-
1
-
-
0028891555
-
The immunology of exceptional individuals: The lesson of centenarians
-
Franceschi C, Monti D, Sansoni P, Cossarizza A. The immunology of exceptional individuals: the lesson of centenarians. Immunol Today 1995;16:12-16.
-
(1995)
Immunol Today
, vol.16
, pp. 12-16
-
-
Franceschi, C.1
Monti, D.2
Sansoni, P.3
Cossarizza, A.4
-
2
-
-
0034194058
-
Shortage of circulating naive CD8+ T cells provides new insights on immunodeficiency in aging
-
Fagnoni FF, Vescovini R, Passeri G, et al. Shortage of circulating naive CD8+ T cells provides new insights on immunodeficiency in aging. Blood 2000;95:2860-2868.
-
(2000)
Blood
, vol.95
, pp. 2860-2868
-
-
Fagnoni, F.F.1
Vescovini, R.2
Passeri, G.3
-
3
-
-
0030035269
-
Expansion of cytotoxic CD8+ CD28- T cells in healthy ageing people, including centenarians
-
Fagnoni FF, Vescovini R, Mazzola M, et al. Expansion of cytotoxic CD8+ CD28- T cells in healthy ageing people, including centenarians. Immunology 1996;88:501-507.
-
(1996)
Immunology
, vol.88
, pp. 501-507
-
-
Fagnoni, F.F.1
Vescovini, R.2
Mazzola, M.3
-
4
-
-
0033975907
-
In vitro senescence models for human T lymphocytes
-
Pawelec G, Adibzadeh M, Rehbein A, Hahnel K, Wagner W, Engel A. In vitro senescence models for human T lymphocytes. Vaccine 2000;18:1666-1674.
-
(2000)
Vaccine
, vol.18
, pp. 1666-1674
-
-
Pawelec, G.1
Adibzadeh, M.2
Rehbein, A.3
Hahnel, K.4
Wagner, W.5
Engel, A.6
-
5
-
-
0033975581
-
Human immunosenescence: The prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space
-
Franceschi C, Bonaf M, Valensin S. Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space. Vaccine 2000;18:1717-1720.
-
(2000)
Vaccine
, vol.18
, pp. 1717-1720
-
-
Franceschi, C.1
Bonaf, M.2
Valensin, S.3
-
6
-
-
0035915794
-
Decreased susceptibility to oxidative stress-induced apoptosis of peripheral blood mononuclear cells from healthy elderly and centenarians
-
Monti D, Salvioli S, Capri M, et al. Decreased susceptibility to oxidative stress-induced apoptosis of peripheral blood mononuclear cells from healthy elderly and centenarians. Mech Ageing Dev 2000;121:239-250.
-
(2000)
Mech Ageing Dev
, vol.121
, pp. 239-250
-
-
Monti, D.1
Salvioli, S.2
Capri, M.3
-
7
-
-
0029061537
-
Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic mice
-
Zhou T, Edwards CK, Mountz JD. Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic mice. J Exp Med 1995;182:129-137.
-
(1995)
J Exp Med
, vol.182
, pp. 129-137
-
-
Zhou, T.1
Edwards, C.K.2
Mountz, J.D.3
-
8
-
-
0032845553
-
Resistance to apoptosis in human CD8+ T cells that reach replicative senescence after multiples rounds of antigenic-specific proliferation
-
Spaulding CS, Guo W, Effros RB. Resistance to apoptosis in human CD8+ T cells that reach replicative senescence after multiples rounds of antigenic-specific proliferation. Exp Gerontol 1999;34:633-644.
-
(1999)
Exp Gerontol
, vol.34
, pp. 633-644
-
-
Spaulding, C.S.1
Guo, W.2
Effros, R.B.3
-
9
-
-
0030009805
-
Excessive apoptosis of mature T lymphocytes is a characteristic feature of human immune senescence
-
Phelouzat MA, Arbogast A, Laforge T, Quadri RA, Proust JJ. Excessive apoptosis of mature T lymphocytes is a characteristic feature of human immune senescence. Mech Ageing Dev 1996;88:25-38.
-
(1996)
Mech Ageing Dev
, vol.88
, pp. 25-38
-
-
Phelouzat, M.A.1
Arbogast, A.2
Laforge, T.3
Quadri, R.A.4
Proust, J.J.5
-
10
-
-
0030981153
-
Susceptibility to apoptosis of T lymphocytes from elderly humans is associated with increased in vivo expression of functional Fas receptors
-
Phelouzat MA, Laforge T, Arbogast A, Quadri RA, Boutet S, Proust JJ. Susceptibility to apoptosis of T lymphocytes from elderly humans is associated with increased in vivo expression of functional Fas receptors. Mech Ageing Dev 1997;96:35-46.
