Inflammation, apoptosis, and Alzheimer's disease

Neuroscientist

Volumn 8, Issue 3, 2002, Pages 276-283

  Bamberger, Maria E ^a   Landreth, Gary E ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Apoptosis; Inflammation; Microglia

Indexed keywords

AMYLOID BETA PROTEIN; GLUCOCORTICOID; NONSTEROID ANTIINFLAMMATORY AGENT; PRESENILIN 1; PRESENILIN 2; TAU PROTEIN; VACCINE;

ALZHEIMER DISEASE; AMYLOID NEUROPATHY; APOPTOSIS; DISEASE COURSE; HUMAN; INFLAMMATION; MICROGLIA; NERVE CELL NECROSIS; NEUROFIBRILLARY TANGLE; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; SENILE PLAQUE; TREATMENT PLANNING; VACCINATION;

EID: 0036114344     PISSN: 10738584     EISSN: None     Source Type: Journal    
DOI: 10.1177/1073858402008003013     Document Type: Review

References (59)

1. Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5
2. A randomized controlled trial of prednisone in Alzheimer's disease. Alzheimer's disease cooperative study
3. Inflammation and Alzheimer's disease
4. Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease
5. Microglial interaction with beta-amyloid: Implications for the pathogenesis of Alzheimer's disease
6. Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
7. Beta-amyloid activates the O-2 forming NADPH oxidase in microglia, monocytes, and neutrophils. A possible inflammatory mechanism of neuronal damage in Alzheimer's disease
8. Complement-dependent proinflammatory properties of the Alzheimer's disease beta-peptide
9. The role of anti-inflammatory drugs in the prevention and treatment of Alzheimer's disease
10. Uptake, degradation, and release of fibrillar and soluble forms of Alzheimer's amyloid beta-peptide by microglial cells
11. Inflammatory mechanisms in Alzheimer's disease: Inhibition of beta- amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists
12. Beta-amyloid stimulation of microglia and monocytes results in TNFalphadependent expression of inducible nitric oxide synthase and neuronal apoptosis
13. Mechanisms of neuronal death in Alzheimer's disease
14. Where Notch and Wnt signaling meet. The presenilin hub
15. The role of complement in Alzheimer's disease pathology
16. Aggregated amyloid-beta protein induces cortical neuronal apoptosis and concomitant "apoptotic" pattern of gene induction
17. Generation of auto-antibodies towards Alzheimer's disease vaccination
18. E2F1 mediates death of B-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3
19. Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F x DP, in B-amyloid-induced neuronal death
20. Reactive mononuclear phagocytes release neurotoxins after ischemic and traumatic injury to the nervous system
21. Synthetic Alzheimer amyloid beta/A4 peptides enhance production of complement C3 component by cultured microglial cells
22. BH3-only Bcl-2 family members are coordinately regulated by the JNK pathway and require Bax to induce apoptosis in neurons
23. Peroxisome proliferator-activated receptor gamma agonists protect cerebellar granule cells from cytokine-induced apoptotic cell death by inhibition of inducible nitric oxide synthase
24. Induction of nitric oxide synthase and nitric oxide-mediated apoptosis in neuronal PC12 cells after stimulation with tumor necrosis factor-alpha/lipopolysaccharide
25. The cell death-promoting gene DP5, which interacts with the BCL2 family, is induced during neuronal apoptosis following exposure to amyloid beta protein
26. Subacute NO generation induced by Alzheimer's beta-amyloid in the living brain: Reversal by inhibition of the inducible NO synthase
27. Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8
28. A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
29. Beta-amyloid activates complement by binding to a specific region of the collagen-like domain of the Clq A chain
30. Microglia and Alzheimer's disease
31. p35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/presenilin-1 interaction
32. Neurotoxicity induces cleavage of p35 to p25 by calpain
33. Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice
34. Anti-inflammatory drugs and Alzheimer-type pathology in aging
35. Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging
36. Apoptosis in neurodegenerative disorders
37. Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia
38. Activation of microglial cells by beta-amyloid protein and interferon-gamma
39. Activation of microglial cells by beta-amyloid protein and interferon-gamma
40. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
41. Cell cycle regulatory failure in neurones: Causes and consequences
42. TNF-alpha mediates inducible nitric oxide synthase expression in human neuroblastoma cell line by cisplatin
43. p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway
44. Nonsteroidal anti-inflammatory drugs in Alzheimer's disease
45. Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's disease
46. Results of a double-blind, randomized, placebo-controlled study of celecoxib in the treatment of Alzheimer's disease
47. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
48. Apoptosis in Alzheimer's disease - An update
49. Widespread peroxynitrite-mediated damage in Alzheimer's disease
50. Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of betaamyloid precursor protein and notch processing
51. Risk of Alzheimer's disease and duration of NSAID use
52. Caspase-2 mediates neuronal cell death induced by beta-amyloid
53. Beta-amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation
54. A new mechanism of neurodegeneration: A proinflammatory cytokine inhibits receptor signaling by a survival peptide
55. Antibody-mediated phagocytosis of the amyloid beta-peptide in microglia is differentially modulated by Clq
56. Fibrillar beta-amyloid induces microglial phagocytosis, expression of inducible nitric oxide synthase, and loss of a select population of neurons in the rat CNS in vivo
57. Beta-amyloid activated microglia induce cell cycling and cell death in cultured cortical neurons
58. DNA replication precedes neuronal cell death in Alzheimer's disease
59. Apoptosis in the nervous system