A stochastic model for CD8+ T cell dynamics in human immunosenescence: Implications for survival and longevity

Journal of Theoretical Biology

Volumn 213, Issue 4, 2001, Pages 587-597

  Luciani, F ^a   Valensin, S ^a   Vescovini, R ^c   Sansoni, P ^c   Fagnoni, F ^d   Franceschi, C ^a,b   Bonafe M ^a   Turchetti, G ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b INRCA   (Italy)

^c UNIVERSITY OF PARMA   (Italy)

^d IRCCS   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CD8 ANTIGEN;

IMMUNE SYSTEM; SENESCENCE;

ANTIGENICITY; ARTICLE; CELL AGING; CELL DEATH; CELL SURVIVAL; EXPOSURE; IMMUNOFLUORESCENCE; LONGEVITY; PRIORITY JOURNAL; SENESCENCE; STOCHASTIC MODEL; STRESS; T LYMPHOCYTE; VALIDATION PROCESS;

EID: 0035930860     PISSN: 00225193     EISSN: None     Source Type: Journal    
DOI: 10.1006/jtbi.2001.2433     Document Type: Article

References (29)

1. + T cell memory, CD45R subsets and the persistence of antigen unifying concept
2. A central role for thymic emigrants in peripheral T cell homeostasis
3. - regulatory T cells
4. CD45 isoforms expression on CD4 + and CD8 + T cells throughout life, from newborns to healthy centenarians: Implications for T cell memory
5. The spe-10 mutant has longer life and increased stress resistance
6. Changes in thymic function with age and during the treatment of HIV infection
7. - T cells in healthy aged people and centenarians
8. Shortage of circulating naive CD8 T cells provides new insights on immunodeficiency in aging
9. The immunology of exceptional individuals: The lesson of centenarians
10. Biomarkers of immunosenescence: The challenge of heterogeneity and the role of antigenic load
11. Human immunosenescence: The prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space
12. The network and the remodelling theories of aging
13. Ageing of lymphocytes and lymphocytes in the aged
14. Phenotypic and functional separation of memory and effector human CD8 + T cells
15. T-cell clonality in immune responses
16. Postthymic development of CD28-CD8 + T cell subset: Age-associated expansion and shift from memory to naive phenotype
17. The invertebrate phagocytic immunocyte: Clues to a common evolution of immune and neuroendocrine systems
18. T cells and aging
19. Differentiation of human CD8 T cells: Implications for in vivo persistence of CD8 + CD28- cytotoxic effector clones
20. Direct evidence for tymic function in adult humans
21. Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians
22. + T cell clones in elderly humans
23. Modulation of CD28 expression: Distinct regulatory pathways during activation and replicative senescence
24. Two parameter logistic and Weibull equation provide better fits to survival data from isogenic population of Caenorhabditis elegans in axenic culture than does the Gompertz model
25. Age-related modifications of the human alphabeta T cell repertoire due to different clonal expansions in the CD4 + and CD8 + subsets
26. Genes, demography and life span: The contribution of demographic data in genetic studies of aging and longevity