메뉴 건너뛰기




Volumn 21, Issue 1, 2000, Pages 31-38

Cell proliferation and apoptosis in the immune system in the elderly

Author keywords

Apoptosis; Cell proliferation; Elderly; Immune system

Indexed keywords

AGED; AGING; ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; CELL DEATH; CELL GROWTH; CELL PROLIFERATION; HUMAN; HUMAN CELL; IMMUNE SYSTEM; IMMUNOCOMPETENT CELL; LYMPHOID CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 0345420668     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1385/IR:21:1:31     Document Type: Article
Times cited : (47)

References (65)
  • 1
    • 84950382925 scopus 로고
    • Cell proliferation, cell death and aging
    • 1 Franceschi C: Cell proliferation, cell death and aging. Aging 1989;1:3-15.
    • (1989) Aging , vol.1 , pp. 3-15
    • Franceschi, C.1
  • 2
    • 0028891555 scopus 로고
    • The immunology of exceptional individuals: The lesson of centenarians
    • 2 Franceschi C, Monti D, Sansoni P, Cossarizza A: The immunology of exceptional individuals: the lesson of centenarians. Immunol Today 1995;16:12-16.
    • (1995) Immunol Today , vol.16 , pp. 12-16
    • Franceschi, C.1    Monti, D.2    Sansoni, P.3    Cossarizza, A.4
  • 4
    • 0030914988 scopus 로고    scopus 로고
    • Altered expression of various receptors on T cells in young and old mice after mitogenic stimulation: A flow cytometric analysis
    • 4 Wakikawa A, Utsuyama M, Hirokawa K: Altered expression of various receptors on T cells in young and old mice after mitogenic stimulation: a flow cytometric analysis. Mech Ageing Dev 1997;94:113-122.
    • (1997) Mech Ageing Dev , vol.94 , pp. 113-122
    • Wakikawa, A.1    Utsuyama, M.2    Hirokawa, K.3
  • 5
    • 0027163464 scopus 로고
    • Replicative senescence of human fibroblast-like cells in culture
    • 5 Cristofalo VJ, Pignolo R.J: Replicative senescence of human fibroblast-like cells in culture Phisiol 1992;Rev 73:795-808.
    • (1992) Phisiol Rev , vol.73 , pp. 795-808
    • Cristofalo, V.J.1    Pignolo, R.J.2
  • 7
    • 0031434175 scopus 로고    scopus 로고
    • Human T-cell clones in long-term culture as a model of immunosenescence
    • 7 Pawelec G, Rehbein A, Haehnel K, Merl A, Adibzadeh M: Human T-cell clones in long-term culture as a model of immunosenescence. Immunol Rev 1997;160: 31-42.
    • (1997) Immunol Rev , vol.160 , pp. 31-42
    • Pawelec, G.1    Rehbein, A.2    Haehnel, K.3    Merl, A.4    Adibzadeh, M.5
  • 8
    • 0031463644 scopus 로고    scopus 로고
    • Tales of tails: Regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation and aging
    • 8 Weng N, Palmer LD, Levine BL, Lane HC, June CH, Modes RJ: Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation and aging. Immunol Rev 1997;160:43-54.
    • (1997) Immunol Rev , vol.160 , pp. 43-54
    • Weng, N.1    Palmer, L.D.2    Levine, B.L.3    Lane, H.C.4    June, C.H.5    Modes, R.J.6
  • 10
    • 0028806679 scopus 로고
    • Long-term culture of monoclonal human Tlympho-cytes: Models for imunosenescence?
    • 10 Adibzadeh M, Pohla H, Rehbein A, Pawelec G: Long-term culture of monoclonal human Tlympho-cytes: models for imunosenescence? Mech Ageing Dev 1995;83:171-183.
