What studies on human longevity tell us about the risk for cancer in the oldest old: Data and hypotheses on the genetics and immunology of centenarians

Experimental Gerontology

Volumn 37, Issue 10-11, 2002, Pages 1263-1271

  Bonafè, Massimiliano ^a   Barbi, Cristiana ^a   Storci, Gianluca ^a   Salvioli, Stefano ^a   Capri, Miriam ^a   Olivieri, Fabiola ^b   Valensin, Silvana ^a   Monti, Daniela ^c   Gonos, Efstathios S ^d   De Benedictis, Giovanna ^e   Franceschi, Claudio ^a,b  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b INRCA   (Italy)

^c UNIVERSITY OF FLORENCE   (Italy)

^d INSTITUTE OF BIOLOGY   (Greece)

^e UNIVERSITY OF CALABRIA   (Italy)

Author keywords

Centenarians; Cytochrome P450 oxidase; Glutathione transferase

Indexed keywords

BRCA1 PROTEIN; CYTOCHROME C OXIDASE; GLUTATHIONE TRANSFERASE; PROTEIN P53; STEROID 5ALPHA REDUCTASE; APOLIPOPROTEIN; CHOLESTENONE 5ALPHA REDUCTASE; HIGH DENSITY LIPOPROTEIN; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE;

ADULT; AGED; AGING; CANCER CELL; CANCER GROWTH; CANCER RISK; CLINICAL STUDY; CONFERENCE PAPER; DISEASE PREDISPOSITION; ENVIRONMENT; GENETIC POLYMORPHISM; GERIATRIC DISORDER; GERM LINE; HOSTILITY; HUMAN; HUMAN GENETICS; HYPOTHESIS; IMMUNE SYSTEM; IMMUNOLOGY; LIFESPAN; MEDICAL LITERATURE; PRIORITY JOURNAL; SENESCENCE; APOPTOSIS; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS; LONGEVITY; MIDDLE AGED; NEOPLASM; ONCOGENE RAS; PHYSIOLOGY; REVIEW; RISK FACTOR; TUMOR SUPPRESSOR GENE;

ADULT; AGED; APOLIPOPROTEINS; APOPTOSIS; CHOLESTENONE 5 ALPHA-REDUCTASE; GENE FREQUENCY; GENES, BRCA1; GENES, P53; GENES, RAS; GENETIC PREDISPOSITION TO DISEASE; GLUTATHIONE TRANSFERASE; HUMANS; LIPOPROTEINS, HDL; LONGEVITY; MIDDLE AGED; NADPH-FERRIHEMOPROTEIN REDUCTASE; NEOPLASMS; OXIDOREDUCTASES; POLYMORPHISM, GENETIC; RISK FACTORS;

EID: 0036814404     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(02)00137-7     Document Type: Conference Paper

References (48)

