메뉴 건너뛰기




Volumn 5, Issue 2, 2007, Pages 99-113

Parkinson's disease: Genetics and beyond

Author keywords

Synuclein; Lewy bodies; Mitochondrial dysfunction; Parkin; Parkinson's disease; Pathophysiology; Protein aggregation

Indexed keywords

3 ETHYNYL 5 (1 METHYL 2 PYRROLIDINYL)PYRIDINE; ADENOSINE A2A RECEPTOR ANTAGONIST; ADROGOLIDE; ALPHA SYNUCLEIN; AMANTADINE; AMPA RECEPTOR ANTAGONIST; ANTIPARKINSON AGENT; BENSERAZIDE; CARBIDOPA; CASPASE INHIBITOR; CATECHOL METHYLTRANSFERASE INHIBITOR; CHOLINERGIC RECEPTOR BLOCKING AGENT; DJ 1 PROTEIN; DOPAMINE RECEPTOR STIMULATING AGENT; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE (NADP)(PHOSPHORYLATING); LEUCINE RICH REPEAT KINASE 2; LEVODOPA; MONOAMINE OXIDASE INHIBITOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR STIMULATING AGENT; NEUROTROPHIC FACTOR; PARKIN; PHOSPHOTRANSFERASE; PROTEIN P53 INHIBITOR; PROTEIN PINK1; ROLIGOTINE; SEROTONIN AGONIST; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TOLCAPONE; UBIQUITIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 34347405256     PISSN: 1570159X     EISSN: None     Source Type: Journal    
DOI: 10.2174/157015907780866893     Document Type: Review
Times cited : (29)

References (292)
  • 1
    • 1842434997 scopus 로고    scopus 로고
    • Review of rapid eye movement behavior sleep disorders
    • Abad, V.C., Guilleminault, C. (2004) Review of rapid eye movement behavior sleep disorders. Curr. Neurol. Neurosci. Rep., 4, 157-63.
    • (2004) Curr. Neurol. Neurosci. Rep , vol.4 , pp. 157-163
    • Abad, V.C.1    Guilleminault, C.2
  • 3
    • 0031899713 scopus 로고    scopus 로고
    • Levodopa: Is toxicity a myth?
    • Agid, Y. (1998) Levodopa: is toxicity a myth? Neurology, 50, 858-863.
    • (1998) Neurology , vol.50 , pp. 858-863
    • Agid, Y.1
  • 4
    • 7444237665 scopus 로고    scopus 로고
    • Mutations in the glucocerebrosidase gene and Parkinson's disease in Ashkenazi Jews
    • Aharan-Peretz, J., Rosnbaum, H., Gershani-Baruch, R. (2004) Mutations in the glucocerebrosidase gene and Parkinson's disease in Ashkenazi Jews. N. Eng. J. Med., 351, 1972-1977.
    • (2004) N. Eng. J. Med , vol.351 , pp. 1972-1977
    • Aharan-Peretz, J.1    Rosnbaum, H.2    Gershani-Baruch, R.3
  • 5
    • 18544364794 scopus 로고    scopus 로고
    • α-synuclein interacts with phospholipase D isozymes and inhibits pervandate induced phospholipase D activation in human embroyo in kidney-293 cells
    • Ahn, B.H., Rhim, H., Kim, S.Y., Sung, Y.M., Lee, M.Y., Choi, J.Y. (2002) α-synuclein interacts with phospholipase D isozymes and inhibits pervandate induced phospholipase D activation in human embroyo in kidney-293 cells. J. Biol. Chem., 277, 12334-12342.
    • (2002) J. Biol. Chem , vol.277 , pp. 12334-12342
    • Ahn, B.H.1    Rhim, H.2    Kim, S.Y.3    Sung, Y.M.4    Lee, M.Y.5    Choi, J.Y.6
  • 6
    • 15244344237 scopus 로고    scopus 로고
    • Parkinson's disease risk factors: Genetic, environmental or both?
    • Allam, M.F., Del Castillo, A.S., Navajas, R.F. (2005) Parkinson's disease risk factors: genetic, environmental or both? Neurol. Res., 27, 206-208.
    • (2005) Neurol. Res , vol.27 , pp. 206-208
    • Allam, M.F.1    Del Castillo, A.S.2    Navajas, R.F.3
  • 7
    • 0026589459 scopus 로고
    • Mutant debrisoquine hydroxylation genes in Parkinson's disease
    • Armstrong, M., Daly, A.K., Cholerten, S., Bateman, D.N., Idle, J.R. (1992) Mutant debrisoquine hydroxylation genes in Parkinson's disease. Lancet, 339, 1017-1018.
    • (1992) Lancet , vol.339 , pp. 1017-1018
    • Armstrong, M.1    Daly, A.K.2    Cholerten, S.3    Bateman, D.N.4    Idle, J.R.5
  • 8
    • 9144245594 scopus 로고    scopus 로고
    • Quinone formation as dopaminergic neuron-specific oxidative stress in the pathogenesis of sporadic PD and neurotoxin induced parkinsonism
    • Asanuma, M., Miyazaki, I., Diaz-Corlaes, F.J., Ogawa, N. (2004) Quinone formation as dopaminergic neuron-specific oxidative stress in the pathogenesis of sporadic PD and neurotoxin induced parkinsonism. Acta Med. Okayama, 58, 221-233.
    • (2004) Acta Med. Okayama , vol.58 , pp. 221-233
    • Asanuma, M.1    Miyazaki, I.2    Diaz-Corlaes, F.J.3    Ogawa, N.4
  • 10
    • 0032970989 scopus 로고    scopus 로고
    • A review of central 5-HT receptors and their functions
    • Barnes, N.M., Sharp, T. (1999) A review of central 5-HT receptors and their functions. Neuropharmacology, 38, 10083-11152.
    • (1999) Neuropharmacology , vol.38 , pp. 10083-11152
    • Barnes, N.M.1    Sharp, T.2
  • 12
    • 0031711224 scopus 로고    scopus 로고
    • Excitotoxicity and nitric oxide in Parkinson's disease pathogenesis
    • Beal, M.F. (1998) Excitotoxicity and nitric oxide in Parkinson's disease pathogenesis. Ann. Neurol., 44, S110-S114.
    • (1998) Ann. Neurol , vol.44
    • Beal, M.F.1
  • 14
    • 14344263884 scopus 로고    scopus 로고
    • The role of α-synuclein in neurodegerative diseases
    • Bennett, M.C. (2005) The role of α-synuclein in neurodegerative diseases. Pharmacol. Ther., 105, 311-331.
    • (2005) Pharmacol. Ther , vol.105 , pp. 311-331
    • Bennett, M.C.1
  • 15
    • 0034776216 scopus 로고    scopus 로고
    • Brain iron pathways and their relevance to Parkinson's disease
    • Berg, D., Gerlach, M., Youdin, M.B., Double, K.L. (2001) Brain iron pathways and their relevance to Parkinson's disease. J. Neurochem., 79, 225-236.
    • (2001) J. Neurochem , vol.79 , pp. 225-236
    • Berg, D.1    Gerlach, M.2    Youdin, M.B.3    Double, K.L.4
  • 16
    • 0030857351 scopus 로고    scopus 로고
    • Inhibition of glutamate transport in synaptosomes by dopamine oxidation and reactive oxygen species
    • Berman, S.B., Hastings, T.G. (1997) Inhibition of glutamate transport in synaptosomes by dopamine oxidation and reactive oxygen species. J. Neurochem., 69, 1185-1195.
    • (1997) J. Neurochem , vol.69 , pp. 1185-1195
    • Berman, S.B.1    Hastings, T.G.2
  • 17
    • 11344262265 scopus 로고    scopus 로고
    • Ubiquitin-proteasome system and Parkinson's disease
    • Betarbet, R., Sherer, T.B., Greenamyre, J.T. (2005) Ubiquitin-proteasome system and Parkinson's disease. Expt. Neurol., 191, S17-S27.
    • (2005) Expt. Neurol , vol.191
    • Betarbet, R.1    Sherer, T.B.2    Greenamyre, J.T.3
  • 19
    • 13444256398 scopus 로고    scopus 로고
    • Serotonergic agents and Parkinson's disease
    • Blackburn, T. (2004) Serotonergic agents and Parkinson's disease. Drug Discov. Today, 1, 35-41.
    • (2004) Drug Discov. Today , vol.1 , pp. 35-41
    • Blackburn, T.1
  • 20
    • 0037208549 scopus 로고    scopus 로고
    • Renaissance of amantadine in the treatment of Parkinson's disease
    • Blanchet, P.J., Metman, L.V., Chase, T.N. (2003) Renaissance of amantadine in the treatment of Parkinson's disease. Adv. Neurol., 91, 251-257.
    • (2003) Adv. Neurol , vol.91 , pp. 251-257
    • Blanchet, P.J.1    Metman, L.V.2    Chase, T.N.3
  • 21
    • 0036326074 scopus 로고    scopus 로고
    • Protective action of the peroxisome proliferator activated receptor γ agonist pioglitazone in mouse models of Parkinson's disease
    • Breidert, T., Calebert, J., Heneka, M.T., Landreth, G., Launay, J.M., Hirsch, E.C. (2002) Protective action of the peroxisome proliferator activated receptor γ agonist pioglitazone in mouse models of Parkinson's disease. J. Neurochem., 82, 615-624.
    • (2002) J. Neurochem , vol.82 , pp. 615-624
    • Breidert, T.1    Calebert, J.2    Heneka, M.T.3    Landreth, G.4    Launay, J.M.5    Hirsch, E.C.6
  • 22
    • 0037041420 scopus 로고    scopus 로고
    • Inherent toxicity of aggregates implies a common mechanism of protein misfolding diseases
    • Bucciantini, M., Giannoni, E., Chiti, F., Baroni, F., Formigli, L., Zurolo, J. (2002) Inherent toxicity of aggregates implies a common mechanism of protein misfolding diseases. Nature, 416, 507-511.
    • (2002) Nature , vol.416 , pp. 507-511
    • Bucciantini, M.1    Giannoni, E.2    Chiti, F.3    Baroni, F.4    Formigli, L.5    Zurolo, J.6
  • 23
    • 0346218258 scopus 로고    scopus 로고
    • Levodopa- induced motor complications are associated with alterations of glutamate receptors in Parkinson's disease
    • Calan, F., Rajput, A.H., Homkiewiez, O., Bedard, P.J., Dipalo, T. (2003) Levodopa- induced motor complications are associated with alterations of glutamate receptors in Parkinson's disease. Neurobiol. Disord., 14, 404-416.
    • (2003) Neurobiol. Disord , vol.14 , pp. 404-416
    • Calan, F.1    Rajput, A.H.2    Homkiewiez, O.3    Bedard, P.J.4    Dipalo, T.5
  • 24
    • 34347380147 scopus 로고
    • Criteria for Parkinson's disease
    • Calne, D.B., Snow, B.J., Lee, C. (1992) Criteria for Parkinson's disease. Adv. Neurol., 32, S121-S127.
    • (1992) Adv. Neurol , vol.32
    • Calne, D.B.1    Snow, B.J.2    Lee, C.3
  • 25
    • 2942684871 scopus 로고    scopus 로고
    • The PD protein DJ-1 is neuroprotective due to cystein-sulfinic acid driven mitochondrial localization
    • Canet-Aviles, R.M., Wilson, M.A., Miller, D.W. (2004) The PD protein DJ-1 is neuroprotective due to cystein-sulfinic acid driven mitochondrial localization. Proc. Natl. Acad. Sci. USA, 101, 9103-9108.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 9103-9108
    • Canet-Aviles, R.M.1    Wilson, M.A.2    Miller, D.W.3
  • 26
    • 0032904412 scopus 로고    scopus 로고
    • An evaluation of the role of mitochondrial mutations and oxidative pathology protective nuclear responses and cell death in neurodegeneration
    • Cassarino, D.S., Benneltt Jr, J.P. (1999) An evaluation of the role of mitochondrial mutations and oxidative pathology protective nuclear responses and cell death in neurodegeneration. Brain Res. Rev., 29, 1-25.
    • (1999) Brain Res. Rev , vol.29 , pp. 1-25
    • Cassarino, D.S.1    Benneltt Jr, J.P.2
  • 27
    • 0037039837 scopus 로고    scopus 로고
    • Hydroxnoneal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans
    • Castellani, R.J., Perry, G., Siedlak, S.L., Nunomura, A., Shimohama, S., Zhang, J. (2002) Hydroxnoneal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans. Neurosci. Lett., 319, 25-28.
    • (2002) Neurosci. Lett , vol.319 , pp. 25-28
    • Castellani, R.J.1    Perry, G.2    Siedlak, S.L.3    Nunomura, A.4    Shimohama, S.5    Zhang, J.6
  • 29
    • 4644290985 scopus 로고    scopus 로고
    • α-synuclein locus duplication as a cause of familial Parkinson's disease
    • Chartier-Harlim, M.C. (2004) α-synuclein locus duplication as a cause of familial Parkinson's disease. Lancet, 364, 1167-1169.
    • (2004) Lancet , vol.364 , pp. 1167-1169
    • Chartier-Harlim, M.C.1
  • 30
    • 0031954732 scopus 로고    scopus 로고
    • Levodopa therapy: Consequences of nonphysiologic replacement of dopamine
    • Chase, T.N. (1998) Levodopa therapy: consequences of nonphysiologic replacement of dopamine. Neurology, 50, S17-S25.
    • (1998) Neurology , vol.50
    • Chase, T.N.1
  • 32
    • 34347401861 scopus 로고    scopus 로고
    • Anxiety, depression and psychosis in Parkinson's disease. Unmet needs and treatment challenges
    • Chen, J.J. (2004) Anxiety, depression and psychosis in Parkinson's disease. Unmet needs and treatment challenges. Neurol. Clin., 41, 15-23.
    • (2004) Neurol. Clin , vol.41 , pp. 15-23
    • Chen, J.J.1
  • 33
    • 13844255766 scopus 로고    scopus 로고
    • Gene therapy for Parkinson's disease: Progress and challenges
    • Chen, Q., He, Y., Keyi, Y. (2005) Gene therapy for Parkinson's disease: progress and challenges. Curr. Gene Ther., 5, 71-80.
    • (2005) Curr. Gene Ther , vol.5 , pp. 71-80
    • Chen, Q.1    He, Y.2    Keyi, Y.3
  • 35
    • 0034776095 scopus 로고    scopus 로고
    • Parkin ubiquitinates the α-synuclein interacting protein, synphilin-1: Implications for Lewy body formation in Parkinson's disease
    • Chung, K.K., Zhang, Y., Lim, K.L., Tanaka, Y., Huang, H., Gao, J., Ross, C.A., Dawson, T.M. (2001) Parkin ubiquitinates the α-synuclein interacting protein, synphilin-1: implications for Lewy body formation in Parkinson's disease. Nat. Med., 10, 1144-1150.