-
(1997)
Mech Ageing Dev
, vol.96
, pp. 35-46
-
-
Phelouzat, M.A.1
Laforge, T.2
Arbogast, A.3
Quadri, R.A.4
Boutet, S.5
Proust, J.J.6
-
13
-
-
0032519426
-
Increased apoptosis of T cell subset in aging humans: Altered expression of Fas (CD95), Fas ligand, Bcl-2, and Bax
-
Aggarwal S, Gupta S. Increased apoptosis of T cell subset in aging humans: altered expression of Fas (CD95), Fas ligand, Bcl-2, and Bax. J Immunol 1998;160:1627-1637.
-
(1998)
J Immunol
, vol.160
, pp. 1627-1637
-
-
Aggarwal, S.1
Gupta, S.2
-
14
-
-
0032817658
-
Increased activity of caspase 3 and caspase 8 in anti-Fas-induced apoptosis in lymphocytes from ageing humans
-
Aggarwal S, Gupta S. Increased activity of caspase 3 and caspase 8 in anti-Fas-induced apoptosis in lymphocytes from ageing humans. Clin Exp Immunol 1999;117:285-290.
-
(1999)
Clin Exp Immunol
, vol.117
, pp. 285-290
-
-
Aggarwal, S.1
Gupta, S.2
-
15
-
-
0033558334
-
Increased TNF-alpha-induced apoptosis in lymphocytes from aged humans: Changes in TNF-alpha receptor expression and activation of caspases
-
Aggarwal S, Gollapudi S, Gupta S. Increased TNF-alpha-induced apoptosis in lymphocytes from aged humans: changes in TNF-alpha receptor expression and activation of caspases. J Immunol 1999;162:2154-2161.
-
(1999)
J Immunol
, vol.162
, pp. 2154-2161
-
-
Aggarwal, S.1
Gollapudi, S.2
Gupta, S.3
-
16
-
-
0029977502
-
Regulation of CD95 (APO-1) expression and the induction of apoptosis in human T-cells: Changes in old age
-
Lechner M, Amort M, Steger MM, Maczek C, Grubeck-Loebstein B. Regulation of CD95 (APO-1) expression and the induction of apoptosis in human T-cells: changes in old age. Int Arch Allergy Immunol 1996;110:238-243.
-
(1996)
Int Arch Allergy Immunol
, vol.110
, pp. 238-243
-
-
Lechner, M.1
Amort, M.2
Steger, M.M.3
Maczek, C.4
Grubeck-Loebstein, B.5
-
18
-
-
0037204539
-
Apoptosis and successful aging
-
Zhang Y, Herman B. Apoptosis and successful aging. Mech Ageing Dev 2002b;123:563-565.
-
(2002)
Mech Ageing Dev
, vol.123
, pp. 563-565
-
-
Zhang, Y.1
Herman, B.2
-
20
-
-
0035989085
-
Ex vivo apoptotic potential of peripheral blood mononuclear cells of the elderly human subject
-
Szmit E, Trzonkowski P, Mysliwska J, Foerster J, Mysliwski A. Ex vivo apoptotic potential of peripheral blood mononuclear cells of the elderly human subject. Cell Biol Int 2002;26:517-527.
-
(2002)
Cell Biol Int
, vol.26
, pp. 517-527
-
-
Szmit, E.1
Trzonkowski, P.2
Mysliwska, J.3
Foerster, J.4
Mysliwski, A.5
-
21
-
-
0034985743
-
The Programmed death phenomena, aging, and the samurai law of biology
-
Skulachev VP. The Programmed death phenomena, aging, and the samurai law of biology. Exp Gerontol 2001;36:995-1024.
-
(2001)
Exp Gerontol
, vol.36
, pp. 995-1024
-
-
Skulachev, V.P.1
-
22
-
-
0034641918
-
The biochemistry of apoptosis
-
Hengartner MO. The biochemistry of apoptosis. Nature 2000;407:770-776.
-
(2000)
Nature
, vol.407
, pp. 770-776
-
-
Hengartner, M.O.1
-
23
-
-
0034641898
-
CD95 s deadly mission in the immune system
-
Krammer PH. CD95 s deadly mission in the immune system. Nature 2000;407:789-795.
-
(2000)
Nature
, vol.407
, pp. 789-795
-
-
Krammer, P.H.1
-
25
-
-
0031080895
-
Cellular environments and apoptosis: Tissue microenvironments control activated T-cell death
-
Akbar AN, Salmon M. Cellular environments and apoptosis: tissue microenvironments control activated T-cell death. Immunol Today 1997;18:72-76.
-
(1997)
Immunol Today
, vol.18
, pp. 72-76
-
-
Akbar, A.N.1
Salmon, M.2
-
26
-
-
0035501062
-
TGF-signaling in cancer: A double-edged sword
-
Akhurst R, Derynck R. TGF-signaling in cancer: a double-edged sword. Trends Cell Biol 2001;11:44-51.