1. Ambrosone C.B., Sweeney C., Coles B.F., Thompson P.A., McClure G.Y., Korourian S., Fares M.Y., Stone A., Kadlubar F.F., Hutchins L.F. Polymorphisms in glutathione S-transferases (GSTM1 and GSTT1) and survival after treatment for breast cancer. Cancer Res. 61:2001;7130-7135.
2. Argentati K., Donnini A., Tucci M.G., Franceschi C., Bartozzi B., Bernardini G., Provinciali M. Numerical and functional alterations of γδT lymphocytes in aged people and centenarians. J. Leukoc. Biol. 72:2002;65-71.
3. Bathum L., Andersen-Ranberg K., Boldsen J., Brosen K., Jeune B. Genotypes for the cytochrome P450 enzymes CYP2D6 and CYP2C19 in human longevity. Role of CYP2D6 and CYP2C19 in longevity. Eur. J. Clin. Pharmacol. 54:1998;427-430.
4. Bettuzzi S., Troiano L., Davalli P., Troppa F., Ingletti M.C., Grasselli E., Monti D., Corti A., Franceschi C. In vivo accumulation of sulphated glycoprotein-2 (SGP-2) mRNA in rat Thymocytes upon dexamethasone-induced cell death. Biochem. Biophys. Res. Commun. 175:1991;810-815.
5. Birgander R., Sjalander A., Rannug A., Alexandrie A.K., Sundberg M.I., Seidegard J., Tornling G., Beckman G., Beckman L. p53 polymorphisms and haplotypes in lung cancer. Carcinogenesis. 16:1995;2233-2236.
6. Bonafè M., Olivieri F., Mari D., Baggio G., Mattace R., Sansoni P., De Benedictis G., De Luca M., Bertolini S., Barbi C., Monti D., Franceschi C. p53 variants predisposing to cancer are present in healthy centenarians. Am. J. Hum. Genet. 64:1999;292-295.
7. Bonafè M., Olivieri F., Mari D., Baggio G., Mattace R., Berardelli M., Sansoni P., De Benedictis G., De Luca M., Marchegiani F., Cavallone L., Cardelli M., Giovagnetti S., Ferrucci L., Amadio L., Lisa R., Tucci M.G., Troiano L., Pini G., Gueresi P., Morellini M., Sorbi S., Passeri G., Barbi C., Valensin S., Monti D., Deiana L., Pes G.M., Carru C., Franceschi C. P53 codon 72 polymorphism and longevity: additional data on centenarians from continental Italy and Sardinia. Am. J. Hum. Genet. 65:1999;1782-1785.
8. Bonafè M., Valensin S., Gianni W., Marigliano V., Franceschi C. The unexpected contribution of immunosenescence to the levelling off of cancer incidence and mortality in the oldest old. Crit. Rev. Oncol. Hematol. 39:2001;227-233.
9. Bonafè M., Barbi C., Olivieri F., Yashin A., Andrew K.F., Vaupel J.W., De Benedictis G., Rose G., Carrieri G., Jazwinski S.M., Franceschi C. An allele of HRAS1 3′VNTR is a frailty allele: implication for an evolutionarily conserved pathway involved in longevity. Gene. 282:2002;121-126.
10. DePinho R.A. The age of cancer. Nature. 408:2000;248-254.
11. Draznin B., Miles P., Kruszynska Y., Olefsky J., Friedman J., Golovchenko I., Stjernholm R., Wall K., Reitman M., Accili D., Cooksey R., McClain D., Goalstone M. Effects of insulin on prenylationas a mechanism of potentially detrimental influence of hyperinsulinemia. Endocrinology. 141:2000;1310-1316.
12. Dumont P., Burton M., Chen Q.M., Gonos E.S., Frippiat C., Mazarati J.B., Eliaers F., Remacle J., Toussaint O. Induction of replicative senescence biomarkers by sublethal successive oxidative stresses in normal human fibroblasts. Free Rad. Biol. Med. 28:2000;361-373.
13. Fagnoni F.F., Vescovini R., Mazzola M., Bologna G., Nigro E., Lavagetto G., Franceschi C., Passeri M., Sansoni P. Expansion of cytotoxic CD8+ CD28- T cells in healthy ageing people, including centenarians. Immunology. 88:1996;501-507.
14. Franceschi C., Monti D., Sansoni P., Cossarizza A. The immunology of exceptional individuals: the lesson of centenarians. Immunol. Today. 1995;12-16.
