The genetics of human longevity

Annals of the New York Academy of Sciences

Volumn 1067, Issue 1, 2006, Pages 252-263

  Capri, Miriam ^a   Salvioli, Stefano ^a   Sevini, Federica ^a   Valensin, Silvana ^a   Celani, Laura ^a   Monti, Daniela ^b   Pawelec, Graham ^c   De Benedictis, Giovanna ^d   Gonos, Efstathios S ^e   Franceschi, Claudio ^a,f  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d UNIVERSITY OF CALABRIA   (Italy)

^e NHR Foundation   (Greece)

^f INRCA   (Italy)

Author keywords

Apolipoproteins; CETP; IL 1 cluster; IL 10; IL 6; insulin IGF 1; Longevity genes; p53, p66shc; PON1; PPAR ; TGF ; TLR 4; TNF

Indexed keywords

APOLIPOPROTEIN; ARYLDIALKYLPHOSPHATASE 1; CHOLESTEROL ESTER TRANSFER PROTEIN; INSULIN; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 6; LIPID; MITOCHONDRIAL DNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN P53; PROTEIN P66; SOMATOMEDIN C; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

AGED; AGING; ALZHEIMER DISEASE; CONFERENCE PAPER; ENVIRONMENTAL FACTOR; EPIGENETICS; GENE CLUSTER; GENE MUTATION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOME; HEART INFARCTION; HUMAN; INFLAMMATION; ITALY; LIPID METABOLISM; LONGEVITY; MITOCHONDRION; NON INSULIN DEPENDENT DIABETES MELLITUS; OXIDATIVE STRESS; PLEIOTROPY; SIGNAL TRANSDUCTION; SURVIVAL;

EID: 33744542074     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1354.033     Document Type: Conference Paper

References (57)

