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Volumn 14, Issue 3, 2008, Pages 226-236

Different types of cell death in organismal aging and longevity: State of the art and possible systems biology approach

Author keywords

[No Author keywords available]

Indexed keywords

BECLIN 1; DEATH ASSOCIATED PROTEIN KINASE; DNA; EPIDERMAL GROWTH FACTOR; HEAT SHOCK PROTEIN; MITOCHONDRIAL PROTEIN; PROTEIN BCL 2; PROTEIN KINASE C EPSILON; PROTEIN P53; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

EID: 39749152243     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/138161208783413266     Document Type: Review
Times cited : (10)

References (166)
  • 2
    • 33845338765 scopus 로고    scopus 로고
    • Cellular senescence, and cancer treatment. Biochim
    • Schmitt CA. Cellular senescence, and cancer treatment. Biochim Biophys Acta 2007; 1775: 5-20.
    • (2007) Biophys Acta , vol.1775 , pp. 5-20
    • Schmitt, C.A.1
  • 3
    • 33750729203 scopus 로고    scopus 로고
    • Theories of biological aging: Genes, proteins, and free radicals
    • Rattan SI. Theories of biological aging: Genes, proteins, and free radicals. Free Radic Res 2006; 40: 1230-8.
    • (2006) Free Radic Res , vol.40 , pp. 1230-1238
    • Rattan, S.I.1
  • 6
    • 0035851216 scopus 로고    scopus 로고
    • Aging enhances the sensitivity of endothelial cells toward apoptotic stimuli: Important role of nitric oxide
    • Hoffmann J, Haendeler J, Aicher A, Rossig L, Vasa M, Zeiher AM, et al. Aging enhances the sensitivity of endothelial cells toward apoptotic stimuli: Important role of nitric oxide. Circ Res 2001; 89: 709-15.
    • (2001) Circ Res , vol.89 , pp. 709-715
    • Hoffmann, J.1    Haendeler, J.2    Aicher, A.3    Rossig, L.4    Vasa, M.5    Zeiher, A.M.6
  • 7
    • 0035131153 scopus 로고    scopus 로고
    • Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53
    • Seluanov A, Gorbunova V, Falcovitz A, Sigal A, Milyavsky M, Zurer I, et al. Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53. Mol Cell Biol 2001; 21: 1552-64.
    • (2001) Mol Cell Biol , vol.21 , pp. 1552-1564
    • Seluanov, A.1    Gorbunova, V.2    Falcovitz, A.3    Sigal, A.4    Milyavsky, M.5    Zurer, I.6
  • 10
  • 11
    • 33749559879 scopus 로고    scopus 로고
    • Vitamin D3 upregulated protein 1 (VDUP1) is a regulator for redox signaling and stress-mediated diseases
    • Chung JW, Jeon JH, Yoon SR, Choi I. Vitamin D3 upregulated protein 1 (VDUP1) is a regulator for redox signaling and stress-mediated diseases. J Dermatol 2006; 33: 662-9.
    • (2006) J Dermatol , vol.33 , pp. 662-669
    • Chung, J.W.1    Jeon, J.H.2    Yoon, S.R.3    Choi, I.4
  • 12
    • 33846576691 scopus 로고    scopus 로고
    • Proteomic analysis of the aging-related proteins in human normal colon epithelia tissue
    • Li M, Xiao ZQ, Chen ZC, Li JL, Li C, Zhang PF, et al. Proteomic analysis of the aging-related proteins in human normal colon epithelia tissue. J Biochem Mol Biol. 2007; 40: 72-81.
    • (2007) J Biochem Mol Biol , vol.40 , pp. 72-81
    • Li, M.1    Xiao, Z.Q.2    Chen, Z.C.3    Li, J.L.4    Li, C.5    Zhang, P.F.6
  • 13
    • 0030911124 scopus 로고    scopus 로고
    • Response of a primary human fibroblast cell line to H2O2: Senescencelike growth arrest or apoptosis?
    • Bladier C, Wolvetang EJ, Hutchinson P, de Haan JB, Kola I. Response of a primary human fibroblast cell line to H2O2: Senescencelike growth arrest or apoptosis? Cell Growth Differ 1997; 8: 589-98.
    • (1997) Cell Growth Differ , vol.8 , pp. 589-598
    • Bladier, C.1    Wolvetang, E.J.2    Hutchinson, P.3    de Haan, J.B.4    Kola, I.5
  • 14
    • 0033606852 scopus 로고    scopus 로고
    • Role of p53 and p21 waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs
    • Chang BD, Xuan Y, Broude EV, Zhu H, Schott B, Fang J, et al. Role of p53 and p21 waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs. Oncogene 1999; 18: 4808-18.
    • (1999) Oncogene , vol.18 , pp. 4808-4818
    • Chang, B.D.1    Xuan, Y.2    Broude, E.V.3    Zhu, H.4    Schott, B.5    Fang, J.6
  • 15
    • 0029901910 scopus 로고    scopus 로고
    • Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytes
    • Härle-Bachor C, Boukamp P. Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytes. Proc Natl Acad Sci USA 1996; 93: 6476-81.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 6476-6481
    • Härle-Bachor, C.1    Boukamp, P.2
  • 16
    • 0034597794 scopus 로고    scopus 로고
    • Telomere states and cell fates
    • Blackburn EH. Telomere states and cell fates. Nature 2000; 408: 53-6
    • (2000) Nature , vol.408 , pp. 53-56
    • Blackburn, E.H.1
  • 18
    • 27744446137 scopus 로고    scopus 로고
    • Intensive inhibition of hTERT expression by a ribozyme induces rapid apoptosis of cancer cells through a telomere length-independent pathway
    • Hao ZM, Luo JY, Chong J, Li L, He D, Wang QY, et al. Intensive inhibition of hTERT expression by a ribozyme induces rapid apoptosis of cancer cells through a telomere length-independent pathway. Cancer Biol Ther 2005; 4: 1098-103.
    • (2005) Cancer Biol Ther , vol.4 , pp. 1098-1103
    • Hao, Z.M.1    Luo, J.Y.2    Chong, J.3    Li, L.4    He, D.5    Wang, Q.Y.6
  • 19
    • 0041659132 scopus 로고    scopus 로고
    • Karyotype instability and anchorage-independent growth in telomerase-immortalized fibroblasts from two centenarian individuals
    • Mondello C, Chiesa M, Rebuzzini P, Zongaro S, Verri A, Colombo T, et al. Karyotype instability and anchorage-independent growth in telomerase-immortalized fibroblasts from two centenarian individuals. Biochem Biophys Res Common 2003; 308: 914-21.
    • (2003) Biochem Biophys Res Common , vol.308 , pp. 914-921
    • Mondello, C.1    Chiesa, M.2    Rebuzzini, P.3    Zongaro, S.4    Verri, A.5    Colombo, T.6
  • 21
    • 3242891953 scopus 로고    scopus 로고
    • The immune system in the elderly: Activation-induced and damage-induced apoptosis
    • Gialdi L, De Martinis M, Monti D, Franceschi C. The immune system in the elderly: Activation-induced and damage-induced apoptosis. Immunol Res 2004; 30: 81-94.
    • (2004) Immunol Res , vol.30 , pp. 81-94
    • Gialdi, L.1    De Martinis, M.2    Monti, D.3    Franceschi, C.4
  • 22
    • 24744463111 scopus 로고    scopus 로고
    • Autophagy in innate and adaptive immunity
    • Deretic V. Autophagy in innate and adaptive immunity. Trends Immunol 2005; 26: 523-8.
    • (2005) Trends Immunol , vol.26 , pp. 523-528
    • Deretic, V.1
  • 24
    • 0035915794 scopus 로고    scopus 로고
    • Decreased susceptibility to oxidative stress-induced apoptosis of peripheral blood mononuclear cells from healthy elderly and centenarians
    • Monti D, Salvioli S, Capri M, Malorni W, Straface E, Cossarizza A, et al. Decreased susceptibility to oxidative stress-induced apoptosis of peripheral blood mononuclear cells from healthy elderly and centenarians. Mech Ageing Dev 2000; 121: 239-50.
    • (2000) Mech Ageing Dev , vol.121 , pp. 239-250
    • Monti, D.1    Salvioli, S.2    Capri, M.3    Malorni, W.4    Straface, E.5    Cossarizza, A.6
  • 25
    • 0032845553 scopus 로고    scopus 로고
    • Resistance to apoptosis in human CD8+ T cells that reach replicative senescence after multiple rounds of antigen-specific proliferation
    • Spaulding C, Guo W, Effros RB. Resistance to apoptosis in human CD8+ T cells that reach replicative senescence after multiple rounds of antigen-specific proliferation. Exp Gerontol 1999; 34: 633-44.