-
(2001)
Trends Cell Biol
, vol.11
, pp. 44-51
-
-
Akhurst, R.1
Derynck, R.2
-
27
-
-
0033911578
-
Hormonal regulation of physiological cell turnover and apoptosis
-
Medh RD, Thompson EB. Hormonal regulation of physiological cell turnover and apoptosis. Cell Tissue Res 2000;301:101-124.
-
(2000)
Cell Tissue Res
, vol.301
, pp. 101-124
-
-
Medh, R.D.1
Thompson, E.B.2
-
28
-
-
0030925868
-
Th1/Th2 changes in aging
-
Shearer GM. Th1/Th2 changes in aging. Mech Ageing Dev 1997;94:1-5.
-
(1997)
Mech Ageing Dev
, vol.94
, pp. 1-5
-
-
Shearer, G.M.1
-
29
-
-
0035253734
-
Il-7 and not stem cell factor reverses both the increase in apoptosis and the decline in thymopoiesis seen in aged mice
-
Andrew D, Aspinall R. Il-7 and not stem cell factor reverses both the increase in apoptosis and the decline in thymopoiesis seen in aged mice. J Immunol 2001;166:1524-1530.
-
(2001)
J Immunol
, vol.166
, pp. 1524-1530
-
-
Andrew, D.1
Aspinall, R.2
-
30
-
-
0032757217
-
Age-associated changes in mitochondrial parameters on peripheral human lymphocytes
-
Drouet M, Lauthier F, Charmes JP, Sauvage P, Ratinaud MH. Age-associated changes in mitochondrial parameters on peripheral human lymphocytes. Exp Gerontol 1999;34:843-852.
-
(1999)
Exp Gerontol
, vol.34
, pp. 843-852
-
-
Drouet, M.1
Lauthier, F.2
Charmes, J.P.3
Sauvage, P.4
Ratinaud, M.H.5
-
31
-
-
0035915781
-
Apoptotic capability in ageing T cells
-
McLeod JD Apoptotic capability in ageing T cells Mech Ageing Dev 2000;121:151-159.
-
(2000)
Mech Ageing Dev
, vol.121
, pp. 151-159
-
-
McLeod, J.D.1
-
32
-
-
0037198033
-
Identification of high caspase-3 mRNA expression as a unique signature profile for extremely old individuals
-
Lancelle C, Xu S, Wang E. Identification of high caspase-3 mRNA expression as a unique signature profile for extremely old individuals. Mech. Ageing Dev 2002;123:1133-1144.
-
(2002)
Mech. Ageing Dev
, vol.123
, pp. 1133-1144
-
-
Lancelle, C.1
Xu, S.2
Wang, E.3
-
33
-
-
0030952630
-
Aging accelerates but life-long dietary restriction suppresses apoptosis-related Fas expression on hepatocytes
-
Higami Y, Shimokawa I, Tomita M, et al. Aging accelerates but life-long dietary restriction suppresses apoptosis-related Fas expression on hepatocytes. Am J Pathol 1997;151:659-663.
-
(1997)
Am J Pathol
, vol.151
, pp. 659-663
-
-
Higami, Y.1
Shimokawa, I.2
Tomita, M.3
-
34
-
-
0031918223
-
BCL-2 family: Regulators of cell death
-
Chao DT, Korsmeyer SJ. BCL-2 family: regulators of cell death. Annu Rev Immunol 1998;16:395-419.
-
(1998)
Annu Rev Immunol
, vol.16
, pp. 395-419
-
-
Chao, D.T.1
Korsmeyer, S.J.2
-
35
-
-
0033920616
-
Effects of aging on expression of genes involved in regulation of proliferation and apoptosis in the colonic epithelium
-
Lee H, Greeley GH Jr, Englander EW. Effects of aging on expression of genes involved in regulation of proliferation and apoptosis in the colonic epithelium. Mech Ageing Dev 2000;155:139-155.
-
(2000)
Mech Ageing Dev
, vol.155
, pp. 139-155
-
-
Lee, H.1
Greeley Jr., G.H.2
Englander, E.W.3
-
36
-
-
0032030581
-
Activation of human T cells with superantigen (SEB) and CD28 confers resistance to apoptosis via CD95
-
McLeod JD, Walker LSK, Patel YI, Boulougouris G, Sansom DM. Activation of human T cells with superantigen (SEB) and CD28 confers resistance to apoptosis via CD95. J Immunol 1998;160:2072-2079.
-
(1998)
J Immunol
, vol.160
, pp. 2072-2079
-
-
McLeod, J.D.1
Walker, L.S.K.2
Patel, Y.I.3
Boulougouris, G.4
Sansom, D.M.5
-
38
-
-
0032524929
-
Functional properties of CD4+CD28-T cells in the ageing immune system
-
Weyand CM, Brandes JC, Schmidt D, Fulbright JW, Goronzy JJ. Functional properties of CD4+CD28-T cells in the ageing immune system. Mech Ageing Dev 1998;102:131-147.