1. Barabasi, A.L. & Z.N., Oltvai. 2004. Network biology: understanding the cell's functional organization. Nat. Rev. Genet. 5 : 101 113.
2. Tieri, P. et al. 2005. Quantifying the relevance of different mediators in the human immune cell network. Bioinformatics 21 : 1639 1643.
3. Fagiolo, U. et al. 1993. Increased cytokine production in mononuclear cells of healthy elderly people. Eur. J. Immunol. 23 : 2375 2378.
4. Di Iorio, A. et al. 2003. Serum IL-1beta levels in health and disease: a population-based study. 'The InCHIANTI study'. Cytokine 22 : 198 205.
5. Gerli, R. et al. 2000. Chemokines, sTNF-Rs and sCD30 serum levels in healthy aged people and centenarians. Mech. Ageing Dev. 121 : 37 46.
6. Wei, J. et al. 1992. Increase of plasma IL-6 concentration with age in healthy subjects. Life Sci. 51 : 1953 1956.
7. Ershler, W.B. et al. 1993. Interleukin-6 and aging: blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction. Lymphokine Cytokine Res. 12 : 225 230.
8. Bruunsgaard, H. et al. 1999. A high plasma concentration of TNF-alpha is associated with dementia in centenarians. J. Gerontol. A Biol. Sci. Med. Sci. 54 : M357 364.
9. Ferrucci, L. et al. 1999. Serum IL-6 level and the development of disability in older persons J. Am. Geriatr. Soc. 47 : 639 646.
10. Cesari, M. et al. 2004. Inflammatory markers and physical performance in older persons: the InCHIANTI study. J. Gerontol. A Biol. Sci. Med. Sci. 59 : 242 248.
11. Bruunsgaard, H. et al. 2003. Predicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people. Clin. Exp. Immunol. 132 : 24 31.
12. Bruunsgaard, H. et al. 2003. Elevated levels of tumor necrosis factor alpha and mortality in centenarians. Am. J. Med. 115 : 278 283.
13. Olivieri, F. et al. 2002. -174 C/G locus affects in vitro/vivo IL-6 production during aging. Exp. Gerontol. 37 : 309 314.
14. Antonicelli, R. et al. 2005. The interleukin-6 -174 G>C promoter polymorphism is associated with a higher risk of death after an acute coronary syndrome in male elderly patients. Intl. J. Cardiol. 103 : 266 271.
15. Rea, I.M. et al. 2003. Interleukin-6-gene C/G 174 polymorphism in nonagenarian and octogenarian subjects in the BELFAST study: reciprocal effects on IL-6, soluble IL-6 receptor and for IL-10 in serum and monocyte supernatants. Mech. Ageing Develop. 124 : 555 561.
16. Ross, O.A. et al. 2003. Study of age-association with cytokine gene polymorphisms in an aged Irish population. Mech. Ageing Develop. 124 : 199 206.
17. Carrieri, G. et al. 2004. The G/C915 polymorphism of transforming growth factor beta1 is associated with human longevity: a study in Italian centenarians. Aging Cell 3 : 443 448.
18. Lio, D. et al. 2002. Gender-specific association between -1082 IL-10 promoter polymorphism and longevity. Genes Immun. 3 : 30 33.
19. Lio, D. et al. 2003. Interleukin-10 promoter polymorphism in sporadic Alzheimer's disease. Genes Immun. 4 : 234 238.
20. Baggio, G. et al. 1998. Lipoprotein(a) and lipoprotein profile in healthy centenarians: a reappraisal of vascular risk factors. FASEB J. 12 : 433 437.
21. Franceschi, C. et al. 2000. Inflamm-aging: an evolutionary perspective on immunosenescence. Ann. N. Y. Acad. Sci. 908 : 244 254.
22. Ginaldi, L. et al. 2005. Chronic antigenic load and apoptosis in immunosenescence. Trends Immunol. 26 : 79 84.
23. Franceschi, C. & M. Bonafè. 2003. Centenarians as a model for healthy aging. Biochem. Soc. Trans. 31 : 457 461.
24. Balistreri, C.R. et al. 2004. Role of Toll-like receptor 4 in acute myocardial infarction and longevity. JAMA 292 : 2339 2340.
25. Schröder, N.W.J. & R.R. Shumann. 2005. Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease. Lancet Infect. Dis. 5 : 156 164.
26. De Benedictis, G. et al. 1998. Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2). Eur. J. Hum. Genet. 6 : 534 541.
27. Bonafè, M. et al. 2002. Genetic analysis of paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians. Eur. J. Hum. Genet. 10 : 292 296.
28. Rea, I.M. et al. 2004. Paraoxonase polymorphisms PON1 192 and 55 and longevity in Italian centenarians and Irish nonagenarians. A pooled analysis. Exp. Gerontol. 39 : 629 635.
29. Heijmans, B.T. et al. 2000. Common paraoxonase gene variants, mortality risk and fatal cardiovascular events in elderly subjects. Atherosclerosis. 149 : 91 97.