    • (1999) Exp Gerontol , vol.34 , pp. 633-644
    • Spaulding, C.1    Guo, W.2    Effros, R.B.3
  • 26
    • 34147222679 scopus 로고    scopus 로고
    • Telomerase induction in T cells: A cure for aging and disease?
    • Effros RB. Telomerase induction in T cells: A cure for aging and disease? Exp Gerontol 2007; 42: 416-20.
    • (2007) Exp Gerontol , vol.42 , pp. 416-420
    • Effros, R.B.1
  • 27
    • 0030035269 scopus 로고    scopus 로고
    • Expansion of cytotoxic CD8+ CD28- T cells in healthy ageing people, including centenarians
    • Fagnoni FF, Vescovini R, Mazzola M, Bologna G, Nigro E, Lavagetto G et al. Expansion of cytotoxic CD8+ CD28- T cells in healthy ageing people, including centenarians. Immunology 1996; 88: 501-7.
    • (1996) Immunology , vol.88 , pp. 501-507
    • Fagnoni, F.F.1    Vescovini, R.2    Mazzola, M.3    Bologna, G.4    Nigro, E.5    Lavagetto, G.6
  • 28
    • 0037396495 scopus 로고    scopus 로고
    • Age-dependent changes in the susceptibility to apoptosis of peripheral blood CD4+ and CD8+ T lymphocytes with virgin or memory phenotype
    • Salvioli S, Capri M, Scarcella E, Mangherini S, Faranca I, Volterra V, et al. Age-dependent changes in the susceptibility to apoptosis of peripheral blood CD4+ and CD8+ T lymphocytes with virgin or memory phenotype. Mech Aging Dev 2003; 124: 409-18.
    • (2003) Mech Aging Dev , vol.124 , pp. 409-418
    • Salvioli, S.1    Capri, M.2    Scarcella, E.3    Mangherini, S.4    Faranca, I.5    Volterra, V.6
  • 29
    • 0035930860 scopus 로고    scopus 로고
    • A stochastic model for CD8(+)T cell dynamics in human immunosenescence: Implications for survival and longevity
    • Luciani F, Valensin S, Vescovini R, Sansoni P, Fagnoni F, Franceschi C, et al. A stochastic model for CD8(+)T cell dynamics in human immunosenescence: Implications for survival and longevity. J Theor Biol 2001; 213: 587-97.
    • (2001) J Theor Biol , vol.213 , pp. 587-597
    • Luciani, F.1    Valensin, S.2    Vescovini, R.3    Sansoni, P.4    Fagnoni, F.5    Franceschi, C.6
  • 31
    • 18744422561 scopus 로고    scopus 로고
    • Proliferation and apoptosis of human CD8(+)CD28(+) and CD8(+)CD28(-) lymphocytes during aging
    • Brzezinska A, Magalska A, Szybinska A, Sikora E. Proliferation and apoptosis of human CD8(+)CD28(+) and CD8(+)CD28(-) lymphocytes during aging. Exp Gerontol 2004; 39: 539-44.
    • (2004) Exp Gerontol , vol.39 , pp. 539-544
    • Brzezinska, A.1    Magalska, A.2    Szybinska, A.3    Sikora, E.4
  • 32
    • 17644425982 scopus 로고    scopus 로고
    • CD27(+) (memory) B cell decrease and apoptosis-resistant CD27(-) (naive) B cell increase in aged humans: Implications for age-related peripheral B cell developmental disturbances
    • Chong Y, Ikematsu H, Yamaji K, Nishimura M, Nabeshima S, Kashiwagi S, et al. CD27(+) (memory) B cell decrease and apoptosis-resistant CD27(-) (naive) B cell increase in aged humans: Implications for age-related peripheral B cell developmental disturbances. Int Immunol 2005; 17: 383-90.
    • (2005) Int Immunol , vol.17 , pp. 383-390
    • Chong, Y.1    Ikematsu, H.2    Yamaji, K.3    Nishimura, M.4    Nabeshima, S.5    Kashiwagi, S.6
  • 34
    • 20344399856 scopus 로고    scopus 로고
    • Impaired apoptosis and immune senescence - cause or effect?
    • Hsu HC, Scott DK, Mountz JD. Impaired apoptosis and immune senescence - cause or effect? Immunol Rev 2005; 205: 130-46.
    • (2005) Immunol Rev , vol.205 , pp. 130-146
    • Hsu, H.C.1    Scott, D.K.2    Mountz, J.D.3
  • 35
    • 0033975581 scopus 로고    scopus 로고
    • Human immunosenescence: The prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space
    • Franceschi C, Bonafe M, Valensin S. Human immunosenescence: The prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space. Vaccine 2000; 18: 1717-20.
    • (2000) Vaccine , vol.18 , pp. 1717-1720
    • Franceschi, C.1    Bonafe, M.2    Valensin, S.3
  • 36
    • 3543141247 scopus 로고    scopus 로고
    • Different contribution of EBV and CMV infections in very long-term carriers to age-related alterations of CD8+ T cells
    • Vescovini R, Telera A, Fagnoni FF, Biasini C, Medici MC, Valcavi P, et al. Different contribution of EBV and CMV infections in very long-term carriers to age-related alterations of CD8+ T cells. Exp Gerontol 2004; 39: 1233-43.
    • (2004) Exp Gerontol , vol.39 , pp. 1233-1243
    • Vescovini, R.1    Telera, A.2    Fagnoni, F.F.3    Biasini, C.4    Medici, M.C.5    Valcavi, P.6
  • 37
    • 33845433364 scopus 로고    scopus 로고
    • Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence
    • Feng L, Hollstein M, Xu Y. Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence. Cell Cycle 2006; 5: 2812-9.
    • (2006) Cell Cycle , vol.5 , pp. 2812-2819
    • Feng, L.1    Hollstein, M.2    Xu, Y.3
  • 38
    • 33749020871 scopus 로고    scopus 로고
    • p53 is preferentially recruited to the promoters of growth arrest genes p21 and GADD45 during replicative senescence of normal human fibroblasts
    • Jackson JG, Pereira-Smith OM. p53 is preferentially recruited to the promoters of growth arrest genes p21 and GADD45 during replicative senescence of normal human fibroblasts. Cancer Res 2006; 66: 8356-60
    • (2006) Cancer Res , vol.66 , pp. 8356-8360
    • Jackson, J.G.1    Pereira-Smith, O.M.2
  • 39
    • 12344258860 scopus 로고    scopus 로고
    • Donehower LA. p53: Guardian AND suppressor of longevity? Exp Gerontol 2005; 40: 7-9.
    • Donehower LA. p53: Guardian AND suppressor of longevity? Exp Gerontol 2005; 40: 7-9.
  • 40
    • 34248385190 scopus 로고    scopus 로고
    • DNA binding and selective gene induction by different forms of the p53 protein
    • Mayelzadeh F, Martinez JD. DNA binding and selective gene induction by different forms of the p53 protein. Oncogene 2007; 26: 2955-63.
    • (2007) Oncogene , vol.26 , pp. 2955-2963
    • Mayelzadeh, F.1    Martinez, J.D.2
  • 42
    • 4544334659 scopus 로고    scopus 로고
    • The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death
    • Bonafe M, Salvioli S, Barbi C, Trapassi C, Tocco F, Storci G, et al. The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death. Cell Death Differ 2004; 11: 962-73.
    • (2004) Cell Death Differ , vol.11 , pp. 962-973
    • Bonafe, M.1    Salvioli, S.2    Barbi, C.3    Trapassi, C.4    Tocco, F.5    Storci, G.6
  • 43
    • 2442689078 scopus 로고    scopus 로고
    • Polymorphism in wild-type p53 modulates response to chemotherapy in vitro and in vivo
    • Sullivan A, Syed N, Gasco M, Bergamaschi D, Trigiante G, Attard M, et al. Polymorphism in wild-type p53 modulates response to chemotherapy in vitro and in vivo. Oncogene 2004; 23: 3328-37.
