A review of central 5-HT receptors and their function

Neuropharmacology

Volumn 38, Issue 8, 1999, Pages 1083-1152

  Barnes, Nicholas M ^a   Sharp, Trevor ^b  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b RADCLIFFE INFIRMARY   (United Kingdom)

Author keywords

5 HT receptor function; 5 hydroxytryptamine; Serotonin

Indexed keywords

1 (1 METHYL 5 INDOLYL) 3 (3 PYRIDYL)UREA; 1 (2 METHOXYPHENYL) 4 (4 PHTHALIMIDOBUTYL)PIPERAZINE; 1 ISOPROPYL 6 METHYLERGOLINE 8 CARBOXYLIC ACID 2 HYDROXY 1 METHYLPROPYL ESTER; 1 METHYL 3 INDOLECARBOXYLIC ACID [1 [2 (METHYLSULFONYLAMINO)ETHYL] 4 PIPERIDINYLMETHYL] ESTER; 1,2,3,5 TETRAHYDRO 5 METHYL 1 (3 PYRIDYLCARBAMOYL)PYRROLO[2,3 F]INDOLE; 2 DIPROPYLAMINO 5 FLUORO 8 HYDROXYTETRALIN; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 2 [(2 DIMETHYLAMINO 2 METHYLPROPYL)THIO] 3 PHENYLQUINOLINE; 2,3,6,7 TETRAHYDRO 1' METHYL 5 [[2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL) 4 BIPHENYLYL]CARBONYL]SPIRO[FURO[2,3 F]INDOLE 3,4' PIPERIDINE]; 3 (1,2,5,6 TETRAHYDRO 4 PYRIDYL)PYRROLO[3,2 B]PYRIDIN 5 ONE; 3 [4 (3 CHLOROPHENYL) 1 PIPERAZINYL] 1,1 DIPHENYL 2 PROPANOL; 4 AMINO 5 CHLORO 2 METHOXYBENZOIC ACID 3 PIPERIDINOPROPYL ESTER; 4 AMINO N [2,6 BIS(METHYLAMINO) 4 PYRIDINYL]BENZENESULFONAMIDE; 4 AMINO N [2,6 BIS(METHYLAMINO) 4 PYRIMIDINYL]BENZENESULFONAMIDE; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; 4 [4 [4 (1,1,3 TRIOXO 2H 1,2 BENZISOTHIAZOL 2 YL)BUTYL] 1 PIPERAZINYL] 1H INDOLE 2 CARBOXYLIC ACID METHYL ESTER; 5 (4 FLUOROBENZAMIDO) 3 (1 METHYL 4 PIPERIDINYL) 1H INDOLE FUMARATE; 5 METHOXY 3 (1,2,3,6 TETRAHYDRO 4 PYRIDYL) 1H INDOLE; 5 METHOXYTRYPTAMINE; 8 AMINO 7 CHLORO 1,4 BENZODIOXAN 5 CARBOXYLIC ACID 1 BUTYL 4 PIPERIDINYLMETHYL ESTER; 8 [2 [(2,3 DIHYDRO 1,4 BENZODIOXIN 2 YL)METHYLAMINO]ETHYL] 8 AZASPIRO[4.5]DECANE 7,9 DIONE MESYLATE; 8 [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 8 AZASPIRO[4.5]DECANE 7,9 DIONE; 8 [3 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]PROPYLCARBAMOYL] 3 METHYLFLAVONE; ALPHA (2,3 DIMETHOXYPHENYL) 1 [2 (4 FLUOROPHENYL)ETHYL] 4 PIPERIDINEMETHANOL; ALPHA METHYLSEROTONIN; BUSPIRONE; CHLORDIAZEPOXIDE; CLOMIPRAMINE; ERGOTAMINE; GEPIRONE; KETANSERIN; LYSERGIDE; METERGOLINE; METHYSERGIDE; METITEPINE; MIANSERIN; N TERT BUTYL 3 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL] 2 PHENYLPROPIONAMIDE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL)[1,1' BIPHENYL] 4 CARBOXAMIDE; NARATRIPTAN; PAROXETINE; PENBUTOLOL; PINDOLOL; RECEPTOR SUBTYPE; RITANSERIN; RIZATRIPTAN; RS 17017; SEROTONIN; SEROTONIN 1A RECEPTOR; SEROTONIN 1B RECEPTOR; SEROTONIN 1D RECEPTOR; SEROTONIN 1E RECEPTOR; SEROTONIN 1F RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN 2B RECEPTOR; SEROTONIN 2C RECEPTOR; SEROTONIN 3 RECEPTOR; SEROTONIN 4 RECEPTOR; SEROTONIN 5A RECEPTOR; SEROTONIN 5B RECEPTOR; SEROTONIN 6 RECEPTOR; SEROTONIN 7 RECEPTOR; SEROTONIN RECEPTOR; SPIPERONE; SUMATRIPTAN; UNCLASSIFIED DRUG; VENLAFAXINE;

ACETYLCHOLINE RELEASE; AMINO ACID COMPOSITION; BEHAVIOR; BINDING SITE; BRAIN REGION; CENTRAL NERVOUS SYSTEM FUNCTION; COGNITION; DORSAL RAPHE NUCLEUS; FOREBRAIN; HIPPOCAMPUS; HUMAN; NONHUMAN; NORADRENALIN RELEASE; PRIORITY JOURNAL; PROTEIN ANALYSIS; RECEPTOR DENSITY; REVIEW;

EID: 0032970989     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(99)00010-6     Document Type: Article

References (638)

1. 3H]LY278 584 binding sites in human brain. J. Neurochem. 60:1993;730-737.