30. Lawlor, D.A. et al. 2004. The challenge of secondary prevention for coronary heart disease in older patients: findings from the British Women's Heart and Health Study and the British Regional Heart Study. Fam. Pract. 21 : 582 586.
31. Xia, Y. et al. 2003. Effect of six candidate genes on early aging in a French population. Aging Clin. Exp. Res. 15 : 111 116.
32. Marchegiani, F. et al. 2006. Paraoxonase activity and genotype predispose to a successful aging. J. Gerontol. Ser. A Biol. Sci. Med. Sci. In press.
33. Franceschi, C. et al. 2005. Genes involved in immune response/ inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians. Mech. Ageing. Dev. 126 : 351 361.
34. Bonafè, M. et al. 2003. Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control. J. Clin. Endocrinol. Metab. 88 : 3299 3304.
35. Cappola, A.R. et al. 2003. Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women. J. Clin. Endocrinol. Metab. 88 : 2019 2025.
36. Pollak, M.N. et al. 2004. Insulin-like growth factors and neoplasia. Nat. Rev. Cancer 4 : 505 518.
37. Barbieri, M. et al. 2003. Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons. Am. J. Physiol. Endocrinol. Metab. 284 : E481 E487.
38. Lau, D.C. et al. 2005. Adipokines: molecular links between obesity and atheroslcerosis. Am. J. Physiol. Heart Circ. Physiol. 288 : H2031 H2041.
39. Barbieri, M. et al. 2005. Role of interaction between variants in the PPARG and interleukin-6 genes on obesity related metabolic risk factors. Exp. Gerontol. 40 : 599 604.
40. Paolisso, G. et al. 2001. Low insulin resistance and preserved beta-cell function contribute to human longevity but are not associated with TH-INS genes. Exp Gerontol. 37 : 149 156.
41. Bonafè, M. et al. 1999. p53 variants predisposing to cancer are present in healthy centenarians. Am. J. Hum. Genet. 64 : 292 295.
42. van Heemst, D. et al. and Long Life Study Group. 2005. Variation in the human TP53 gene affects old age survival and cancer mortality. Exp. Gerontol. 40 : 11 15.
43. Bonafè, M. et al. 2003. Retention of the p53 codon 72 arginine allele is associated with a reduction of disease-free and overall survival in arginine/proline heterozygous breast cancer patients. Clin. Cancer Res. 9 : 4860 4864.
44. Bonafè, M. et al. 2002. p53 codon 72 genotype affects apoptosis by cytosine arabinoside in blood leukocytes. Biochem. Biophys. Res. Commun. 299 : 539 541.
45. Bonafè, M. et al. 2004. The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischemia-induced cell death. Cell Death Differ. 11 : 962 973.
46. Salvioli, S. et al. 2005. p53 codon 72 alleles influence the response to anticancer drugs in cells from aged people by regulating the cell cycle inhibitor p21WAF1. Cell Cycle 4 : 1264 1271.
47. Carrieri, G. et al. 2001. Mitochondrial DNA haplogroups and ApoE4 allele are non-independent variables in sporadic Alzheimer's disease. Hum. Genet. 108 : 194 198.
48. De Benedictis, G. et al. 1998. Age-related changes of the 3′APOB-VNTR genotype pool in ageing cohorts. Ann. Hum. Genet. 62 Pt 2 115 122.
49. Garasto, S. et al. 2004. A study of the average effect of the 3′APOB-VNTR polymorphism on lipidemic parameters could explain why the short alleles (<35 repeats) are rare in centenarians. BMC Med. Genet. 5 : 3 9.
50. Varcasia, O. et al. 2001. Replication studies in longevity: puzzling findings in Danish centenarians at the 3′ApoB-VNTR locus. Ann. Hum. Genet. 65 Pt 4 371 376.
51. Garasto, S. et al. 2003. The study of ApoA1, ApoC3 and ApoA4 variability in healthy ageing people reveals another paradox in the oldest old subjects. Ann. Hum. Genet. 67 : 54 62.
52. Coppola, R. et al. 2003. Von Willebrand factor in Italian centenarians. Haematologica 88 : 39 43.
53. Baggio, G. et al. 1998. Lipoprotein(a) and lipoprotein profile in healthy centenarians: a reappraisal of vascular risk factors. FASEB J. 12 : 433 437.
54. Barzilai, N. et al. 2003. Unique lipoprotein phenotype and genotype associated with exceptional longevity. JAMA 290 : 2030 2040.
55. Cellini, E. et al. 2005. Cholesteryl ester transfer protein (CETP) I405V polymorphism and longevity in Italian centenarians. Mech. Ageing Dev. 126 : 826 828.
56. Migliaccio, E. et al. 1999. The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature 402 : 309 313.
57. Pandolfi, S. et al. 2005. p66(shc) is highly expressed in fibroblasts from centenarians. Mech. Ageing Dev. 126 : 839 844.