    • (2004) Oncogene , vol.23 , pp. 3328-3337
    • Sullivan, A.1    Syed, N.2    Gasco, M.3    Bergamaschi, D.4    Trigiante, G.5    Attard, M.6
  • 44
    • 25444529023 scopus 로고    scopus 로고
    • p53 codon 72 alleles influence the response to anticancer drugs in cells from aged people by regulating the cell cycle inhibitor p21WAF1
    • Salvioli S, Bonafe M, Barbi C, Storci G, Trapassi C, Tocco F, et al. p53 codon 72 alleles influence the response to anticancer drugs in cells from aged people by regulating the cell cycle inhibitor p21WAF1. Cell Cycle 2005; 4:1264-71.
    • (2005) Cell Cycle , vol.4 , pp. 1264-1271
    • Salvioli, S.1    Bonafe, M.2    Barbi, C.3    Storci, G.4    Trapassi, C.5    Tocco, F.6
  • 47
    • 33747201603 scopus 로고    scopus 로고
    • Heritability of DNA-damage-induced apoptosis and its relationship with age in lymphocytes from female twins
    • Camplejohn RS, Hodgson S, Carter N, Kato BS, Spector TD. Heritability of DNA-damage-induced apoptosis and its relationship with age in lymphocytes from female twins. Br J Cancer 2006; 95: 520-4.
    • (2006) Br J Cancer , vol.95 , pp. 520-524
    • Camplejohn, R.S.1    Hodgson, S.2    Carter, N.3    Kato, B.S.4    Spector, T.D.5
  • 48
    • 34248333318 scopus 로고    scopus 로고
    • Cancer regression by senescence
    • Serrano M. Cancer regression by senescence. N Engl J Med 2007; 356: 1996-7.
    • (2007) N Engl J Med , vol.356 , pp. 1996-1997
    • Serrano, M.1
  • 50
    • 33745712849 scopus 로고    scopus 로고
    • The power and the promise of oncogene-induced senescence markers
    • Collado M, Serrano M. The power and the promise of oncogene-induced senescence markers. Nat Rev Cancer 2006; 6: 472-6.
    • (2006) Nat Rev Cancer , vol.6 , pp. 472-476
    • Collado, M.1    Serrano, M.2
  • 51
    • 33846086146 scopus 로고    scopus 로고
    • Is cell death and replacement a factor in aging?
    • Warner HR. Is cell death and replacement a factor in aging? Mech Aging Dev 2007; 128: 13-6.
    • (2007) Mech Aging Dev , vol.128 , pp. 13-16
    • Warner, H.R.1
  • 52
    • 0035834121 scopus 로고    scopus 로고
    • Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging
    • Krtolica A, Parrinello S, Lockett S, Desprez PY, Campisi J. Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging. Proc Natl Acad Sci USA 2001; 98: 12072-7.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 12072-12077
    • Krtolica, A.1    Parrinello, S.2    Lockett, S.3    Desprez, P.Y.4    Campisi, J.5
  • 53
    • 23244452684 scopus 로고    scopus 로고
    • Suppressing cancer: The importance of being senescent
    • Campisi J. Suppressing cancer: The importance of being senescent. Science 2005; 309: 896-7.
    • (2005) Science , vol.309 , pp. 896-897
    • Campisi, J.1
  • 54
    • 84950382925 scopus 로고
    • Cell proliferation, cell death and aging
    • Franceschi C. Cell proliferation, cell death and aging. Aging (Milano). 1989; 1: 3-15.
    • (1989) Aging (Milano) , vol.1 , pp. 3-15
    • Franceschi, C.1
  • 55
    • 0031452173 scopus 로고    scopus 로고
    • Structure and physiological function of calpains
    • Sorimachi H, Ishiura S, Suzuki K. Structure and physiological function of calpains. Biochem J 1997; 328:721-32.
    • (1997) Biochem J , vol.328 , pp. 721-732
    • Sorimachi, H.1    Ishiura, S.2    Suzuki, K.3
  • 56
  • 57
  • 58
    • 4544385218 scopus 로고    scopus 로고
    • Autophagy: Many paths to the same end
    • Cuervo AM. Autophagy: Many paths to the same end. Mol Cell Biochem 2004; 263: 55-72.
    • (2004) Mol Cell Biochem , vol.263 , pp. 55-72
    • Cuervo, A.M.1
  • 59
    • 4344563878 scopus 로고    scopus 로고
    • Role and regulation of starvation-induced autophagy in the Drosophila fat body
    • Scott RC, Schuldiner O, Neufeld TP. Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev Cell 2004; 7: 167-78.
    • (2004) Dev Cell , vol.7 , pp. 167-178
    • Scott, R.C.1    Schuldiner, O.2    Neufeld, T.P.3
  • 60
    • 12944303650 scopus 로고    scopus 로고
    • Growth factor regalation of autophagy and cell survival in the absence of apoptosis
    • Lum JJ, Bauer DE, Kong M, Harris MH, Li C, Lindsten T et al. Growth factor regalation of autophagy and cell survival in the absence of apoptosis. Cell 2005; 120: 237-48.
    • (2005) Cell , vol.120 , pp. 237-248
    • Lum, J.J.1    Bauer, D.E.2    Kong, M.3    Harris, M.H.4    Li, C.5    Lindsten, T.6
  • 62
    • 0036125868 scopus 로고    scopus 로고
    • The analytical approach to the nature of lipofuscin (age pigment)
    • Jolly RD, Palmer DN, Dalefield RR. The analytical approach to the nature of lipofuscin (age pigment). Arch Gerontol Geriatr 2002; 34: 205-17
    • (2002) Arch Gerontol Geriatr , vol.34 , pp. 205-217
    • Jolly, R.D.1    Palmer, D.N.2    Dalefield, R.R.3
  • 63
    • 8344242220 scopus 로고    scopus 로고
    • Autophagy in health and disease: A double-edged sword
    • Shintani T, Klionsky DJ. Autophagy in health and disease: A double-edged sword. Science 2004; 306: 990-5.
    • (2004) Science , vol.306 , pp. 990-995
    • Shintani, T.1    Klionsky, D.J.2
  • 64
    • 27644526917 scopus 로고    scopus 로고
    • Testing the "garbage" accumulation theory of ageing: Mitotic activity protects cells from death induced by inhibition of autophagy
    • Stroikin Y, Dalen H, Brunk UT, Terman A. Testing the "garbage" accumulation theory of ageing: Mitotic activity protects cells from death induced by inhibition of autophagy. Biogerontology 2005; 6: 39-47.
    • (2005) Biogerontology , vol.6 , pp. 39-47
    • Stroikin, Y.1    Dalen, H.2    Brunk, U.T.3    Terman, A.4
  • 65
    • 33947401070 scopus 로고    scopus 로고
    • Hars ES, Qi H, Ryazanov AG, Jin S, Cai L, Hu C, et al. Autophagy regulates ageing in C. elegans. Autophagy 2007; 3: 93-5.
    • Hars ES, Qi H, Ryazanov AG, Jin S, Cai L, Hu C, et al. Autophagy regulates ageing in C. elegans. Autophagy 2007; 3: 93-5.
  • 66
    • 0042691506 scopus 로고    scopus 로고
    • Autophagy genes are essential for dauer development and life-span extension in C. elegans
    • Melendez A, Talloczy Z, Seaman M, Eskelinen EL, Hall DH, Levine B. Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science 2003; 301: 1387-91.
    • (2003) Science , vol.301 , pp. 1387-1391
    • Melendez, A.1    Talloczy, Z.2    Seaman, M.3    Eskelinen, E.L.4    Hall, D.H.5    Levine, B.6
  • 67
    • 34249714158 scopus 로고    scopus 로고
    • The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress
    • Nakai A, Yamaguchi O, Takeda T, Higuchi Y, Hikoso S, Taniike M, et al. The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med 2007; 13(5):619-24.
    • (2007) Nat Med , vol.13 , Issue.5 , pp. 619-624
    • Nakai, A.1    Yamaguchi, O.2    Takeda, T.3    Higuchi, Y.4    Hikoso, S.5    Taniike, M.6
  • 68
    • 33644639061 scopus 로고    scopus 로고
    • Proteasomal defense of oxidative protein modifications
    • Poppek D, Grune T. Proteasomal defense of oxidative protein modifications. Antioxid Redox Signal 2006; 8: 173-84.
