CD8 T-cell immune phenotype of successful aging

Mechanisms of Ageing and Development

Volumn 127, Issue 3, 2006, Pages 231-239

  Hsu, Hui Chen ^a   Scott, Donald K ^b,e   Zhang, Pili ^b,e   Zhou, Juling ^a   Yang, PingAr ^a   Wu, Qi ^a   Schroeder, Harry W ^a   Gerald, Lynn B ^a   Ravussin, Eric ^c,e   Jazwinski, S Michal ^b,e   Mountz, John D ^a,d   Batzer, Mark ^e   Black, Meghan ^e   Broussard, Evest A ^e   Byerley, Laurie ^e   Callinan, Pauline ^e   Cherry, Katie E ^e   Chiu, Yu Wen ^e   Cooper, Annie ^e   DeLany, James P ^e   Deutsch, W Andrew ^e   Fontham, Elizabeth T H ^e   Frisard, Madlyn ^e   Geiselman, Paula ^e   Greco, Valentina ^e   Hawley, Karri S ^e   Herke, Scott W ^e   Kendzor, Darla ^e   Kim, Sangkyu ^e   Kimball, Beth ^e   Li, Li ^e   Lopez, Kay ^e   Robertson, Yolanda ^e   Rothschild, Henry ^e   Schmidt, Beth ^e   Standberry, F Nicole ^e   Su, L Joseph ^e   Lin, Hui Yi ^e   Traylor, Crystal P ^e   Wood, Robert H ^e   more..

^a University of Alabama at Birmingham   (United States)

^b LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^d BIRMINGHAM VA MEDICAL CENTER   (United States)

^e NONE

Author keywords

CD28; CD8 T cells; Fas; Nonagenarians

Indexed keywords

CD28 ANTIGEN; FAS ANTIGEN;

AGED; AGING; ARTICLE; CELL ACTIVATION; CELL DEATH; CELL FUNCTION; CELL LABELING; CELL POPULATION; CELL STIMULATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN CELL; MALE; MONONUCLEAR CELL; NORMAL HUMAN; PHENOTYPE; PRIORITY JOURNAL; SENESCENCE; T LYMPHOCYTE;

EID: 32244442841     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mad.2005.10.001     Document Type: Article

References (36)