    • (1995) Mech Ageing Dev , vol.83 , pp. 171-183
    • Adibzadeh, M.1    Pohla, H.2    Rehbein, A.3    Pawelec, G.4
  • 11
    • 0028850465 scopus 로고
    • Human naive and memory T lymphocytes differ in telomeric length and replicative potential
    • 11 Weng NP, Levine BL, June CH, Hodes RJ: Human naive and memory T lymphocytes differ in telomeric length and replicative potential. Proc Natl Acad Sci USA 1995;92:11,091-11,094.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 11091-11094
    • Weng, N.P.1    Levine, B.L.2    June, C.H.3    Hodes, R.J.4
  • 12
    • 0029877250 scopus 로고    scopus 로고
    • Insights on immunological aging derived from the T lymphocyte cellular senescence model
    • 12 Effros RB: Insights on immunological aging derived from the T lymphocyte cellular senescence model. Exp Gerontol 1996;31:21-27.
    • (1996) Exp Gerontol , vol.31 , pp. 21-27
    • Effros, R.B.1
  • 13
    • 0027976958 scopus 로고
    • Clonal populations of T cells in normal elderly humans - The T cell equivalent to benign monoclonal gammopathy
    • 13 Posnett DN, Sinha R, Kahak S, Russo C: Clonal populations of T cells in normal elderly humans -the T cell equivalent to benign monoclonal gammopathy. J Exp Med 1994;179:609-618.
    • (1994) J Exp Med , vol.179 , pp. 609-618
    • Posnett, D.N.1    Sinha, R.2    Kahak, S.3    Russo, C.4
  • 14
    • 0029973490 scopus 로고    scopus 로고
    • Expansion of T cells negative for CD28 expression in HIV infection. Relation to activation markers and cell adhesio molecules, and correlation with prognostic markers
    • 14 Kannerer R, Iten A, Frei PC, Burgisser P: Expansion of T cells negative for CD28 expression in HIV infection. Relation to activation markers and cell adhesio molecules, and correlation with prognostic markers. Med Microbiol Immunol 1996;185:19-25.
    • (1996) Med Microbiol Immunol , vol.185 , pp. 19-25
    • Kannerer, R.1    Iten, A.2    Frei, P.C.3    Burgisser, P.4
  • 15
    • 0029942655 scopus 로고    scopus 로고
    • Zeta chain and CD28 are poorly expressed on T lymphocytes from chronic lymphocytic leukemia
    • 15 Rossi E, Matutes E, Morilla R, Owusu-Ankomah K, Heffernan AM, Catovsky D: Zeta chain and CD28 are poorly expressed on T lymphocytes from chronic lymphocytic leukemia. Leukemia 1996;10:494-497.
    • (1996) Leukemia , vol.10 , pp. 494-497
    • Rossi, E.1    Matutes, E.2    Morilla, R.3    Owusu-Ankomah, K.4    Heffernan, A.M.5    Catovsky, D.6
  • 16
    • 0029958821 scopus 로고    scopus 로고
    • CD4+ CD7-CD28-T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity
    • 16 Schmidt D, Goronzy JJ, Weyand CM: CD4+ CD7-CD28-T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity. J Clin Invest 1996;97:2027-2037.
    • (1996) J Clin Invest , vol.97 , pp. 2027-2037
    • Schmidt, D.1    Goronzy, J.J.2    Weyand, C.M.3
  • 17
    • 0030002828 scopus 로고    scopus 로고
    • Expanded CD4+ CD45RO+ phenotype and defective proliferative response in T lymphocytes from patients with Crohn's disease
    • 17 Roman LI, Manzano L, Delahera A, Abreu L, Rossi I, Alvarezmon M: Expanded CD4+ CD45RO+ phenotype and defective proliferative response in T lymphocytes from patients with Crohn's disease. Gastroenterology 1996;110:1008-1019.
    • (1996) Gastroenterology , vol.110 , pp. 1008-1019
    • Roman, L.I.1    Manzano, L.2    Delahera, A.3    Abreu, L.4    Rossi, I.5    Alvarezmon, M.6
  • 18
    • 0026505797 scopus 로고
    • Memory T lymphocyte hyporesponsiveness to non-cognate stimuli: A key factor in age-related immunodeficiency
    • 18 Flurkey K, Stadecker M, Miller RA: Memory T lymphocyte hyporesponsiveness to non-cognate stimuli: a key factor in age-related immunodeficiency. Eur J Immunol 1992;22:931-935.