    • (2001) Nat. Med , vol.10 , pp. 1144-1150
    • Chung, K.K.1    Zhang, Y.2    Lim, K.L.3    Tanaka, Y.4    Huang, H.5    Gao, J.6    Ross, C.A.7    Dawson, T.M.8
  • 36
    • 0000061042 scopus 로고    scopus 로고
    • Ropinirole is a D3-selective agonist at cloned human D2 analog D3 and D4 receptors in functional studies using microphysiometry
    • abstract
    • Coldwell, M.C., Haga, J., Middlemiss, D., Telloch, I., Boyfield, I. (1997) Ropinirole is a D3-selective agonist at cloned human D2 analog D3 and D4 receptors in functional studies using microphysiometry. Br. J. Pharmacol., 119, S346 (abstract).
    • (1997) Br. J. Pharmacol , vol.119
    • Coldwell, M.C.1    Haga, J.2    Middlemiss, D.3    Telloch, I.4    Boyfield, I.5
  • 37
    • 0035834360 scopus 로고    scopus 로고
    • Kinetic stabilization of α-synuclein protofibril by a dopamine-α-synuclein adduct
    • Conway, K., Rochet, J.C., Bieganski, R.M., Lanbury, P.T.J. (2001) Kinetic stabilization of α-synuclein protofibril by a dopamine-α-synuclein adduct. Science, 294, 1346-1349.
    • (2001) Science , vol.294 , pp. 1346-1349
    • Conway, K.1    Rochet, J.C.2    Bieganski, R.M.3    Lanbury, P.T.J.4
  • 38
    • 0025348894 scopus 로고
    • A hypothesis on the pathophysiological mechanisms that underlie levodopa or dopamine agonist-induced dyskinesia in Parkinson's disease: Implications for the future strategies in treatment
    • Crossman, A.R. (1990) A hypothesis on the pathophysiological mechanisms that underlie levodopa or dopamine agonist-induced dyskinesia in Parkinson's disease: implications for the future strategies in treatment. Mov. Disord., 5, 100-108.
    • (1990) Mov. Disord , vol.5 , pp. 100-108
    • Crossman, A.R.1
  • 39
    • 4344659685 scopus 로고    scopus 로고
    • Impaired degradation of mutant α-synuclein by chaperone-mediated autophagy
    • Cuervo, A.M., Stefani, L., Fredenburg, R., Lansburry, P.T., Sulzer, D. (2004) Impaired degradation of mutant α-synuclein by chaperone-mediated autophagy. Science, 305, 1292-95.
    • (2004) Science , vol.305 , pp. 1292-1295
    • Cuervo, A.M.1    Stefani, L.2    Fredenburg, R.3    Lansburry, P.T.4    Sulzer, D.5
  • 40
    • 0035255227 scopus 로고    scopus 로고
    • Adenosine as a neuromodulator and as a homeostatic regulator in the nervous system: Different roles, different sources and different receptors
    • Cunha, P.A. (2001) Adenosine as a neuromodulator and as a homeostatic regulator in the nervous system: different roles, different sources and different receptors. Neurochem. Int., 38, 107-125.
    • (2001) Neurochem. Int , vol.38 , pp. 107-125
    • Cunha, P.A.1
  • 42
    • 0037240325 scopus 로고    scopus 로고
    • Rare genetics mutations shed light on the pathogenesis of Parkinson's disease
    • Dawson, T.M., Dawson, V.L. (2003) Rare genetics mutations shed light on the pathogenesis of Parkinson's disease. J. Clin. Invest., 111, 145-151.
    • (2003) J. Clin. Invest , vol.111 , pp. 145-151
    • Dawson, T.M.1    Dawson, V.L.2
  • 43
    • 0031795484 scopus 로고    scopus 로고
    • Nitric oxide in neurodegeneration
    • Dawson, V.L., Dawson, T.M. (1998) Nitric oxide in neurodegeneration. Prog. Brain Res., 118, 215-29.
    • (1998) Prog. Brain Res , vol.118 , pp. 215-229
    • Dawson, V.L.1    Dawson, T.M.2
  • 44
    • 85037785158 scopus 로고    scopus 로고
    • Prevalence of Parkinson's disease in Europe: A collaborative study of population based cohorts
    • de Rijk, M.C., Launer, L.J., Berger, K. (2000). Prevalence of Parkinson's disease in Europe: a collaborative study of population based cohorts. Neurology, 55, 1358-63.
    • (2000) Neurology , vol.55 , pp. 1358-1363
    • de Rijk, M.C.1    Launer, L.J.2    Berger, K.3
  • 46
    • 0037728958 scopus 로고    scopus 로고
    • Proteasome inhibitors induce intracellular protein aggregation and cell death by an oxygen dependant mechanism
    • Demasi, M., Davies, K.J. (2003) Proteasome inhibitors induce intracellular protein aggregation and cell death by an oxygen dependant mechanism. FEBS Lett., 542, 89-94.
    • (2003) FEBS Lett , vol.542 , pp. 89-94
    • Demasi, M.1    Davies, K.J.2
  • 47
    • 0036283426 scopus 로고    scopus 로고
    • Modeling RD in rats: An evolution of 6- OH DA lesions of the nigrostriatal pathway
    • Deumens, R., Blokland, A., Prickaerts, J. (2002) Modeling RD in rats: an evolution of 6- OH DA lesions of the nigrostriatal pathway. Exp. Neurol., 175, 303-317.
    • (2002) Exp. Neurol , vol.175 , pp. 303-317
    • Deumens, R.1    Blokland, A.2    Prickaerts, J.3
  • 48
    • 0038460184 scopus 로고    scopus 로고
    • Dev, K.K., Hofele, K., Barbieri, S., Buchman, V.L., van der Putten, H. Part II (2003) α- synuclein and its molecular pathophysiological role in neurodegenerative disease. Neuropharmacology, 45, 14-44.
    • Dev, K.K., Hofele, K., Barbieri, S., Buchman, V.L., van der Putten, H. Part II (2003) α- synuclein and its molecular pathophysiological role in neurodegenerative disease. Neuropharmacology, 45, 14-44.
  • 50
    • 14244259493 scopus 로고    scopus 로고
    • Autonomic dysfunction in Parkinson's disease
    • Dewy Jr, R.B. (2004) Autonomic dysfunction in Parkinson's disease. Neurol. Clin., 22, S127-S139.
    • (2004) Neurol. Clin , vol.22
    • Dewy Jr, R.B.1
  • 51
    • 19944431081 scopus 로고    scopus 로고
    • A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease
    • Di Fonzo, A., Rohe, C.F., Ferreira, J. (2005) A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease. Lancet, 365, 412-415.
    • (2005) Lancet , vol.365 , pp. 412-415
    • Di Fonzo, A.1    Rohe, C.F.2    Ferreira, J.3
  • 52
    • 3042755065 scopus 로고    scopus 로고
    • Deleterous effects of minocycline in animal models of Parkinson's disease and Huntington's disease
    • Diguet, E., Fernagut, P.O., Wei, X., Du Rouland, R., Gross, C., Bezard, E., Tison, F. (2004) Deleterous effects of minocycline in animal models of Parkinson's disease and Huntington's disease. Eur. J. Neurosci., 19, 3266-3276.
    • (2004) Eur. J. Neurosci , vol.19 , pp. 3266-3276
    • Diguet, E.1    Fernagut, P.O.2    Wei, X.3    Du Rouland, R.4    Gross, C.5    Bezard, E.6    Tison, F.7
  • 53
    • 0037072284 scopus 로고    scopus 로고
    • Annular α-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain derived membranes
    • Ding, T.T., Lee, S.J., Rochet, J.C., Lansbury, P.T.J. (2002) Annular α-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain derived membranes. Biochemistry, 41, 10209-10217.
    • (2002) Biochemistry , vol.41 , pp. 10209-10217
    • Ding, T.T.1    Lee, S.J.2    Rochet, J.C.3    Lansbury, P.T.J.4
  • 54
    • 0030006032 scopus 로고    scopus 로고
    • Levodopa fluctuations in Parkinson's disease
    • Djaldetti, R., Melamed, E. (1996) Levodopa fluctuations in Parkinson's disease. Ann. Neurol., 390, 400-404.
    • (1996) Ann. Neurol , vol.390 , pp. 400-404
    • Djaldetti, R.1    Melamed, E.2
  • 55
    • 0024471542 scopus 로고
    • 2b receptor involvement in the hypermobility effects of adenosine analogues in mice
    • 2b receptor involvement in the hypermobility effects of adenosine analogues in mice. Eur. J. Pharmacol., 168, 285-290.
    • (1989) Eur. J. Pharmacol , vol.168 , pp. 285-290
    • Druncan, M.J.1    Morgan, P.F.2
  • 56
    • 0036829557 scopus 로고    scopus 로고
    • p53 inhibitors preserve dopamine neurons and motor function in experimental Parkinsonism
    • Duan, W., Zhi, X., Landenheim, B., Yu, Q.S., Guo, Z., Oyler, J. (2002) p53 inhibitors preserve dopamine neurons and motor function in experimental Parkinsonism. Ann. Neurol., 52, 597-606.
    • (2002) Ann. Neurol , vol.52 , pp. 597-606
    • Duan, W.1    Zhi, X.2    Landenheim, B.3    Yu, Q.S.4    Guo, Z.5    Oyler, J.6
  • 57
    • 0031060220 scopus 로고    scopus 로고
    • Cognitive deficit in Parkinson's disease
    • Dubois, B., Pillon, B. (1997) Cognitive deficit in Parkinson's disease. J. Neurol., 244, 2-8.
    • (1997) J. Neurol , vol.244 , pp. 2-8
    • Dubois, B.1    Pillon, B.2
  • 58
    • 0033678217 scopus 로고    scopus 로고
    • Widespread nitration pathological inclusions in neurodegenerative synucleinopathies
    • Duda, J.E., Giasson, B.I., Chen, Q., Gur, T.L., Hartig, H.I., Stern, M.B. (2000) Widespread nitration pathological inclusions in neurodegenerative synucleinopathies. Am. J. Pathol., 157, 1439-45.
    • (2000) Am. J. Pathol , vol.157 , pp. 1439-1445
    • Duda, J.E.1    Giasson, B.I.2    Chen, Q.3    Gur, T.L.4    Hartig, H.I.5    Stern, M.B.6
  • 59
    • 0035839562 scopus 로고    scopus 로고
    • Subthalamic GAD gene transfer in Parkinson's disease patients who are candidates for deep brain stimulation
    • During, M.J., Kaplitt, M.G., Stern, M.P., Eidelberg, D. (2001) Subthalamic GAD gene transfer in Parkinson's disease patients who are candidates for deep brain stimulation. Hum. Gene Ther., 12, 1589-1591.
    • (2001) Hum. Gene Ther , vol.12 , pp. 1589-1591
    • During, M.J.1    Kaplitt, M.G.2    Stern, M.P.3    Eidelberg, D.4
  • 60
    • 9444229299 scopus 로고    scopus 로고
    • A strategy for designing inhibitors of αSN aggregation and toxicity as a novel treatment for PD and related disorders
    • El-Agnaf, O.M., Paleologou, K.E., Greer, B., Abogrein, A.M., King, J.E., Salem, S.A., Fullwood, N.J. (2004) A strategy for designing inhibitors of αSN aggregation and toxicity as a novel treatment for PD and related disorders. FASEB J., 18, 1315-1317.
    • (2004) FASEB J , vol.18 , pp. 1315-1317
    • El-Agnaf, O.M.1    Paleologou, K.E.2    Greer, B.3    Abogrein, A.M.4    King, J.E.5    Salem, S.A.6    Fullwood, N.J.7
  • 61
    • 0036670712 scopus 로고    scopus 로고
    • Aggregation and neurotoxicity of α-synuclein and related peptides
    • El-Agnaf, O.M., Irvine, G.B. (2002) Aggregation and neurotoxicity of α-synuclein and related peptides. Biochem. Soc. Trans., 30, 559-565.
    • (2002) Biochem. Soc. Trans , vol.30 , pp. 559-565
    • El-Agnaf, O.M.1    Irvine, G.B.2
  • 62
    • 0033782260 scopus 로고    scopus 로고
    • Caspase pathways, neuronal apoptosis and CNS injury
    • Eldadah, B.A., Faden, A.T. (2000) Caspase pathways, neuronal apoptosis and CNS injury. J. Neurotrauma, 17, 811-829.
    • (2000) J. Neurotrauma , vol.17 , pp. 811-829
    • Eldadah, B.A.1    Faden, A.T.2
  • 63
    • 0035815115 scopus 로고    scopus 로고
    • Conformational properties of α- synuclein in its free and lipid-associated states
    • Eliezer, D., Kutluay, E., Bussell, R., Brown, G. (2001) Conformational properties of α- synuclein in its free and lipid-associated states. J. Mol. Biol., 307, 1061-1073.
    • (2001) J. Mol. Biol , vol.307 , pp. 1061-1073
    • Eliezer, D.1    Kutluay, E.2    Bussell, R.3    Brown, G.4
  • 64
    • 1642483509 scopus 로고    scopus 로고
    • Neurodegenerative diseases and oxidative stress
    • Emerit, J., Edeas, M., Bricaire, F. (2004) Neurodegenerative diseases and oxidative stress. Biomed. Pharmacother., 58, 39-46.
    • (2004) Biomed. Pharmacother , vol.58 , pp. 39-46
    • Emerit, J.1    Edeas, M.2    Bricaire, F.3
  • 65
    • 0032829657 scopus 로고    scopus 로고
    • Dopamine receptors-physiological understanding to therapeutic intervention potential
    • Emilien, G., Maloteaux, J., Geurts, M., Hoogenberg, K., Cragg, S. (1999) Dopamine receptors-physiological understanding to therapeutic intervention potential. Pharmacol. Ther., 84, 133-156.
    • (1999) Pharmacol. Ther , vol.84 , pp. 133-156
    • Emilien, G.1    Maloteaux, J.2    Geurts, M.3    Hoogenberg, K.4    Cragg, S.5
  • 66
    • 0042970162 scopus 로고    scopus 로고
    • Dementia associated with Parkinson's disease
    • Emre, M. (2003) Dementia associated with Parkinson's disease. Lancet Neurol., 2, 229-37.