15. Franceschi C., Motta L., Valensin S., Rapisarda R., Frantone A., Berardelli M., Motta M., Monti D., Bonafè M., Ferrucci L., Deiana L., Pes G.M., Carru C., Desole M.S., Barbi C., Sartoni G., Gemelli C., Lescai F., Olivieri F., Marchigiani F., Cardelli M., Cavallone L., Gueresi P., Cossarizza A., Troiano L., Pini G., Sansoni P., Passeri G., Lisa R., Spazzafumo L., Amadio L., Giunta S., Stecconi R., Morresi R., Viticchi C., Mattace R., De Benedictis G., Baggio G. Do men and women follow different trajectories to reach extreme longevity? Aging. 12:2000;77-84.
16. Franceschi C., Valensin S., Bonafè M., Prolisso P., Yashin A., De Benedictis G. The network and the remodelling theories of aging. Exp. Gerontol. 35:2000;879-896.
17. Gartner U., Holzer M.T. Elevated expression of p21ras is an early event in Alzheimer's disease and precedes neurofibrillary degeneration. Neuroscience. 91:1999;1-5.
18. Gonos E.S., Derventzi A., Kveiborg M., Agiostratidou G., Kassem M., Clark B.F.C., Jat P.S., Rattan S.I.S. Cloning and identification of genes that associate with mammalian replicative senescence. Exp. Cell Res. 240:1998;66-74.
19. Grassilli E., Bettuzzi S., Monti D., Ingletti M.C., Franceschi C., Corti A. Studies on the relationship between cell proliferation and cell death: opposite patterns of SGP-2 and ornithine decarboxilase mRNA accumulation in PHA-stimulated human lymphocytes. Biochem. Biophys. Res. Commun. 180:1991;59-63.
20. Kojima S., Goto Y., Nonogi H., Horie H., Kinoshita M., Iwai N. Role of a p53 polymorphism in luminal narrowing after balloon coronary angioplasty. Atherosclerosis. 151:2000;585-586.
21. Krontiris T.G., Devlin B., Karp D.D., Robert N.J., Risch N. An association between the risk of cancer and mutations in the HRAS1 minisatellite locus. N. Engl. J. Med. 329:1993;517-523.
22. Lander H.M., Ogiste J.S., Teng K.K., Novogrodsky A. p21ras as a common signalling target of reactive free radicals and cellular redox stress. J. Biol. Chem. 270:1995;1195-1198.
23. Li Y.S., Shyy J.Y., Li S., Lee J., Su B., Karin M., Chien S. The Ras-JNK pathway is involved in shear-induced gene expression. Mol. Cell Biol. 16:1996;5947-5954.
24. Margotti K., Sangiuolo F., De Luca A., Froio F., Pearce C.L., Ricci-Barbini V., Micali F., Bonafè M., Franceschi C., Dalla Piccola B., Novelli G., Reichardt J.K. Evidence for an association between the SRD5A2 (type II steroid 5alpha-reductase) locus and prostate cancer in Italian patients. Dis. Markers. 16:2000;147-150.
25. Mariani E., Ravaglia G., Forti P., Meneghetti A., Tarozzi A., Maioli F., Boschi F., Fratelli L., Pizzoferrato A., Piras F., Facchini A. Vitamin D, thyroid hormones and muscle mass influence natural killer (NK) innate immunity in healthy nonagenarians and centenarians. Clin. Exp. Immunol. 116:1999;19-27.
26. Marin M.C., Jost L.A., Brooks M.S., Irwin J., O'Nions J.A., Tidy N., James J.M., McGregor C.A., Harwood I.G., Yulug K.H., Vousden M.J., Alliday B., Gusterson S., Ikawa P.W., Hinds T., Crook W.G., Kaelin Jr. A common polymorphism acts as a intragenic modifier of mutant p53 behaviour. Nat. Genet. 25:2000;47-54.
27. Miyaishi O., Ando F., Matsuzawa K., Kanawa R., Isobe K. Cancer incidence in old age. Mech. Ageing Dev. 117:2000;47-55.
28. Miyaji C., Watanabe H., Toma H., Akisaka M., Tomiyama K., Sato Y., Abo T. Functional alteration of granulocytes, NK cells, and natural killer T cells in centenarians. Hum. Immunol. 61:2000;908-916.
29. Mondello C., Petropoulou C., Monti D., Gonos E.S., Franceschi C., Nuzzo F. Telomere length in fibroblasts and blood cells from healthy centenarians. Exp. Cell Res. 248:1999;234-242.
30. Monti D., Salvioli S., Capri M., Cossarizza A., Malorn W., Straface E., Botti B., Piacentini M., Baggio G., Barbi C., Valensin S., Bonafè M., Franceschi C. Decreased susceptibility to 2-deoxy-D-ribose-induced apoptosis of peripheral blood mononuclear cells from healthy elderly and centenarians. Mech. Ageing Dev. 121:2000;239-250.
