Analysis of gene expression patterns and chromosomal changes associated with aging

Cancer Research

Volumn 64, Issue 23, 2004, Pages 8550-8557

  Geigl, Jochen B ^a,b   Langer, Sabine ^a,b   Barwisch, Simone ^a,b   Pfleghaar, Katrin ^a,b   Lederer, Gaby ^a,b   Speicher, Michael R ^a,b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

OLIGONUCLEOTIDE;

AGE; AGING; ANEUPLOIDY; ARTICLE; CANCER RISK; CARCINOGENESIS; CELL CYCLE; CELL LINE; CELL PROLIFERATION; CENTROMERE; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA MICROARRAY; FIBROBLAST; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION REGULATION; GENETIC ANALYSIS; GENETIC STABILITY; HUMAN; HUMAN CELL; LYMPHOCYTE CULTURE; MALE; MICROSATELLITE INSTABILITY; PRIORITY JOURNAL; TELOMERE;

ADULT; AGED; AGED, 80 AND OVER; AGING; ANEUPLOIDY; CELL AGING; CELL CYCLE; CELL GROWTH PROCESSES; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOMAL INSTABILITY; FEMALE; FIBROBLASTS; GENE EXPRESSION; HUMANS; LYMPHOCYTES; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; MITOTIC INDEX; PHYTOHEMAGGLUTININS; TELOMERE;

EID: 9244240317     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-2151     Document Type: Article

References (61)