-
(1998)
Mech Ageing Dev
, vol.102
, pp. 131-147
-
-
Weyand, C.M.1
Brandes, J.C.2
Schmidt, D.3
Fulbright, J.W.4
Goronzy, J.J.5
-
39
-
-
0037012044
-
Age associated decline in CD25 and CD28 expression correlate with increased susceptibility to CD95 mediated apoptosis in T cells
-
Dennet NS, Barcia RN, McLeod JD. Age associated decline in CD25 and CD28 expression correlate with increased susceptibility to CD95 mediated apoptosis in T cells. Exp Gerontol 2002;37:271-283.
-
(2002)
Exp Gerontol
, vol.37
, pp. 271-283
-
-
Dennet, N.S.1
Barcia, R.N.2
McLeod, J.D.3
-
40
-
-
0033968815
-
Molecular and biochemical pathways of apoptosis in lymphocytes from aged humans
-
Gupta S. Molecular and biochemical pathways of apoptosis in lymphocytes from aged humans. Vaccine 2000;18:1596-1601.
-
(2000)
Vaccine
, vol.18
, pp. 1596-1601
-
-
Gupta, S.1
-
41
-
-
0033853735
-
Molecular steps of cell suicide: An insight into immune senescence
-
Gupta S. Molecular steps of cell suicide: an insight into immune senescence. J Clin Immunol 2000;20:229-239.
-
(2000)
J Clin Immunol
, vol.20
, pp. 229-239
-
-
Gupta, S.1
-
42
-
-
0037012006
-
Tumor necrosis factor-α-induced apoptosis in T cells from aged humans: A role of TNFR-I and downstream signaling molecules
-
Gupta S. Tumor necrosis factor-α-induced apoptosis in T cells from aged humans: a role of TNFR-I and downstream signaling molecules. Exp Gerontol 2002;37:293-299.
-
(2002)
Exp Gerontol
, vol.37
, pp. 293-299
-
-
Gupta, S.1
-
43
-
-
0037012022
-
Age dependent impact of LMP polymorphism on TNFα-induced apoptosis in human peripheral blood mononuclear cells
-
Mishto M, Bonaf M, Salvioli S, Olivieri F, Franceschi C. Age dependent impact of LMP polymorphism on TNFα-induced apoptosis in human peripheral blood mononuclear cells. Exp Gerontol 2002;37:301-308.
-
(2002)
Exp Gerontol
, vol.37
, pp. 301-308
-
-
Mishto, M.1
Bonaf, M.2
Salvioli, S.3
Olivieri, F.4
Franceschi, C.5
-
44
-
-
0037396495
-
Age-dependent changes in the susceptibility to apoptosis of peripheral blood CD4+ and CD8+ T lymphocytes with virgin or memory phenotype
-
in press
-
Salvioli S, Capri M, Scarcella E, et al. Age-dependent changes in the susceptibility to apoptosis of peripheral blood CD4+ and CD8+ T lymphocytes with virgin or memory phenotype. Mech Ageing Dev 2003 (in press).
-
(2003)
Mech Ageing Dev
-
-
Salvioli, S.1
Capri, M.2
Scarcella, E.3
-
45
-
-
0035956929
-
Increased mitochondrial oxidative stress in the Sod2 (+/-) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis
-
Kokoszka JE, Coskun P, Esposito LA, Wallace DC. Increased mitochondrial oxidative stress in the Sod2 (+/-) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis. Proc Natl Acad Sci USA 2001;98:2278-2283.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 2278-2283
-
-
Kokoszka, J.E.1
Coskun, P.2
Esposito, L.A.3
Wallace, D.C.4
-
46
-
-
0035831218
-
Mitochondria, aging and longevity - A new perspective
-
Salvioli S, Bonaf M, Capri M, Monti D, Franceschi C. Mitochondria, aging and longevity - a new perspective. FEBS Letters 2001;492:9-13.
-
(2001)
FEBS Letters
, vol.492
, pp. 9-13
-
-
Salvioli, S.1
Bonaf, M.2
Capri, M.3
Monti, D.4
Franceschi, C.5
-
47
-
-
0034988397
-
Oxidative damage to mitochondria and aging
-
Remmen HV, Richardson A. Oxidative damage to mitochondria and aging. Exp Gerontol 2001;36:957-968.
-
(2001)
Exp Gerontol
, vol.36
, pp. 957-968
-
-
Remmen, H.V.1
Richardson, A.2
-
48
-
-
0035978954
-
Suppression of brain aging and neurodegenerative disorders by dietary restriction and environmental enrichment: Molecular mechanisms
-
Mattson MP, Duan W, Lee J, Guo Z. Suppression of brain aging and neurodegenerative disorders by dietary restriction and environmental enrichment: molecular mechanisms. Mech Ageing Dev 2001;122:757-778.