    • (1992) Eur J Immunol , vol.22 , pp. 931-935
    • Flurkey, K.1    Stadecker, M.2    Miller, R.A.3
  • 19
    • 0028201870 scopus 로고
    • Aged T cells are hyporesponsive to costimulation mediated by CD28
    • 19 Engwerda CR, Handwerger BS, Fox BS: Aged T cells are hyporesponsive to costimulation mediated by CD28. J Immunol 1994;152:3740-3747.
    • (1994) J Immunol , vol.152 , pp. 3740-3747
    • Engwerda, C.R.1    Handwerger, B.S.2    Fox, B.S.3
  • 20
    • 0029160436 scopus 로고
    • Age-related changes in lhymphoproliferation, cytotoxic T lymphocyte responses, and natural killer activity of senescence-accellerated mouse (SAM)-P/8 and SAM-R/1 substrains
    • 20 Powers DC, Manning MC, Morley JE, Flood IF: Age-related changes in lhymphoproliferation, cytotoxic T lymphocyte responses, and natural killer activity of senescence-accellerated mouse (SAM)-P/8 and SAM-R/1 substrains. Aging Immunol Infect Dis 1995;6:43-52.
    • (1995) Aging Immunol Infect Dis , vol.6 , pp. 43-52
    • Powers, D.C.1    Manning, M.C.2    Morley, J.E.3    Flood, I.F.4
  • 21
    • 0023640683 scopus 로고
    • Age-related changes of splenic T cells in mice. Flow cytometric analysis
    • 21 Utsuyama M, Hirokawa K: Age-related changes of splenic T cells in mice. Flow cytometric analysis. Mech Ageing Dev 1987;40:89-102.
    • (1987) Mech Ageing Dev , vol.40 , pp. 89-102
    • Utsuyama, M.1    Hirokawa, K.2
  • 24
    • 0028891555 scopus 로고
    • The immunology of exceptional individual: The lesson of centenarians
    • 24 Franceschi C, Monti D, Sansoni P, Cossarizza A: The immunology of exceptional individual: the lesson of centenarians. Immunol Today 1995;16:12-16.
    • (1995) Immunol Today , vol.16 , pp. 12-16
    • Franceschi, C.1    Monti, D.2    Sansoni, P.3    Cossarizza, A.4
  • 28
    • 0022377145 scopus 로고
    • Delayed enzyme expression: A defect of aging rat gut
    • 28 Holt PR, Tierney AR, Kotler DP: Delayed enzyme expression: a defect of aging rat gut. Gastroenterology 1985;89:1026-1034.
    • (1985) Gastroenterology , vol.89 , pp. 1026-1034
    • Holt, P.R.1    Tierney, A.R.2    Kotler, D.P.3
  • 29
    • 0023901132 scopus 로고
    • Altered controls of proliferation in proxymal small intestine of the senescent rat
    • 29 Holt PR, Yeh KY, Kotler DP: Altered controls of proliferation in proxymal small intestine of the senescent rat. Proc Natl Acad Sci 1988;85:2771-2775.
    • (1988) Proc Natl Acad Sci , vol.85 , pp. 2771-2775
    • Holt, P.R.1    Yeh, K.Y.2    Kotler, D.P.3
  • 33
    • 0025950667 scopus 로고
    • Programmed cell death in the immune system
    • 33 Cohen JJ: Programmed cell death in the immune system. Adv Immunol 1991;50:55-85.
    • (1991) Adv Immunol , vol.50 , pp. 55-85
    • Cohen, J.J.1
  • 36
    • 0024596722 scopus 로고
    • A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor for tumor necrosis factor
    • 36 Yonehara S, Ishii A, Yonehara M: A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor for tumor necrosis factor. J Exp Med 1989;169:1747-1756.