    • (2003) Lancet Neurol , vol.2 , pp. 229-237
    • Emre, M.1
  • 67
    • 0029775677 scopus 로고    scopus 로고
    • Is levodopa toxic?
    • Fahn, S. (1996) Is levodopa toxic? Neurology, 47, S184-S195.
    • (1996) Neurology , vol.47
    • Fahn, S.1
  • 68
    • 0031969137 scopus 로고    scopus 로고
    • Welcome news about levodopa, but uncertainty remains
    • Fahn, S. (1998) Welcome news about levodopa, but uncertainty remains. Ann. Neurol., 43, 551-554.
    • (1998) Ann. Neurol , vol.43 , pp. 551-554
    • Fahn, S.1
  • 69
    • 0026636491 scopus 로고
    • A pilot trial of high dose alpha-tocopherol and ascorbate in early Parkinson's disease
    • Fahn, S.A. (1992) A pilot trial of high dose alpha-tocopherol and ascorbate in early Parkinson's disease. Ann. Neurol., 32, S128-S132.
    • (1992) Ann. Neurol , vol.32
    • Fahn, S.A.1
  • 71
    • 0034848395 scopus 로고    scopus 로고
    • Lewy bodies and Parkinsonism in families with Parkin mutations
    • Farrer, M., Chan, P., Chen, R., Tan, L., Lincoln, S., Hernandez, D. (2001) Lewy bodies and Parkinsonism in families with Parkin mutations. Ann. Neurol., 50, 293-300.
    • (2001) Ann. Neurol , vol.50 , pp. 293-300
    • Farrer, M.1    Chan, P.2    Chen, R.3    Tan, L.4    Lincoln, S.5    Hernandez, D.6
  • 72
    • 0037031609 scopus 로고    scopus 로고
    • Cyclooxygenase-2 deficient mice are resistant to 1-methyl-4- phenyl-1,2,3,6 tetrahydropyridine induced damage of dopaminergic neurons in the substantia nigra
    • Feng, Z.H., Wang, T.G., Li, D.D., Fung, P., Wilson, B.C., Liu, B., Ali, S.F., Langenbach, R., Hong, J.S. (2002) Cyclooxygenase-2 deficient mice are resistant to 1-methyl-4- phenyl-1,2,3,6 tetrahydropyridine induced damage of dopaminergic neurons in the substantia nigra. Neurosci. Lett., 329, 354-358.
    • (2002) Neurosci. Lett , vol.329 , pp. 354-358
    • Feng, Z.H.1    Wang, T.G.2    Li, D.D.3    Fung, P.4    Wilson, B.C.5    Liu, B.6    Ali, S.F.7    Langenbach, R.8    Hong, J.S.9
  • 73
    • 0025768754 scopus 로고    scopus 로고
    • Stimulation of high affinity adenosine A2 receptors decrease the affinity of dopamine D2 receptors in rat striatal membranes
    • Ferre, S., Von Euler, G., Johansson, B., Fredholm, B.B., Fuxe, K. Stimulation of high affinity adenosine A2 receptors decrease the affinity of dopamine D2 receptors in rat striatal membranes. Proc. Natl. Acad. Sci. USA, 88, 7238-7241.
    • Proc. Natl. Acad. Sci. USA , vol.88 , pp. 7238-7241
    • Ferre, S.1    Von Euler, G.2    Johansson, B.3    Fredholm, B.B.4    Fuxe, K.5
  • 74
    • 0029981526 scopus 로고    scopus 로고
    • Neuropathology of Parkinson's disease
    • Forono, L.S. (1996) Neuropathology of Parkinson's disease. J. Neuropathol. Expt. Neurol., 55, 259-272.
    • (1996) J. Neuropathol. Expt. Neurol , vol.55 , pp. 259-272
    • Forono, L.S.1
  • 79
    • 0032731974 scopus 로고    scopus 로고
    • Dopa-responsive dystonia: Recent advances and remaining issues to be addressed
    • Furukawa, Y., Kish, S.J. (1999) Dopa-responsive dystonia: recent advances and remaining issues to be addressed. Mov. Disord., 14, 709-15.
    • (1999) Mov. Disord , vol.14 , pp. 709-715
    • Furukawa, Y.1    Kish, S.J.2
  • 80
    • 0032937059 scopus 로고    scopus 로고
    • Diagnostic criteria for Parkinson's disease
    • Gelb, D.J., Oliver, E., Gilman, S. (1999) Diagnostic criteria for Parkinson's disease. Arch. Neurol., 56, 33-39.
    • (1999) Arch. Neurol , vol.56 , pp. 33-39
    • Gelb, D.J.1    Oliver, E.2    Gilman, S.3
  • 81
    • 0036150971 scopus 로고    scopus 로고
    • The synucleins
    • George, J.M. (2002) The synucleins. Genome Biol., 3, 3002-3006.
    • (2002) Genome Biol , vol.3 , pp. 3002-3006
    • George, J.M.1
  • 82
    • 0035951869 scopus 로고    scopus 로고
    • A hydrophobic stretch of 12 amino acid residues in the middle of α-synuclein is essential for filament stability
    • Giasson, B.I., Muray, J.V.J., Trojanowski, J.Q., Lee, V.M. (2001) A hydrophobic stretch of 12 amino acid residues in the middle of α-synuclein is essential for filament stability. J. Biol. Chem., 276, 2380-2386.
    • (2001) J. Biol. Chem , vol.276 , pp. 2380-2386
    • Giasson, B.I.1    Muray, J.V.J.2    Trojanowski, J.Q.3    Lee, V.M.4
  • 84
    • 0038249170 scopus 로고    scopus 로고
    • Direct brain infusion of GDNF in Parkinson's disease
    • Gill, S.S., Patel, N.K., Hotton, G.R., O'Sullivan, K. (2003) Direct brain infusion of GDNF in Parkinson's disease. Nat. Med., 9, 589-595.
    • (2003) Nat. Med , vol.9 , pp. 589-595
    • Gill, S.S.1    Patel, N.K.2    Hotton, G.R.3    O'Sullivan, K.4
  • 85
    • 0025973526 scopus 로고
    • Young onset Parkinson's disease: A clinical review
    • Globe, L.I. (1991) Young onset Parkinson's disease: a clinical review. Neurology, 41, 168-73.
    • (1991) Neurology , vol.41 , pp. 168-173
    • Globe, L.I.1
  • 87
    • 0346727127 scopus 로고    scopus 로고
    • Protein degradation and protection against misfolded or damaged proteins
    • Goldberg, A.L. (2003) Protein degradation and protection against misfolded or damaged proteins. Nature, 426, 895-9.
    • (2003) Nature , vol.426 , pp. 895-899
    • Goldberg, A.L.1
  • 88
    • 0033037034 scopus 로고
    • Occupational exposure to manganese, copper, lead, iron, mercury and zinc and risk of Parkinson's disease
    • Gorell, J.M., Jhonson, C.C., Rybicki, B.A. (1990) Occupational exposure to manganese, copper, lead, iron, mercury and zinc and risk of Parkinson's disease. Neurotoxicology, 20, 239-48.
    • (1990) Neurotoxicology , vol.20 , pp. 239-248
    • Gorell, J.M.1    Jhonson, C.C.2    Rybicki, B.A.3
  • 89
    • 0031843721 scopus 로고    scopus 로고
    • The risk of Parkinson's disease with exposure to pesticides, farming, well water and rural living
    • Gorell, J.M., Johnson, C.C., Rybicki, B.A., Peterson, E.L., Richardson, R.J. (1998) The risk of Parkinson's disease with exposure to pesticides, farming, well water and rural living. Neurology, 50, 1346-50.
    • (1998) Neurology , vol.50 , pp. 1346-1350
    • Gorell, J.M.1    Johnson, C.C.2    Rybicki, B.A.3    Peterson, E.L.4    Richardson, R.J.5
  • 91
    • 0037073748 scopus 로고    scopus 로고
    • Golgi fragmentation occurs in the cells with protofibrillar α-synuclein aggregates and proceeds the formation of fibrillar inclusion
    • Gosavi, N., Lee, H.J., Lee, J.S., Patel, S., Lee, S.J. (2002) Golgi fragmentation occurs in the cells with protofibrillar α-synuclein aggregates and proceeds the formation of fibrillar inclusion. J. Biol. Chem., 277, 48984-92.
    • (2002) J. Biol. Chem , vol.277 , pp. 48984-48992
    • Gosavi, N.1    Lee, H.J.2    Lee, J.S.3    Patel, S.4    Lee, S.J.5
  • 92
    • 0029992108 scopus 로고    scopus 로고
    • Bioenergetics and glutamate excitotoxicity
    • Green, J.G., Greenamyre, J.T. (1996) Bioenergetics and glutamate excitotoxicity. Prog. Neurobiol., 48, 613-34.
    • (1996) Prog. Neurobiol , vol.48 , pp. 613-634
    • Green, J.G.1    Greenamyre, J.T.2
  • 93
    • 0042160300 scopus 로고    scopus 로고
    • The rotenone model of Parkinson's disease: Genes environment and mitochondria
    • Greenamyre, J.T., Betarbet, R., Sherer, T.B. (2003) The rotenone model of Parkinson's disease: genes environment and mitochondria. Parkinsonism Relat. Disord., 9(Suppl. 2), 59-64.
    • (2003) Parkinsonism Relat. Disord , vol.9 , Issue.SUPPL. 2 , pp. 59-64
    • Greenamyre, J.T.1    Betarbet, R.2    Sherer, T.B.3
  • 94
    • 4344677922 scopus 로고    scopus 로고
    • Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid and aggreosomes during oxidative stress, aging and disease
    • Grune, T., Jung, T., Merker, K., Davies, K.J. (2004) Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid and aggreosomes during oxidative stress, aging and disease. Int. J. Biochem. Cell Biol., 36, 2579-2630.
    • (2004) Int. J. Biochem. Cell Biol , vol.36 , pp. 2579-2630
    • Grune, T.1    Jung, T.2    Merker, K.3    Davies, K.J.4
  • 95
    • 0035799569 scopus 로고    scopus 로고
    • BDNF controls D3 receptor expression and triggers behavioral sensitization
    • Guillin, O., Diaz, J., Carrol, P., Griffen, N. (2001) BDNF controls D3 receptor expression and triggers behavioral sensitization. Nature, 411, 86-89.
    • (2001) Nature , vol.411 , pp. 86-89
    • Guillin, O.1    Diaz, J.2    Carrol, P.3    Griffen, N.4
  • 97
    • 18144406539 scopus 로고    scopus 로고
    • Oxidative stress and inflammation in Parkinson's disease: Is there a causal link?
    • Hald, A., Lotharius, J. (2005) Oxidative stress and inflammation in Parkinson's disease: is there a causal link? Exp. Neurol., 193, 279-290.
    • (2005) Exp. Neurol , vol.193 , pp. 279-290
    • Hald, A.1    Lotharius, J.2
  • 98
    • 2542431131 scopus 로고    scopus 로고
    • Rationale for the use of NMDA receptor antagonists in Parkinson's disease
    • Hallelt, P., Standaert, D.G. (2004) Rationale for the use of NMDA receptor antagonists in Parkinson's disease. Pharmacol. Ther., 102, 155-174.
    • (2004) Pharmacol. Ther , vol.102 , pp. 155-174
    • Hallelt, P.1    Standaert, D.G.2
  • 100
    • 0038472472 scopus 로고    scopus 로고
    • α-synuclein upregulates expression of caveolin-1 and down regulates extracellular signal regulated kinase activity in B1O3 neuroblastoma cells: Role in the pathogenesis of PD
    • Hashimoto, M., Takenouchi, T., Rockenstein, E., Masliah, E. (2003) α-synuclein upregulates expression of caveolin-1 and down regulates extracellular signal regulated kinase activity in B1O3 neuroblastoma cells: role in the pathogenesis of PD. J. Neurochem., 85, 1468-1479.
    • (2003) J. Neurochem , vol.85 , pp. 1468-1479
    • Hashimoto, M.1    Takenouchi, T.2    Rockenstein, E.3    Masliah, E.4
  • 102
    • 0043126954 scopus 로고    scopus 로고
    • Istradefylline US001 study group. Randomized trial of adenosine A2A receptor antagonist istradefylline in advanced Parkinson's disease
    • Hauser, R.A., Hubble, J.P. (2003) Istradefylline US001 study group. Randomized trial of adenosine A2A receptor antagonist istradefylline in advanced Parkinson's disease. Neurology, 61, 297-303.
    • (2003) Neurology , vol.61 , pp. 297-303
    • Hauser, R.A.1    Hubble, J.P.2
  • 105
    • 0026668827 scopus 로고
    • Preliminary examination of comorbidity of anxiety and depression in Parkinson's disease
    • Henderson, R., Kurlan, R., Kersyn, J.M., Como, P. (1992) Preliminary examination of comorbidity of anxiety and depression in Parkinson's disease. J. Neuropsychiatry Clin. Neurosci., 4, 257-64.
    • (1992) J. Neuropsychiatry Clin. Neurosci , vol.4 , pp. 257-264
    • Henderson, R.1    Kurlan, R.2    Kersyn, J.M.3    Como, P.4
  • 106
    • 1042265288 scopus 로고    scopus 로고
    • Neurorestoration in Parkinson's disease by cell replacement and endogenous regeneratioin
    • Hermann, A., Gerlach, M., Scharz, J., Starch, A. (2004) Neurorestoration in Parkinson's disease by cell replacement and endogenous regeneratioin. Exp. Opin. Biol. Ther., 4, 131-143.
    • (2004) Exp. Opin. Biol. Ther , vol.4 , pp. 131-143
    • Hermann, A.1    Gerlach, M.2    Scharz, J.3    Starch, A.4
  • 109
    • 0001833325 scopus 로고
    • Expression of calbindin D 28K-like immunoreactivity in catecholaminergic cell groups of human midbrain normal distribution in Parkinson's disease
    • Hirsch, E.C., Mouatt, A., Thomassa, M. (1992) Expression of calbindin D 28K-like immunoreactivity in catecholaminergic cell groups of human midbrain normal distribution in Parkinson's disease. Neurodegeneration, 1, 83-93.
    • (1992) Neurodegeneration , vol.1 , pp. 83-93
    • Hirsch, E.C.1    Mouatt, A.2    Thomassa, M.3
  • 110
    • 0031947244 scopus 로고    scopus 로고
    • Iron metabolism and Parkinson's disease
    • Hirsch, E.C., Faucheux, B.A. (1998) Iron metabolism and Parkinson's disease. Mov. Disord., 13, 39-45.