2. 2C receptor protein in human and rat brain using specific antisera. Neuropharmacology. 34:1995;1635-1645.
3. 1F receptor to multiple signal transduction pathways. Naunyn-Schmiedeberg's Arch. Pharmacol. 348:1993;566-575.
4. 1 receptor subtype coupled to the inhibition of adenylate cyclase. Proc. Natl. Acad. Sci. USA. 90:1993;408-412.
5. 1Dβ receptor. Mol. Pharmacol. 41:1992;1-7.
6. 1F receptors for beta-adrenergic antagonists. Neuropharmacology. 33:1994;387-391.
7. 1E receptor couples to inhibition and activation of adenylyl cyclase via two distinct pathways in transfected BS-C-1 cells. Neuropharmacology. 33:1994;403-410.
8. Aghajanian G.K. Influence of drugs on the firing of serotonin-containing neurons in the brain. Fed. Proc. 31:1972;91-96.
9. Aghajanian G.K. Electrophysiology of serotonin receptor subtypes and signal transduction pathways. Bloom F.R., Kupfer D.J. Psychopharmacology: The Fourth Generation of Progress. 1995;1451-1459 Raven, New York.
10. Aghajanian G.K., Marek G.J. Serotonin induces excitatory postsynaptic potentials in apical dendrites of neocortical pyramidal cells. Neuropharmacology. 4/5:1997;589-600.
11. 1A receptor: signaling, desensitization, and gene transcription. Neuropsychopharmacology. 14:1996;19-25.
12. 1A receptor gene. J. Biol. Chem. 265:1990;5825-5832.
13. Altman H.J., Normile H.J., Gershon S. Non-cholinergic pharmacology in human cognitive disorders. Stahl S.M., Iversen S.D., Goodman E.L. Cognitive Neurochemistry. 1987;346-371 Oxford University, Oxford.
14. 1E-like serotonin receptor expressed predominantly in hippocampus. J. Biol. Chem. 267:1992;19761-19764.
15. 4-like receptors mediate the slow excitatory response to serotonin in the rat hippocampus. J. Pharmacol. Exp. Ther. 257:1991;930-937.
16. Andrade R., Nicoll R.A. Pharmacologically distinct actions of serotonin on single pyramidal neurones of the rat hippocampus recorded in vitro. J. Physiol. Lond. 394:1987;99-124.
17. Andrews N., File S.E. Increased 5-HT release mediates the anxiogenic response during benzodiazepine withdrawal - a review of supporting neurochemical and behavioural evidence. Psychopharmacology. 112:1993;21-25.
18. 1A receptors in the median raphe and dorsal hippocampus may mediate anxiolyic and anxiogenic behaviours respectively. Eur. J. Pharmacol. 264:1994;259-264.
19. Andrews N., File S.E., Fernandes C. et al. Evidence that the median raphe nucleus-dorsal hippocampal pathway mediates diazepam withdrawal-induced anxiety. Psychopharmacology. 130:1997;228-234.
20. 4 receptor desensitisation in colliculi neurons. Mol. Pharmacol. 42:1992;808-816.
21. 4 receptors in neurons. Eur. J. Pharmacol. 298:1996;165-174.
22. 1A receptors mediate opposing responses on membrane excitability in rat association cortex. Neuroscience. 40:1991;399-412.
