle Scholarship (K.S.).