    • (1989) J Exp Med , vol.169 , pp. 1747-1756
    • Yonehara, S.1    Ishii, A.2    Yonehara, M.3
  • 37
    • 0028129894 scopus 로고
    • Effect of the lpr mutation on elimination and inactivation of self-reactive B cells
    • 37 Rathmell JC, Goodnow CC: Effect of the lpr mutation on elimination and inactivation of self-reactive B cells. J Immunol 1994;153:2831-2842.
    • (1994) J Immunol , vol.153 , pp. 2831-2842
    • Rathmell, J.C.1    Goodnow, C.C.2
  • 38
    • 0025253398 scopus 로고
    • Decreased steady-state c-myc mRNA in activated T cell cultures from old humans is caused by a smaller proportion of T cells that transcribe the c-myc gene
    • 38 Gamble DA, Schwab R, Weksler ME, Szabo P: Decreased steady-state c-myc mRNA in activated T cell cultures from old humans is caused by a smaller proportion of T cells that transcribe the c-myc gene. J Immunol 1990;144:3569-3573.
    • (1990) J Immunol , vol.144 , pp. 3569-3573
    • Gamble, D.A.1    Schwab, R.2    Weksler, M.E.3    Szabo, P.4
  • 39
    • 0026508422 scopus 로고
    • Phytohemagglutinin-induced changes of membrane lipid packing, c-myc and c-myb encoded protein expression in human lymphocytes during aging
    • 39 Pieri C, Recchioni R, Moroni F, Marcheselli F, Lipponi G: Phytohemagglutinin-induced changes of membrane lipid packing, c-myc and c-myb encoded protein expression in human lymphocytes during aging. Mech Ageing Dev 1992;64:177-187.
    • (1992) Mech Ageing Dev , vol.64 , pp. 177-187
    • Pieri, C.1    Recchioni, R.2    Moroni, F.3    Marcheselli, F.4    Lipponi, G.5
  • 42
    • 0029935914 scopus 로고    scopus 로고
    • Age-related decrease in IL-2 production by human T cells are associated with impaired activation of nuclear transcription factors AP-1 and NF-AT
    • 42 Whisler RL, Liu BQ, Chen M: Age-related decrease in IL-2 production by human Tcells are associated with impaired activation of nuclear transcription factors AP-1 and NF-AT. Cell Immunol 1996;169:185-195.
    • (1996) Cell Immunol , vol.169 , pp. 185-195
    • Whisler, R.L.1    Liu, B.Q.2    Chen, M.3
  • 43
    • 0030009805 scopus 로고    scopus 로고
    • Excessive apoptosis of mature T lymphocytes is a characteristic feature of human immune senescence
    • 43 Phelouzat MA, Arbogast A, Laforge T, Quadri RA, Proust JJ: Excessive apoptosis of mature T lymphocytes is a characteristic feature of human immune senescence. Mech Ageing Dev 1996;88:25-38.
    • (1996) Mech Ageing Dev , vol.88 , pp. 25-38
    • Phelouzat, M.A.1    Arbogast, A.2    Laforge, T.3    Quadri, R.A.4    Proust, J.J.5
  • 44
    • 0030981153 scopus 로고
    • Susceptibility to apoptosis of T lymphocytes from elderly humans is associated with increased in vivo expression of functional Fas receptors
    • 44 Phelouzat MA, Laforge T, Arbogast A, Quadri RA, Boulet S, Proust JJ: Susceptibility to apoptosis of T lymphocytes from elderly humans is associated with increased in vivo expression of functional Fas receptors. Mech Ageing Dev 1977;96:35-46.
    • (1977) Mech Ageing Dev , vol.96 , pp. 35-46
    • Phelouzat, M.A.1    Laforge, T.2    Arbogast, A.3    Quadri, R.A.4    Boulet, S.5    Proust, J.J.6
  • 45
    • 0026482756 scopus 로고
    • Induction of apoptosis by monoclonal antibody anti-APO-1 class switch variants is dependent on cross-linking of APO-1 cell surface antigens
    • 45 Dhein J, Daniel PT, Trauth BC, Oehm A, Moller P, Krammer PH: Induction of apoptosis by monoclonal antibody anti-APO-1 class switch variants is dependent on cross-linking of APO-1 cell surface antigens. J Immunol 1992;149:3116-3173.