    • (2006) Antioxid Redox Signal , vol.8 , pp. 173-184
    • Poppek, D.1    Grune, T.2
  • 69
    • 0038460231 scopus 로고    scopus 로고
    • Conditional knockdown of proteasomes results in cell-cycle arrest and enhanced expression of molecular chaperones Hsp70 and Hsp40 in chicken DT40 cells
    • Tanahashi-Hori T, Tanahashi N, Tanaka K, Chiba T. Conditional knockdown of proteasomes results in cell-cycle arrest and enhanced expression of molecular chaperones Hsp70 and Hsp40 in chicken DT40 cells. J Biol Chem 2003; 278: 16237-43.
    • (2003) J Biol Chem , vol.278 , pp. 16237-16243
    • Tanahashi-Hori, T.1    Tanahashi, N.2    Tanaka, K.3    Chiba, T.4
  • 72
    • 0036236006 scopus 로고    scopus 로고
    • The mitochondrial-lysosomal axis theory of aging: Accumulation of damage mitochondria as a result of imperfect autophagocytosis
    • Brunk UT, Terman A. The mitochondrial-lysosomal axis theory of aging: accumulation of damage mitochondria as a result of imperfect autophagocytosis. Eur J Biochem 2002; 269: 1996-2002.
    • (2002) Eur J Biochem , vol.269 , pp. 1996-2002
    • Brunk, U.T.1    Terman, A.2
  • 73
  • 74
    • 0038637217 scopus 로고    scopus 로고
    • Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: Cues for an evolutionarily conserved mechanism of life span control
    • Bonafe M, Barbieri M, Marchegiani F, Olivieri F, Ragno E, Giampieri C, et al. Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: Cues for an evolutionarily conserved mechanism of life span control. J Clin Endocrinol Metab 2003; 88: 3299-304.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 3299-3304
    • Bonafe, M.1    Barbieri, M.2    Marchegiani, F.3    Olivieri, F.4    Ragno, E.5    Giampieri, C.6
  • 75
    • 0142052858 scopus 로고    scopus 로고
    • Insulin/IGF-I-signaling pathway: An evolutionarily conserved mechanism of longevity from yeast to humans
    • Barbieri M, Bonafe M, Franceschi C, Paolisso G. Insulin/IGF-I-signaling pathway: An evolutionarily conserved mechanism of longevity from yeast to humans. Am J Physiol Endocrinol Metab 2003; 285: E1064-71.
    • (2003) Am J Physiol Endocrinol Metab , vol.285
    • Barbieri, M.1    Bonafe, M.2    Franceschi, C.3    Paolisso, G.4
  • 77
    • 19944392873 scopus 로고    scopus 로고
    • Genes involved in immune response/inflammation, IGF1/ insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: The lesson of centenarians
    • Franceschi C, Olivieri F, Marchegiani F, Cardelli M, Cavallone L., Capri M, et al. Genes involved in immune response/inflammation, IGF1/ insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: The lesson of centenarians. Mech Ageing Dev 2005; 126: 351-61.
    • (2005) Mech Ageing Dev , vol.126 , pp. 351-361
    • Franceschi, C.1    Olivieri, F.2    Marchegiani, F.3    Cardelli, M.4    Cavallone, L.5    Capri, M.6
  • 79
    • 33749052075 scopus 로고    scopus 로고
    • Signalling and autophagy regulation in health, aging and disease
    • Meijer AJ, Codogno P. Signalling and autophagy regulation in health, aging and disease. Mol Aspects Med 2006; 27: 411-25.
    • (2006) Mol Aspects Med , vol.27 , pp. 411-425
    • Meijer, A.J.1    Codogno, P.2
  • 80
    • 0043204997 scopus 로고    scopus 로고
    • The anti-ageing effects of caloric restriction may involve stimulation of macroautophagy and lysosomal degradation, and can be intensified pharmacologically
    • Bergamini E, Cavallini G, Donati A, Gori Z. The anti-ageing effects of caloric restriction may involve stimulation of macroautophagy and lysosomal degradation, and can be intensified pharmacologically. Biomed Pharmacother 2004; 57: 203-8.
    • (2004) Biomed Pharmacother , vol.57 , pp. 203-208
    • Bergamini, E.1    Cavallini, G.2    Donati, A.3    Gori, Z.4
  • 81
    • 33750818150 scopus 로고    scopus 로고
    • Autophagy in neuronal cell loss: A road to death
    • Takacs-Vellai K, Bayci A, Vellai T. Autophagy in neuronal cell loss: A road to death. Bioessays 2006; 28: 1126-31.
    • (2006) Bioessays , vol.28 , pp. 1126-1131
    • Takacs-Vellai, K.1    Bayci, A.2    Vellai, T.3
  • 82
    • 33645750798 scopus 로고    scopus 로고
    • Cannibalism of live lymphocytes by hu,an metastatic but not primary melanoma cells
    • Lugini L, Matarrese P, Tinari A, Lozupone F, Federici C, Icssi E, et al. Cannibalism of live lymphocytes by hu,an metastatic but not primary melanoma cells. Cancer Res 2006; 66: 3629-38.
    • (2006) Cancer Res , vol.66 , pp. 3629-3638
    • Lugini, L.1    Matarrese, P.2    Tinari, A.3    Lozupone, F.4    Federici, C.5    Icssi, E.6
  • 83
    • 77049308856 scopus 로고
    • Aging: A theory based on free radical and radiation chemistry
    • Harman D. Aging: A theory based on free radical and radiation chemistry. J Gerontol 1956; 11: 298-300.
    • (1956) J Gerontol , vol.11 , pp. 298-300
    • Harman, D.1
  • 84
  • 85
    • 33846796263 scopus 로고    scopus 로고
    • Cell signaling. Mitochondrial longevity pathways
    • Hajnocz-ky G, Hoek JB. Cell signaling. Mitochondrial longevity pathways. Science 2007; 315: 607-9.
    • (2007) Science , vol.315 , pp. 607-609
    • Hajnocz-ky, G.1    Hoek, J.B.2
  • 86
    • 10744232772 scopus 로고    scopus 로고
    • Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly
    • Rose G, Dato S, Altomare K, Bellizzi D, Garasto S, Greco V, et al. Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly. Exp Gerontol 2003; 3 8: 1065-70.
    • (2003) Exp Gerontol , vol.3 , Issue.8 , pp. 1065-1070
    • Rose, G.1    Dato, S.2    Altomare, K.3    Bellizzi, D.4    Garasto, S.5    Greco, V.6
  • 87
    • 2942584910 scopus 로고    scopus 로고
    • The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential
    • Orsini F, Migliaccio E, Moroni M, Contursi C, Raker VA, Piccini D, et al. The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential. J Biol Chem 2004; 279: 25689-95.
    • (2004) J Biol Chem , vol.279 , pp. 25689-25695
    • Orsini, F.1    Migliaccio, E.2    Moroni, M.3    Contursi, C.4    Raker, V.A.5    Piccini, D.6
  • 88
    • 0033581704 scopus 로고    scopus 로고
    • The p66she adaptor protein controls oxidative stress response and life span in mammals
    • Migliaccio E, Giorgio M, Mele S, Pelicci G, Reboldi P, Pandolfi PP, et al. The p66she adaptor protein controls oxidative stress response and life span in mammals. Nature 1999; 402: 309-13.
    • (1999) Nature , vol.402 , pp. 309-313
    • Migliaccio, E.1    Giorgio, M.2    Mele, S.3    Pelicci, G.4    Reboldi, P.5    Pandolfi, P.P.6
  • 89
    • 33744519939 scopus 로고    scopus 로고
    • Nemoto S, Combs CA, French 8, Ahn BH, Fergusson MM, Balaban RS, et al. The mammalian longevity-associated gene product p66she regulates mitochondrial metabolism. J Biol Chem 2006; 281: 10555-60.
    • Nemoto S, Combs CA, French 8, Ahn BH, Fergusson MM, Balaban RS, et al. The mammalian longevity-associated gene product p66she regulates mitochondrial metabolism. J Biol Chem 2006; 281: 10555-60.
  • 90
    • 22744447211 scopus 로고    scopus 로고
    • Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis
    • Giorgio M, Migliaccio E, Orsini F, Paolucci D, Moroni M, Contursi C, et al. Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis. Cell 2005; 122: 221-33.
    • (2005) Cell , vol.122 , pp. 221-233
    • Giorgio, M.1    Migliaccio, E.2    Orsini, F.3    Paolucci, D.4    Moroni, M.5    Contursi, C.6
  • 91
    • 33645905712 scopus 로고    scopus 로고
    • Autophagy, mitochondrial quality control, and oncogenesis
    • Jin S. Autophagy, mitochondrial quality control, and oncogenesis. Autophagy 2006; 2: 80-4.