-
(2001)
Mech Ageing Dev
, vol.122
, pp. 757-778
-
-
Mattson, M.P.1
Duan, W.2
Lee, J.3
Guo, Z.4
-
49
-
-
0037123654
-
Genomic priorities in aging
-
Hasty P, Vijg J. Genomic priorities in aging. Science 2002;296:1250-1251.
-
(2002)
Science
, vol.296
, pp. 1250-1251
-
-
Hasty, P.1
Vijg, J.2
-
50
-
-
0033581704
-
The p66shc adaptor protein controls oxidative stress response and life span in mammals
-
Migliaccio E, Giorgio M, Mele S, et al. The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature 1999;402:309-313.
-
(1999)
Nature
, vol.402
, pp. 309-313
-
-
Migliaccio, E.1
Giorgio, M.2
Mele, S.3
-
51
-
-
0037136563
-
Forkhead transcription factor FOXO3α protects quiescents cells from oxidative stress
-
Kops GJL, Dansen TB, Polderman PE, et al. Forkhead transcription factor FOXO3α protects quiescents cells from oxidative stress. Nature 2002;419:316-321.
-
(2002)
Nature
, vol.419
, pp. 316-321
-
-
Kops, G.J.L.1
Dansen, T.B.2
Polderman, P.E.3
-
52
-
-
0034068601
-
Mitochondrial control of cell death
-
Kroemer G, Reed JC. Mitochondrial control of cell death. Nature Med 2000;6:513-519.
-
(2000)
Nature Med
, vol.6
, pp. 513-519
-
-
Kroemer, G.1
Reed, J.C.2
-
53
-
-
0033902601
-
Aging enhances the activation of the permeability transition pore in mitochondria
-
Mather M, Rottenberg H. Aging enhances the activation of the permeability transition pore in mitochondria. Biochem Biophys Res Commun 2000;273:603-608.
-
(2000)
Biochem Biophys Res Commun
, vol.273
, pp. 603-608
-
-
Mather, M.1
Rottenberg, H.2
-
54
-
-
0032824718
-
The mitochondrial theory of aging: Is the culprit a faulty disposal system rather than indigenous mithocondrial alterations?
-
Gershon D. The mitochondrial theory of aging: is the culprit a faulty disposal system rather than indigenous mithocondrial alterations? Exp Gerontol 1999;34:613-619.
-
(1999)
Exp Gerontol
, vol.34
, pp. 613-619
-
-
Gershon, D.1
-
55
-
-
0036154895
-
Aging alters the apoptotic response to genotoxic stress
-
Suh Y, Lee K, Kim W, Han B, Vijg J, Park SC. Aging alters the apoptotic response to genotoxic stress. Nature Med 2002;8:3-4.
-
(2002)
Nature Med
, vol.8
, pp. 3-4
-
-
Suh, Y.1
Lee, K.2
Kim, W.3
Han, B.4
Vijg, J.5
Park, S.C.6
-
56
-
-
0037198061
-
Cell signaling in aging and apoptosis
-
Suh Y. Cell signaling in aging and apoptosis. Mech Ageing Dev 2002;123:881-890.
-
(2002)
Mech Ageing Dev
, vol.123
, pp. 881-890
-
-
Suh, Y.1
-
57
-
-
0034857113
-
Aging is associated with increased proliferation and decreased apoptosis in the colonic mucosa
-
Xiao Z, Moragoda L, Jaszewski R, Hatfield JA, Fligiel SEG, Majumdar APN. Aging is associated with increased proliferation and decreased apoptosis in the colonic mucosa. Mech Ageing Dev 2002;122:1849-1864.
-
(2002)
Mech Ageing Dev
, vol.122
, pp. 1849-1864
-
-
Xiao, Z.1
Moragoda, L.2
Jaszewski, R.3
Hatfield, J.A.4
Fligiel, S.E.G.5
Majumdar, A.P.N.6
-
58
-
-
0036368596
-
Loss in oxidative stress tolerance with aging linked to reduced extracellular signal-regulated kinase and Akt kinase activities
-
Ikeyama S, Kokkonen G, Shack S, Wang XT, Holbrook NJ. Loss in oxidative stress tolerance with aging linked to reduced extracellular signal-regulated kinase and Akt kinase activities. FASEB J 2002;16:114-116.
-
(2002)
FASEB J
, vol.16
, pp. 114-116
-
-
Ikeyama, S.1
Kokkonen, G.2
Shack, S.3
Wang, X.T.4
Holbrook, N.J.5
-
59
-
-
0036860951
-
Dose effect of oxidative stress on signal transduction in aging
-
Yoon SO, Yun CH, Chung AS. Dose effect of oxidative stress on signal transduction in aging. Mech Ageing Dev 2002;123:1597-1604.
