SCFPof1-ubiquitin and its target Zip1 transcription factor mediate cadmium response in fission yeast

EMBO Journal

Volumn 24, Issue 3, 2005, Pages 599-610

  Harrison, Clare ^a   Katayama, Satoshi ^a,d   Dhut, Susheela ^a   Chen, Dongrong ^b,c   Jones, Nie ^c   Bähler, Jürg ^b   Toda, Takashi ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

^d SAGA UNIVERSITY   (Japan)

Author keywords

Cadmium; DNA microarray; Proteolysis; SCF; Ubiquitin

Indexed keywords

CADMIUM; F BOX PROTEIN; LEUCINE ZIPPER PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ZIP1; UBIQUITIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ARTICLE; CELL BUDDING; CELL SIZE; CELL VIABILITY; CONTROLLED STUDY; DNA MICROARRAY; EUKARYOTE; FUNGAL GENE; GENE EXPRESSION REGULATION; GROWTH INHIBITION; IN VIVO STUDY; NONHUMAN; POF1 GENE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; STRESS; TEMPERATURE SENSITIVE MUTANT; UBIQUITINATION; YEAST;

BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; CADMIUM; CARRIER PROTEINS; DNA-BINDING PROTEINS; F-BOX PROTEINS; G-BOX BINDING FACTORS; GENES, FUNGAL; MODELS, BIOLOGICAL; MUTATION; PHOSPHORYLATION; PROTEIN BINDING; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; SKP CULLIN F-BOX PROTEIN LIGASES; SUPPRESSION, GENETIC; TEMPERATURE; TRANSCRIPTION FACTORS; UBIQUITIN; UP-REGULATION;

EUKARYOTA; SACCHAROMYCETALES; SCHIZOSACCHAROMYCES POMBE;

EID: 14844303289     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600536     Document Type: Article

References (41)