    • (1992) J Immunol , vol.149 , pp. 3116-3173
    • Dhein, J.1    Daniel, P.T.2    Trauth, B.C.3    Oehm, A.4    Moller, P.5    Krammer, P.H.6
  • 47
    • 0028097822 scopus 로고
    • Purification and characterization of the Fas-ligand that induces apoptosis
    • 47 Suda T, Nagata S: Purification and characterization of the Fas-ligand that induces apoptosis. J Exp Med 1994;179:873-879.
    • (1994) J Exp Med , vol.179 , pp. 873-879
    • Suda, T.1    Nagata, S.2
  • 49
    • 0028149786 scopus 로고
    • Check-point of dueling dimers foil death wishes
    • 49 Oltvai ZN, Korsmeyer SJ: Check-point of dueling dimers foil death wishes. Cell 1994;19:189-192.
    • (1994) Cell , vol.19 , pp. 189-192
    • Oltvai, Z.N.1    Korsmeyer, S.J.2
  • 50
    • 0028802845 scopus 로고
    • Fas and FasL in the homeostatic regulation of immune responses
    • 50 Lynch DH, Ramsdell F, Alderson MR: Fas and FasL in the homeostatic regulation of immune responses. Immunol Today 1995;16:569-574.
    • (1995) Immunol Today , vol.16 , pp. 569-574
    • Lynch, D.H.1    Ramsdell, F.2    Alderson, M.R.3
  • 51
    • 0030009805 scopus 로고    scopus 로고
    • Excessive apoptosis of mature T lymphocytes is a characteristic feature of human immune senescence
    • 51 Phelouzat MA, Arbogast A, Laforge T. Quadri RA, Proust JJ: Excessive apoptosis of mature T lymphocytes is a characteristic feature of human immune senescence. Mech Ageing Dev 1996;88:25-38.
    • (1996) Mech Ageing Dev , vol.88 , pp. 25-38
    • Phelouzat, M.A.1    Arbogast, A.2    Laforge, T.3    Quadri, R.A.4    Proust, J.J.5
  • 52
    • 0031011169 scopus 로고    scopus 로고
    • Increased apoptosis of CD45RO T cells with aging
    • 52 Herndon FJ, Hsu HC, Mountz JD: Increased apoptosis of CD45RO T cells with aging. Mech Ageing Dev 1997;94:123-134.
    • (1997) Mech Ageing Dev , vol.94 , pp. 123-134
    • Herndon, F.J.1    Hsu, H.C.2    Mountz, J.D.3
  • 53
    • 0031463643 scopus 로고    scopus 로고
    • Cell death and longevity: Implications of Fas-mediated apoptosis in T-cell senescence
    • 53 Mountz JD, Wu J, Zhou T, Hsu HC: Cell death and longevity: implications of Fas-mediated apoptosis in T-cell senescence. Immunol Rev 1997;160:19-30.
    • (1997) Immunol Rev , vol.160 , pp. 19-30
    • Mountz, J.D.1    Wu, J.2    Zhou, T.3    Hsu, H.C.4
  • 54
    • 0028670386 scopus 로고
    • Physiological T-cell death: Susceptibility is modulated by activation, aging, and transformation, but the mechanism is constant
    • 54 Ucker DS, Hebshi LD, Blomquist JF, Toebett BE: Physiological T-cell death: susceptibility is modulated by activation, aging, and transformation, but the mechanism is constant. Immunol Rev 1994;142:273-299.
    • (1994) Immunol Rev , vol.142 , pp. 273-299
    • Ucker, D.S.1    Hebshi, L.D.2    Blomquist, J.F.3    Toebett, B.E.4
  • 55
    • 0029061537 scopus 로고
    • Prevention of age-related T cell apoptosis defect in CD2-fas transgenic mice
    • 55 Zhou T, Edwards CK, Mountz JD: Prevention of age-related T cell apoptosis defect in CD2-fas transgenic mice. J Exp Med 1995;182:129-137.