    • (1998) Mov. Disord , vol.13 , pp. 39-45
    • Hirsch, E.C.1    Faucheux, B.A.2
  • 111
    • 0014082977 scopus 로고
    • Parkinson's disease: Onset, progression and mortality
    • Hoehn, M.M., Yahr, M.D. (1967) Parkinson's disease: onset, progression and mortality. Neurology, 17, 427-42.
    • (1967) Neurology , vol.17 , pp. 427-442
    • Hoehn, M.M.1    Yahr, M.D.2
  • 112
    • 5644284321 scopus 로고    scopus 로고
    • Polymorphism of α-synuclein promoter: Expression analysis and association studies in Parkinson's disease
    • Holzmann, C., Kruger, R., Saecker, A.M., Schmitt, E., Schols, L., Berger, K., Reiss, O. (2003) Polymorphism of α-synuclein promoter: expression analysis and association studies in Parkinson's disease. J. Neurol. Trans., 110, 67-76.
    • (2003) J. Neurol. Trans , vol.110 , pp. 67-76
    • Holzmann, C.1    Kruger, R.2    Saecker, A.M.3    Schmitt, E.4    Schols, L.5    Berger, K.6    Reiss, O.7
  • 113
    • 0037019859 scopus 로고    scopus 로고
    • The role of cyclooxygenase 1 and 2 activity in prostaglandin E2 secretion by cultured human adult microglia: Implication for Alzheimer's disease
    • Hoozemans, J.J., Veerhuis, R., Janssen, I., Janvan, E.I.K.E., Rozemuller, A.J.M., Eikelenboom, P. (2002) The role of cyclooxygenase 1 and 2 activity in prostaglandin E2 secretion by cultured human adult microglia: implication for Alzheimer's disease. Brain Res., 951, 218-226.
    • (2002) Brain Res , vol.951 , pp. 218-226
    • Hoozemans, J.J.1    Veerhuis, R.2    Janssen, I.3    Janvan, E.I.K.E.4    Rozemuller, A.J.M.5    Eikelenboom, P.6
  • 114
    • 0033890821 scopus 로고    scopus 로고
    • α-synuclein promotes mitochondrial deficit and oxidative stress
    • Hsu, L.J., Sagara, Y., Arroyo, A., Rockenstein, E., Sisk, A. (2000) α-synuclein promotes mitochondrial deficit and oxidative stress. Am. J. Pathol., 157, 401-10.
    • (2000) Am. J. Pathol , vol.157 , pp. 401-410
    • Hsu, L.J.1    Sagara, Y.2    Arroyo, A.3    Rockenstein, E.4    Sisk, A.5
  • 115
    • 0042063899 scopus 로고    scopus 로고
    • Crystal structure of DJ-1/RS and implication on familial Parkinson's disease
    • Huai, Q., Sun, Y., Wang, H., Clain, L., Li, L., Rabinson, H., Ke, H. (2003) Crystal structure of DJ-1/RS and implication on familial Parkinson's disease. FEBS Lett., 549, 171-175.
    • (2003) FEBS Lett , vol.549 , pp. 171-175
    • Huai, Q.1    Sun, Y.2    Wang, H.3    Clain, L.4    Li, L.5    Rabinson, H.6    Ke, H.7
  • 116
    • 0036209085 scopus 로고    scopus 로고
    • The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service
    • Hughes, A.J., Daniel, S.E., Ben-Shlomo, Y., Lees, A.J. (2002) The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service. Brain, 125, 861-870.
    • (2002) Brain , vol.125 , pp. 861-870
    • Hughes, A.J.1    Daniel, S.E.2    Ben-Shlomo, Y.3    Lees, A.J.4
  • 118
    • 0842299122 scopus 로고    scopus 로고
    • Proteasomes and molecular chaperones: Cellular machinery responsible for folding and destruction of unfolded proteins
    • Imai, J., Yashiroda, H., Maruya, M., Yahara, I., Tanaka, K. (2003) Proteasomes and molecular chaperones: cellular machinery responsible for folding and destruction of unfolded proteins. Cell Cycle, 2, 585-590.
    • (2003) Cell Cycle , vol.2 , pp. 585-590
    • Imai, J.1    Yashiroda, H.2    Maruya, M.3    Yahara, I.4    Tanaka, K.5
  • 119
    • 0034680913 scopus 로고    scopus 로고
    • Parkin suppresses unfolded protein stress- induced cell death through E3 ubiquitin-protein ligase activity
    • Imai, Y., Soda, M., Takahashi, R. (2000) Parkin suppresses unfolded protein stress- induced cell death through E3 ubiquitin-protein ligase activity. J. Biol. Chem., 275, 35661-35664.
    • (2000) J. Biol. Chem , vol.275 , pp. 35661-35664
    • Imai, Y.1    Soda, M.2    Takahashi, R.3
  • 120
    • 0035967883 scopus 로고    scopus 로고
    • An unfolded putative transmembrane polypeptide which can lead to endoplasmic reticulum stress, a substrate for parkin
    • Imai, Y., Soda, M., Inoue, H., Hattori, N., Mizuono, Y., Takahashi, R. (2001) An unfolded putative transmembrane polypeptide which can lead to endoplasmic reticulum stress, a substrate for parkin. Cell, 105, 891-902.
    • (2001) Cell , vol.105 , pp. 891-902
    • Imai, Y.1    Soda, M.2    Inoue, H.3    Hattori, N.4    Mizuono, Y.5    Takahashi, R.6
  • 122
    • 0024615894 scopus 로고
    • Essential tremor and Parkinson's disease
    • Jankovic, J. (1989) Essential tremor and Parkinson's disease. Ann. Neurol., 25, 211-12.
    • (1989) Ann. Neurol , vol.25 , pp. 211-212
    • Jankovic, J.1
  • 123
    • 0032492689 scopus 로고    scopus 로고
    • Regulation of phospholipase D2: Selective inhibition of mammalian phospholipase D isoenzymes by α- and β-synucleins
    • Jenco, J.M., Rawlingson, A., Daniels, B., Morris, A.J. (1998) Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by α- and β-synucleins. Biochemistry, 37, 4901-4909.
    • (1998) Biochemistry , vol.37 , pp. 4901-4909
    • Jenco, J.M.1    Rawlingson, A.2    Daniels, B.3    Morris, A.J.4
  • 124
    • 0027940106 scopus 로고
    • Incidental Lewy body disease in black Africans
    • Jendroska, K., Olasode, D.J. (1994) Incidental Lewy body disease in black Africans. Lancet, 344, 882-3.
    • (1994) Lancet , vol.344 , pp. 882-883
    • Jendroska, K.1    Olasode, D.J.2
  • 125
    • 0026440079 scopus 로고
    • Motor activity following the administration of selective D1 and D2 dopaminergic drugs to MPTP treated common marmosets
    • Jenner, P., Marsden, C.D. (1992) Motor activity following the administration of selective D1 and D2 dopaminergic drugs to MPTP treated common marmosets. Psychopharmacol (Berlin), 109, 49-56.
    • (1992) Psychopharmacol (Berlin) , vol.109 , pp. 49-56
    • Jenner, P.1    Marsden, C.D.2
  • 126
    • 22544444943 scopus 로고    scopus 로고
    • A novel dopamine agonist for the transdermal treatment of PD cases
    • Jenner, P. (2005) A novel dopamine agonist for the transdermal treatment of PD cases. Neurology, 65, S3-S5.
    • (2005) Neurology , vol.65
    • Jenner, P.1
  • 127
    • 0031899172 scopus 로고    scopus 로고
    • Oxidative mechanism in nigral cell death in Parkinson's disease
    • Jenner, P. (1998) Oxidative mechanism in nigral cell death in Parkinson's disease. Mov. Disord., 13, 24-34.
    • (1998) Mov. Disord , vol.13 , pp. 24-34
    • Jenner, P.1
  • 128
    • 0037378026 scopus 로고    scopus 로고
    • Oxidative stress in Parkinson's disease
    • Jenner, P. (2003) Oxidative stress in Parkinson's disease. Ann. Neurol., 53, S26-S36.
    • (2003) Ann. Neurol , vol.53
    • Jenner, P.1
  • 129
    • 0029269229 scopus 로고
    • The rational use of dopamine agonist in PD
    • Jenner, P. (1995) The rational use of dopamine agonist in PD. Neurology, 45, S6-S12.
    • (1995) Neurology , vol.45
    • Jenner, P.1
  • 132
    • 0025128071 scopus 로고
    • Twin studies and the genetics of Parkinson's disease: A reappraisal
    • Johnson, W.G., Hodge, S.E., Duvoisin, R. (1990) Twin studies and the genetics of Parkinson's disease: a reappraisal. Mov. Disord., 5, 187-94.
    • (1990) Mov. Disord , vol.5 , pp. 187-194
    • Johnson, W.G.1    Hodge, S.E.2    Duvoisin, R.3
  • 133
    • 13444249899 scopus 로고    scopus 로고
    • Adenosine A2A receptor antagonists beyond dopaminergic therapies for Parkinson's disease
    • Kase, H., Mori, A., Jenner, P. (2004) Adenosine A2A receptor antagonists beyond dopaminergic therapies for Parkinson's disease. Drug Discov. Today, 1, 51-57.
    • (2004) Drug Discov. Today , vol.1 , pp. 51-57
    • Kase, H.1    Mori, A.2    Jenner, P.3
  • 134
    • 0038290644 scopus 로고    scopus 로고
    • Developmental stages of cortical Lewy bodies and their reduction to axonal transport blockage in brains of patients with demential with Lewy bodies
    • Katsuse, O., Iseki, E., Marui, W., Kosaka, Y. (2003) Developmental stages of cortical Lewy bodies and their reduction to axonal transport blockage in brains of patients with demential with Lewy bodies. J. Neurol. Sci., 211, 29-35.
    • (2003) J. Neurol. Sci , vol.211 , pp. 29-35
    • Katsuse, O.1    Iseki, E.2    Marui, W.3    Kosaka, Y.4
  • 135
    • 20144366287 scopus 로고    scopus 로고
    • Continuous subcutaneous apomorphine therapy improves dyskinesias in Parkinson's disease: A prospective study using single- dose challenges
    • Katzenschlager, R., Hughes, A., Evans, A., Manson, A.J., Hoffman, M., Swinn, L., Watt, H., Bhatia, K., Quinn, N., Lees, A.J. (2005) Continuous subcutaneous apomorphine therapy improves dyskinesias in Parkinson's disease: a prospective study using single- dose challenges. Mov. Disord., 20, 151-157.
    • (2005) Mov. Disord , vol.20 , pp. 151-157
    • Katzenschlager, R.1    Hughes, A.2    Evans, A.3    Manson, A.J.4    Hoffman, M.5    Swinn, L.6    Watt, H.7    Bhatia, K.8    Quinn, N.9    Lees, A.J.10
  • 137
    • 0035937522 scopus 로고    scopus 로고
    • Dopamine induced protein damage in mitochondrial- synaptosomal fraction in rat brain
    • Khan, F.M., Saha, M., Chakrabarti, S. (2001) Dopamine induced protein damage in mitochondrial- synaptosomal fraction in rat brain. Brain Res., 895, 245-249.
    • (2001) Brain Res , vol.895 , pp. 245-249
    • Khan, F.M.1    Saha, M.2    Chakrabarti, S.3
  • 138
    • 0034492520 scopus 로고    scopus 로고
    • Structural changes in α-synuclein affect its chaperone-like activity in vitro
    • Kim, T.D., Paik, S.R., Yang, C.H., Kim, J. (2000) Structural changes in α-synuclein affect its chaperone-like activity in vitro. Protein Sci., 9, 2489-2496.
    • (2000) Protein Sci , vol.9 , pp. 2489-2496
    • Kim, T.D.1    Paik, S.R.2    Yang, C.H.3    Kim, J.4
  • 139
    • 0037137224 scopus 로고    scopus 로고
    • Structural and functional implication of C- terminal regions of α-synuclein
    • Kim, T.D., Paik, S.R., Yang, C.H. (2002) Structural and functional implication of C- terminal regions of α-synuclein. Biochemistry, 41, 13782-13790.
    • (2002) Biochemistry , vol.41 , pp. 13782-13790
    • Kim, T.D.1    Paik, S.R.2    Yang, C.H.3
  • 140
    • 0033773403 scopus 로고    scopus 로고
    • Sensitization of neuronal cells to oxidative stress with mutated human α-synuclein
    • Ko, L., Mehta, N.D., Farrer, M., Eassen, C., Hussey, J. (2000) Sensitization of neuronal cells to oxidative stress with mutated human α-synuclein. J. Neurochem., 75, 2546-54.
    • (2000) J. Neurochem , vol.75 , pp. 2546-2554
    • Ko, L.1    Mehta, N.D.2    Farrer, M.3    Eassen, C.4    Hussey, J.5
  • 141
    • 0021239498 scopus 로고
    • Sensory symptoms in Parkinson's disease
    • Koller, W.C. (1984) Sensory symptoms in Parkinson's disease. Neurology, 34, 1957-59.
    • (1984) Neurology , vol.34 , pp. 1957-1959
    • Koller, W.C.1
  • 142
    • 0034721690 scopus 로고    scopus 로고
    • Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease
    • Kordower, J.H., Emborg, M.E., Bloch, J., Ma, S.Y., Chu, Y., Leventhal, L., McBride, J., Chen, E.Y., Palfi, S. (2000) Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science, 290, 767-73.
    • (2000) Science , vol.290 , pp. 767-773
    • Kordower, J.H.1    Emborg, M.E.2    Bloch, J.3    Ma, S.Y.4    Chu, Y.5    Leventhal, L.6    McBride, J.7    Chen, E.Y.8    Palfi, S.9
  • 144
    • 34347376955 scopus 로고    scopus 로고
    • Tyrosine hydroxylase is inactivated by catechol-quinones and converted to redoxcycling quinoprotein: Possible relevance to Parkinson's disease
    • Kuhn, D.M., Arthur, Jr. A.E., Thomas, D.M., Elferink, L.A. (1999) Tyrosine hydroxylase is inactivated by catechol-quinones and converted to redoxcycling quinoprotein: possible relevance to Parkinson's disease. J. Neurochem., 279, 48384-96.
    • (1999) J. Neurochem , vol.279 , pp. 48384-48396
    • Kuhn, D.M.1    Arthur Jr., A.E.2    Thomas, D.M.3    Elferink, L.A.4
  • 146
    • 0034090879 scopus 로고    scopus 로고
    • Risk of Parkinson's disease: Twin studies for the detection of asymptomic subject using 6 fluro dopa PET
    • Laihinen, A., Ruottien, H., Rinne, J.O., Haaparanta, M., Bergman, J., Salin, O. (2000) Risk of Parkinson's disease: twin studies for the detection of asymptomic subject using 6 fluro dopa PET. J. Neurol., 247, 110-3.