-
(2002)
Mech Ageing Dev
, vol.123
, pp. 1597-1604
-
-
Yoon, S.O.1
Yun, C.H.2
Chung, A.S.3
-
60
-
-
0037308404
-
Association between telomere length in blood and mortality in people aged 60 years or older
-
Cawthon RM, Smith KR, O'Brien E, Sivatchenko A, Kerber RA. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 2003;361:393-395.
-
(2003)
Lancet
, vol.361
, pp. 393-395
-
-
Cawthon, R.M.1
Smith, K.R.2
O'Brien, E.3
Sivatchenko, A.4
Kerber, R.A.5
-
61
-
-
0034597794
-
Telomere states and cell fates
-
Blackburn EH. Telomere states and cell fates Nature 2000;408:53-56.
-
(2000)
Nature
, vol.408
, pp. 53-56
-
-
Blackburn, E.H.1
-
62
-
-
0030761351
-
ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase
-
Vaziri H, West MD, Allsopp RC, et al. ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase. EMBO J 16:6018-6033.
-
EMBO J
, vol.16
, pp. 6018-6033
-
-
Vaziri, H.1
West, M.D.2
Allsopp, R.C.3
-
64
-
-
0035131153
-
Change in the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53
-
Seluanov A, Falcovitz A, Sigol A, et al. Change in the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53. Mol Cell Biol 2001;21:1552-1564.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 1552-1564
-
-
Seluanov, A.1
Falcovitz, A.2
Sigol, A.3
-
65
-
-
0028901167
-
Replicative senescence and cell death
-
Linskens M, Harley CB, West MD, Campisi J, Hayflick L. Replicative senescence and cell death. Science 1995;267:17.
-
(1995)
Science
, vol.267
, pp. 17
-
-
Linskens, M.1
Harley, C.B.2
West, M.D.3
Campisi, J.4
Hayflick, L.5
-
66
-
-
0033621279
-
Role of NF-kappaB in the apoptotic-resistant phenotype of keratinocytes
-
Qin JZ, Chaturvedi V, Denning MF, Choubey D, Diaz MO, Nickoloff BJ. Role of NF-kappaB in the apoptotic-resistant phenotype of keratinocytes. J Biol Chem 1999;274:37957-37964.
-
(1999)
J Biol Chem
, vol.274
, pp. 37957-37964
-
-
Qin, J.Z.1
Chaturvedi, V.2
Denning, M.F.3
Choubey, D.4
Diaz, M.O.5
Nickoloff, B.J.6
-
67
-
-
0029047362
-
A novel biomarker identifies senescent cells in culture and in aging skin in vivo
-
Dimri GP, Lee X, Basile G, et al. A novel biomarker identifies senescent cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 1995;92:9363-9367.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 9363-9367
-
-
Dimri, G.P.1
Lee, X.2
Basile, G.3
-
68
-
-
0035079864
-
Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas
-
Paradis V, Youssef N, Dargere D, Ba N, Bonvoust F, Bedossa P. Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas. Hum Pathol 2001;32:327-332.
-
(2001)
Hum Pathol
, vol.32
, pp. 327-332
-
-
Paradis, V.1
Youssef, N.2
Dargere, D.3
Ba, N.4
Bonvoust, F.5
Bedossa, P.6
-
69
-
-
0035570480
-
Tubular cell senescence and expression of TGF-beta1 and p21 (WAF1/CIP1) in tubulointerstitial fibrosis of aging rats
-
Ding G, Franki N, Kapasi AA, Reddy K, Gibbons N, Singhal PC. Tubular cell senescence and expression of TGF-beta1 and p21 (WAF1/CIP1) in tubulointerstitial fibrosis of aging rats. Exp Mol Pathol 2001;70:43-53.
-
(2001)
Exp Mol Pathol
, vol.70
, pp. 43-53
-
-
Ding, G.1
Franki, N.2
Kapasi, A.A.3
Reddy, K.4
Gibbons, N.5
Singhal, P.C.6
-
70
-
-
0036343645
-
Induction of apoptosis in human replicative senescent fibroblasts
-
DeJesus V, Rios I, Davis C, et al. Induction of apoptosis in human replicative senescent fibroblasts. Exp Cell Res 2002;274:92-99.
-
(2002)
Exp Cell Res
, vol.274
, pp. 92-99
-
-
DeJesus, V.1
Rios, I.2
Davis, C.3
-
71
-
-
0028325052
-
Control of fibroblast senescence and activation of programmed cell death
-
Wang E, Lee MJ, Pandey S. Control of fibroblast senescence and activation of programmed cell death. J Cell Biochem 1994;54:432-439.
-
(1994)
J Cell Biochem
, vol.54
, pp. 432-439
-
-
Wang, E.1
Lee, M.J.2
Pandey, S.3
-
72
-
-
0029023626
-
Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl-2 is involved
-
Wang E. Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl-2 is involved. Cancer Res 1995;55:2284-2292.