23. 1A receptor antagonist (S)-UH-301 blocks the (R)-8-OH-DPAT-induced inhibition of serotonergic dorsal raphe cell firing in the rat. J. Neural Transm. 96:1994;179-186.
24. Arnt J., Hyttel J., Larsen J.J. The citalopram/5-HTP-induced head shake syndrome is correlated to 5-HT2 receptor affinity and also influenced by other transmitters. Acta Pharmacol. Toxicol. 55:1984;363-372.
25. 1A antagonists. Trends Neurosci. 19:1996;378-383.
26. 2A receptors in the rat medial prefrontal cortex: an iontophoretic study. Synapse. 17:1994;173-181.
27. 3 receptor antagonist BRL46470 on the number of spontaneously active midbrain dopamine cells in the rat. Drug Dev. Res. 31:1994;228-236.
28. 1B receptors. Neurophramacology. 35:1996;213-222.
29. 1A receptor in primate brain neurons and glial cells. Neuropsychopharmacology. 14:1996;35-46.
30. 3 receptors in vitro and in vivo. Eur. J. Pharmacol. 237:1993;299-309.
31. 1C) receptor. Mol. Pharmacol. 38:1990;31-37.
32. 2+/calmodulin-sensitive adenylyl cyclases by the Gs-coupled 5-hydroxytryptamine subtype 5-HT7A receptor. J. Biol. Chem. 273:1998;17469-17476.
33. 7) positively linked to adenylate cyclase. J. Biol. Chem. 268:1993;23422-23426.
34. 2C receptors reveal novel inverse agonist activity of receptor ligands. J. Biol. Chem. 269:1994;11687-11690.
35. 3H]-(S)-zacopride in the forebrain of the rat. Neuropharmacology. 29:1990;1037-1045.
36. 3 recognition sites in human brain tissue. J. Neurochem. 53:1989;1787-1793.
37. 3 receptors mediate inhibition of acetylcholine release in cortical tissue. Nature. 338:1989;762-763.
38. 3 receptor antagonist, on cognition in rodents and primates. Pharmacol. Biochem. Behav. 35:1990;955-962.
39. Barnes J.M., Henley J.M. Molecular characteristics of excitatory amino acid receptors. Programme Neurobiol. 39:1992;113-133.
40. Barnes N.M., Cheng C.H.K., Costall B. et al. Differential modulation of extracellular levels of 5-hydroxytryptamine in the rat frontal cortex by (R)- and (S)-zacopride. Br. J. Pharmacol. 107:1992;233-239.
41. 1E binding sites in rodent brains: effect of lesion of serotonergic neurones. Eur. J. Pharmacol. 249:1993;221-230.
42. Bartus R.T., Dean R.L., Beer B. et al. The cholinergic hypothesis of geriatric memory dysfunction. Science. 217:1982;408-417.
43. 2B receptors. Behav. Brain Res. 73:1996;149-152.
44. 2B) in rat stomach fundus longitudinal muscle. Br. J. Pharmacol. 112:1994;323-331.
45. 2 receptor subtypes: a family re-united? Trends Pharmacol. Sci. 16:1995;105-110.
46. 7 receptor mediated inhibition of sAHP in CA3 hippocampal pyramidal cells. Fourth IUPHAR Satellite meeting on Serotonin, Rotterdam, S1.3.
47. 7 receptor mediated inhibition of sAHP in CA3 hippocampal pyramidal cells. Soc. Neurosci. Abstr. 24:1998;435.4.
48. 1D receptor binding affinity of 5-hydroxytryptamine, 5-carboxyamidotryptamine and sumatriptan in the central nervous system of seven species. Eur. J. Pharmacol. 213:1992;193-197.
49. As receptor subunit. Mol. Pharmacol. 48:1995;1054-1062.
50. Benloucif S., Keegan M.J., Galloway M.P. Serotonin-facilitated dopamine release in vivo-pharmacological characterisation. J. Pharmacol. Exp. Ther. 265:1993;373-377.
51. 3 receptor antagonists in neuropsychiatric disorders. CNS Drugs. 3:1995;363-392.
52. 1C-receptors in drug-induced penile erections in rats. Psychopharmacology. 101:1990;57-61.
53. Berman R.M., Darnell A.M., Miller H.L. et al. Effect of pindolol in hastening response to fluoxetine in the treatment of major depression: a double-blind, placebo-controlled trial. Am. J. Psychiatry. 154:1997;37-43.
54. 1A receptors postsynaptic to serotoninergic neurones mediate spontaneous tail-flicks in the rat. J. Pharmacol. Exp. Ther. 264:1993;95-104.