1. DePinho RA. The age of cancer. Nature (Lond) 2000;408:248-54.
2. Blasco MA, Lee HW, Hande MP, et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 1997;91:25-34.
3. Rudolph KL, Chang S, Lee HW, et al. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell 1999;96:701-12.
4. Artandi SE, Chang S, Lee SL, et al. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature (Lond) 2000;406:641-5.
5. Jacobs PA, Brunton M, Brown WMC, Doll R, Goldstein H. Change of human chromosome count distribution with age: evidence for a sex differences. Nature (Lond) 1963;197:1080.
6. Duesberg P, Rausch C, Rasnick D, Hehlmann R. Genetic instability of cancer cells is proportional to their degree of aneuploidy. Proc Natl Acad Sci USA 1998;95:13692-7.
7. Li R, Sonik A, Stindl R, Rasnick D, Duesberg P, Aneuploidy vs. gene mutation hypothesis of cancer: recent study claims mutation but is found to support aneuploidy. Proc Natl Acad Sci USA 2000;97:3236-41.
8. Ly DH, Lockhart DJ, Lerner RA, Schultz PG. Mitotic misregulation and human aging. Science (Wash DC) 2000;287:2486-92.
9. Kyng KJ, May A, Kolvraa S, Bohr VA. Gene expression profiling in Werner syndrome closely resembles that of normal aging. Proc Natl Acad Sci USA 2003;100:12259-64.
10. Abdel-Rahman WM, Katsura K, Rens W, et al. Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement. Proc Natl Acad Sci USA 2001;98:2538-43.
11. Li C, Wong WH. Model-based analysis of oligonucleotide arrays: Expression index computation and outlier detection. Proc Natl Acad Sci USA 2001;98:31-6.
12. Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 2001;98:5116-21.
13. Azofeifa J, Fauth C, Kraus J, et al. An optimized probe set for the detection of small interchromosomal aberrations by 24-color FISH. Am J Hum Genet 2000;66:1684-8.
14. Eils R, Uhrig S, Saracoglu K, et al. An optimized, fully automated system for fast and accurate identification of chromosomal rearrangements by multiplex-FISH (M-FISH). Cytogenet Cell Genet 1998;82:160-71.
15. Lansdorp PM, Verwoerd NP, van de Rijke FM, et al. Heterogeneity in telomere length of human chromosomes. Hum Mol Genet 1996;5:685-91.
16. Poon SS, Martens UM, Ward RK, Lansdorp PM. Telomere length measurements using digital fluorescence microscopy. Cytometry 1999;36:267-78.
17. Maierhofer C, Gangnus R, Diebold J, Speicher MR. Multicolor deconvolution microscopy of thick biological specimens. Am J Path 2003;162:373-9.
18. Lengauer C, Kinzler KW, Vogelstein B. Genetic instability in colorectal cancers. Nature (Lond) 1997;386:623-7.
19. Allsopp RC, Vaziri H, Patterson C, et al. Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci USA 1992;89:10114-8.
20. Bayreuther K, Rodemann HP, Hommel R, Dittmann K, Albiez M, Francz PI. Human skin fibroblasts in vitro differentiate along a terminal cell lineage. Proc Natl Acad Sci USA 1988;85:5112-6.
21. Cristofalo VJ. A DNA chip off the aging block. Nat Med 2000;6:507.
22. Weng NP, Levine BL, June CH, Hodes RJ. Human naive and memory T lymphocytes differ in telomeric length and replicative potential. Proc Natl Acad Sci USA 1995;92:11091-4.
23. Hodes RJ, Hathcock KS, Weng NP. Telomeres in T and B cells. Nat Rev Immun 2002;2:699-706.
24. Trazzi S, Bernardoni R, Diolaiti D, et al. In vivo functional dissection of human inner kinetochore protein CENP-C. J Struct Biol 2002;140:39-48.
25. Okano M, Bell DW, Haber DA, Li E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 1999;99:247-57.
26. McDowell TL, Gibbons RJ, Sutherland H, et al. Localization of a putative transcriptional regulator (ATRX) at pericentromeric heterochromatin and the short arms of acrocentric chromosomes. Proc Natl Acad Sci USA 1999;96:13983-8.
27. Clark SW, Staub O, Clark IB, et al. Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins. Mol Biol Cell 1994;5:1301-10.
28. Malone CJ, Fixsen WD, Horvitz HR, Han M. UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during C. elegans development. Development 1999;126:3171-81.
29. Chang DC, Xu N, Luo KQ. Degradation of cyclin B is required for the onset of anaphase in Mammalian cells. J Biol Chem 2003;278:37865-73.
30. Bernstein HS, Coughlin SR. A mammalian homolog of fission yeast Cdc5 regulates G2 progression and mitotic entry. J Biol Chem 1998;273:4666-71.
31. Costanzi C, Pehrson JR. MACROH2A2, a new member of the MARCOH2A core histone family. J Biol Chem 2001;276:21776-84.
32. Lin X, Wells DE. Localization of the human H3F3A histone gene to 1q41, outside of the normal histone gene clusters. Genomics 1997;46:526-8.
33. Nan X, Ng HH, Johnson CA, et al. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature (Lond) 1998;393:386-389.