    • (2000) J. Neurol , vol.247 , pp. 110-113
    • Laihinen, A.1    Ruottien, H.2    Rinne, J.O.3    Haaparanta, M.4    Bergman, J.5    Salin, O.6
  • 147
    • 0032497504 scopus 로고    scopus 로고
    • Parkinson's disease
    • Lang, A.E., Lozano, A.M. (1998) Parkinson's disease. N. Eng. J. Med., 339, 1044-53.
    • (1998) N. Eng. J. Med , vol.339 , pp. 1044-1053
    • Lang, A.E.1    Lozano, A.M.2
  • 148
    • 0020680904 scopus 로고
    • Chronic Parkinsonism in humans due to a product of mepridine analog synthesis
    • Langston, J.W., Ballard, P.A., Tetrud, J.W., Irwin, I. (1983) Chronic Parkinsonism in humans due to a product of mepridine analog synthesis. Science, 219, 979-80.
    • (1983) Science , vol.219 , pp. 979-980
    • Langston, J.W.1    Ballard, P.A.2    Tetrud, J.W.3    Irwin, I.4
  • 149
    • 0037130174 scopus 로고    scopus 로고
    • Neurodegenerative disease: Amyloid pores from pathogenic mutation
    • Lashuel, H.A., Hartley, D., Petre, B.M., Waltz, T., Lansbury, P.T.J. (2002) Neurodegenerative disease: amyloid pores from pathogenic mutation. Nature, 418, 291.
    • (2002) Nature , vol.418 , pp. 291
    • Lashuel, H.A.1    Hartley, D.2    Petre, B.M.3    Waltz, T.4    Lansbury, P.T.J.5
  • 151
    • 0035109909 scopus 로고    scopus 로고
    • Effect of the over expression of wild type mutant α-synuclein on cell susceptibility to insult
    • Lee, M., Hyuan, D., Halliwell, B., Jenner, P. (2001) Effect of the over expression of wild type mutant α-synuclein on cell susceptibility to insult. J. Neurochem., 76, 998-1009.
    • (2001) J. Neurochem , vol.76 , pp. 998-1009
    • Lee, M.1    Hyuan, D.2    Halliwell, B.3    Jenner, P.4
  • 152
    • 0035503074 scopus 로고    scopus 로고
    • Microglial activation of dopaminergic cell injury: An in vitro model relevant to Parkinson's disease
    • Lee, W., Rowe, D., Yie, W., Ortiz, I., He, Y., Apple, S.H. (2001) Microglial activation of dopaminergic cell injury: an in vitro model relevant to Parkinson's disease. J. Neurosci., 21, 8447-8455.
    • (2001) J. Neurosci , vol.21 , pp. 8447-8455
    • Lee, W.1    Rowe, D.2    Yie, W.3    Ortiz, I.4    He, Y.5    Apple, S.H.6
  • 153
    • 0032190090 scopus 로고    scopus 로고
    • The ubiquitin pathway in Parkinson's disease
    • Leroy, E., Baer, R., Auburgen, G., Leube, B., Ulm, G. (1998). The ubiquitin pathway in Parkinson's disease. Nature, 395, 451-452.
    • (1998) Nature , vol.395 , pp. 451-452
    • Leroy, E.1    Baer, R.2    Auburgen, G.3    Leube, B.4    Ulm, G.5
  • 154
  • 155
    • 1842424791 scopus 로고    scopus 로고
    • Proteasomal inhibition of α-synuclein filaments and oligomers
    • Lindersson, E., Beedholm, R., Hojrup, P., Moos, T., Gai, W. (2004) Proteasomal inhibition of α-synuclein filaments and oligomers. J. Biol. Chem., 279, 12924-34.
    • (2004) J. Biol. Chem , vol.279 , pp. 12924-12934
    • Lindersson, E.1    Beedholm, R.2    Hojrup, P.3    Moos, T.4    Gai, W.5
  • 157
    • 0036884733 scopus 로고    scopus 로고
    • Pathogenesis of Parkinson's disease: Dopamine, vesicles and α-synuclein
    • Lotharius, J., Brundin, B. (2002) Pathogenesis of Parkinson's disease: dopamine, vesicles and α-synuclein. Nat. Rev. Neurosci., 3, 1-11.
    • (2002) Nat. Rev. Neurosci , vol.3 , pp. 1-11
    • Lotharius, J.1    Brundin, B.2
  • 158
    • 0036797552 scopus 로고    scopus 로고
    • Impaired dopamine storage resulting from α-synuclein mutations may contribute to the pathogenesis of Parkinson's disease
    • Lotharius, J., Brundin, P. (2002) Impaired dopamine storage resulting from α-synuclein mutations may contribute to the pathogenesis of Parkinson's disease. Hum. Mol. Genet., 11, 2395-2407.
    • (2002) Hum. Mol. Genet , vol.11 , pp. 2395-2407
    • Lotharius, J.1    Brundin, P.2
  • 160
    • 0342368772 scopus 로고    scopus 로고
    • Association between early onset Parkinson's disease and mutations in the parkin gene
    • Lucking, C.B., Durr, A., Bonifati, V., Vaughan, J., De Michele, G. (2000) Association between early onset Parkinson's disease and mutations in the parkin gene. N. Eng. J. Med., 342, 1560-67.
    • (2000) N. Eng. J. Med , vol.342 , pp. 1560-1567
    • Lucking, C.B.1    Durr, A.2    Bonifati, V.3    Vaughan, J.4    De Michele, G.5
  • 162
    • 0037273830 scopus 로고    scopus 로고
    • Glutamate receptors and Parkinson's disease: Opportunities for intervention
    • Maino, M.J., Valenti, O., Cann, P.J. (2003) Glutamate receptors and Parkinson's disease: opportunities for intervention. Drugs Aging, 20, 377-397.
    • (2003) Drugs Aging , vol.20 , pp. 377-397
    • Maino, M.J.1    Valenti, O.2    Cann, P.J.3
  • 163
    • 0037127197 scopus 로고    scopus 로고
    • The herbicide paraquat causes upregulation and aggregation of α-synuclein in mice:paraquat and α-synuclein
    • Manning-Bog, A.B., McComack, A.L., Li, J., Uversky, V.N., Fink, A.L., Di Monte, D.A. (2002) The herbicide paraquat causes upregulation and aggregation of α-synuclein in mice:paraquat and α-synuclein. J. Biol. Chem., 277, 1641-1644.
    • (2002) J. Biol. Chem , vol.277 , pp. 1641-1644
    • Manning-Bog, A.B.1    McComack, A.L.2    Li, J.3    Uversky, V.N.4    Fink, A.L.5    Di Monte, D.A.6
  • 164
    • 0346154811 scopus 로고    scopus 로고
    • Dopamine derived salsolinol derivatives as exogenous MAO inhibitor: Occurrence, metabolism and function in human brains
    • Maoi, M., Marugam, W. (2004) Dopamine derived salsolinol derivatives as exogenous MAO inhibitor: occurrence, metabolism and function in human brains. Neurotoxicology, 25, 193-204.
    • (2004) Neurotoxicology , vol.25 , pp. 193-204
    • Maoi, M.1    Marugam, W.2
  • 165
    • 0030056696 scopus 로고    scopus 로고
    • Risk of Parkinson's disease among fist degree relatives: A community based study
    • Marder, K., Tang, M.X., Mejia, H., Alfaro, B., Cote, L. (1996) Risk of Parkinson's disease among fist degree relatives: a community based study. Neurology, 47, 155-60.
    • (1996) Neurology , vol.47 , pp. 155-160
    • Marder, K.1    Tang, M.X.2    Mejia, H.3    Alfaro, B.4    Cote, L.5
  • 166
    • 0030583640 scopus 로고    scopus 로고
    • Levodopa induced motor response alterations in Parkinsonian rats
    • Marin, C., Papa, S., Engber, T.M., Bonastre, M. (1996) Levodopa induced motor response alterations in Parkinsonian rats. Brain Res., 736, 202-205.
    • (1996) Brain Res , vol.736 , pp. 202-205
    • Marin, C.1    Papa, S.2    Engber, T.M.3    Bonastre, M.4
  • 167
    • 0033959888 scopus 로고    scopus 로고
    • Neuropsychiatric aspects of Parkinson's disease
    • Marsh, L. (2000) Neuropsychiatric aspects of Parkinson's disease. Psychosomatics, 41, 15-23.
    • (2000) Psychosomatics , vol.41 , pp. 15-23
    • Marsh, L.1
  • 168
    • 0030499486 scopus 로고    scopus 로고
    • Drugs inducing or aggrevating Parkinsonism: A review
    • Marti-Masso, J.F., Poza, J.J., Lopez de Munain, A. (1996) Drugs inducing or aggrevating Parkinsonism: a review. Therapie, 5, 568-577.
    • (1996) Therapie , vol.5 , pp. 568-577
    • Marti-Masso, J.F.1    Poza, J.J.2    Lopez de Munain, A.3
  • 170
    • 12444281013 scopus 로고    scopus 로고
    • Identification and functional characterization of novel R621C mutations in the synphilin-1 gene in PD
    • Marx, F.P., Holzmann, C., Strauss, K.M. (2003) Identification and functional characterization of novel R621C mutations in the synphilin-1 gene in PD. Hum. Mol. Genet., 12, 1223-1231.
    • (2003) Hum. Mol. Genet , vol.12 , pp. 1223-1231
    • Marx, F.P.1    Holzmann, C.2    Strauss, K.M.3
  • 172
    • 1842455356 scopus 로고    scopus 로고
    • Parkin genetics: One model for Parkinson's disease
    • Mata, I.F., Lockhart, P.J., Farrer, M. (2004) Parkin genetics: one model for Parkinson's disease. Hum. Mol. Genet., 13, R27-33.
    • (2004) Hum. Mol. Genet , vol.13
    • Mata, I.F.1    Lockhart, P.J.2    Farrer, M.3
  • 173
    • 23944521608 scopus 로고    scopus 로고
    • Sumanirole a highly dopamine D2 selective receptor agonist: In vitro and in vivo pharmacological characterization and efficacy in animal model of Parkinson's disease
    • McCall, R.B., Lookingland, K.J., Bedard, P.J., Huff, R.M. (2005) Sumanirole a highly dopamine D2 selective receptor agonist: in vitro and in vivo pharmacological characterization and efficacy in animal model of Parkinson's disease. J. Pharmacol. Exp. Ther., 314, 1248-1256.
    • (2005) J. Pharmacol. Exp. Ther , vol.314 , pp. 1248-1256
    • McCall, R.B.1    Lookingland, K.J.2    Bedard, P.J.3    Huff, R.M.4
  • 174
    • 34347390458 scopus 로고    scopus 로고
    • Presence of reactive microglia in monkey substantia nigra after MPTP administration
    • McGeer, P.L., Schwab, C., Parent, A., Doudet, D. (2001) Presence of reactive microglia in monkey substantia nigra after MPTP administration. Ann. Neurol., 169, 219-230.
    • (2001) Ann. Neurol , vol.169 , pp. 219-230
    • McGeer, P.L.1    Schwab, C.2    Parent, A.3    Doudet, D.4
  • 175
    • 4344569643 scopus 로고    scopus 로고
    • Geldanamycin induces Hsp 70 and prevents..SN aggregation and toxicity in vitro
    • McLean, P.J., Klucken, J., Shin, Y., Hyman, B.T. (2004) Geldanamycin induces Hsp 70 and prevents..SN aggregation and toxicity in vitro. Biochem. Biophys. Res. Commun., 321, 665-669.
    • (2004) Biochem. Biophys. Res. Commun , vol.321 , pp. 665-669
    • McLean, P.J.1    Klucken, J.2    Shin, Y.3    Hyman, B.T.4
  • 176
    • 0037378898 scopus 로고    scopus 로고
    • Proteolytic stress: A unifying concept in the etiopathogenesis of familial and sporadic Parkinson's disease
    • McNaught, K.S., Olanow, C.W. (2003) Proteolytic stress: a unifying concept in the etiopathogenesis of familial and sporadic Parkinson's disease. Ann. Neurol., 53, S73-86.
    • (2003) Ann. Neurol , vol.53
    • McNaught, K.S.1    Olanow, C.W.2
  • 177
    • 33344461775 scopus 로고    scopus 로고
    • Protein aggregation in the pathogenesis of familial and sporadic Parkinson's disease
    • McNaught, K.S., Olanow, C.W. (2006) Protein aggregation in the pathogenesis of familial and sporadic Parkinson's disease. Neurobiol. Aging, 27, 530-545.
    • (2006) Neurobiol. Aging , vol.27 , pp. 530-545
    • McNaught, K.S.1    Olanow, C.W.2
  • 178
    • 0025063462 scopus 로고    scopus 로고
    • Toxicity of 6-hydroxy dopamine and dopamine for dopaminergic neurons in culture
    • Michel, P.P., Hefti, F. (2004) Toxicity of 6-hydroxy dopamine and dopamine for dopaminergic neurons in culture. J. Neurosci. Res., 26, 428-35.
    • (2004) J. Neurosci. Res , vol.26 , pp. 428-435
    • Michel, P.P.1    Hefti, F.2
  • 179
    • 23844450357 scopus 로고    scopus 로고
    • Intrabody applications in neurological disorders: Progress and future prospects
    • Miller, T.W., Messer, A. (2005) Intrabody applications in neurological disorders: progress and future prospects. Mol. Ther., 12, 394-401.
    • (2005) Mol. Ther , vol.12 , pp. 394-401
    • Miller, T.W.1    Messer, A.2
  • 180
    • 0028338865 scopus 로고
    • Prevalence of movement disorder in elderly community residents
    • Moghal, S., Rajput, A.H., D'Arcy, C., Rajput, R. (1994) Prevalence of movement disorder in elderly community residents. Neuroepidemiology, 13, 175-178.
    • (1994) Neuroepidemiology , vol.13 , pp. 175-178
    • Moghal, S.1    Rajput, A.H.2    D'Arcy, C.3    Rajput, R.4
  • 181
    • 0030582991 scopus 로고    scopus 로고
    • Interleukin 1-beta, interleukin 6, epidermal growth factor and transforming growth factor-alpha are activated in ventricular cerebrospinal fluid in juvanile parkinsonism and Parkinson's disease
    • Mogi, M., Harada, M., Kondo, T., Riederer, P., Inayaki, H., Minami, M. (1996) Interleukin 1-beta, interleukin 6, epidermal growth factor and transforming growth factor-alpha are activated in ventricular cerebrospinal fluid in juvanile parkinsonism and Parkinson's disease. Neurosci. Lett., 211, 13-16.