55. 3 agonists decrease acetylcholine efflux from the cerebral cortex of freely-moving guinea-pigs. Br. J. Pharmacol. 101:1990;448-452.
56. Bill D.J., Knight M., Forster E.A. et al. Direct evidence for an important species difference in the mechanism of 8-OH-DPAT-induced hypothermia. Br. J. Pharmacol. 103:1991;1857-1864.
57. Bird E.D. Huntington's disease. Riederer P., Kopp N., Pearson J. An Introduction to Neurotransmission. Health and Disease. 1990;221-233 Oxford Medical, Oxford.
58. 1A receptor antagonist (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: inhibition of (R)-8-hydroxy-2-(dipropylamino)tetralin-induced effects. J. Pharmacol. Exp. Ther. 258:1991;58-65.
59. 3 receptor releases dopamine from rat striatal slices. Eur. J. Pharmacol. 155:1988;349-350.
60. Blandina P., Goldfarb J., Craddock-Royal B., Green J.P. Realease of endogenous dopamine by stimulation of 5-hydroxytryptamine-3 receptors in rat striatum. J. Pharm. Exp. Ther. 251:1989;803-809.
61. 3H]5-HT release in the guinea-pig hypothalamus are not autoreceptors. Synapse. 15:1993;143-148.
62. 1 receptor agonists and p-chloroamphetamine. Synapse. 5:1990;120-133.
63. Bliss T.V.P., Collingridge G.L. A synaptic model of memory-long-term potentiation in the hippocampus. Nature. 361:1993;31-39.
64. 4 receptor cloned from human atrium. FEBS Lett. 412:1997;465-474.
65. 4 receptor isoforms produced by alternative splicing in the carboxyl terminus. J. Neurochem. 70:1998;2252-2261.
66. 4(C) receptor. Br. J. Pharmacol. 125:1998b;595-597.
67. 2 receptors and serotonergic axons in rat neocortex. Brain Res. 453:1988;315-328.
68. 2 receptors in nucleus prepositus hypoglossi. J. Neurosci. 14:1994;2428-2434.
69. 1B receptors. J. Pharmacol. Exp. Ther. 250:1989;37-43.
70. 4) receptors positively coupled to adenylate cyclase in adult guinea pig hippocampal membranes: effect of substituted benzamide derivatives. Mol. Pharmacol. 37:1990;408-411.
71. 4 receptors. Naunyn-Schmiedeberg's Arch. Pharmacol. 358(1):1998;1.4.
72. Boddeke H.W.G.M., Kalkman H.O. Zacopride and BRL24924 induce an increase in EEG-energy in rats. Br. J. Pharmacol. 101:1990;281-284.
73. Boddeke H.W.G.M., Kalkman H.O. Agonist effects at putative central 5-HT4 receptors in rat hippocampus by R(+)- and S(-)-zacopride: no evidence for stereoselectivity. Neurosci. Lett. 134:1992;261-263.
74. 1B receptors. Naunyn-Schmiedeberg's Arch. Pharmacol. 348:1993;553-557.
75. 1B receptors suppresses low but not high frequency synaptic transmission in the rat subicular cortex in vitro. Brain Res. 721:1996;59-65.
76. (3). J. Neurochem. 64:1995;1401-1405.
77. Boess F.G., Martin I.L. Molecular biology of 5-HT receptors. Neuropharmacology. 33:1994;275-317.
78. 6 receptors stably expressed in HEK293 cells. Neuropharmacology. 36:1997;713-720.
79. 3H]Ro 63-0563 labels 5-hydroxytryptamine receptor binding sites in rat and porcine striatum. Mol. Pharmacol. 54:1998;577-583.
80. 2C receptors. Br. J. Pharmacol. 115:1995;622-628.
81. 2C receptor antagonist. Neuropharmacology. 36:1997;621-629.
82. 4 receptor subtype involvement in the enhancement of striatal dopamine release induced by serotonin: a microdialysis study in the halothane-anesthetized rat. Neuropharmacology. 34:1995;269-279.
83. 1B receptor is localized predominantly on axon terminals. Neuroscience. 58:1994;167-182.
84. 1B receptors are negatively coupled with adenylate cyclase in rat substantia nigra. Eur. J. Pharmacol. 151:1988;189-196.
85. 6 receptor in the rat brain: a study using antisense oligonucleotides. J. Pharmacol. Exp. Ther. 274:1995;173-180.