    • (2006) Autophagy , vol.2 , pp. 80-84
    • Jin, S.1
  • 92
    • 33846187292 scopus 로고    scopus 로고
    • Evidence for selective mitochondrial autophagy and failure in aging
    • Cavallini G, Donati A, Taddei M, Bergamini E. Evidence for selective mitochondrial autophagy and failure in aging. Autophagy 2007; 3: 26-7.
    • (2007) Autophagy , vol.3 , pp. 26-27
    • Cavallini, G.1    Donati, A.2    Taddei, M.3    Bergamini, E.4
  • 93
    • 5444236546 scopus 로고    scopus 로고
    • Uth1p: A yeast mitochondrial protein at the crossroads of stress, degradation and cell death
    • Camougrand N, Kissova I, Velours G, Manon S. Uth1p: A yeast mitochondrial protein at the crossroads of stress, degradation and cell death. FEMS Yeast Res 2004; 5: 133-40.
    • (2004) FEMS Yeast Res , vol.5 , pp. 133-140
    • Camougrand, N.1    Kissova, I.2    Velours, G.3    Manon, S.4
  • 94
    • 4644273585 scopus 로고    scopus 로고
    • Uth1p is involved in the autophagic degradation of mitochondria
    • Kissova I, Deffieu M, Manon S, Camougrand N. Uth1p is involved in the autophagic degradation of mitochondria. J Biol Chem 2004; 279: 39068-74.
    • (2004) J Biol Chem , vol.279 , pp. 39068-39074
    • Kissova, I.1    Deffieu, M.2    Manon, S.3    Camougrand, N.4
  • 95
    • 33749066763 scopus 로고    scopus 로고
    • Mitochondrial damage and intralysosomal degradation in cellular aging
    • Terman A, Gustafsson B, Brunk UT. Mitochondrial damage and intralysosomal degradation in cellular aging. Mol Aspects Med 2006; 27: 471-82.
    • (2006) Mol Aspects Med , vol.27 , pp. 471-482
    • Terman, A.1    Gustafsson, B.2    Brunk, U.T.3
  • 96
    • 0037009120 scopus 로고    scopus 로고
    • Membrane protein degradation by AAA proteases in mitochondria
    • Arnold I, Langer T. Membrane protein degradation by AAA proteases in mitochondria. Biochim Biophys Acta 2002; 1592: 89-96.
    • (2002) Biochim Biophys Acta , vol.1592 , pp. 89-96
    • Arnold, I.1    Langer, T.2
  • 97
    • 0037517056 scopus 로고    scopus 로고
    • Changes in rat liver mitochondria with aging. Lon protease-like reactivity and N(epsilon)-carboxymethyllysine accumulation in the matrix
    • Bakala H, Delaval E, Hamelin M, Bismuth J, Borot-Laloi C, Corman B, et al. Changes in rat liver mitochondria with aging. Lon protease-like reactivity and N(epsilon)-carboxymethyllysine accumulation in the matrix. Eur J Biochem 2003; 270: 2295-302.
    • (2003) Eur J Biochem , vol.270 , pp. 2295-2302
    • Bakala, H.1    Delaval, E.2    Hamelin, M.3    Bismuth, J.4    Borot-Laloi, C.5    Corman, B.6
  • 98
    • 0036713692 scopus 로고    scopus 로고
    • Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism
    • Bota DA, Davies KJ. Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism. Nat Cell Biol 2002; 4: 674-80.
    • (2002) Nat Cell Biol , vol.4 , pp. 674-680
    • Bota, D.A.1    Davies, K.J.2
  • 99
    • 33644674439 scopus 로고    scopus 로고
    • The organization and inheritance of the mitochondrial genome
    • Chen XJ, Butow RA. The organization and inheritance of the mitochondrial genome. Nat Rev Genet 2005; 6: 815-25.
    • (2005) Nat Rev Genet , vol.6 , pp. 815-825
    • Chen, X.J.1    Butow, R.A.2
  • 100
  • 101
    • 0037417898 scopus 로고    scopus 로고
    • Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes
    • Zhang J, Asin-Cayuela J, Fish J, Michikawa Y, Bonafe M, Olivieri F, et al. Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes. Proc Natl Acad Sci USA 2003; 100: 1116-21.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 1116-1121
    • Zhang, J.1    Asin-Cayuela, J.2    Fish, J.3    Michikawa, Y.4    Bonafe, M.5    Olivieri, F.6
  • 102
    • 15744384860 scopus 로고    scopus 로고
    • Downregulation of the human Lon protease impairs mitochondrial structure and function and causes cell death
    • Bota DA, Ngo JK, Davies KJ. Downregulation of the human Lon protease impairs mitochondrial structure and function and causes cell death. Free Radic Biol Med 2005; 38: 665-77.
    • (2005) Free Radic Biol Med , vol.38 , pp. 665-677
    • Bota, D.A.1    Ngo, J.K.2    Davies, K.J.3
  • 103
    • 0037021453 scopus 로고    scopus 로고
    • Modulation of Lon protease activity and aconitase turnover during aging and oxidative stress
    • Bota DA, Van Remmen H, Davies KJ. Modulation of Lon protease activity and aconitase turnover during aging and oxidative stress. FEBS Lett 2002; 532: 103-6.
    • (2002) FEBS Lett , vol.532 , pp. 103-106
    • Bota, D.A.1    Van Remmen, H.2    Davies, K.J.3
  • 104
    • 33845209693 scopus 로고    scopus 로고
    • Skeletal muscle apoptosis, sarcopenia and frailty at old age
    • Marzetti E, Leeuwenburgh C. Skeletal muscle apoptosis, sarcopenia and frailty at old age. Exp Gerontol 2006; 41: 1234-8.
    • (2006) Exp Gerontol , vol.41 , pp. 1234-1238
    • Marzetti, E.1    Leeuwenburgh, C.2
  • 105
    • 0037178781 scopus 로고    scopus 로고
    • Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
    • Hara K, Maruki Y, Long X, Yoshino K, Oshiro N, Hidayat S, et al. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 2002; 110: 177-89.
    • (2002) Cell , vol.110 , pp. 177-189
    • Hara, K.1    Maruki, Y.2    Long, X.3    Yoshino, K.4    Oshiro, N.5    Hidayat, S.6
  • 106
    • 0037178786 scopus 로고    scopus 로고
    • mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
    • Kim DH, SarbassovDD, Ali SM, King JE, Latek RR, Erdjument-Bromage H, et al. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 2002; 110: 163-75.
    • (2002) Cell , vol.110 , pp. 163-175
    • Kim, D.H.1    Sarbassov, D.D.2    Ali, S.M.3    King, J.E.4    Latek, R.R.5    Erdjument-Bromage, H.6
  • 107
    • 20444363122 scopus 로고    scopus 로고
    • The coordinate regulation of the p53 and mTOR pathways in cells
    • Feng Z, Zhang H, Levine AJ, Jin S. The coordinate regulation of the p53 and mTOR pathways in cells. Proc Natl Acad Sci USA 2005; 102: 8204-9
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 8204-8209
    • Feng, Z.1    Zhang, H.2    Levine, A.J.3    Jin, S.4
  • 108
    • 33745885329 scopus 로고    scopus 로고
    • DRAM, a p53-induced modulator of autophagy, is critical for apoptosis
    • Crighton D, Wilkinson S, O'Prey J, Syed N, Smith P, Harrison PR, et al. DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell 2006; 126: 121-34.
    • (2006) Cell , vol.126 , pp. 121-134
    • Crighton, D.1    Wilkinson, S.2    O'Prey, J.3    Syed, N.4    Smith, P.5    Harrison, P.R.6
  • 109
    • 0036814404 scopus 로고    scopus 로고
    • What studies on human longevity tell us about the risk for cancer in the oldest old: Data and hypotheses on the genetics and immunology of centenarians
    • Bonafe M, Barbi C, Storci G, Salvioli S, Capri M, Olivieri F, et al. What studies on human longevity tell us about the risk for cancer in the oldest old: Data and hypotheses on the genetics and immunology of centenarians. Exp Gerontol 2002; 37: 1263-71.
    • (2002) Exp Gerontol , vol.37 , pp. 1263-1271
    • Bonafe, M.1    Barbi, C.2    Storci, G.3    Salvioli, S.4    Capri, M.5    Olivieri, F.6
  • 110
    • 0442323561 scopus 로고    scopus 로고
    • Autophagy: In sickness and in health
    • Cuervo AM. Autophagy: In sickness and in health. Trends Cell Biol 2004b; 14: 70-7.
