Cell signaling: A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis

Science

Volumn 310, Issue 5754, 2005, Pages 1646-1653

  Janes, Kevin A ^a   Albeck, John G ^a   Gaudet, Suzanne ^a   Sorger, Peter K ^a   Lauffenburger, Douglas A ^a   Yaffe, Michael B ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDEMIOLOGY; TUMORS;

CELL SIGNALING; INTRACELLULAR SIGNALS; SYSTEM MODEL;

CELLS;

CYTOKINE; EPIDERMAL GROWTH FACTOR; INSULIN; INTERLEUKIN 1ALPHA; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR NECROSIS FACTOR; INTERLEUKIN 1; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

NEUROLOGY;

ACCURACY; APOPTOSIS; ARTICLE; AUTOCRINE EFFECT; CELL SURVIVAL; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; PREDICTION; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TIME; BIOLOGICAL MODEL; CELL STRAIN HT29; METABOLISM; PHYSIOLOGY; REGRESSION ANALYSIS; SYSTEMS BIOLOGY; SYSTEMS THEORY;

APOPTOSIS; AUTOCRINE COMMUNICATION; CELL SURVIVAL; CYTOKINES; EPIDERMAL GROWTH FACTOR; HT29 CELLS; HUMANS; INSULIN; INTERLEUKIN-1; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LEAST-SQUARES ANALYSIS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION; SYSTEMS BIOLOGY; SYSTEMS THEORY; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 28844441230     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1116598     Document Type: Article

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