86. Bourson A., Wanner D., Wyler R. et al. Pharmacologic evaluation of the discriminative stimulus of metachlorophenylpiperazine. Pharmacol. Biochem. Behav. 53:1996;107-114.
87. 6 receptors in nigro-striatal function in rodents. Br. J. Pharmacol. 125:1998;1562-1566.
88. Bradley P.B., Engel G., Feniuk W. et al. Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine. Neuropharmacology. 25:1986;563-576.
89. Bradwejn J., Koszycki D. The cholecystokinin hypothesis of anxiety and panic disorder. Ann. N.Y. Acad. Sci. 713:1994;273-282.
90. 6 receptor function. Soc. Neurosci. Abstr. 23:1997;116.9.
91. 2C receptors expressed in the human neuroblastoma cell line 5H-SY-5Y. Br. J. Pharmacol. 125:1998;727-734.
92. 1B binding sites in rat brain. Naunyn-Schmiedeberg's Arch. Pharmacol. 347:1993;569-582.
93. 1F, receptor messenger RNA in rodent and primate brain. Neuropharmacology. 33:1994;367-386.
94. 1D binding sites in human and guinea-pig brain using different radioligands. Brain Res. Mol. Brain Res. 21:1994;19-29.
95. 1A/1C binding sites revealed by quantitative receptor autoradiography. Neuroscience. 53:1994;465-473.
96. 1C receptors. Br. J. Pharmacol. 88:1986;367P.
97. 3 receptor in the human forebrain. Neuropharmacology. 32:1993;1325-1332.
98. 1D beta-like autoreceptors in the guinea-pig brain cortex. Naunyn-Schmiedeberg's Arch. Pharmacol. 353:1996;281-289.
99. Burns C.M., Chu H., Rueter S.M. et al. Regulation of serotonin-2C receptor G-protein coupling by RNA editing. Nature. 387:1997;303-308.
100. Burt D.R., Kanatchi GABAA receptor subtypes: from pharmacology to molecular biology. FASEB J. 5:1991;2916-2923.
101. Busatto G.F., Kerwin R.W. Perspectives on the role of serotonergic mechanisms in the pharmacology of schizophrenia. J. Psychopharmacol. 11:1997;3-12.
102. 2A receptor mRNA in human brain. Brain Res. 676:1995;157-168.
103. Cadogan A.K., Kendall D.A., Fink H. et al. Social interaction increases 5-HT release and cAMP efflux in the rat ventral hippocampus in vivo. Behav. Pharmacol. 5:1994;299-305.
104. 2 sites: clozapine potently interacts with 5-HT1C sites. Eur. J. Pharmacol. 191:1990;93-96.
105. 2C receptor produced by alternative splicing. Mol. Pharmacol. 50:1996;799-807.
106. 4 receptors couple positively to tetrodotoxin-insensitive sodium channels in a subpopulation of capsaicin-sensitive rat sensory neurons. J. Neurosci. 17:1997;7181-7189.
107. Carey G.J., Costall B., Domeney A.M., Gerrard P.A., Jones D.N.C., Naylor R.J., Tyers M.B. Ondansetrron and arecoline prevent scopolamine-induced cognitive deficits in the marmoset. Pharmacol. Biochem. Behav. 42:1992;143-153.
108. 1A receptor antagonist, prevents the impairment of spatial learning caused by intrahippocampal scopolamine. Eur. J. Pharmacol. 283:1995;133-139.
109. 1A antagonist, prevents the impairment of spatial learning caused by intrahippocampal administration of scopolamine or 7-chloro-kyneurenic acid. Eur. J. Pharmacol. 774:1997;167-174.
110. 5A serotonin receptor is expressed predominantly by astrocytes in which it inhibits cAMP accumulation: a mechanism for neuronal suppression of reactive astrocytes. Glia. 17:1996;317-326.
111. Casanovas J.M., Artigas F. Differential effects of ipsapirone on 5-hydroxytryptamine release in the dorsal and median raphe neuronal pathways. J. Neurochem. 67:1996;1945-1952.
112. 3H]acetylcholine release in hippocampal slices of rats with fimbria-fornix lesions and intrahippocampal grafts of septal origin. Brain Res. 704:1995;153-166.
113. 1F) in human brain: focus on brain stem and spinal cord. Neuropharmacology. 36:1997;535-542.
114. Castro E., Romón T., Castillo J. et al. Identification and characterisation of a new serotonergic recognition site with high affinity for 5-carboxamidotryptamine in mammalian brain. J. Neurochem. 69:1997;2123-2131.