31. Muiras M.L., Verasdonck P., Cottet F., Schachter F. Lack of association between human longevity and genetic polymorphisms in drug-metabolising enzymes at the NAT2, GSTM1 and CYP2D6 loci. Hum. Genet. 102:1998;526-532.
32. Nociari M.M., Telford W., Russo C. Postthymic development of CD28-CD8+ T cell subset: age-associated expansion and shift from memory to naive phenotype. J. Immunol. 162:1999;3327-3335.
33. Paganelli R., Scala E., Rosso R., Cossarizza A., Bertollo L., Barbieri D., Fabrizi A., Lusi E.A., Fagiolo U., Franceschi C. A shift to Th0 cytokine production by CD4+ cells in human longevity: studies on two healthy centenarians. Eur. J. Immunol. 26:1996;2030-2034.
34. Pahlavani M.A. T cell signalling: effect of age. Front. Biosci. 3:1998;D1120-D1133.
35. Pawelec G., Barnett Y., Forsey R., Frasca D., Globerson A., McLeod J., Caruso C., Franceschi C., Fulop T., Gupta S., Mariani E., Mocchegiani E., Solana R. T cells and aging. Front. Biosci. 7:2002;D1056-D1183.
36. Petropoulou C., Trougakos I.P., Kolettas E., Toussaint O., Gonos E.S. Clusterin/Apolipoprotein J is a novel biomarker of cellular senescence that does not affect the proliferative capacity of human diploid fibroblasts. FEBS Lett. 509:2001;287-297.
37. Piantanelli L. Cancer and aging: from the kinetics of biological parameters to the kinetics of cancer incidence and mortality. Ann. NY Acad. Sci. 521:1988;99-109.
38. Smith D.W.E. Resistance to causes of death: a study of cancer mortality resistance in the oldest old. Robine J.M., Forette B., Franceschi C., Allard M. Research and Perspectives in Longevity: the Paradoxes of Longevity. 1999;61-71 Springer, Berlin.
39. Stanta G., Campagner L., Cavallieri F., Giarelli L. Cancer of the oldest old. What we have learned from autopsy studies. Clin. Geriatr. Med. 13:1997;55-68.
40. Storey A., Thomas M., Kalita A., Harwood C., Gardiol D., Mantovani F., Breuer J., Leigh I.M., Matlashewski G., Banks L. Role of a p53 polymorphism in the development of human papillomavirus-associated cancer. Nature. 393:1998;229-234.
41. Sjalander A., Birgander R., Athlin L., Stenling R., Rutegard J., Beckman L., Beckman G. P53 germ line haplotypes associated with increased risk for colorectal cancer. Carcinogenesis. 16:1995;1461-1464.
42. Taioli E., Mari D., Franceschi C., Bonafè M., Monti D., Bertolini S., Marinelli D., Garte S. Polymorphisms of drug-metabolising enzymes in healthy nonagenarians and centenarians: difference at GSTT1 locus. Biochem. Biophys. Res. Commun. 280:2001;1389-1392.
43. Thomas M., Kalita A., Labrecque S., Pim D., Banks L., Matlashewski G. Two polymorphic variants of wild-type p53 differ biochemically and biologically. Mol. Cell Biol. 19:1999;1092-1100.
44. Trougakos I.P., Gonos E.S. Clusterin/Apolipoprotein J in human ageing and cancer. Int. J. Biochem. Cell Biol. 34:2002;1430-1448.
45. Trougakos I.P., Poulakou M., Stathatos M., Chalikia A., Melidonis A., Gonos E.S. Serum levels of the senescent biomarker Clusterin/Apolipoprotein J increase significantly in diabetes type II and during development of coronary heart disease or at myocardial infarction. Exp. Gerontol. 37:2002;735.
46. Vijg J., Perls T., Franceschi C., van Orsouw N.J. BRCA1 gene sequence variation in centenarians. Ann. NY Acad. Sci. 928:2001;85-96.
47. Wu X., Zhao H., Amos C.I., Shete S., Makan N., Hong W.K., Kadlubar F.F., Spitz M.R. p53 Genotypes and haplotypes associated with lung cancer susceptibility and ethnicity. J. Natl Cancer. Inst. 94:2002;681-690.
48. Yamamura K., Iketani O., Yamayoshi Y., Arai Y., Abe Y., Inagaki K., Gondo Y., Morita K., Hirose N., Tanigawara Y. Contribution of CYP2D6 to longevity in Japanese centenarians. J. Am. Geriat. Soc. 50:(Suppl S):2002;263.