Low insulin resistance and preserved β-cell function contribute to human longevity but are not associated with TH-INS genes

Experimental Gerontology

Volumn 37, Issue 1, 2001, Pages 149-156

  Paolisso, Giuseppe ^a   Barbieri, Michelangela ^a   Rizzo, Maria Rosaria ^a   Carella, Carlo ^a   Rotondi, Mario ^a   Bonafè, Massimiliano ^b   Franceschi, Claudio ^b   Rose, Giuseppina ^c   De Benedictis, Giovanna ^c  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c UNIVERSITY OF CALABRIA   (Italy)

Author keywords

Centenarians; Glucose metabolism; Human longevity; TH INS genes

Indexed keywords

INSULIN; TYROSINE 3 MONOOXYGENASE;

ADULT; AGED; AGING; ALLELE; ANTHROPOMETRIC PARAMETERS; ARTICLE; CELL FUNCTION; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA POLYMORPHISM; FEMALE; GENETIC VARIABILITY; GLUCOSE METABOLISM; GROUPS BY AGE; HIGH RISK POPULATION; HUMAN; INSULIN RESISTANCE; LONGEVITY; MAJOR CLINICAL STUDY; MALE; MARKER GENE; PANCREAS ISLET BETA CELL; PHENOTYPE; PRIORITY JOURNAL; TANDEM REPEAT;

ADULT; AGED; AGED, 80 AND OVER; ANTHROPOMETRY; BODY MASS INDEX; CHOLESTEROL; FEMALE; HUMANS; INSULIN; INSULIN RESISTANCE; ISLETS OF LANGERHANS; LONGEVITY; MALE; MIDDLE AGED; TYROSINE 3-MONOOXYGENASE;

EID: 0035216820     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(01)00148-6     Document Type: Article

References (33)

1. Definition, diagnosis and classification of diabetes mellitus and its complication. Part 1. Diagnosis and classification of diabetes mellitus. Provisional report of a WHO consultation
2. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity. Studies in subjects with various degrees of glucose tolerance and insulin sensitivity
3. Assessment of the primary adrenal cortical and pancreatic hormone basal levels in relation to plasma glucose and age in the unstressed Ames dwarf mouse
4. Pathogenesis of age-related glucose intolerance in man: Insulin resistance and decreased β-cell function
5. Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2)
6. The network and the remodeling theories of aging
7. Estimation of serum low-density lipoprotein without the use of a preparative ultracentrifuge
8. Decreased insulin secretion and increased insulin resistance are independently related to the 7-year risk of NIDDM in Mexican-Americans
9. A prospective analysis of the HOMA model: The Mexico City diabetes study
10. Prevalence of diabetes and impaired glucose tolerance and plasma glucose tolerance and plasma glucose levels in US population aged 20-74 yrs
11. Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles
12. Longevity, genes and aging
13. Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
14. Insulin resistance and insulin secretary dysfunction as precursors of non-insulin dependent diabetes mellitus. Prospective studies of Pima Indians
15. Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DANN spanning the insulin gene and associated VNTR
16. Homeostasis model assessment: Insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man
17. Body composition, body fat distribution and resting metabolic rate in healthy centenarians
18. Glucose tolerance and insulin action in healthy centenarians
19. Advancing age and insulin resistance: New fact for an ancient history
20. Metabolic age remodeling: The lessons from centenarians
21. Comparison of different analytic and precipitation methods for direct estimation of serum high-density lipoprotein cholesterol
22. Reagent for enzymatic determination of serum total cholesterol with improved lipolytic efficiency
23. The forces of mortality at age 80-120
24. Polymorphism in 5′ flanking region of human insulin gene. Relationships with atherosclerosis, lipid levels and age in three samples from DNK
25. Triglyceride determination after enzymatic hydrolysis
26. Linkage and association of insulin gene VNTR regulatory polymorphism with polycystic ovary syndrome
27. Central obesity and hyperinsulinaemia in women are associated with polymorphism in the 5′ flanking region of the human insulin gene
28. Epidemiology of diabetes mellitus in the elderly
29. Community-based study of incidence of NIDDM in older adults
30. Regulation of C. elegans life span by insulin-like signaling in the nervous system
31. Gene, demography and life span: The contribution of demographic data in genetic studies on aging and longevità