115. Ceci A., Baschirotto A., Borsini F. The inhibitory effect of 8-OH-DPAT on the firing activity of dorsal raphe serotoninergic neurons in rats is attenuated by lesion of the frontal cortex. Neuropharmacology. 33:1994;709-713.
116. 1A binding in rat brain-a combined in situ hybridisation/in vitro receptor autoradiographic study. Brain Res. 561:1991;51-60.
117. Chaput Y., Aranda R.C., Andrade R. Pharmacological and functional analysis of a novel serotonin receptor in the rat hippocampus. Eur. J. Pharmacol. 182:1990;441-456.
118. Charney D.S., Krystal J., Delgado P.L. et al. Serotonin-specific drugs for anxiety and depressive disorders. Ann. Rev. Med. 41:1990;437-446.
119. 1B receptor. Br. J. Pharmacol. 110:1993;1621-1629.
120. Chen N.H., Reith M.E. Monoamine interactions measured by microdialysis in the ventral tegmental area of rats treated systemically with (±)-8-hydroxy-2-(di-n-propylamino)tetralin. J. Neurochem. 64:1995;1585-1597.
121. 2 receptor is encoded by a multiple intron-exon gene. Mol. Brain Res. 14:1992;20-26.
122. Cheng C.H.K., Costall B., Kelly M.E., Naylor R.J. Actions of 5-hydroxytryptophan to inhibit and disinhibit mouse behaviour in the light/dark test. Eur. J. Pharmacol. 255:1994;39-49.
123. 2B receptor-mediated serotonin morphogenetic functions in mouse cranial neural crest and myocardiac cells. Development. 124:1997;1745-1755.
124. 4) to the long arm of chromosome 5 (5q31-q33). Mol. Memr. Biol. 15:1998;75-78.
125. 1A-mediated inhibition of adenylyl cyclase in dorsal raphe of male and female rats. J. Pharmacol. Exp. Ther. 277:1996;1259-1266.
126. 4) to human chromosome 5 bands q31-q33 by in situ hybridisation. Cytogenet. Cell Genet. 78:1997;133-134.
127. 4S receptors. Effect of receptor density on their coupling to adenylyl cyclase. NeuroReport. 8:1997;3189-3196.
128. 4 receptors: from gene to function. In: Proceedings of the Advances in serotonin receptor research. San Francisco, USA, 8-10th October.
129. 4L receptor. FEBS Lett. 398:1996;19-25.
130. 7 receptors in the rat hypothalamus without alteration in exploratory behaviour or neuroendocrine function. J. Neurochem. 71:1998;1271-1279.
131. 7 receptor levels in the rat brain. Br. J. Pharmacol. (in press).
132. 1A autoreceptor in vivo. Br. J. Pharmacol. 124:1998;206-212.
133. Cockcroft V.B., Osguthorpe D.J., Barnard E.A. et al. Ligand-gated ion channels: homology and diversity. Mol. Neurobiol. 4:1990;129-169.
134. Collingridge G.L., Singer W. Excitatory amino acid receptors and synaptic plasticity. Trends Pharmacol. Sci. 11:1990;290-296.
135. 2 binding site. J. Neurosci. 6:1986;3669-3675.
136. 1C) receptors. J. Pharmacol. Exp. Ther. 242:1987;552-557.
137. 2 antagonists inhibit serotonin stimulated phosphatidyl inositol metabolism in cerebral cortex. Neuropharmacology. 23:1984;993-996.
138. Conner D.A., Mansour T.E. Serotonin receptor-mediated activation of adenylate cyclase in the neuroblastoma NCB20: a novel 5-hydroxytryptamine receptor. Mol. Pharmacol. 37:1990;742-751.
139. 4 receptor stimulation facilitates acetylcholine release in rat frontal cortex. NeuroReport. 5:1994;1230-1232.
140. 3 receptors. J. Neurochem. 62:1994;2254-2261.
141. 1B receptors. J. Pharmacol. Exp. Ther. 277:1996;823-830.
142. 2A receptor. J. Neurochem. 63:1994;465-469.
143. Corradetti R., Ballerinin L., Pugliese A.M. et al. Serotonin blocks the long-term potentiation induced by primed burst stimulation in the CA1 region of rat hippocampal slices. Neuroscience. 46:1992;511-518.
144. Corradetti R., Le Poul E., Laaris N. et al. Electrophysiological effects of N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl) cyclohexane carboxamide (WAY 100 635) on dorsal raphe serotonergic neurons and CA1 hippocampal pyramidal cells in vitro. J. Pharmacol. Exp. Ther. 278:1996;679-688.