    • (1996) Neurosci. Lett , vol.211 , pp. 13-16
    • Mogi, M.1    Harada, M.2    Kondo, T.3    Riederer, P.4    Inayaki, H.5    Minami, M.6
  • 182
    • 0028971708 scopus 로고    scopus 로고
    • Molho, E.S., Facter, S.A., Weiner, W.T., Sanchez-Ramas, J.R., Singer, C., Shulman, L., Brown, D., Sheldon, C. (1995) The use of pramipexole a novel dopamine agonist in advanced Parkinson's disease. J. Neurol. Transm., S45, 225-230.
    • Molho, E.S., Facter, S.A., Weiner, W.T., Sanchez-Ramas, J.R., Singer, C., Shulman, L., Brown, D., Sheldon, C. (1995) The use of pramipexole a novel dopamine agonist in advanced Parkinson's disease. J. Neurol. Transm., S45, 225-230.
  • 184
    • 0346434141 scopus 로고    scopus 로고
    • A missense mutation (L166P) is DJ-1 linked to familial Parkinson's disease confers reduced protein stability and impairs homo-oligomerization
    • Moore, D.J., Zhang, L., Dawson, T.M., Dawson, V.L. (2003) A missense mutation (L166P) is DJ-1 linked to familial Parkinson's disease confers reduced protein stability and impairs homo-oligomerization. J. Neurochem., 87, 1558-67.
    • (2003) J. Neurochem , vol.87 , pp. 1558-1567
    • Moore, D.J.1    Zhang, L.2    Dawson, T.M.3    Dawson, V.L.4
  • 185
    • 17844365594 scopus 로고    scopus 로고
    • Genetics of Parkinson's disease
    • Morris, H.R. (2005) Genetics of Parkinson's disease. Ann. Med., 37, 86-96.
    • (2005) Ann. Med , vol.37 , pp. 86-96
    • Morris, H.R.1
  • 186
    • 0037014426 scopus 로고    scopus 로고
    • Protein misfolding, amyloid formation and neurodegeneration: A critical role for molecular chaperones?
    • Muchowski, P.J. (2002) Protein misfolding, amyloid formation and neurodegeneration: a critical role for molecular chaperones? Neuron, 35, 9-12.
    • (2002) Neuron , vol.35 , pp. 9-12
    • Muchowski, P.J.1
  • 187
    • 0024678458 scopus 로고
    • Glutamate toxicity in neuronal cell line involves inhibition of cysteine transport leading to oxidative stress
    • Murphy, T.H., Miyamoto, M., Sastre, A., Achnaar, R.L., Coyle, J.T. (1989) Glutamate toxicity in neuronal cell line involves inhibition of cysteine transport leading to oxidative stress. Neuron, 2, 1547-58.
    • (1989) Neuron , vol.2 , pp. 1547-1558
    • Murphy, T.H.1    Miyamoto, M.2    Sastre, A.3    Achnaar, R.L.4    Coyle, J.T.5
  • 189
    • 0036828226 scopus 로고    scopus 로고
    • Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. II. Agonist and antagonist properties at subtypes of dopamine D(2)-like receptor and α(1)/α(2)-adrenoceptor
    • Newman-Tancredi, A., Cussac, D., Audinot, V., Nicolas, J., De Ceuninck, F., Boutin, J.A., Millan, M.J. (2002) Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. II. Agonist and antagonist properties at subtypes of dopamine D(2)-like receptor and α(1)/α(2)-adrenoceptor. J. Pharmacol. Exp. Ther., 303, 805-814.
    • (2002) J. Pharmacol. Exp. Ther , vol.303 , pp. 805-814
    • Newman-Tancredi, A.1    Cussac, D.2    Audinot, V.3    Nicolas, J.4    De Ceuninck, F.5    Boutin, J.A.6    Millan, M.J.7
  • 190
    • 0037734163 scopus 로고    scopus 로고
    • Endotoxins: Is it an environmental factor in the cause of Parkinson's disease?
    • Niehaus, I., Lange, J.H. (2003) Endotoxins: is it an environmental factor in the cause of Parkinson's disease? Occup. Environ. Med., 60, 378.
    • (2003) Occup. Environ. Med , vol.60 , pp. 378
    • Niehaus, I.1    Lange, J.H.2
  • 191
    • 0037291493 scopus 로고    scopus 로고
    • DJBP: A novel DJ 1 binding protein, negatively regulates the androgen receptor by recruiting histome deacetylase complex and DJ 1 antagonizes this inhibition by abrogation of this complex
    • Niki, T., Takahashi-Nik, A., Taira, T., Iguchi-Agira, S.M., Agira, H. (2003) DJBP: a novel DJ 1 binding protein, negatively regulates the androgen receptor by recruiting histome deacetylase complex and DJ 1 antagonizes this inhibition by abrogation of this complex. Mol. Cancer Res., 1, 247-261.
    • (2003) Mol. Cancer Res , vol.1 , pp. 247-261
    • Niki, T.1    Takahashi-Nik, A.2    Taira, T.3    Iguchi-Agira, S.M.4    Agira, H.5
  • 192
    • 20444401187 scopus 로고    scopus 로고
    • Reversible inhibition of αSN fibrillization by dopaminochrome mediated conformational alterations
    • Norris, F.H., Giasson, B.I., Hodara, R., Xu, S., Trojanowski, J.Q. (2005) Reversible inhibition of αSN fibrillization by dopaminochrome mediated conformational alterations. J. Biol. Chem., 280, 21212-21219.
    • (2005) J. Biol. Chem , vol.280 , pp. 21212-21219
    • Norris, F.H.1    Giasson, B.I.2    Hodara, R.3    Xu, S.4    Trojanowski, J.Q.5
  • 193
    • 0033977448 scopus 로고    scopus 로고
    • Tolcapane and hepatic effects
    • Olanow, C.W. (2000) Tolcapane and hepatic effects. Arch. Neurol., 57, 263-267.
    • (2000) Arch. Neurol , vol.57 , pp. 263-267
    • Olanow, C.W.1
  • 196
    • 0036935553 scopus 로고    scopus 로고
    • An inflammatory review of Parkinson's disease
    • Orr, C.F., Rowe, D.B., Halliday, G.M. (2002) An inflammatory review of Parkinson's disease. Prog. Neurobiol., 68, 325-340.
    • (2002) Prog. Neurobiol , vol.68 , pp. 325-340
    • Orr, C.F.1    Rowe, D.B.2    Halliday, G.M.3
  • 197
    • 0036182026 scopus 로고    scopus 로고
    • Mitochondrial involvement in Parkinson's disease
    • Orth, M., Schapira, A.H. (2002) Mitochondrial involvement in Parkinson's disease. Neurochem. Int., 40, 53-41.
    • (2002) Neurochem. Int , vol.40 , pp. 53-41
    • Orth, M.1    Schapira, A.H.2
  • 199
    • 8844266996 scopus 로고    scopus 로고
    • Cloning of the gene containing mutations that cause PARK 8 linked Parkinson's disease
    • Paisan-Ruiz, C., Jain, S., Evans, E.W., Gilks, W.P., Simon, J. (2004) Cloning of the gene containing mutations that cause PARK 8 linked Parkinson's disease. Neuron, 44, 595-600.
    • (2004) Neuron , vol.44 , pp. 595-600
    • Paisan-Ruiz, C.1    Jain, S.2    Evans, E.W.3    Gilks, W.P.4    Simon, J.5
  • 200
    • 4844222408 scopus 로고    scopus 로고
    • α-synuclein promoter confers susceptibility to Parkinson's disease
    • Pals, P., Lincoln, S., Manning, J., Heckman, M., Skipper, L. (2004) α-synuclein promoter confers susceptibility to Parkinson's disease. Ann. Neurol., 56, 591-95.
    • (2004) Ann. Neurol , vol.56 , pp. 591-595
    • Pals, P.1    Lincoln, S.2    Manning, J.3    Heckman, M.4    Skipper, L.5
  • 202
    • 1342264250 scopus 로고    scopus 로고
    • Parkinson's disease, pesticides and individual vulnerability
    • Paolini, M., Sapone, A., Gonzalez, E.J. (2004) Parkinson's disease, pesticides and individual vulnerability. Trends Pharmacol. Sci., 25, 124-129.
    • (2004) Trends Pharmacol. Sci , vol.25 , pp. 124-129
    • Paolini, M.1    Sapone, A.2    Gonzalez, E.J.3
  • 203
    • 0037047371 scopus 로고    scopus 로고
    • Distinct roles of N-terminal binding domain and C-terminal solubilizing domain of α-synuclein, a molecular chaperone
    • Park, S.M., Jung, H.Y., Kim, T.D., Park, J.H., Yang, C.H., Kim, J. (2002) Distinct roles of N-terminal binding domain and C-terminal solubilizing domain of α-synuclein, a molecular chaperone. J. Biol. Chem., 277, 28512-28520.
    • (2002) J. Biol. Chem , vol.277 , pp. 28512-28520
    • Park, S.M.1    Jung, H.Y.2    Kim, T.D.3    Park, J.H.4    Yang, C.H.5    Kim, J.6
  • 204
    • 0034793204 scopus 로고    scopus 로고
    • Evaluation of dyskinesias in a pilot, randomized, placebo-controlled trial of the remacemide in advanced Parkinson's disease
    • Parkinson's Study Group
    • Parkinson's Study Group. (2001) Evaluation of dyskinesias in a pilot, randomized, placebo-controlled trial of the remacemide in advanced Parkinson's disease. Arch. Neurol., 58, 1660-1668.
    • (2001) Arch. Neurol , vol.58 , pp. 1660-1668
  • 205
    • 9044226896 scopus 로고    scopus 로고
    • Impact of deprenyl and tocopherol treatment of Parkinson's disease in DATATOP patients requiring levodopa
    • Parkinson's Study Group
    • Parkinson's Study Group. (1996) Impact of deprenyl and tocopherol treatment of Parkinson's disease in DATATOP patients requiring levodopa. Ann. Neurol., 39, 37-45.
    • (1996) Ann. Neurol , vol.39 , pp. 37-45
  • 206
    • 0010547649 scopus 로고    scopus 로고
    • Lazabenide
    • Parkinson's Study Group
    • Parkinson's Study Group. (1996) Lazabenide. Ann. Neurol., 39, 37-45.
    • (1996) Ann. Neurol , vol.39 , pp. 37-45
  • 207
    • 0842324952 scopus 로고    scopus 로고
    • The safety and tolerability of a mixed linkage kinase inhibitor (CEP-1347) in PD
    • Parkinson's Study Group
    • Parkinson's Study Group. (2004) The safety and tolerability of a mixed linkage kinase inhibitor (CEP-1347) in PD. Neurology, 62, 330-332.
    • (2004) Neurology , vol.62 , pp. 330-332
  • 208
    • 0028060492 scopus 로고
    • Increased risk of Parkinson's disease in parents and siblings of patients
    • Payami, H., Larsen, K., Bernard, S., Nutt, J. (1994) Increased risk of Parkinson's disease in parents and siblings of patients. Ann. Neurol., 36, 659-69.
    • (1994) Ann. Neurol , vol.36 , pp. 659-669
    • Payami, H.1    Larsen, K.2    Bernard, S.3    Nutt, J.4
  • 209
    • 0037092442 scopus 로고    scopus 로고
    • A role for α-synuclein in the regulation of dopamine biosynthesis
    • Perez, R.G., Waymire, J.C., Lin, E., Liu, J.J., Guo, F., Zigmond, M.J. (2002) A role for α-synuclein in the regulation of dopamine biosynthesis. J. Neurosci., 22, 3090-3099.
    • (2002) J. Neurosci , vol.22 , pp. 3090-3099
    • Perez, R.G.1    Waymire, J.C.2    Lin, E.3    Liu, J.J.4    Guo, F.5    Zigmond, M.J.6
  • 210
    • 0035092090 scopus 로고    scopus 로고
    • Origin of the mutations in the parkin gene in Europe: Exon rearrangements are independent recurrent events, where as point mutations may result from founder effects
    • Periquet, M., Lucking, C., Vaughan, J., Bonifat, V., Durr, A., De Michele, G., Horstink, M, Farrer, M. (2001) Origin of the mutations in the parkin gene in Europe: exon rearrangements are independent recurrent events, where as point mutations may result from founder effects. Am. J. Hum. Genet., 68, 617-627.
    • (2001) Am. J. Hum. Genet , vol.68 , pp. 617-627
    • Periquet, M.1    Lucking, C.2    Vaughan, J.3    Bonifat, V.4    Durr, A.5    De Michele, G.6    Horstink, M.7    Farrer, M.8
  • 211
    • 0018778418 scopus 로고
    • Brain grafts reduce motor abnormalities produced destruction of nigrostriatal dopamine system
    • Perlow, M.J., Fred, W.J., Hoffer, B.J., Seiger, A., Olsen, L., Wyatt, R.J. (1979) Brain grafts reduce motor abnormalities produced destruction of nigrostriatal dopamine system. Science, 204, 643-647.
    • (1979) Science , vol.204 , pp. 643-647
    • Perlow, M.J.1    Fred, W.J.2    Hoffer, B.J.3    Seiger, A.4    Olsen, L.5    Wyatt, R.J.6
  • 212
    • 0034602271 scopus 로고    scopus 로고
    • Interaction of human α-synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis
    • Perrin, R.J., Woods, W.S., Clayton, D.F., George, J.M. (2000) Interaction of human α-synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis. J. Biol. Chem., 275, 34393-34398.
    • (2000) J. Biol. Chem , vol.275 , pp. 34393-34398
    • Perrin, R.J.1    Woods, W.S.2    Clayton, D.F.3    George, J.M.4
  • 213
  • 215
    • 0034915764 scopus 로고    scopus 로고
    • Mechanisms of underlying ubiquitination
    • Pickart, C.M. (2001) Mechanisms of underlying ubiquitination. Ann. Rev. Biochem., 70, 503-533.
    • (2001) Ann. Rev. Biochem , vol.70 , pp. 503-533
    • Pickart, C.M.1
  • 216
    • 20144389920 scopus 로고    scopus 로고
    • Mitochondrial DNA haplogroup cluster UKJT reduces the risk of PD
    • Pyle, A., Foltynie, T., Tiangyou, W. (2005) Mitochondrial DNA haplogroup cluster UKJT reduces the risk of PD. Ann. Neurol., 57, 564-67.