    • (2004) Trends Cell Biol , vol.14 , pp. 70-77
    • Cuervo, A.M.1
  • 111
    • 3042723794 scopus 로고    scopus 로고
    • Autophagy: Molecular mechanisms, physiological functions and relevance in human pathology
    • Mariño G, López-Otin C. Autophagy: Molecular mechanisms, physiological functions and relevance in human pathology. Cell Mol Life Sci 2004; 61:1439-54.
    • (2004) Cell Mol Life Sci , vol.61 , pp. 1439-1454
    • Mariño, G.1    López-Otin, C.2
  • 112
    • 1842583789 scopus 로고    scopus 로고
    • Development by self-digestion: Molecular mechanisms and biological functions of autopbagy
    • Levine B, Klionsky DJ. Development by self-digestion: Molecular mechanisms and biological functions of autopbagy. Dev Cell 2004; 6: 463-77.
    • (2004) Dev Cell , vol.6 , pp. 463-477
    • Levine, B.1    Klionsky, D.J.2
  • 113
    • 0942265544 scopus 로고    scopus 로고
    • Selective disruption of lysosomes in Hela cells triggers apoptosis mediated by cleavage of bid by multiple papain-like lysosomal cathepsins
    • Cirman T, Oresic K, Mazovec GD, Turk V, Reed JC, Myers RM, et al. Selective disruption of lysosomes in Hela cells triggers apoptosis mediated by cleavage of bid by multiple papain-like lysosomal cathepsins. J Biol Chem 2004; 279: 3578-87.
    • (2004) J Biol Chem , vol.279 , pp. 3578-3587
    • Cirman, T.1    Oresic, K.2    Mazovec, G.D.3    Turk, V.4    Reed, J.C.5    Myers, R.M.6
  • 115
    • 0035861903 scopus 로고    scopus 로고
    • Delayed oxidant-induced cell death involves activation of phospholipase A2
    • Zhao M, Brunk UT, Eaton JW. Delayed oxidant-induced cell death involves activation of phospholipase A2. FEBS Lett 2001; 509: 399-404.
    • (2001) FEBS Lett , vol.509 , pp. 399-404
    • Zhao, M.1    Brunk, U.T.2    Eaton, J.W.3
  • 116
    • 18244392443 scopus 로고    scopus 로고
    • Cell death independent of caspases: A review
    • Broker LE, Kruyt FA, Giaccone G. Cell death independent of caspases: A review. Clin Cancer Res 2005; 11: 3155-62.
    • (2005) Clin Cancer Res , vol.11 , pp. 3155-3162
    • Broker, L.E.1    Kruyt, F.A.2    Giaccone, G.3
  • 117
    • 0035887215 scopus 로고    scopus 로고
    • Sphingosine-induced apoptosis is dependent on lysosomal proteases
    • Kagedal K, Zhao M, Svensson I, Brunk UT. Sphingosine-induced apoptosis is dependent on lysosomal proteases. Biochem J 2001; 359: 335-43.
    • (2001) Biochem J , vol.359 , pp. 335-343
    • Kagedal, K.1    Zhao, M.2    Svensson, I.3    Brunk, U.T.4
  • 118
    • 28844490007 scopus 로고    scopus 로고
    • The lysosome-associated apoptosis-inducing protein containing the pleckstrin homology (PH) and FYVE domains (LAPF), representative of a novel family of PH and FYVE domain-containing proteins, induces caspase-independent apoptosis via the lysosomal-mitochondrial pathway
    • Chen W, Li N, Chen T, Han Y, Li C, Wang Y, et al. The lysosome-associated apoptosis-inducing protein containing the pleckstrin homology (PH) and FYVE domains (LAPF), representative of a novel family of PH and FYVE domain-containing proteins, induces caspase-independent apoptosis via the lysosomal-mitochondrial pathway. J Biol Chem 2005; 280: 40985-95.
    • (2005) J Biol Chem , vol.280 , pp. 40985-40995
    • Chen, W.1    Li, N.2    Chen, T.3    Han, Y.4    Li, C.5    Wang, Y.6
  • 119
    • 0037193474 scopus 로고    scopus 로고
    • DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death
    • Inbal B, Bialik S, Sabanay I, Shani G, Kimchi A. DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death. J Cell Biol 2002; 157: 455-68.
    • (2002) J Cell Biol , vol.157 , pp. 455-468
    • Inbal, B.1    Bialik, S.2    Sabanay, I.3    Shani, G.4    Kimchi, A.5
  • 120
    • 33746359639 scopus 로고    scopus 로고
    • The death-associated protein kinases: Structure, function, and beyond
    • Bialik S, Kimchi A. The death-associated protein kinases: Structure, function, and beyond. Annu Rev Biochem 2006; 75: 189-210.
    • (2006) Annu Rev Biochem , vol.75 , pp. 189-210
    • Bialik, S.1    Kimchi, A.2
  • 121
    • 25144457455 scopus 로고    scopus 로고
    • Bc1-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
    • Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N, et al. Bc1-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 2005; 122: 927-39.
    • (2005) Cell , vol.122 , pp. 927-939
    • Pattingre, S.1    Tassa, A.2    Qu, X.3    Garuti, R.4    Liang, X.H.5    Mizushima, N.6
  • 122
    • 2342585484 scopus 로고    scopus 로고
    • Autolysosomes accumulate during in vitro CD8+ T-lymphocyte aging and may participate in induced death sensitization of senescent cells
    • Gerland LM, Genestier L, Peyrol S, Michallet MC, Hayette S, Urbanowicz I, et al. Autolysosomes accumulate during in vitro CD8+ T-lymphocyte aging and may participate in induced death sensitization of senescent cells. Exp Gerontol 2004; 39: 789-800.
    • (2004) Exp Gerontol , vol.39 , pp. 789-800
    • Gerland, L.M.1    Genestier, L.2    Peyrol, S.3    Michallet, M.C.4    Hayette, S.5    Urbanowicz, I.6
  • 123
    • 0042206639 scopus 로고    scopus 로고
    • Association of increased autophagic inclusions labeled for beta-galactosidase with fibroblastic aging
    • Gerfand LM, Peyrol S, Lallemand C, Branche R, Mgaud JP, Ffrench M. Association of increased autophagic inclusions labeled for beta-galactosidase with fibroblastic aging. Exp Gerontol 2003; 38: 887-95.
    • (2003) Exp Gerontol , vol.38 , pp. 887-895
    • Gerfand, L.M.1    Peyrol, S.2    Lallemand, C.3    Branche, R.4    Mgaud, J.P.5    Ffrench, M.6
  • 124
    • 33846120542 scopus 로고    scopus 로고
    • Increased resistance of lipofuscin-loaded prematurely senescent fibroblasts to starvation-induced programmed cell death
    • Stroikin Y, Johansson U, Asplund S, Ollinger K. Increased resistance of lipofuscin-loaded prematurely senescent fibroblasts to starvation-induced programmed cell death, Biogerontology 2007; 8: 43-53.
    • (2007) Biogerontology , vol.8 , pp. 43-53
    • Stroikin, Y.1    Johansson, U.2    Asplund, S.3    Ollinger, K.4
  • 125
    • 0035216820 scopus 로고    scopus 로고
    • Low insulin resistance and preserved beta-cell function contribute to human longevity but are not associated with TH-INS genes
    • Paolisso G, Barbieri M, Rizzo MR, Carella C, Rotondi M, Bonafe M, et al. Low insulin resistance and preserved beta-cell function contribute to human longevity but are not associated with TH-INS genes. Exp Gerontol 2001; 37: 149-56.
    • (2001) Exp Gerontol , vol.37 , pp. 149-156
    • Paolisso, G.1    Barbieri, M.2    Rizzo, M.R.3    Carella, C.4    Rotondi, M.5    Bonafe, M.6
  • 126
    • 0037852202 scopus 로고    scopus 로고
    • The proteasome: Structure, function, and role in the cell
    • Adams J. The proteasome: Structure, function, and role in the cell. Cancer Treat Rev 2003; 29 Suppl 1: 3-9.