145. 4 receptor antagonists attenuate the disinhibitory effects of diazepam in the mouse light/dark test. Br. J. Pharmacol. 119:1996;352P.
146. 3 receptors. Pharmacol. Toxicol. 71:1992;401-415.
147. 4 receptor antagonists to modify drug induced disinhibitory effects in the mouse light/dark test. Br. J. Pharmacol. 122:1997;1105-1118.
148. 3 receptor antagonist GR38032F, on raised dopaminergic activity in the mesolimbic system of the rat and marmoset brain. Br. J. Pharmacol. 92:1987;881-894.
149. 3 receptor agonists and antagonists for alteration of aversive behaviour in the mouse. Br. J. Pharmacol. 96:1989;325-332.
150. Cowen P.J., Anderson I.M., Gartside S.E. Endocrinological responses to 5-HT. Ann. N.Y. Acad. Sci. 600:1990;250-257.
151. 2C receptor supersensitivity. Psychol. Med. 26:1996;1155-1159.
152. 4 receptor. J. Pharmacol. Exp. Ther. 252:1990;1378-1386.
153. Craven R.M., Grahame-Smith D.G., Newberry N.R. WAY-100 635 and GR127 935: effects on 5-hydroxytryptamine-containing neurones. Eur. J. Pharmacol. 271:1994;1-3.
154. 2-like receptor-mediated depolarization of 5-HT-containing dorsal raphe neurons in vitro. Br. J. Pharmacol. 120:1997;261P.
155. 3H]acetylcholine release in rat cortical synaptosomes. Pharmacol. Res. 35:1997;351-354.
156. 1A receptor antagonist WAY 100 635. Eur. J. Pharmacol. 264:1994;95-97.
157. 7 receptor agonist, on locomotor activity in golden hamster in constant darkness. Neurosci. Lett. 210:1996;1-4.
158. Dahlström, A., Fuxe, K., 1964. Evidence for the existence of monoamine-containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons. Acta Physiol. Scand. 62, Suppl. 232.
159. 1D receptors. Br. J. Pharmacol. 121:1997;737-742.
160. 1D autoreceptors. Br. J. Pharmacol. 114:1995;1107-1109.
161. 3B subunit is a major determinant fo serotonin-receptor function. Nature. 397:1999;359-363.
162. 4 receptors indirectly enhances in vivo dopamine release in the rat striatum. J. Neurochem. 68:1997;195-203.
163. 3 receptors. J. Neurosci. 18:1998;6528-6538.
164. 2+ responses in rat primary astrocyte cultures. J. Neurosci. Res. 35:1993;246-256.
165. DeLean A., Kilpatrick B.F., Caron M.G. Dopamine receptor of the porcine anterior-pituitary gland - evidence for two affinity states discriminated by both agonists and antagonists. Mol. Pharmacol. 22:1982;290-297.
166. 1D beta) encoded by an intronless gene on chromosome 6. Proc. Natl. Acad. Sci. USA. 89:1992;5522-5526.
167. De Montigny C., Blier P., Chaput Y. Electrophysiologically-identified serotonin receptors in the rat CNS: effect of antidepressant treatment. Neuropharmacology. 23:1984;1511-1520.
168. 3 receptors are membrane ion channels. Nature. 339:1989;706-709.
169. 1A-receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in guinea-pig and rat hippocampal membranes. J. Pharmacol. Exp. Ther. 238:1986;248-252.
170. 1A receptor agonists: recent developments and controversial issues. Psychopharmacology. 121:1995;1-26.
171. 3 receptors and GABAergic neurons inhibiting acetylcholine release in rat entorhinal cortex slices. Brain Res. 801:1998;228-232.
172. 1A antagonist. Br. J. Pharmacol. 115:1995;1169-1174.
173. 2C/2B receptros enhances dopamine release in the rat nucleus accumbens. Neuropharmacology. 37:1998;265-272.
174. 4 receptor binding sites in human brain: comparison with other mammalian species. Mol. Brain Res. 21:1994;176-180.
175. 2 receptors: microdialysis studies in the awake and anaesthetized rat. Neuropharmacology. 33:1994;411-421.
176. 2 receptor activation decreases noradrenaline release in rat hippocampus in vivo. Br. J. Pharmacol. 107:1992;240-245.
177. 1B receptor in serotoninergic neurons of anterior raphe nuclei in the rat brain. Synapse. 19:1995;18-28.
