CD27+ (memory) B cell decrease and apoptosis-resistant CD27- (naive) B cell increase in aged humans: Implications for age-related peripheral B cell developmental disturbances

International Immunology

Volumn 17, Issue 4, 2005, Pages 383-390

  Chong, Yong ^a   Ikematsu, Hideyuki ^b   Yamaji, Kouzaburo ^a   Nishimura, Mika ^b   Nabeshima, Shigeki ^a   Kashiwagi, Seizaburo ^c   Hayashi, Jun ^a,d  

^a KYUSHU UNIVERSITY HOSPITAL   (Japan)

^b Hara Doi Hospital   (Japan)

^c Japanese Red Cross Kyushu Block Blood Center   (Japan)

^d KYUSHU UNIVERSITY   (Japan)

Author keywords

Aging; Apoptosis; B cells; Memory; Naive

Indexed keywords

CD27 ANTIGEN; CD38 ANTIGEN; FAS ANTIGEN; KI 67 ANTIGEN; LIPOCORTIN 5; PROTEIN BCL 2;

ADULT; AGED; AGING; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL CULTURE; CELL MATURATION; CELL SIZE; CELL SURFACE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; MALE; MEMORY CELL; NORMAL HUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS;

ADP-RIBOSYL CYCLASE; ADULT; AGED; AGED, 80 AND OVER; AGING; ANTIGENS, CD; ANTIGENS, CD27; ANTIGENS, CD38; ANTIGENS, CD95; APOPTOSIS; B-LYMPHOCYTES; CELL DIFFERENTIATION; FEMALE; HUMANS; IMMUNOLOGIC MEMORY; MALE; MEMBRANE GLYCOPROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 17644425982     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/dxh218     Document Type: Article

References (24)

1. Armstrong, G. L., Conn, L. A. and Pinner, R. W. 1999. Trends in infectious disease mortality in the United States during the 20th century. JAMA 281:61.
2. Hernandez, J. A., Land, K. J. and McKenna, R. W. 1995. Leukemias, myeloma, and other lymphoreticular neoplasms. Cancer 75:381.
3. The Non-Hodgkin's Lymphoma Classification Project. 1997. A clinical evaluation of the international lymphoma study group classification of non-Hodgkin's lymphoma. Blood 89:3909.
4. Chong, Y., Ikematsu, H., Yamaji, K., Nishimura, M., Kashiwagi, S. and Hayashi, J. 2003. Age-related accumulation of Ig VH gene somatic mutations in peripheral B cells from aged humans. Clin. Exp. Immunol. 133:59.
5. Kobata, T., Jacquot, S., Kozlowski, S., Agematsu, K., Schlossman, S. F. and Morimoto, C. 1995. CD27-CD70 interactions regulate B-cell activation by T cells. Proc. Natl Acad. Sci. USA 92:11249.
6. Nagumo, H., Agematsu, K., Shinozaki, K. et al. 1998. CD27/CD70 interaction augments IgE secretion by promoting the differentiation of memory B cells into plasma cells. J. Immunol. 161: 6496.
7. + peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (Memory) B cells. J. Exp. Med. 188:1679.
8. Agematsu, K., Hokibara, S., Nagumo, H. and Komiyama, A. 2000. CD27: a memory B-cell marker. Immunol. Today 21:204.
9. Agematsu, K., Nagumo, H., Yang, F. C. et al. 1997. B cell subpopulations separated by CD27 and crucial collaboration of CD27+ B cells and helper T cells in immunoglobulin production. Eur. J. Immunol. 27:2073.
10. Rathmell, J. C., VanTer Heiden, M. G., Harris, M. H., Frauwirth, K. A. and Thompson, C. B. 2000. In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. Mol. Cell 6:683.
11. Vermes, I., Haanen, C., Steffens-Nakken, H. and Reutelingsperger, C. 1995. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J. Immunol. Methods 184:39.
12. Aubry, J. P., Blaecke, A., Lecoanet-Henchoz, S. et al. 1999. Annexin V used for measuring apoptosis in the early events of cellular cytotoxicity. Cytometry 37:197.
13. Klein, U., Goossens, T., Fischer, M. et al. 1998. Somatic hypermutation in normal and transformed human B cells. Immunol. Rev. 162:261.
14. Lund, F. E., Cockayne, D. A., Randall, T. D., Solvason, N., Schuber, F. and Howard, M. C. 1998. CD38: a new paradigm in lymphocyte activation and signal transduction. Immunol. Rev. 161:79.
15. Gerdes, J., Lemke, H., Baisch, H., Wacker, H. H., Schwab, U. and Stein, H. 1984. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J. Immunol. 133:1710.
16. + T lymphocytes in HIV-1 infection as measured by Ki-67 antigen. J. Exp. Med. 187:1295.
17. Bishop, G. A. and Hostager, B. S. 2001. B lymphocyte activation by contact-mediated interactions with T lymphocytes. Curr. Opin. Immunol. 13:278.
18. Opferman, J. T. and Korsmeyer, S. J. 2003. Apoptosis in the development and maintenance of the immune system. Nat. Immunol. 4:410.
19. Bohnhorst, J., Bjørgan, M. B., Thoen, J. E., Natvig, J. B. and Thompson, K. M. 2001. Bm1-Bm5 classification of peripheral blood B cells reveals circulating germinal center founder cells in healthy individuals and disturbance in the B cell subpopulations in patients with primary Sjögren's syndrome. J. Immunol. 167:3610.
20. Deterre, P., Berthelier, V., Bauvois, B., Dalloul, A., Schuber, F. and Lund, F. 2000. CD38 in T- and B-cell functions. Chem. Immunol. 75:146.
21. Sohn, S. J., Rajpal, A. and Winoto, A. 2003. Apoptosis during lymphoid development. Curr. Opin. Immunol. 15:209.
22. - (naive) B cells and their phenotypic alteration in HIV-1 infected patients. AIDS Res. Hum. Retrovir. 20:621.
23. Paganelli, R., Quinti, I., Fagiolo, U. et al. 1992. Changes in circulating B cells and immunoglobulin classes and subclasses in a healthy aged population. Clin. Exp. Immunol. 90:351.
24. de Greef, G. E., van Tol, M. J. D., van den Berg, J. W. K. et al. 1992. Serum immunoglobulin class and IgG subclass levels and the occurrence of homogeneous immunoglobulins during the course of ageing in humans. Mech. Ageing Dev. 66:29.