    • (2003) Cancer Treat Rev , vol.29 , Issue.SUPPL. 1 , pp. 3-9
    • Adams, J.1
  • 127
    • 34047257880 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib acts independently of p53 and induces cell death via apoptosis and mitotic catastrophe in B-cell lymphoma cell fines
    • Strauss SJ, Higginbottom K, Juliger S, Maharaj L, Allen P, Schenkein D, et al. The proteasome inhibitor bortezomib acts independently of p53 and induces cell death via apoptosis and mitotic catastrophe in B-cell lymphoma cell fines. Cancer Res 2007; 67: 2783-90
    • (2007) Cancer Res , vol.67 , pp. 2783-2790
    • Strauss, S.J.1    Higginbottom, K.2    Juliger, S.3    Maharaj, L.4    Allen, P.5    Schenkein, D.6
  • 130
    • 33947356281 scopus 로고    scopus 로고
    • Bortezomib-mediated 26S proteasome inhibition causes cell-cycle arrest and induces apoptosis in CD-30+ anaplastic large cell lymphoma
    • Bonvini P, Zorzi E, Basso G, Rosolen A. Bortezomib-mediated 26S proteasome inhibition causes cell-cycle arrest and induces apoptosis in CD-30+ anaplastic large cell lymphoma. Leukemia 2007; 21: 838-42.
    • (2007) Leukemia , vol.21 , pp. 838-842
    • Bonvini, P.1    Zorzi, E.2    Basso, G.3    Rosolen, A.4
  • 131
    • 0342393043 scopus 로고    scopus 로고
    • Pasquini LA, Besio Moreno M, Adamo AM, Pasquini JM, Soto EF. Lactacystin, a specific inhibitor of the proteasome, induces apoptosis and activates caspase-3 in cultured cerebellar granule cells. J Neurosci Res 2000; 59: 601-11.
    • Pasquini LA, Besio Moreno M, Adamo AM, Pasquini JM, Soto EF. Lactacystin, a specific inhibitor of the proteasome, induces apoptosis and activates caspase-3 in cultured cerebellar granule cells. J Neurosci Res 2000; 59: 601-11.
  • 132
    • 0036867687 scopus 로고    scopus 로고
    • Apoptosis in schwann cell cultures is closely interrelated with the activity of the ubiquitin-proteasome proteolytic pathway
    • Pasquini LA, Besio Moreno M, Lopez Salon M, Soto EF. Apoptosis in schwann cell cultures is closely interrelated with the activity of the ubiquitin-proteasome proteolytic pathway. Neurochem Res 2002; 27: 1401-19.
    • Neurochem Res 2002
    • Pasquini, L.A.1    Besio Moreno, M.2    Lopez Salon, M.3    Soto, E.F.4
  • 133
    • 25144459851 scopus 로고    scopus 로고
    • The ubiquitin-proteasome pathway is necessary for maintenance of the postmitotic status of neurons
    • Staropoli F, Abeliovich A. The ubiquitin-proteasome pathway is necessary for maintenance of the postmitotic status of neurons. J Mol Neurosci 2005; 27: 175-83.
    • (2005) J Mol Neurosci , vol.27 , pp. 175-183
    • Staropoli, F.1    Abeliovich, A.2
  • 134
    • 0036500993 scopus 로고    scopus 로고
    • Systems Biology: A brief overview
    • Kitano H. Systems Biology: A brief overview. Science 2002; 295: 1662-4.
    • (2002) Science , vol.295 , pp. 1662-1664
    • Kitano, H.1
  • 135
    • 33747603487 scopus 로고    scopus 로고
    • Integrated mechanistic and data-driven modelling for multivariate analysis of signalling pathways
    • Hua F, Hautaniemi S, Yokoo R, Lauffenburger DA. Integrated mechanistic and data-driven modelling for multivariate analysis of signalling pathways. J R Soc Interface 2006; 3: 515-26.
    • (2006) J R Soc Interface , vol.3 , pp. 515-526
    • Hua, F.1    Hautaniemi, S.2    Yokoo, R.3    Lauffenburger, D.A.4
  • 136
    • 33750351769 scopus 로고    scopus 로고
    • Data-driven modelling of signal-transduction networks
    • Janes KA, Yaffe MB. Data-driven modelling of signal-transduction networks. Nat Rev Mol Cell Biol 2006; 7: 820-8.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 820-828
    • Janes, K.A.1    Yaffe, M.B.2
  • 138
    • 28844441230 scopus 로고    scopus 로고
    • A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis
    • Janes KA, Albeck JG, Gaudet S, Sorger PK, Lauffenburger DA, Yaffe MB. A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis. Science 2005; 310: 1646-53.
    • (2005) Science , vol.310 , pp. 1646-1653
    • Janes, K.A.1    Albeck, J.G.2    Gaudet, S.3    Sorger, P.K.4    Lauffenburger, D.A.5    Yaffe, M.B.6
  • 139
    • 46749158750 scopus 로고    scopus 로고
    • The modular systems biology approach to investigate the control of apoptosis in Alzheimer's disease neurodegeneration
    • Alberghina L, Colangelo AM. The modular systems biology approach to investigate the control of apoptosis in Alzheimer's disease neurodegeneration. BMC Neurosci 2006; 7 Suppl 1: S2.
    • (2006) BMC Neurosci , vol.7 , Issue.SUPPL. 1
    • Alberghina, L.1    Colangelo, A.M.2
  • 140
    • 0035280480 scopus 로고    scopus 로고
    • Towards a blueprint of the cell-cycle
    • Alberghina L, Porro D, Cazzador L. Towards a blueprint of the cell-cycle. Oncogene 2001; 20: 1128-34.
    • (2001) Oncogene , vol.20 , pp. 1128-1134
    • Alberghina, L.1    Porro, D.2    Cazzador, L.3
  • 141
    • 42049098917 scopus 로고    scopus 로고
    • Alberghina L, Rossi RL, Porto D, Vanoni M. A modular systems biology analysis of cell cycle entrance in S phase. In systems biology: Definitions and perspectives (L. Alberghina and H. Westerhoff editors) - Topics in Current Genetics 2005; 13: 325-47, Springer Verlag
    • Alberghina L, Rossi RL, Porto D, Vanoni M. A modular systems biology analysis of cell cycle entrance in S phase. In systems biology: Definitions and perspectives (L. Alberghina and H. Westerhoff editors) - Topics in Current Genetics 2005; 13: 325-47, Springer Verlag
  • 142
    • 34247627985 scopus 로고    scopus 로고
    • Cell size at S phase initiation: An emergent property of the G1/S network
    • Barberis M, Klipp E, Vanoni M, Alberghina L. Cell size at S phase initiation: An emergent property of the G1/S network. PLoS Comput Biol 2007; 3: 64.
    • (2007) PLoS Comput Biol , vol.3 , pp. 64
    • Barberis, M.1    Klipp, E.2    Vanoni, M.3    Alberghina, L.4
  • 144
    • 34250346095 scopus 로고    scopus 로고
    • Analysis of CD95 threshold signaling: Triggering of CD95 (FAS/APO-1) at low concentrations primarily results in survival signaling
    • Lavrik IN, Golks A, Riess D, Bentele M, Eils R, Krammer PH. Analysis of CD95 threshold signaling: Triggering of CD95 (FAS/APO-1) at low concentrations primarily results in survival signaling. J Biol Chem 2007; 282: 13664-71.
    • (2007) J Biol Chem , vol.282 , pp. 13664-13671
    • Lavrik, I.N.1    Golks, A.2    Riess, D.3    Bentele, M.4    Eils, R.5    Krammer, P.H.6
  • 146
    • 31144431501 scopus 로고    scopus 로고
    • Robustness properties of apoptosis models with respect to parameter variations and intrinsic noise
    • Eissing T, Allgower F, Bullinger E. Robustness properties of apoptosis models with respect to parameter variations and intrinsic noise. Syst Biol 2005; 152: 221-8.
    • (2005) Syst Biol , vol.152 , pp. 221-228
    • Eissing, T.1    Allgower, F.2    Bullinger, E.3
  • 147
    • 34247555454 scopus 로고    scopus 로고
    • Response to bistability in apoptosis: Roles of bax, bc1-2, and mitochondrial permeability transition pores
    • Eissing T, Waldherr S, Allgower F, Scheurich P, Bollinger E. Response to bistability in apoptosis: Roles of bax, bc1-2, and mitochondrial permeability transition pores. Biophys J 2007; 92: 3332-4.