    • (2005) Ann. Neurol , vol.57 , pp. 564-567
    • Pyle, A.1    Foltynie, T.2    Tiangyou, W.3
  • 218
    • 0026588604 scopus 로고
    • Frequency and cause of Parkinson's disease
    • Rajput, A.H. (1992) Frequency and cause of Parkinson's disease. Can. J. Neurol. Sci., 19 (Suppl. 1), 103-107.
    • (1992) Can. J. Neurol. Sci , vol.19 , Issue.SUPPL. 1 , pp. 103-107
    • Rajput, A.H.1
  • 219
    • 0034682308 scopus 로고    scopus 로고
    • A five-year study of the incidence of dyskinesia in patients with early Parkinson's disease who were treated with ropinirole or levodopa
    • Rascol, O., Brooks, D.J., Korczyn, A.D., De Deyn, P.P., Clarke, C.E., Lang, A.E. (2000) A five-year study of the incidence of dyskinesia in patients with early Parkinson's disease who were treated with ropinirole or levodopa. N. Engl. J. Med., 342, 1484-1491.
    • (2000) N. Engl. J. Med , vol.342 , pp. 1484-1491
    • Rascol, O.1    Brooks, D.J.2    Korczyn, A.D.3    De Deyn, P.P.4    Clarke, C.E.5    Lang, A.E.6
  • 220
    • 2642586352 scopus 로고    scopus 로고
    • Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington's disease
    • Ravikumar, B., Vacher, C., Berer, Z., Davies, J.E., Luo, S. (2004) Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington's disease. Nat. Genet., 36, 589-595.
    • (2004) Nat. Genet , vol.36 , pp. 589-595
    • Ravikumar, B.1    Vacher, C.2    Berer, Z.3    Davies, J.E.4    Luo, S.5
  • 222
    • 0034888540 scopus 로고    scopus 로고
    • Caspase inhibitors: A potential therapeutic strategy in neurological diseases
    • Rideout, H.J., Stefanis, L. (2001) Caspase inhibitors: a potential therapeutic strategy in neurological diseases. Histo. Histopathol., 16, 895-908.
    • (2001) Histo. Histopathol , vol.16 , pp. 895-908
    • Rideout, H.J.1    Stefanis, L.2
  • 223
    • 0037380725 scopus 로고    scopus 로고
    • mt4216C variant in linkage with the mtDNA TJ cluster may confer a susceptibility to mitochondrial dysfunction resulting in an increased risk of Parkinson's disease in the Irish
    • Ross, O.A., McCormack, R., Maxwell, L.D. (2003) mt4216C variant in linkage with the mtDNA TJ cluster may confer a susceptibility to mitochondrial dysfunction resulting in an increased risk of Parkinson's disease in the Irish. Exp. Gerontol., 38, 397-405.
    • (2003) Exp. Gerontol , vol.38 , pp. 397-405
    • Ross, O.A.1    McCormack, R.2    Maxwell, L.D.3
  • 224
    • 0018736142 scopus 로고
    • Bias in analytical research
    • Sackett, D.L. (1979) Bias in analytical research. J. Chronic. Dis., 32, 51-63.
    • (1979) J. Chronic. Dis , vol.32 , pp. 51-63
    • Sackett, D.L.1
  • 225
    • 0032030787 scopus 로고    scopus 로고
    • Prospects for new drug treatment in idiopathic Parkinsonism
    • Samii, A., Letwin, S.R., Calne, D.B. (1998) Prospects for new drug treatment in idiopathic Parkinsonism. Drug Discov. Today, 3, 131-140.
    • (1998) Drug Discov. Today , vol.3 , pp. 131-140
    • Samii, A.1    Letwin, S.R.2    Calne, D.B.3
  • 226
    • 2542596183 scopus 로고    scopus 로고
    • Parkinson's disease
    • Samii, A., Nutt, J.G., Ransom, B.R. (2004) Parkinson's disease. Lancet, 363, 1783-93.
    • (2004) Lancet , vol.363 , pp. 1783-1793
    • Samii, A.1    Nutt, J.G.2    Ransom, B.R.3
  • 227
    • 0347133331 scopus 로고    scopus 로고
    • Neuroprotection in Parkinson's disease mysteries, myths and misconception
    • Schapira, A.H., Olanow, C.W. (2004) Neuroprotection in Parkinson's disease mysteries, myths and misconception. JAMA, 291, 358-364.
    • (2004) JAMA , vol.291 , pp. 358-364
    • Schapira, A.H.1    Olanow, C.W.2
  • 229
    • 0023897535 scopus 로고
    • Astrocytic responses to the dopaminergic neurotoxin MPTP in cat and mouse brain
    • Schneider, J.S., Denaro, F.J. (1988) Astrocytic responses to the dopaminergic neurotoxin MPTP in cat and mouse brain. J. Neuropathol. Exp. Neurol., 47, 452-458.
    • (1988) J. Neuropathol. Exp. Neurol , vol.47 , pp. 452-458
    • Schneider, J.S.1    Denaro, F.J.2
  • 231
    • 0026711037 scopus 로고
    • Parkinson's disease and exposure to agricultural work and pesticide chemicals
    • Semchuk, K.M., Love, E.J., Lee, R.C. (1992) Parkinson's disease and exposure to agricultural work and pesticide chemicals. Neurology, 42, 1328-1335.
    • (1992) Neurology , vol.42 , pp. 1328-1335
    • Semchuk, K.M.1    Love, E.J.2    Lee, R.C.3
  • 232
    • 0346849912 scopus 로고    scopus 로고
    • Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6- hydroxydopamine lesion in rats
    • Shachar, D.B., Kahana, N., Kampel, V., Warshawsky, A., Youdim, M.B. (2004) Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6- hydroxydopamine lesion in rats. Neuropharmacology, 46, 254-263.
    • (2004) Neuropharmacology , vol.46 , pp. 254-263
    • Shachar, D.B.1    Kahana, N.2    Kampel, V.3    Warshawsky, A.4    Youdim, M.B.5
  • 233
    • 0242362280 scopus 로고    scopus 로고
    • An inhibitor of complex I rotenone inactivates proteasome by oxidative modification and induces aggregation of oxidized protein in SH-SY5Y cells
    • Shamato-Nagai, M., Maruyama, W., Kato, Y., Isobe, K., Tanaka, M., Naoi, M. (2003) An inhibitor of complex I rotenone inactivates proteasome by oxidative modification and induces aggregation of oxidized protein in SH-SY5Y cells. J. Neurosci. Res., 74, 589-97.
    • (2003) J. Neurosci. Res , vol.74 , pp. 589-597
    • Shamato-Nagai, M.1    Maruyama, W.2    Kato, Y.3    Isobe, K.4    Tanaka, M.5    Naoi, M.6
  • 235
    • 4043079949 scopus 로고    scopus 로고
    • Mitochondria and dopamine - new insights into recessive parkinsonism
    • Shen, J., Cookson, M.R. (2004) Mitochondria and dopamine - new insights into recessive parkinsonism. Neuron, 43, 301-304.
    • (2004) Neuron , vol.43 , pp. 301-304
    • Shen, J.1    Cookson, M.R.2
  • 236
    • 0035139109 scopus 로고    scopus 로고
    • Cellular defenses against unfolded proteins: A cell biologist thinks about neurodegenerative diseases
    • Sherman, M.Y., Goldberg, A.L. (2001) Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases. Neuron, 29, 15-32.
    • (2001) Neuron , vol.29 , pp. 15-32
    • Sherman, M.Y.1    Goldberg, A.L.2
  • 238
    • 0035854437 scopus 로고    scopus 로고
    • Ubiquitination of a new form of α-synuclein by parkin from human brain: Implications for Parkinson's disease
    • Shimura, H., Schlossmacher, M.G., Hattori, N., Frosch, M.P., Trockenbacher, A., Schneider, R. (2001) Ubiquitination of a new form of α-synuclein by parkin from human brain: implications for Parkinson's disease. Science, 293, 263-269.
    • (2001) Science , vol.293 , pp. 263-269
    • Shimura, H.1    Schlossmacher, M.G.2    Hattori, N.3    Frosch, M.P.4    Trockenbacher, A.5    Schneider, R.6
  • 239
    • 3442876461 scopus 로고    scopus 로고
    • Psychiatric aspects of Parkinson's disease - an update
    • Shrag, A. (2004) Psychiatric aspects of Parkinson's disease - an update. J. Neurol., 251, 795-804.
    • (2004) J. Neurol , vol.251 , pp. 795-804
    • Shrag, A.1
  • 240
    • 0034643336 scopus 로고    scopus 로고
    • Rapid degradation of a large fraction of newly synthesized proteins by proteasomes
    • Shubert, V., Anton, L.C., Gibbs, J., Norbury, C.C., Yewdell, J.W., Bennink, J.R. (2000) Rapid degradation of a large fraction of newly synthesized proteins by proteasomes. Nature, 404, 770-774.
    • (2000) Nature , vol.404 , pp. 770-774
    • Shubert, V.1    Anton, L.C.2    Gibbs, J.3    Norbury, C.C.4    Yewdell, J.W.5    Bennink, J.R.6
  • 241
    • 0036771852 scopus 로고    scopus 로고
    • Effects of coenzyme Q10 in early Parkinson's disease: Evidence of slowing the functional decline
    • Shutts, C.W., Oakes, D., Kieburtz, K., Beal, M.E., Hao, S.R. (2002) Effects of coenzyme Q10 in early Parkinson's disease: evidence of slowing the functional decline. Arch. Neurol., 59, 1541-1550.
    • (2002) Arch. Neurol , vol.59 , pp. 1541-1550
    • Shutts, C.W.1    Oakes, D.2    Kieburtz, K.3    Beal, M.E.4    Hao, S.R.5
  • 243
    • 0242300619 scopus 로고    scopus 로고
    • α-synuclein locus triplication causes Parkinson's disease
    • Singleton, A.B., Farrer, M., Jhonson, J. (2003) α-synuclein locus triplication causes Parkinson's disease. Science, 302, 481.
    • (2003) Science , vol.302 , pp. 481
    • Singleton, A.B.1    Farrer, M.2    Jhonson, J.3
  • 244
    • 0028075410 scopus 로고
    • Alternation in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia
    • Sion, J., Dexter, D.T., Lee, A.J., Daniel, S., Agid, Y. (1994) Alternation in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia. Ann. Neurol., 36, 348-355.
    • (1994) Ann. Neurol , vol.36 , pp. 348-355
    • Sion, J.1    Dexter, D.T.2    Lee, A.J.3    Daniel, S.4    Agid, Y.5
  • 245
    • 0036777846 scopus 로고    scopus 로고
    • Parkinson's genetics: Molecular insights for the new millennium
    • Skipper, L., Farrer, M. (2002) Parkinson's genetics: molecular insights for the new millennium. Neurotoxicology, 23, 503-514.
    • (2002) Neurotoxicology , vol.23 , pp. 503-514
    • Skipper, L.1    Farrer, M.2
  • 246
    • 0026747176 scopus 로고
    • Debrisoquin hydroxylase gene polymorphism and susceptibility to Parkinson's disease
    • Smith, C.A., Gough, A.C., Leigh, P.N. (1992) Debrisoquin hydroxylase gene polymorphism and susceptibility to Parkinson's disease. Lancet, 339, 1375-1377.
    • (1992) Lancet , vol.339 , pp. 1375-1377
    • Smith, C.A.1    Gough, A.C.2    Leigh, P.N.3
  • 247
    • 0038413759 scopus 로고    scopus 로고
    • Aggregated and monomeric α-synuclein bind S6 proteasomal protein and inhibit proteasomal function
    • Snyder, H., Mensah, K., Theisler, C., Lee, J., Matouschek, A., Wolozin, B. (2003) Aggregated and monomeric α-synuclein bind S6 proteasomal protein and inhibit proteasomal function. J. Biol. Chem., 278, 11753-59.
    • (2003) J. Biol. Chem , vol.278 , pp. 11753-11759
    • Snyder, H.1    Mensah, K.2    Theisler, C.3    Lee, J.4    Matouschek, A.5    Wolozin, B.6
  • 248
    • 0023804321 scopus 로고
    • Increased Iron (III) and total iron content in postmortem SN of Parkinsonian brain
    • Sofic, E., Riderer, P., Heinsen, H., Beckmann, H., Reynolds, G.P. (1988) Increased Iron (III) and total iron content in postmortem SN of Parkinsonian brain. J. Neurol. Transm., 74, 199-205.
    • (1988) J. Neurol. Transm , vol.74 , pp. 199-205
    • Sofic, E.1    Riderer, P.2    Heinsen, H.3    Beckmann, H.4    Reynolds, G.P.5
  • 249
    • 0029161068 scopus 로고    scopus 로고
    • Novel dopamine receptors: Half a decade later
    • Sokoloff, P., Schwartz, J.C., Novel dopamine receptors: half a decade later. Trends Pharmacol. Sci., 16, 270-275.
    • Trends Pharmacol. Sci , vol.16 , pp. 270-275
    • Sokoloff, P.1    Schwartz, J.C.2
  • 250
    • 0032568534 scopus 로고    scopus 로고
    • α-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
    • Spillantini, M.G., Crowther, R.A., Jakes, R., Hasegawa, M., Goedert, M. (1998) α-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA, 95, 6469-6473.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 6469-6473
    • Spillantini, M.G.1    Crowther, R.A.2    Jakes, R.3    Hasegawa, M.4    Goedert, M.5
  • 252
    • 0036424962 scopus 로고    scopus 로고
    • Sleep disorders in Parkinson's disease: Epidemiology and management
    • Stacy, M. (2002) Sleep disorders in Parkinson's disease: epidemiology and management. Drugs Aging, 19, 733-39
    • (2002) Drugs Aging , vol.19 , pp. 733-739
    • Stacy, M.1
  • 253
    • 4444338196 scopus 로고    scopus 로고
    • Double blind randomized controlled trials of rasagilin as monotherapy in early Parkinson's patients
    • Stern, M.B., Marck, K.L., Friedman, J., Hauser, R.A., Lewitt, P.A., Tarsy, D. (2004) Double blind randomized controlled trials of rasagilin as monotherapy in early Parkinson's patients. Mov. Disord., 19, 916-923.
    • (2004) Mov. Disord , vol.19 , pp. 916-923
    • Stern, M.B.1    Marck, K.L.2    Friedman, J.3    Hauser, R.A.4    Lewitt, P.A.5    Tarsy, D.6
  • 254
    • 0033559008 scopus 로고    scopus 로고
    • Cytotoxic and genotoxic potential of dopamine
    • Stokes, A.H., Hastings, T.G., Vrana, K.E. (1999) Cytotoxic and genotoxic potential of dopamine. J. Neurosci. Res., 55, 659-665.