1. S.L. Anderson, D.F. Terry, M.A. Wilcox, T. Babineau, K. Malek, and T.T. Perls Cancer in the oldest old Mech. Ageing Dev. 126 2005 263 267
2. R. Aspinall, J. Carroll, and S. Jiang Age-related changes in the absolute number of CD95 positive cells in T cell subsets in the blood Exp. Gerontol. 33 1998 581 591
3. F. Batliwalla, J. Monteiro, D. Serrano, and P.K. Gregersen Oligoclonality of CD8+ T cells in health and disease: aging, infection, or immune regulation? Hum. Immunol. 48 1996 68 76
4. E. Bryl, A.N. Vallejo, C.M. Weyand, and J.J. Goronzy Down-regulation of CD28 expression by TNF-alpha J. Immunol. 167 2001 3231 3238
5. A. Brzezinska, A. Magalska, A. Szybinska, and E. Sikora Proliferation and apoptosis of human CD8(+)CD28(+) and CD8(+)CD28(-) lymphocytes during aging Exp. Gerontol. 39 2004 539 544
6. C. Caruso, A. Aquino, G. Candore, L. Scola, G. Colonna-Romano, and D. Lio Looking for immunological risk genotypes Ann. N. Y. Acad. Sci. 1019 2004 141 146
7. A. Colombatti, R. Doliana, M. Schiappacassi, C. Argentini, E. Tonutti, C. Feruglio, and P. Sala Age-related persistent clonal expansions of CD28(-) cells: phenotypic and molecular TCR analysis reveals both CD4(+) and CD4(+)CD8(+) cells with identical CDR3 sequences Clin. Immunol. Immunopathol. 89 1998 61 70
8. R.B. Effros Loss of CD28 expression on T lymphocytes: a marker of replicative senescence Dev. Comp. Immunol. 21 1997 471 478
9. C. Franceschi, M. Bonafe, and S. Valensin Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space Vaccine 18 2000 1717 1720
10. K.A. Frauwirth, J.L. Riley, M.H. Harris, R.V. Parry, J.C. Rathmell, D.R. Plas, R.L. Elstrom, C.H. June, and C.B. Thompson The CD28 signaling pathway regulates glucose metabolism Immunity 16 2002 769 777
11. J.J. Goronzy, J.W. Fulbright, C.S. Crowson, G.A. Poland, W.M. O'Fallon, and C.M. Weyand Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals J. Virol. 75 2001 12182 12187
12. F.J. Herndon, H.C. Hsu, and J.D. Mountz Increased apoptosis of CD45RO- T cells with aging Mech. Ageing Dev. 94 1997 123 134
13. H.C. Hsu, J. Shi, P. Yang, X. Xu, C. Dodd, Y. Matsuki, H.G. Zhang, and J.D. Mountz Activated CD8(+) T cells from aged mice exhibit decreased activation-induced cell death Mech. Ageing Dev. 122 2001 1663 1684
14. H.C. Hsu, T. Zhou, J. Shi, P.A. Yang, D. Liu, H.G. Zhang, H. Bluethmann, and J.D. Mountz Aged mice exhibit in vivo defective peripheral clonal deletion of D(b)/H-Y reactive CD8(+) T cells Mech. Ageing Dev. 122 2001 305 326
15. J. Jiang, F. Anaraki, K.J. Blank, and D.M. Murasko Cutting edge: T cells from aged mice are resistant to depletion early during virus infection J. Immunol. 171 2003 3353 3357
16. A. Krause, H.F. Guo, J.B. Latouche, C. Tan, N.K. Cheung, and M. Sadelain Antigen-dependent CD28 signaling selectively enhances survival and proliferation in genetically modified activated human primary T lymphocytes J. Exp. Med. 188 1998 619 626
17. D.E. Lewis, M. Merched-Sauvage, J.J. Goronzy, C.M. Weyand, and A.N. Vallejo Tumor necrosis factor-alpha and CD80 modulate CD28 expression through a similar mechanism of T-cell receptor-independent inhibition of transcription J. Biol. Chem. 279 2004 29130 29138
18. J.D. Mountz, J. Wu, T. Zhou, and H.C. Hsu Cell death and longevity: implications of Fas-mediated apoptosis in T-cell senescence Immunol. Rev. 160 1997 19 30
19. T.F. Mueller Phenotypic changes with immunosuppression in human recipients Front. Biosci. 8 2003 d1254 d1274
20. G. Pawelec, Q. Ouyang, W. Wagner, and A. Wikby Pathway to a robust immune response in the elderly Immunol. Allergy Clin. N. Am. 23 2003 1 13
21. N.J. Philpott, A.J. Turner, J. Scopes, M. Westby, J.C. Marsh, E.C. Gordon-Smith, A.G. Dalgleish, and F.M. Gibson The use of 7-amino actinomycin D in identifying apoptosis: simplicity of use and broad spectrum of application compared with other techniques Blood 87 1996 2244 2251
22. D.N. Posnett, J.W. Edinger, J.S. Manavalan, C. Irwin, and G. Marodon Differentiation of human CD8 T cells: implications for in vivo persistence of CD8+ CD28- cytotoxic effector clones Int. Immunol. 11 1999 229 241
23. M. Potestio, G. Pawelec, G. Di Lorenzo, G. Candore, C. D'Anna, F. Gervasi, D. Lio, G. Tranchida, C. Caruso, and G.C. Romano Age-related changes in the expression of CD95 (APO1/FAS) on blood lymphocytes Exp. Gerontol. 34 1999 659 673
24. M. Saurwein-Teissl, T.L. Lung, F. Marx, C. Gschosser, E. Asch, I. Blasko, W. Parson, G. Bock, D. Schonitzer, E. Trannoy, and B. Grubeck-Loebenstein Lack of antibody production following immunization in old age: association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines J. Immunol. 168 2002 5893 5899
25. H. Sepulveda, A. Cerwenka, T. Morgan, and R.W. Dutton CD28, IL-2-independent costimulatory pathways for CD8 T lymphocyte activation J. Immunol. 163 1999 1133 1142
26. C. Spaulding, W. Guo, and R.B. Effros Resistance to apoptosis in human CD8+ T cells that reach replicative senescence after multiple rounds of antigen-specific proliferation Exp. Gerontol. 34 1999 633 644
27. C.C. Spaulding, R.L. Walford, and R.B. Effros The accumulation of non-replicative, non-functional, senescent T cells with age is avoided in calorically restricted mice by an enhancement of T cell apoptosis Mech. Ageing Dev. 93 1997 25 33
28. H.F. Valenzuela, and R.B. Effros Divergent telomerase and CD28 expression patterns in human CD4 and CD8 T cells following repeated encounters with the same antigenic stimulus Clin. Immunol. 105 2002 117 125
29. A.N. Vallejo, A.R. Nestel, M. Schirmer, C.M. Weyand, and J.J. Goronzy Aging-related deficiency of CD28 expression in CD4+ T cells is associated with the loss of gene-specific nuclear factor binding activity J. Biol. Chem. 273 1998 8119 8129
30. A.N. Vallejo, C.M. Weyand, and J.J. Goronzy Functional disruption of the CD28 gene transcriptional initiator in senescent T cells J. Biol. Chem. 276 2001 2565 2670
31. K.J. Warrington, A.N. Vallejo, C.M. Weyand, and J.J. Goronzy CD28 loss in senescent CD4+ T cells: reversal by interleukin-12 stimulation Blood 101 2003 3543 3549
32. C.M. Weyand, J.C. Brandes, D. Schmidt, J.W. Fulbright, and J.J. Goronzy Functional properties of CD4+ CD28- T cells in the aging immune system Mech. Ageing Dev. 102 1998 131 147
33. A. Wikby, F. Ferguson, R. Forsey, J. Thompson, J. Strindhall, S. Lofgren, B.O. Nilsson, J. Ernerudh, G. Pawelec, and B. Johansson An immune risk phenotype, cognitive impairment, and survival in very late life: impact of allostatic load in Swedish octogenarian and nonagenarian humans J. Gerontol. A. Biol. Sci. Med. Sci. 60 2005 556 565
34. F. Zanni, R. Vescovini, C. Biasini, F. Fagnoni, L. Zanlari, A. Telera, P. Di Pede, G. Passeri, M. Pedrazzoni, M. Passeri, C. Franceschi, and P. Sansoni Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8+ T cells in humans: a contribution to understand the relationship between inflammation and immunosenescence Exp. Gerontol. 38 2003 981 987
35. T. Zhou, C.K. Edwards 3rd, and J.D. Mountz Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic mice J. Exp. Med. 182 1995 129 137
36. G.S. Zubenko, J.S. Stiffler, H.B. Hughes 3rd, M.J. Fatigati, and W.N. Zubenko Genome survey for loci that influence successful aging: sample characterization, method validation, and initial results for the Y chromosome Am. J. Geriatr. Psychiatry 10 2002 619 630