-
(1995)
Cancer Res
, vol.55
, pp. 2284-2292
-
-
Wang, E.1
-
73
-
-
0034894667
-
Replicative senescence of human endothelial cells in vitro involves G1 arrest, poyploidization and senescence-associated apoptosis
-
Wagner M, Hampel B, Bernhard D, Hala M, Zwerschke W, Jansen-Durr P. Replicative senescence of human endothelial cells in vitro involves G1 arrest, poyploidization and senescence-associated apoptosis. Exp Gerontol 2001;36:1327-1347.
-
(2001)
Exp Gerontol
, vol.36
, pp. 1327-1347
-
-
Wagner, M.1
Hampel, B.2
Bernhard, D.3
Hala, M.4
Zwerschke, W.5
Jansen-Durr, P.6
-
75
-
-
0036407698
-
Bcl-2 can promote p53-dependent senescence versus apoptosis without affecting the G1/S transition
-
Rincheval V, Renaud F, Lemaire C, et al. Bcl-2 can promote p53-dependent senescence versus apoptosis without affecting the G1/S transition. Biochem Biophys Res Commun 2002;298:282-288.
-
(2002)
Biochem Biophys Res Commun
, vol.298
, pp. 282-288
-
-
Rincheval, V.1
Renaud, F.2
Lemaire, C.3
-
76
-
-
0037123638
-
Premature aging in mice deficient in DNA repair and transcription
-
De Boer J, Andressoo JO, de Wit J, et al. Premature aging in mice deficient in DNA repair and transcription. Science 2002;296:1276-1279.
-
(2002)
Science
, vol.296
, pp. 1276-1279
-
-
De Boer, J.1
Andressoo, J.O.2
De Wit, J.3
-
77
-
-
0034626769
-
The age of cancer
-
DePinho RA. The age of cancer. Nature 2000;408:248-254.
-
(2000)
Nature
, vol.408
, pp. 248-254
-
-
DePinho, R.A.1
-
78
-
-
0035834121
-
Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging
-
Krtolica A, Parrinello S, Lockett S, Desprez PY, Campisi J. Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc Natl Acad Sci USA 2001;98:12072-12077.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 12072-12077
-
-
Krtolica, A.1
Parrinello, S.2
Lockett, S.3
Desprez, P.Y.4
Campisi, J.5
-
80
-
-
0037238101
-
Cellular senescence and apoptosis: How cellular responses might influence aging phenotypes
-
Campisi J. Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes. Exp Gerontol 2003;38:5-11.
-
(2003)
Exp Gerontol
, vol.38
, pp. 5-11
-
-
Campisi, J.1
-
82
-
-
0034282322
-
Age-related changes of apoptotic cell death in human lymphocytes
-
Schindowski K, Leutner S, Muller WE, Eckert A. Age-related changes of apoptotic cell death in human lymphocytes, Neurobiol Aging 2000;21:661-670.
-
(2000)
Neurobiol Aging
, vol.21
, pp. 661-670
-
-
Schindowski, K.1
Leutner, S.2
Muller, W.E.3
Eckert, A.4
-
83
-
-
0037413726
-
Ablation of telomerase and telomere loss leads to cardiac dilatation and herat failure associated with p53 upregulation
-
Leri A, Franco S, Zacheo A, et al. Ablation of telomerase and telomere loss leads to cardiac dilatation and herat failure associated with p53 upregulation. EMBO J 2003;22:131-139.
-
(2003)
EMBO J
, vol.22
, pp. 131-139
-
-
Leri, A.1
Franco, S.2
Zacheo, A.3
-
84
-
-
0034852223
-
Activated CD8+ T cells from aged mice exhibit decreased activation-induced cell death
-
Hsu H, Shi J, Yang P, et al. Activated CD8+ T cells from aged mice exhibit decreased activation-induced cell death. Mech Ageing Dev 2001;122:1663-1684.
-
(2001)
Mech Ageing Dev
, vol.122
, pp. 1663-1684
-
-
Hsu, H.1
Shi, J.2
Yang, P.3
-
86
-
-
0035348408
-
Neuronal cell death in nervous system development, disease, and injury
-
Martin LJ. Neuronal cell death in nervous system development, disease, and injury. Int J Mol Med 2001;7:455-478.
-
(2001)
Int J Mol Med
, vol.7
, pp. 455-478
-
-
Martin, L.J.1
-
87
-
-
0036847858
-
Apoptosis in myocardial ischaemia and infarction
-
Krijnen PAJ, Nijmeijer R, Meijer CJLM, Visser CA, Hack CE, Niessen HWM. Apoptosis in myocardial ischaemia and infarction. J Clin Pathol 2002;55:801-811.
-
(2002)
J Clin Pathol
, vol.55
, pp. 801-811
-
-
Krijnen, P.A.J.1
Nijmeijer, R.2
Meijer, C.J.L.M.3
Visser, C.A.4
Hack, C.E.5
Niessen, H.W.M.6
-
88
-
-
0037011949
-
The price of tumour suppression?