    • (1999) J. Neurosci. Res , vol.55 , pp. 659-665
    • Stokes, A.H.1    Hastings, T.G.2    Vrana, K.E.3
  • 255
    • 0026751312 scopus 로고
    • Amantadine as N-methyl-Daspartic acid receptor antagonist: New possibilities for therapeutic applications?
    • Stoof, J.C., Booij, J., Drukcarch, B. (1992) Amantadine as N-methyl-Daspartic acid receptor antagonist: new possibilities for therapeutic applications? Clin. Neurol. Neurosurg., 94, S4-S6.
    • (1992) Clin. Neurol. Neurosurg , vol.94
    • Stoof, J.C.1    Booij, J.2    Drukcarch, B.3
  • 256
    • 13444261143 scopus 로고    scopus 로고
    • Pharmacology and perspective therapeutic usefulness of negative allosteric modulators of AMPA receptors
    • Szenasi, G., Harsing Jr, L.G. (2004) Pharmacology and perspective therapeutic usefulness of negative allosteric modulators of AMPA receptors. Drug Discov. Today, 1, 69-76.
    • (2004) Drug Discov. Today , vol.1 , pp. 69-76
    • Szenasi, G.1    Harsing Jr, L.G.2
  • 257
    • 13444270783 scopus 로고    scopus 로고
    • Analysis of the trinucleotide CAG repeat from the DNA polymerase gamma gene (POLG) in patients with Parkinson's disease
    • Taanman, J.W., Schapira, A.H. (2005) Analysis of the trinucleotide CAG repeat from the DNA polymerase gamma gene (POLG) in patients with Parkinson's disease. Neurosci. Lett., 376, 56-59.
    • (2005) Neurosci. Lett , vol.376 , pp. 56-59
    • Taanman, J.W.1    Schapira, A.H.2
  • 260
    • 0035813135 scopus 로고    scopus 로고
    • DJ-1 positively regulates androgen receptor by imparing the binding of PISAXα to the receptor
    • Takahashi, K., Taira, T., Niki, T., Seino, C., Iguchi-Ariga, S.M.M., Ariga, H. (2001) DJ-1 positively regulates androgen receptor by imparing the binding of PISAXα to the receptor. J. Biol. Chem., 276, 37556-37563.
    • (2001) J. Biol. Chem , vol.276 , pp. 37556-37563
    • Takahashi, K.1    Taira, T.2    Niki, T.3    Seino, C.4    Iguchi-Ariga, S.M.M.5    Ariga, H.6
  • 262
    • 0035870881 scopus 로고    scopus 로고
    • Inducible expression of mutant α-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependant apoptosis
    • Tanuka, Y., Engelender, S., Igarashi, S., Rao, R.K., Wanner, T. (2001) Inducible expression of mutant α-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependant apoptosis. Hum. Mol. Genet., 10, 919-26.
    • (2001) Hum. Mol. Genet , vol.10 , pp. 919-926
    • Tanuka, Y.1    Engelender, S.2    Igarashi, S.3    Rao, R.K.4    Wanner, T.5
  • 263
    • 32044458576 scopus 로고    scopus 로고
    • LRRK 2: A common pathway for parkinsonism pathogenesis and prevention
    • Taylor, J.P., Mata, I.F., Farrer, M.J. (2006) LRRK 2: a common pathway for parkinsonism pathogenesis and prevention. Trends Mol. Med., 12, 76-82.
    • (2006) Trends Mol. Med , vol.12 , pp. 76-82
    • Taylor, J.P.1    Mata, I.F.2    Farrer, M.J.3
  • 266
    • 0037246310 scopus 로고    scopus 로고
    • Systematic review of incidence of studies of Parkinson's disease
    • Twelves, D., Perkins, K.S., Counsell, C. (2003) Systematic review of incidence of studies of Parkinson's disease. Mov. Disord., 18, 19-31.
    • (2003) Mov. Disord , vol.18 , pp. 19-31
    • Twelves, D.1    Perkins, K.S.2    Counsell, C.3
  • 268
    • 0035941305 scopus 로고    scopus 로고
    • Stabilization of partially folded conformation during α-synuclein oligomerization in both purified and cytosolic preparations
    • Uversky, V.N., Lee, H.J, Li, J., Fink, A.L., Lee, S.J. (2001) Stabilization of partially folded conformation during α-synuclein oligomerization in both purified and cytosolic preparations. J. Biol. Chem., 276, 43495-43498.
    • (2001) J. Biol. Chem , vol.276 , pp. 43495-43498
    • Uversky, V.N.1    Lee, H.J.2    Li, J.3    Fink, A.L.4    Lee, S.J.5
  • 269
    • 0035941201 scopus 로고    scopus 로고
    • Metal triggered structural transformation, aggregation and fibrillation of human α-synuclein: A molecular link between Parkinson's disease and heavy metal exposure
    • Uversky, V.N., Li, J., Fink, A.L. (2001) Metal triggered structural transformation, aggregation and fibrillation of human α-synuclein: A molecular link between Parkinson's disease and heavy metal exposure. J. Biol. Chem., 276, 44284-44296.
    • (2001) J. Biol. Chem , vol.276 , pp. 44284-44296
    • Uversky, V.N.1    Li, J.2    Fink, A.L.3
  • 270
    • 0035816404 scopus 로고    scopus 로고
    • Pesticides directly accelerate the rate of α-synuclein fibril formation: A possible factor in Parkinson's disease
    • Uversky, V.N., Li, J., Fink, A.L. (2001) Pesticides directly accelerate the rate of α-synuclein fibril formation: a possible factor in Parkinson's disease. FEBS Lett., 500, 105-108.
    • (2001) FEBS Lett , vol.500 , pp. 105-108
    • Uversky, V.N.1    Li, J.2    Fink, A.L.3
  • 271
    • 0035976814 scopus 로고    scopus 로고
    • Trimethylamine-N-oxide induced folding of α-synuclein
    • Uversky, V.N., Li, J., Fink, A.L. (2001) Trimethylamine-N-oxide induced folding of α-synuclein. FEBS Lett., 509, 31-35.
    • (2001) FEBS Lett , vol.509 , pp. 31-35
    • Uversky, V.N.1    Li, J.2    Fink, A.L.3
  • 272
    • 0025972525 scopus 로고
    • Subcutaneous lisuride infusion in Parkinson's disease, response to chronic administration in 34 patients
    • Vaamonde, J., Luquin, M.R., Obeso, J.A. (1991) Subcutaneous lisuride infusion in Parkinson's disease, response to chronic administration in 34 patients. Brain, 114, 601-614.
    • (1991) Brain , vol.114 , pp. 601-614
    • Vaamonde, J.1    Luquin, M.R.2    Obeso, J.A.3
  • 274
    • 0037046163 scopus 로고    scopus 로고
    • Vesicle permiabilization by protofibrillar α-synuclein is sensitive to Parkinson's disease linked mutations and occurs by a pore-like mechanism
    • Valente, M.J., Lansbury, P.T.J. (2002) Vesicle permiabilization by protofibrillar α-synuclein is sensitive to Parkinson's disease linked mutations and occurs by a pore-like mechanism. Biochemistry, 41, 4595-4602.
    • (2002) Biochemistry , vol.41 , pp. 4595-4602
    • Valente, M.J.1    Lansbury, P.T.J.2
  • 275
    • 1242338861 scopus 로고    scopus 로고
    • Interrupting apoptosis in neurodegenerative disease potential for effective therapy?
    • Waldmeir, P.C., Tatton, W.G. (2004) Interrupting apoptosis in neurodegenerative disease potential for effective therapy? Drug Discov. Today, 9, 210-218.
    • (2004) Drug Discov. Today , vol.9 , pp. 210-218
    • Waldmeir, P.C.1    Tatton, W.G.2
  • 276
    • 0033520461 scopus 로고    scopus 로고
    • Amyloid beta-protein fibrillogenesis structure and biological activity of protofibrillar intermediates
    • Walsh, D.M., Hartley, D.M., Kusumoto, Y., Fezoui, Y., Condron, M.M., Lomakin, A. (1999) Amyloid beta-protein fibrillogenesis structure and biological activity of protofibrillar intermediates. J. Biol. Chem., 274, 25945-25952.
    • (1999) J. Biol. Chem , vol.274 , pp. 25945-25952
    • Walsh, D.M.1    Hartley, D.M.2    Kusumoto, Y.3    Fezoui, Y.4    Condron, M.M.5    Lomakin, A.6
  • 279
    • 16544395173 scopus 로고    scopus 로고
    • Parkinson's disease and quality of life: Issues and challenges beyond motor symptoms
    • Welsh, M. (2004) Parkinson's disease and quality of life: issues and challenges beyond motor symptoms. Neurol. Clin., 22, S141-S148.
    • (2004) Neurol. Clin , vol.22
    • Welsh, M.1
  • 280
    • 0037108727 scopus 로고    scopus 로고
    • Functional dissociation of parkin gene promoter with idiopathic Parkinson's disease
    • West, A.B., Maraganore, D., Crook, J. (2002) Functional dissociation of parkin gene promoter with idiopathic Parkinson's disease. Hum. Mol. Genet., 11, 2787-2792.
    • (2002) Hum. Mol. Genet , vol.11 , pp. 2787-2792
    • West, A.B.1    Maraganore, D.2    Crook, J.3
  • 281
    • 0031225736 scopus 로고    scopus 로고
    • Improved therapies for Parkinson's disease: Life beyond dopamine D2/D3 receptor agonist
    • Williams, M., Wright, S., Lloyd, G.K. (1997) Improved therapies for Parkinson's disease: life beyond dopamine D2/D3 receptor agonist. Trends Pharmacol. Sci., 18, 307-310.
    • (1997) Trends Pharmacol. Sci , vol.18 , pp. 307-310
    • Williams, M.1    Wright, S.2    Lloyd, G.K.3
  • 282
    • 0036278335 scopus 로고    scopus 로고
    • Dopamine dependent neurotoxicity of α-synuclein: A mechanism for selective neurodegeneration in Parkinson's disease
    • Xu, J., Kao, S.Y., Lee, F.J., Song, L.W., Yanker, B.A. (2002) Dopamine dependent neurotoxicity of α-synuclein: a mechanism for selective neurodegeneration in Parkinson's disease. Nat. Med., 8, 600-606.
    • (2002) Nat. Med , vol.8 , pp. 600-606
    • Xu, J.1    Kao, S.Y.2    Lee, F.J.3    Song, L.W.4    Yanker, B.A.5
  • 284
    • 10144229354 scopus 로고    scopus 로고
    • A novel azulenyl nitrone antioxidant protects against MPTP and 3-nitropropionic acid neurotoxicities
    • Yang, L., Calingasan, N.Y., Chen, J., Ley, J.J., Becker, D.A. (2005) A novel azulenyl nitrone antioxidant protects against MPTP and 3-nitropropionic acid neurotoxicities. Exp. Neurol., 191, 86-93.
    • (2005) Exp. Neurol , vol.191 , pp. 86-93
    • Yang, L.1    Calingasan, N.Y.2    Chen, J.3    Ley, J.J.4    Becker, D.A.5
  • 285
    • 0345357664 scopus 로고    scopus 로고
    • Downregulation of DJ-1 enhances cell death by oxidative stress, ER stress and proteasome inhibition
    • Yokata, T., Sugawara, K., Ito, K., Takahashi, R., Ariga, H., Mizusawa, H. (2003) Downregulation of DJ-1 enhances cell death by oxidative stress, ER stress and proteasome inhibition. Biochem. Biophy. Res. Commun., 312, 1342-1348.
    • (2003) Biochem. Biophy. Res. Commun , vol.312 , pp. 1342-1348
    • Yokata, T.1    Sugawara, K.2    Ito, K.3    Takahashi, R.4    Ariga, H.5    Mizusawa, H.6
  • 286
    • 4344689871 scopus 로고    scopus 로고
    • Autophagic vacuoles are enriched in amyloid precursor protein secretase activities: Implications for beta-amyloid peptides over production and localization in Alzheimer's disease
    • Yu, W.H., Kumar, A., Peterhoff, C., Kulnane, L.S., Vachiyama, Y. (2004) Autophagic vacuoles are enriched in amyloid precursor protein secretase activities: implications for beta-amyloid peptides over production and localization in Alzheimer's disease. Int. J. Biochem. Cell Biol., 36, 2531-2540.
    • (2004) Int. J. Biochem. Cell Biol , vol.36 , pp. 2531-2540
    • Yu, W.H.1    Kumar, A.2    Peterhoff, C.3    Kulnane, L.S.4    Vachiyama, Y.5
  • 287
    • 0034641936 scopus 로고    scopus 로고
    • Apoptosis in the nervous system
    • Yuan, J., Yanker, B.A. (2000) Apoptosis in the nervous system. Nature, 407, 802-809.
    • (2000) Nature , vol.407 , pp. 802-809
    • Yuan, J.1    Yanker, B.A.2
  • 289
    • 0034700158 scopus 로고    scopus 로고
    • Parkin function as an E2 dependent ubiquitin protein ligase and promotes the degradation of the synaptic vesicle associated protein CDCrel 1
    • Zhang, Y., Gao, J., Chung, K.K., Huang, H., Dawson, V.L., Dawson, T.M. (2000) Parkin function as an E2 dependent ubiquitin protein ligase and promotes the degradation of the synaptic vesicle associated protein CDCrel 1. Proc. Natl. Acad. Sci. USA, 97, 13354-59.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 13354-13359
    • Zhang, Y.1    Gao, J.2    Chung, K.K.3    Huang, H.4    Dawson, V.L.5    Dawson, T.M.6
  • 290
    • 0027358350 scopus 로고
    • Worldwide occurrence of Parkinson's disease: An updated review
    • Zhang, Z.X., Roman, G.C. (1993) Worldwide occurrence of Parkinson's disease: an updated review. Neuroepidemiology, 12, 195-208.
    • (1993) Neuroepidemiology , vol.12 , pp. 195-208
    • Zhang, Z.X.1    Roman, G.C.2
  • 291
    • 28444498107 scopus 로고    scopus 로고
    • Role of nitric oxide in Parkinson's disease
    • Zhang, L., Dawson, V.L., Bricaire, F. (2006) Role of nitric oxide in Parkinson's disease. Pharmacol. Ther., 109, 33-41.
    • (2006) Pharmacol. Ther , vol.109 , pp. 33-41
    • Zhang, L.1    Dawson, V.L.2    Bricaire, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.