Budding yeast Cdc6p induces re-replication in fission yeast by inhibition of SCF(Pop)-mediated proteolysis

Molecular and General Genetics

Volumn 262, Issue 3, 1999, Pages 473-480

  Wolf, D A ^a   McKeon, F ^b   Jackson, P K ^c  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cdc6p; Cell cycle control; DNA replication; Proteolysis; SCF

Indexed keywords

PROTEIN KINASE; PROTEIN KINASE INHIBITOR; UBIQUITIN PROTEIN LIGASE;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL DIVISION; COMPLEX FORMATION; CONTROLLED STUDY; DNA REPLICATION; DNA SYNTHESIS; ENZYME ACTIVITY; GENE OVEREXPRESSION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; YEAST CELL;

CDC2 PROTEIN KINASE; CELL CYCLE PROTEINS; DNA REPLICATION; FUNGAL PROTEINS; PHENOTYPE; REPRESSOR PROTEINS; RIBONUCLEASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; TRANSCRIPTION FACTORS;

EID: 0032718827     PISSN: 00268925     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004380051108     Document Type: Article

References (32)

1. Aparicio OM, Weinstein DM, Bell SP (1997) Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase. Cell 91:59-69
2. Baum B, Nishitani H, Yanow S, Nurse P (1998) Cdc18 transcription and proteolysis couple S phase to passage through mitosis. EMBO J 17:5689-5698
3. Benito J, Martin-Castellanos C, Moreno S (1998) Regulation of the G1 phase of the cell cycle by periodic stabilization and degradation of the p25rum1 CDK inhibitor. EMBO J 17:482-497
4. Brown GW, Jallepalli PV, Huneycutt BJ, Kelly TJ (1997) Interaction of the S phase regulator cdclS with cyclin-dependent kinase in fission yeast. Proc Natl Acad Sci USA 94:6142-6147
5. Cocker JH, Piatti S, Santocanale C, Nasmyth K, Diffley JF (1996) An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast. Nature 379:180-182
6. Coleman TR, Carpenter PB, Dunphy WG (1996) The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts. Cell 87:53-63
7. Correa-Bordes J, Nurse P (1995) p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase. Cell 83:1001-1009
8. Dahmann C, Diffley JF, Nasmyth KA (1995) S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state. Curr Biol 5:1257-1269
9. Diffley JF (1996) Once and only once upon a time: specifying and regulating origins of DNA replication in eukaryotic cells. Genes Dev 10:2819-2830
10. Donovan S, Harwood J, Drury LS, Diffley JF (1997) Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast. Proc Natl Acad Sci USA 94:5611-5616
11. Drury LS, Perkins G, Diffley JF (1997) The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast. EMBO J 16:5966-5976
12. Elsasser S, Lou F, Wang B, Campbell JL, Jong A (1996) Interaction between yeast Cdc6 protein and B-type cyclin/Cdc28 kinases. Mol Biol Cell 7:1723-1735
13. Feldman RM, Correll CC, Kaplan KB, Deshaies RJ (1997) A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell 91:221-230
14. Jallepalli PV, Kelly TJ (1996) Rum1 and Cdc18 link inhibition of cyclin-dependent kinase to the initiation of DNA replication in Schizosaccharomyces pombe. Genes Dev 10:541-552
15. Jallepalli PV, Brown GW, Muzi-Falconi M, Tien D, Kelly TJ (1997) Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation. Genes Dev 11:2767-2779
16. Jallepalli PV, Tien D, Kelly TJ (1998) sud1(+) targets cyclin-dependent kinase-phosphorylated Cdc18 and Rum1 proteins for degradation and stops unwanted diploidization in fission yeast. Proc Natl Acad Sci USA 95:8159-8164
17. Kominami K, Toda T (1997) Fission yeast WD-repeat protein pop1 regulates genome ploidy through ubiquitin-proteasome-mediated degradation of the CDK inhibitor Rum1 and the S-phase initiator Cdc18. Genes Dev 11:1548-1560
18. Kominami K, Ochotorena I, Toda T (1998) Two F-box/WD-repeat proteins Pop1 and Pop2 form hetero-and homo-complexes together with cullin-1 in the fission yeast SCF (Skp1-Cullin-1-F-box) ubiquitin ligase. Genes Cells 3:721-735
19. Lopez-Girona A, Mondesert O, Leatherwood J, Russell P (1998) Negative regulation of Cdc18 DNA replication protein by Cdc2. Mol Biol Cell 9:63-73
20. Maekawa H, Kitamura K, Shimoda C (1998) The Ste16 WD-repeat protein regulates cell-cycle progression under starvation through the Rum1 protein in Schizosaccharomyces pombe. Curr Genet 33:29-37
21. Martin-Castellanos C, Moreno S (1996) Regulation of G1 progression in fission yeast by the rum1+ gene product. Prog Cell Cycle Res 2:29-35
22. Maundrell K (1990) nmt1 of fission yeast. A highly transcribed gene completely repressed by thiamine. J Biol Chem 265:10857-10864
23. Moreno S, Nurse P (1994) Regulation of progression through the G1 phase of the cell cycle by the rum1+ gene. Nature 367:236-242
24. Muzi Falconi M, Brown GW, Kelly TJ (1996) cdc18+ regulates initiation of DNA replication in Schizosaccharomyces pombe. Proc Natl Acad Sci USA 93:1566-1570
25. Nishitani H, Nurse P (1995) p65cdc18 plays a major role controlling the initiation of DNA replication in fission yeast. Cell 83:397-405
26. Piatti S, Bohm T, Cocker JH, Diffley JF, Nasmyth K (1996) Activation of S-phase-promoting CDKs in late G1 defines a "point of no return" after which Cdc6 synthesis cannot promote DNA replication in yeast. Genes Dev 10:1516-1531
27. Piatti S, Lengauer C, Nasmyth K (1995) Cdc6 is an unstable protein whose de novo synthesis in G1 is important for the onset of S phase and for preventing a 'reductional' anaphase in the budding yeast Saccharomyces cerevisiae. EMBO J 14:3788-3799
28. Schwob E, Bohm T, Mendenhall MD, Nasmyth K (1994) The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae. Cell 79:233-244 (see Erratum Cell 84, following 174)
29. Skowyra D, Craig KL, Tyers M, Elledge SJ, Harper JW (1997) F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91:209-219
30. Tanaka T, Knapp D, Nasmyth K (1997) Loading of an Mem protein onto DNA replication origins is regulated by Cdc6p and CDKs. Cell 90:649-660
31. Wolf DA, Wu D, McKeon F (1996) Disruption of re-replication control by overexpression of human ORC1 in fission yeast. J Biol Chem 271:32503-32506
32. Wolf DA, McKeon F, Jackson PK (1999) F-box/WD-repeat proteins Pop1p and Sud1p/Pop2p form complexes that bind and direct the proteolysis of Cdc18p. Curr Biol 9:373-376