    • (1995) J Exp Med , vol.182 , pp. 129-137
    • Zhou, T.1    Edwards, C.K.2    Mountz, J.D.3
  • 57
    • 0029618266 scopus 로고
    • DNA repair in humans
    • 57 Sancar A: DNA repair in humans. Annu Rev Genet 1993;29:69-105.
    • (1993) Annu Rev Genet , vol.29 , pp. 69-105
    • Sancar, A.1
  • 58
    • 0028102478 scopus 로고
    • Cleavage of poly(ADP-ribose)polymerase by a proteinase with properties like ICE
    • 58 Lazebnik YA, Kaufmann SH, Desnoyers S, Poirler GG, Earnshaw WC:Cleavage of poly(ADP-ribose)polymerase by a proteinase with properties like ICE. Nature 1995;346:346-347.
    • (1995) Nature , vol.346 , pp. 346-347
    • Lazebnik, Y.A.1    Kaufmann, S.H.2    Desnoyers, S.3    Poirler, G.G.4    Earnshaw, W.C.5
  • 59
    • 0028881847 scopus 로고
    • DNA-dependent protein kinase is one of subsets of autoantigens specifically cleaved early during apoptosis
    • 59 Casciola-Rosen RA, Anhalt GJ, Rosen A: DNA-dependent protein kinase is one of subsets of autoantigens specifically cleaved early during apoptosis. J Exp Med 1995;182:1625-1634.
    • (1995) J Exp Med , vol.182 , pp. 1625-1634
    • Casciola-Rosen, R.A.1    Anhalt, G.J.2    Rosen, A.3
  • 60
    • 0031093496 scopus 로고    scopus 로고
    • The DNA-dependent protein kinase (p460) is cleaved during Fas-mediated apoptosis in Jurkat cells
    • 60 McConnell KR, Dynan WS, Hardin JA: The DNA-dependent protein kinase (p460) is cleaved during Fas-mediated apoptosis in Jurkat cells. J Immunol 1997;158: 2083-2089.
    • (1997) J Immunol , vol.158 , pp. 2083-2089
    • McConnell, K.R.1    Dynan, W.S.2    Hardin, J.A.3
  • 61
    • 50549218525 scopus 로고
    • The limited in vitro lifetime of human diploid cell strains
    • 61 Hayflick L: The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 1965;37:614-636.
    • (1965) Exp Cell Res , vol.37 , pp. 614-636
    • Hayflick, L.1
  • 62
    • 0029781591 scopus 로고    scopus 로고
    • Influence of aging on B-cell apoptosis and expression of the activation marker alkaline phosphatase
    • 62 Souvannavong V, Lemaire C, Andreau K, Brown S, Adam A: Influence of aging on B-cell apoptosis and expression of the activation marker alkaline phosphatase. Aging Immunol Infect Dis 1996;6:197-207.
    • (1996) Aging Immunol Infect Dis , vol.6 , pp. 197-207
    • Souvannavong, V.1    Lemaire, C.2    Andreau, K.3    Brown, S.4    Adam, A.5
  • 63
    • 0029023626 scopus 로고
    • Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved
    • 63 Wang E: Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved. Cancer Res,1995;55:2284-2292.
    • (1995) Cancer Res , vol.55 , pp. 2284-2292
    • Wang, E.1
  • 65
    • 0027938156 scopus 로고
    • Bcl-2 and Bcl-x: Regulatory switches for lymphoid death and survival
    • 65 Nunez G, Merino R, Grillot D, Gonzales-Garcia M: Bcl-2 and Bcl-x: regulatory switches for lymphoid death and survival. Immunol Today 1994;15:582-588.
    • (1994) Immunol Today , vol.15 , pp. 582-588
    • Nunez, G.1    Merino, R.2    Grillot, D.3    Gonzales-Garcia, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.