1. Bai C, Sen P, Hofmann K, Ma L, Goebl M, Harper JW, Elledge SJ (1996) SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell 86: 263-274
2. Basi G, Schmid E, Maundrell K (1993) TATA box mutations in the Schizosaccharomyces pombe nmt1 promoter affect transcriptional efficiency but not the transcription start point or thiamine repressibility. Gene 123: 131-136
3. Cardozo T, Pagano M (2004) The SCF ubiquitin ligase: insights into a molecular machine. Nat Rev Mol Cell Biol 5: 739-751
4. Causton HC, Ren B, Koh SS, Harbison CT, Kanin E, Jennings EG, Lee TI, True HL, Lander ES, Young RA (2001) Remodeling of yeast genome expression in response to environmental changes. Mol Biol Cell 12: 323-337
5. Chattopadhyay MK, Tabor CW, Tabor H (2002) Absolute requirement of spermidine for growth and cell cycle progression of fission yeast (Schizosaccharomyces pombe). Proc Nat Acad Sci USA 99: 10330-10334
6. Chen D, Toone WM, Mata J, Lyne R, Burns G, Kivinen K, Brazma A, Jones N, Bahler J (2003) Global transcriptional responses of fission yeast to environmental stress. Mol Cell Biol 14: 214-229
7. Clemens S, Simm C (2003) Schizosaccharomyces pombe as a model for metal homeostasis in plant cells: the phytochelatin-dependent pathway is the main cadmium detoxification mechanism. New Phytol 159: 323-330
8. Cullinan SB, Gordan JD, Jin J, Harper W, Diehl JA (2004) The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase. Mol Cell Biol 24: 8477-8486
9. Dormer UH, Westwater J, McLaren NF, Kent NA, Mellor J, Jamieson DJ (2000) Cadmium-inducible expression of the yeast GSH1 gene requires a functional sulfur-amino acid regulatory network. J Biol Chem 275: 32611-32616
10. Fauchon M, Lagniel G, Aude J-C, Lombardia L, Soularue P, Petat C, Marguerie G, Sentenac A, Werner M, Labarre J (2002) Sulfur sparing in the yeast proteome in response to sulfur demand. Mol Cell 9: 713-723
11. Feldman RMR, Correll CC, Kaplan KB, Deshaies RJ (1997) A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell 91: 221-230
12. Flick K, Ouni I, Wohlschlegel JA, Capati C, McDonald WH, Yates III JR, Kaiser P (2004) Proteolysis-independent regulation of the transcription factor Met4 by a single Lys 48-linked ubiquitin chain. Nat Cell Biol 6: 634-641
13. Gasch AP, Spellman PT, Kao CM, Carmel-Harel O, Eisen MB, Storz G, Botstein D, Brown PO (2000) Genomic expression programs in the response of yeast cells to environmental changes. Mol Cell Biol 11: 4241-4257
14. Hartwell LH, Weinert TA (1989) Checkpoints: controls that ensure the order of cell cycle events. Science 246: 629-634
15. Hayes JD, Chanas SA, Henderson CJ, McMahon M, Sun C, Moffat GJ, Wolf CR, Yamamoto M (2000) The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin. Biochem Soc Trans 28: 33-41
16. Hengstler JG, Bolm-Audorff U, Faldum A, Janssen K, Reifenrath M, Gotte W, Jung D, Mayer-Popken O, Fuchs J, Gebhard S, Bienfait HG, Schlink K, Dietrich C, Faust D, Epe B, Oesch F (2003) Occupational exposure to heavy metals: DNA damage induction and DNA repair inhibition prove co-exposures to cadmium, cobalt and lead as more dangerous than hitherto expected. Carcinogenesis 24: 63-73
17. Hermand D, Bamps S, Tafforeau L, Vandenhaute J, Makela TP (2003) Skp1 and the F-box protein Pof6 are essential for cell separation in fission yeast. J Biol Chem 278: 9671-9677
18. Hershko A, Ciechanover A (1998) The ubiquitin system. Annu Rev Biochem 67: 425-479
19. Hochstrasser M (1996) Ubiquitin-dependent protein degradation. Annu Rev Genet 30: 405-439
20. Ikebe C, Kominami K, Toda T, Nakayama K (2002) Isolation and characterization of a novel F-box protein Pof10 in fission yeast. Biochem Biophys Res Commun 290: 1399-1407
21. Met30-mediated inactivation of the transcription factor Met4. Cell 102: 303-314
22. Kobayashi A, Kang MI, Okawa H, Ohtsuji M, Zenke Y, Chiba T, Igarashi K, Yamamoto M (2004) Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol 24: 7130-7139
23. Kominami K, Ochotorena I, Toda T (1998) TWo F-box/WD-repeat proteins Pop1 and Pop2 form hetero- and homo-complexes together with cullin-1 in the fission yeast SCF (Skp1-Cullin-1-F-box) ubiquitin ligase. Genes Cells 3: 721-735
24. Kuras L, Rouillon A, Lee T, Barbey R, Tyers M, Thomas D (2002) Dual regulation of the Met4 transcription factor by ubiquitin-dependent degradation and inhibition of promoter recruitment. Mol Cell 10: 69-80
25. Kuras L, Thomas D (1995) Functional analysis of Met4, a yeast transcriptional activator responsive to S-adenosylmethionione. Mol Cell Biol 15: 208-216
26. Lehmann A, Katayama S, Harrison C, Dhut S, Kitamura K, McDonald N, Toda T (2004) Molecular interactions of fission yeast Skp1 and its role in the DNA damage checkpoint. Genes Cells 9: 367-382
27. Marzluf GA (1997) Molecular genetics of sulfur assimilation in filamentous fungi and yeast. Annu Rev Microbiol 51: 73-96
28. Nash P, Tang X, Orlicky S, Chen Q, Gertler FB, Mendenhall MD, Sicheri F, Pawson T, Tyers M (2001) Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature 414: 514-521
29. Nurse P (1990) Universal control mechanism regulating onset of M-phase. Nature (Lond.) 344: 503-508
30. Ohmiya R, Kato C, Yamada H, Aiba H, Mizuno T (1999) Isolation of multicopy suppressors of the calcium sensitivity of a mutant lacking the bZIP transcription factor Atf1 in fission yeast. Mol Gen Genet 261: 297-306
31. Pahl HL, Baeuerle PA (1996) Control of gene expression by proteolysis. Curr Opin Cell Biol 8: 340-347
32. Met30-mediated control of the transcriptional activator Met4 is required for the G1-S transition. EMBO J 19: 1613-1624
33. Patton EE, Willems AR, Tyers M (1998) Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis. Trends Genet 14: 236-243
34. Met30 complex. EMBO J 19: 282-294
35. Seeger M, Gordon C, Ferrell K, Dubiel W (1996) Characteristics of 26 S proteasomes from fission yeast mutants, which arrest in mitosis. J Mol Biol 263: 423-431
36. Skowyra D, Craig KL, Tyers M, Elledge SJ, Harper JW (1997) F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91: 209-219
37. Stewart D, Killeen E, Naquin R, Alam S, Alam J (2003) Degradation of transcription factor Nrf2 via the ubiquitin-proteosome pathway and stabilization by cadmium. J Biol Chem 278: 2396-2402
38. Tabor CW, Tabor H (1984) Polyamines. Annu Rev Biochem 53: 749-790
39. Thomas D, Kuras L, Barbey R, Cherest H, Blaiseau P-L, Surdin-Kerjan Y (1995) Met30p, a yeast transcriptional inhibitor that responds to S-adenosylmethionine, is an essential protein with WD40 repeats. Mol Cell Biol 15: 6526-6534
40. Toone WM, Jones N (1998) Stress-activated signalling pathways in yeast. Genes Cells 3: 485-498
41. Wheeler GL, Quinn KA, Perrone G, Dawes IW, Grant CM (2002) Glutathione regulates the expression of γ-glutamycysteine synthetase via the Met4 transcription factor. Mol Micobiol 46: 545-556