Is cell death and replacement a factor in aging?

Mechanisms of Ageing and Development

Volumn 128, Issue 1, 2007, Pages 13-16

  Warner, Huber R ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Apoptosis; Cell replacement; Premature ageing; Stem cells

Indexed keywords

AGING; APOPTOSIS; ARTICLE; BIOLOGICAL MODEL; CELL COUNT; CELL DEATH; CELL FUNCTION; HUMAN; MOUSE MUTANT; NONHUMAN; PHENOTYPE; PREMATURE AGING; PRIORITY JOURNAL; PROGERIA; STEM CELL; SYNDROME;

AGING; ANIMALS; APOPTOSIS; CELL PROLIFERATION; HUMANS;

EID: 33846086146     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mad.2006.11.004     Document Type: Article

References (28)

1. Agrelo R., Cheng W.H., Setien F., Ropero S., Espada J., Fraga M.E., Herranz M., Paz M.F., Sanchez-Cespedes M., Artiga M.J., Guerrero D., Castells A., von Kobbe C., Bohr V.A., and Esteller M. Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 8822-8827
2. Bartek J., and Lukas J. The stress of finding NEMO. Science 311 (2006) 1110
3. Bridger J.M., and Kill I.R. Aging of Hutchinson-Gilford progeria syndrome fibroblasts is characterized by hyperproliferation and increased apoptosis. Exp. Gerontol. 39 (2004) 717-724
4. Burke B., and Stewart C.L. Life at the edge: The nuclear envelope and human disease. Nat. Rev. Mol. Cell Biol. 3 (2002) 575-585
5. Campisi J. Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes. Exp. Gerontol. 38 (2003) 5-11
6. Chen L., Huang S., Lee L., Davalos A., Schiesti R.H., Campisi J., and Oshima J. WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair. Aging Cell 2 (2003) 191-199
7. Conboy I.M., and Rando T.A. Aging, stem cells and tissue regeneration: lessons from muscle. Cell Cycle 4 (2005) 407-410
8. Davalos A.R., and Campisi J. Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NB1 repair complexes at stalled replication forks. J. Cell Biol. 162 (2003) 1197-1209
9. de Boer J., Andressoo J.O., de Wit J., Huilmans J., Beems R.B., van Steeg H., Weeda G., Van der Horst G.T.J., van Leeuwen W., Themmen A.P.N., Meradji M., and Hoeijmakers J.H.J. Premature ageing in mice deficient in DNA repair and transcription. Science 296 (2002) 1276-1279
10. Dolle M.E.T., Giese H., Hopkins C.L., Martus H.-J., Hausdorff J.M., and Vijg J. Rapid accumulation of genome rearrangements, in liver but not brain of old mice. Nat. Genet. 17 (1997) 431-434
11. Du X., Shen J., Kugan N., Furth E.E., Lombard D.B., Cheung C., Pak S., Luo G., De Pinho R.A., Guarente L., and Johnson F.B. Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes. Mol. Cell Biol. 24 (2004) 8437-8446
12. Dumble M., Gatza C., Tyner S., Venkatachalam S., and Donehower L.A. Insights into aging obtained from p53 mouse models. Ann. N.Y. Acad. Sci. 1019 (2004) 171-177
13. Frock R.L., Kudlow B.A., Evans A.M., Jameson S.A., Hauschka S.D., and Kennedy B.K. Lamin A/C amd emerin are critical for skeletal muscle satellite cell differentiation. Genes Dev. 20 (2006) 486-500
14. Keyes W.M., Wu Y., Vogel H., Guo X., Lowe S.W., and Mills A.A. p63 deficiency activates a program of cellular senescence and leads to accelerated aging. Genes Dev. 19 (2005) 1986-1999
15. Kujoth G.C., Hiona A., Pugh T.D., Someya S., Panzer K., Wohlgemuth S.E., Hofer T., Seo A.Y., Sullivan R., Jobling W.A., Morrow J.D., Van Remmen H., Sedivy J.M., Yamasoba T., Tanokura M., Weindruch R., Leeuwenburgh C., and Prolla T.A. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science 309 (2005) 481-484
16. Martin G.M. Segmental and unimodal progeroid syndromes of man. In: Harrison D.E. (Ed). Genetic Effects on Aging II (1990), Telford Press, Caldwell, NJ 423-520
17. Mounkes L.C., Kozlov S., Hernandez L., Sullivan T., and Stewart C.L. A progeroid syndrome in mice is caused by defects in A-type lamins. Nature 423 (2003) 298-301
18. Nebel A., Schaffitzel E., and Hertweck M. Aging at the interface of stem cell renewal, apoptosis, senescence, and cancer. Sci. Aging. Knowl. Environ. (2006) pe14
19. Nishimura E.K., Granter S.R., and Fischer D.E. Mechanisms of hair graying: incomplete stem cell maintenance in the niche. Science 307 (2005) 720-724
20. Rando T.A. Stem cells, ageing, and the quest for immortality. Nature 441 (2006) 1080-1086
21. Sampaolesi M., Torrente Y., Innocenzi A., Tonlozzi R., Barresi R., Bresolin N., De Angelis M.G.C., Campbell K.P., Bottinelli R., and Cossu G. Cell therapy of ∝-sarcoglycan null mice through arterial delivery of mesoangioblasts. Science 301 (2003) 487-492
22. Scaffidi P., and Misteli T. Lamin A-dependent nuclear defects in human aging. Science 312 (2006) 1059-1063
23. Staba S.L., Escolar M.L., Poe M., Kim Y., Martin P.L., Szabolcs P., Allison-Thacker J., Wood S., Wenger D.A., Rubinstein P., Hopwood J.J., Krivit W., and Kurtzberg J. Cord-blood transplants from unrelated donors in patients with Hurler's syndrome. N. Eng. J. Med. 350 (2004) 1960-1969
24. Trifunovic A., Wredenberg A., Falkenberg M., Spebrink J.N., Rovio A.T., Bruder C.E., Gidlof S., Oldfors A., Wibrom R., Tornell J., Jacobs H.T., and Larsson N.G. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429 (2004) 357-359
25. Tyner S.D., Venkatachalam S., Choi J., Jones S., Ghebranious N., Igelmann H., Lu X., Soron G., Cooper B., Brayton C., Hee Park S., Karsenty G., Bradley A., and Donehower L.A. p53 mutant mice that display early ageing-associated phenotypes. Nature 415 (2002) 45-53
26. Vogel H., Lim D.-S., Karsenty G., Finegold M., and Hasty P. Deletion of ku86 causes early onset of senescence in mice. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 10770-10775
27. Warner H.R. Apoptosis: a two-edged sword in aging. Anti-cancer Res. 19 (1999) 2837-2842
28. Warner H.R., and Sierra F. Models of accelerated ageing can be informative about the mechanism of ageing and/or age-related pathology. Mech. Ageing Dev. 124 (2003) 581-587