    • (2007) Biophys J , vol.92 , pp. 3332-3334
    • Eissing, T.1    Waldherr, S.2    Allgower, F.3    Scheurich, P.4    Bollinger, E.5
  • 148
    • 33646124974 scopus 로고    scopus 로고
    • Bistability in apoptosis: Roles of Bax, Bc1-2 and mitochondrial permeability transition pores
    • Bagci EZ, Vodovotz Y, Bilhar TR, Ermentrout GB, Bahar I. Bistability in apoptosis: Roles of Bax, Bc1-2 and mitochondrial permeability transition pores. Biophys J 2006; 90: 1546-59.
    • (2006) Biophys J , vol.90 , pp. 1546-1559
    • Bagci, E.Z.1    Vodovotz, Y.2    Bilhar, T.R.3    Ermentrout, G.B.4    Bahar, I.5
  • 149
    • 34047128760 scopus 로고    scopus 로고
    • APOPTOCELL - a simulation tool and interactive database for analyzing cellular susceptibility to apoptosis
    • Huber HJ, Rehm M, Plchut M, Dussmann H, Rrehn JH. APOPTOCELL - a simulation tool and interactive database for analyzing cellular susceptibility to apoptosis. Bioinformatics 2007; 23: 648-50.
    • (2007) Bioinformatics , vol.23 , pp. 648-650
    • Huber, H.J.1    Rehm, M.2    Plchut, M.3    Dussmann, H.4    Rrehn, J.H.5
  • 150
    • 21144441198 scopus 로고    scopus 로고
    • Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia
    • Zheng PZ, Wang KK, Zhang QY, Huang QH, Du YZ, Zhang QH, et al. Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci USA 2005; 102: 7653-8.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 7653-7658
    • Zheng, P.Z.1    Wang, K.K.2    Zhang, Q.Y.3    Huang4    QH, D.Y.5    Zhang, Q.H.6
  • 151
    • 33644791862 scopus 로고    scopus 로고
    • Prediction of debacle points for robustness of biological pathways by using recurrent neural networks
    • Kitakaze H, Matsuno H, Ikeda N, Miyano S. Prediction of debacle points for robustness of biological pathways by using recurrent neural networks. Genome Inform 2005; 16: 192-202.
    • (2005) Genome Inform , vol.16 , pp. 192-202
    • Kitakaze, H.1    Matsuno, H.2    Ikeda, N.3    Miyano, S.4
  • 152
    • 31444432847 scopus 로고    scopus 로고
    • The influence of the signal dynamics of activated form of IKK on NF-kappaB and anti-apoptotic gene expressions: A systems biology approach
    • Park SG, Lee T, Kang HY, Park K, Cho KH, Jung G. The influence of the signal dynamics of activated form of IKK on NF-kappaB and anti-apoptotic gene expressions: A systems biology approach. FEBS Lett 2006; 580: 822-30.
    • (2006) FEBS Lett , vol.580 , pp. 822-830
    • Park, S.G.1    Lee, T.2    Kang, H.Y.3    Park, K.4    Cho, K.H.5    Jung, G.6
  • 153
    • 10644259648 scopus 로고    scopus 로고
    • Probing control mechanisms of cell cycle and ageing in budding yeast
    • Alberghina L, Vai M, Vanoni M. Probing control mechanisms of cell cycle and ageing in budding yeast. Curr Genomics 2004; 5: 615-627.
    • (2004) Curr Genomics , vol.5 , pp. 615-627
    • Alberghina, L.1    Vai, M.2    Vanoni, M.3
  • 154
    • 1542781659 scopus 로고    scopus 로고
    • When cells get stressed: An integrative view of cellular senescence
    • Ben-Porath I, Weinberg RA. When cells get stressed: An integrative view of cellular senescence. J Clin Invest 2004; 113, 8-13.
    • (2004) J Clin Invest , vol.113 , pp. 8-13
    • Ben-Porath, I.1    Weinberg, R.A.2
  • 155
    • 34249028642 scopus 로고    scopus 로고
    • Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence
    • Passos JF, Saretzki G, Ahmed S, Nelson G, Richter T, Peters H et al. Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence. PLoS Biology 2007; 5: 1138-51.
    • (2007) PLoS Biology , vol.5 , pp. 1138-1151
    • Passos, J.F.1    Saretzki, G.2    Ahmed, S.3    Nelson, G.4    Richter, T.5    Peters, H.6
  • 157
    • 42049115529 scopus 로고    scopus 로고
    • Systems biology of apoptosis, in systems biology - Definitions and perspectives, alberghina L, Westerhoff HV, eds
    • Bentele M, Eils R. Systems biology of apoptosis, in systems biology - Definitions and perspectives, alberghina L, Westerhoff HV, eds. Topics in Current Genetics, 2005; 13: 349-72.
    • (2005) Topics in Current Genetics , vol.13 , pp. 349-372
    • Bentele, M.1    Eils, R.2
  • 158
    • 32044471825 scopus 로고    scopus 로고
    • A biological approach to computational models of proteomic networks
    • Janes KA, Lauffenburger DA. A biological approach to computational models of proteomic networks. Curr Opin Chem Biol 2006; 10: 73-80.
    • (2006) Curr Opin Chem Biol , vol.10 , pp. 73-80
    • Janes, K.A.1    Lauffenburger, D.A.2
  • 159
    • 0036082392 scopus 로고    scopus 로고
    • The rise of computational biology
    • Noble D. The rise of computational biology. Nat Rev Mol Cell Biol 2002; 3: 459-63.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 459-463
    • Noble, D.1
  • 160
    • 42049088825 scopus 로고    scopus 로고
    • The music of life
    • Oxford University Press
    • Noble D. The music of life. Biology beyond the genome, Oxford University Press 2006.
    • (2006) Biology beyond the genome
    • Noble, D.1
  • 161
    • 0141641117 scopus 로고    scopus 로고
    • Targeting apoptosis in the control of inflammation
    • Simon HU. Targeting apoptosis in the control of inflammation. Eur Respir J 2003; 22: 20S-21S.
    • (2003) Eur Respir J , vol.22
    • Simon, H.U.1
  • 162
    • 0036114344 scopus 로고    scopus 로고
    • Inflammation, apoptosis, and alzheimer's disease
    • Bamberger ME, Landreth GE. Inflammation, apoptosis, and alzheimer's disease. Neuroscientist 2002; 8: 276-83.
    • (2002) Neuroscientist , vol.8 , pp. 276-283
    • Bamberger, M.E.1    Landreth, G.E.2
  • 163
    • 3342961626 scopus 로고    scopus 로고
    • van der Woude CJ1, Kleibeuker JH, Jansen PLM, Moshage H. Chronic inflammation, apoptosis and (pre-)malignant lesions in the gastro-intestinal tract. Apoptosis 2004; 9: 123-30.
    • van der Woude CJ1, Kleibeuker JH, Jansen PLM, Moshage H. Chronic inflammation, apoptosis and (pre-)malignant lesions in the gastro-intestinal tract. Apoptosis 2004; 9: 123-30.
  • 164
    • 34247324385 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase inhibitors: New pharmacological functions and potential clinical implications
    • de la Lastra CA, Villegas I, Sanchez-Fidalgo S. Poly(ADP-ribose) polymerase inhibitors: New pharmacological functions and potential clinical implications. Curr Pharm Des 2007; 13(9): 933-62.
    • (2007) Curr Pharm Des , vol.13 , Issue.9 , pp. 933-962
    • de la Lastra, C.A.1    Villegas, I.2    Sanchez-Fidalgo, S.3
  • 165
    • 33751541194 scopus 로고    scopus 로고
    • Role of alterations in the apoptotic machinery in sensitivity of cancer cells to treatment
    • Rodriguez-Nieto S, Zhivotovsky B. Role of alterations in the apoptotic machinery in sensitivity of cancer cells to treatment. Curr Pharm Des 2006; 12(34): 4411-25.
    • (2006) Curr Pharm Des , vol.12 , Issue.34 , pp. 4411-4425
    • Rodriguez-Nieto, S.1    Zhivotovsky, B.2
  • 166
    • 33745136102 scopus 로고    scopus 로고
    • The voltage-dependent anion channel (VDAC): Function in intracellular signalling, cell life and cell death
    • Shoshan-Barmatz V, Israelson A, Brdiczka D, Sheu SS. The voltage-dependent anion channel (VDAC): Function in intracellular signalling, cell life and cell death. Curr Pharm Des 2006; 12(18): 2249-70.
    • (2006) Curr Pharm Des , vol.12 , Issue.18 , pp. 2249-2270
    • Shoshan-Barmatz, V.1    Israelson, A.2    Brdiczka, D.3    Sheu, S.S.4


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