34. Carrera P, Moshkin YM, Gronke S, et al. Tousled-like kinase functions with the chromatin assembly pathway regulating nuclear divisions. Genes Dev 2003;17:2578-90.
35. DiSepio D, Ghosn C, Eckert RL, et al. Identification and characterization of a retinoid-induced class II tumor suppressor/growth regulatory gene. Proc Natl Acad Sci USA 1998;95:14811-5.
36. Kleer CG, van Golen KL, Zhang Y, Wu ZF, Rubin MA, Merajver SD. Characterization of RhoC expression in benign and malignant breast disease: a potential new marker for small breast carcinomas with metastatic ability. Am J Pathol 2002;160:579-84.
37. Hellborg F, Qian W, Mendez-Vidal C, et al. Human wig-1, a p53 target gene that encodes a growth inhibitory zinc finger protein. Oncogene 2001;20:5466-74.
38. Enomoto H, Ozaki T, Takahashi E, et al. Identification of human DAN gene, mapping to the putative neuroblastoma tumor suppressor locus. Oncogene 1994;9:2785-91.
39. Sriuranpong V, Borges MW, Ravi RK, et al. Notch signaling induces cell cycle arrest in small cell lung cancer cells. Cancer Res 2001;61:3200-5.
40. Mourtada-Maarabouni M, Sutherland LC, Meredith JM, Williams GT. Simultaneous acceleration of the cell cycle and suppression of apoptosis by splice variant delta-6 of the candidate tumour suppressor LUCA-15/RBM5. Genes Cells 2003;8:109-19.
41. Chen CF, Chen Y, Dai K, Chen PL, Riley DJ, Lee WH. A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock. Mol Cell Biol 1996;16:4691-9.
42. Hall CL, Yang B, Yang X, et al. Overexpression of the hyaluronan receptor RHAMM is transforming and is also required for H-ras transformation. Cell 1995;82:19-26.
43. D'Sa-Eipper C, Subramanian T, Chinnadurai G, bfl-1, a bcl-2 homologue, suppresses p53-induced apoptosis and exhibits potent cooperative transforming activity. Cancer Res 1996;56:3879-82.
44. Fu L, Pelicano H, Liu J, Huang P, Lee C. The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell 2002;111:41-50.
45. Palmisano WA, Crume KP, Grimes MJ, et al. Aberrant promoter methylation of the transcription factor genes PAX5 alpha and beta in human cancers. Cancer Res 2003;63:4620-5.
46. Sgarra R, Diana F, Bellarosa C, et al. During apoptosis of tumor cells HMGA1a protein undergoes methylation: identification of the modification site by mass spectrometry. Biochemistry 2003;42:3575-85.
47. Kim R, Trubetskoy A, Suzuki T, Jenkins NA, Copeland NG, Lenz J. Genome-based identification of cancer genes by proviral tagging in mouse retrovirus-induced T-cell lymphomas. J Virol 2003;77:2056-62.
48. Colombo E, Marine JC, Danovi D, Falini B, Pelicci PG. Nucleophosmin regulates the stability and transcriptional activity of p53. Nat Cell Biol 2002;4:529-33.
49. Wadhwa R, Yaguchi T, Hasan MK, Mitsui Y, Reddel RR, Kaul SC. Hsp70 family member, mot-2/mthsp70/GRP75, binds to the cytoplasmic sequestration domain of the p53 protein. Exp Cell Res 2002;274:246-53.
50. Otte JM, Chen C, Brunke G, et al. Mechanisms of Lectin (Phytohemagglutinin)-induced growth in small intestinal epithelial cells. Digestion 2001;64:169-78.
51. Cowan KJ, Storey KB. Mitogen-activated protein kinases: new signaling pathways functioning in cellular responses to environmental stress. J Exp Biol 2003;206:1107-15.
52. Rajagopalan H, Nowak MA, Vogelstein B, Lengauer C. The significance of unstable chromosomes in colorectal cancer. Nat Rev Cancer 2003;3:695-701.
53. Sieber OM, Heinimann K, Tomlinson IP. Genomic instability - the engine of tumorigenesis? Nat Rev Cancer 2003;3:701-8.
54. Shih IM, Zhou W, Goodman SN, Lengauer C, Kinzler KW, Vogelstein B. Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis. Cancer Res 2001;61:818-22.
55. Cahill DP, Lengauer C, Yu J, et al. Mutations of mitotic checkpoint genes in human cancers. Nature (Lond) 1998;392:300-3.
56. Michel LS, Liberal V, Chatterjee A, et al. MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells. Nature (Lond) 2001;409:355-9.
57. Jallepalli PV, Waizenegger IC, Bunz F, et al. Securin is required for chromosomal stability in human cells. Cell 2001;105:445-57.
58. Rajagopalan H, Jallepalli PV, Rago C, et al. Inactivation of hCDC4 can cause chromosomal instability. Nature (Lond) 2004;428:77-81.
59. Richardson B. Impact of aging on DNA methylation. Ageing Res Rev 2003;2:245-61.
60. Pritchard CC, Hsu L, Delrow J, Nelson PS. Project normal: defining normal variance in mouse gene expression. Proc Natl Acad Sci USA 2001;98:13266-71.
61. Cheung VG, Conlin LK, Weber TM, Arcaro M, Jen KY, Morley M, Spielman RS. Natural variation in human gene expression assessed in lymphoblastoid cells. Nat Genet 2003;33:422-5.