-
Ferbeyre G, Lowe SW. The price of tumour suppression? Nature 2002;415:26-27.
-
(2002)
Nature
, vol.415
, pp. 26-27
-
-
Ferbeyre, G.1
Lowe, S.W.2
-
89
-
-
0032931517
-
The p53 pathway
-
Prives C, Hall PA. The p53 pathway. J Pathol 1999;187: 112-126.
-
(1999)
J Pathol
, vol.187
, pp. 112-126
-
-
Prives, C.1
Hall, P.A.2
-
90
-
-
0037011958
-
P53 mutant mice that display early ageing-associated phenotypes
-
Tyner SD, Venkatachalam S, Choi J, et al. P53 mutant mice that display early ageing-associated phenotypes. Nature 2002;415:45-53.
-
(2002)
Nature
, vol.415
, pp. 45-53
-
-
Tyner, S.D.1
Venkatachalam, S.2
Choi, J.3
-
91
-
-
0037112844
-
Super p53 mice exhibit enhanced DNA damage response, are tumor resistano and age normally
-
Garcia-Cao I, Garcia-Cao M, Martin-Caballero J, et al. Super p53 mice exhibit enhanced DNA damage response, are tumor resistano and age normally. EMBO J 2002;21:6225-6235.
-
(2002)
EMBO J
, vol.21
, pp. 6225-6235
-
-
Garcia-Cao, I.1
Garcia-Cao, M.2
Martin-Caballero, J.3
-
92
-
-
0037195158
-
Selenomethionine regulation of p53 by a ref-1-dependent redox mechanism
-
Seo YR, Kelley M, Smith ML. Selenomethionine regulation of p53 by a ref-1-dependent redox mechanism. Proc Natl Acad Sci USA 2002;99:14548-14553.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 14548-14553
-
-
Seo, Y.R.1
Kelley, M.2
Smith, M.L.3
-
93
-
-
0036852823
-
Converting p53 from a killer into a healer
-
Gudkov AV. Converting p53 from a killer into a healer. Nature Med 2002;8:1196-1198.
-
(2002)
Nature Med
, vol.8
, pp. 1196-1198
-
-
Gudkov, A.V.1
-
95
-
-
0345420668
-
Cell Proliferation and apoptosis in the immune system in the elderly
-
Ginaldi L, De Martinis M, D'Ostilio A, et al. Cell Proliferation and apoptosis in the immune system in the elderly. Immunol Res 2000;21:31-38.
-
(2000)
Immunol Res
, vol.21
, pp. 31-38
-
-
Ginaldi, L.1
De Martinis, M.2
D'Ostilio, A.3
-
97
-
-
0037017378
-
Aging leads to disturbed homeostasis of memory phenotype CD8+ cells
-
Zhang X, Fujii H, Kishimoto H, LeRoy E, Surh CD, Sprent J. Aging leads to disturbed homeostasis of memory phenotype CD8+ cells. J Exp Med 2002;195:283-293.
-
(2002)
J Exp Med
, vol.195
, pp. 283-293
-
-
Zhang, X.1
Fujii, H.2
Kishimoto, H.3
LeRoy, E.4
Surh, C.D.5
Sprent, J.6
-
98
-
-
0036784603
-
Differential sensitivity of naive and memory CD8+ T cells to apoptosis in vivo
-
Grayson JM, Harrington LE, Lanier JG, Wherry EJ, Ahmed R. Differential sensitivity of naive and memory CD8+ T cells to apoptosis in vivo. J Immunol 2002;169:3760-3770.
-
(2002)
J Immunol
, vol.169
, pp. 3760-3770
-
-
Grayson, J.M.1
Harrington, L.E.2
Lanier, J.G.3
Wherry, E.J.4
Ahmed, R.5
-
99
-
-
0032971440
-
Differentiation of human CD8 T cells: Implications for in vivo persistence of CD8+CD28- cytotoxic effector clones
-
Posnett DN, Edinger JW, Manavalan JS, Irwin C, Marodan G. Differentiation of human CD8 T cells:implications for in vivo persistence of CD8+CD28- cytotoxic effector clones. Int Immunol 1999;11:229-241.
-
(1999)
Int Immunol
, vol.11
, pp. 229-241
-
-
Posnett, D.N.1
Edinger, J.W.2
Manavalan, J.S.3
Irwin, C.4
Marodan, G.5
-
100
-
-
0036644265
-
Memory functions and death proneness in three CD4+ CD45RO+ human T cell subsets
-
Ohara T, Koyama K, Kusunoki Y, et al. Memory functions and death proneness in three CD4+ CD45RO+ human T cell subsets. J Immunol 2002;169:39-48.
-
(2002)
J Immunol
, vol.169
, pp. 39-48
-
-
Ohara, T.1
Koyama, K.2
Kusunoki, Y.3
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