178. 1B receptor antagonist. Naunyn-Schmiedeberg's Arch. Pharmacol. 356:1997;328-334.
179. 3 receptors. Br. J. Pharmacol. 114:1995;1641-1651.
180. Dulawa S.C., Graihle R., Hen R., Geyer M.A. Characterisation of exploratory behavior and sensorimotor gating in wild type and serotonin 5A knockout mice. Soc. Neurosci. Abstr. 23:1997;482.20.
181. Duman R.S., Heninger G.R., Nestler E.J. A molecular and cellular theory of depression. Arch. Gen. Psychiatry. 54:1997;597-606.
182. Dumuis A., Bouhelal R., Sebben M. et al. A nonclassical 5-hydroxytryptamine receptor positively coupled with adenylate cyclase in the central nervous system. Mol. Pharmacol. 34:1988;880-887.
183. 2B receptor protein in the rat central nervous system. Neuroscience. 76:1997;323-329.
184. 2B receptors in the medial amygdala causes anxiolysis in the social interaction test in the rat. Neuropharmacology. 36:1997;601-608.
185. Edgar D.M., Miller J.D., Prosser R.A. et al. Serotonin and the mammalian circadian system. II. Phase-shifting rat behaviour rhythms with serotonergic agonists. J. Biol. Rhythms. 8:1993;17-31.
186. 7 receptor: orphan found. Trends Pharmacol. Sci. 18:1997;104-107.
187. Eiselé J.-L., Bertrand S., Galzi J.-L. et al. Chimaeric nicotinic-serotonergic receptor combines distinct ligand binding and channel specificities. Nature. 366:1993;479-483.
188. Eison A.S., Eison M.S., Iversen S.D. The behavioural effects of a novel substance P analogue following infusion into the ventral tegmental area and like substantia nigra of the rat brain. Brain Res. 238:1992;137-152.
189. 4 receptors in guinea-pig ascending colon. Eur. J. Pharmacol. 196:1991;149-155.
190. 1B binding sites. Naunyn-Schmiedeberg's Arch. Pharmacol. 332:1986;1-7.
191. 7) receptor gene: genomic organisation and systematic mutation screening in schizophrenia and bipolar affective disorder. Mol. Psychiatry. 1:1996;392-397.
192. Erlander M.G., Lovenberg T.W., Baron B.M. et al. Two members of a distinct subfamily of 5-hydroxytryptamine receptors differentially expressed in rat brain. Proc. Natl. Acad. Sci. 90:1993;3452-3456.
193. + current in colliculi neurones via activation of a cyclic AMP-dependent protein kinase. Br. J. Pharmacol. 105:1992;973-979.
194. 1A receptor. Nature. 335:1988;358-360.
195. 1C. Fundam. Clin. Pharmacol. 2:1988;195-214.
196. Feng D.F., Doolittle R.F. Progressive sequence alignment as a prerequisite to correct phylogenetic trees. J. Mol. Evol. 25:1987;351-360.
197. 3H]GABA in human, but not in rabbit, neocortex. Neurosci. Lett. 209:1996;210-214.
198. Fillion G., Rousselle J.C., Beaudoin D. et al. Serotonin sensitive adenylate cyclase in horse brain synaptosomal membranes. Life Sci. 24:1975;1813-1822.
199. 1Dβ receptors. Naunyn-Schmiedeberg's Arch. Pharmacol. 352:1995;451-454.
200. 2C receptor-mediated phosphoinositide turnover and the stimulus effects of m-chlorophenylpiperazine. Psychopharmacology. 122:1995;237-243.
201. 1A receptors. Eur. J. Pharmacol. 237:1993;283-291.
202. 1A receptor antagonists: utility as research tools and therapeutic agents. Trends Pharmacol. Sci. 14:1993;41-48.
203. 1A receptor antagonist. Behav. Brain Res. 73:1996;337-353.
204. 3 receptors from porcine brain. Br. J. Pharmacol. 122:1997;655-662.
205. 3 receptors really homomeric complexes? Trends Pharmacol. Sci. 19:1998;212-215.
206. 3 receptors do not contain nicotinic acetylcholine receptor subunits. Neuropharmacology. 37:1998;397-399.
207. Foguet M., Hoyer D., Pardo L.A. et al. Cloning and functional characterization of the rat stomach fundus serotonin receptor. EMBO J. 11:1992;3481-3487.
208. 2 and stomach fundus serotonin receptor genes. NeuroReport. 3:1992;345-348.
209. 4 receptor ligands in rat spatial navigation. Neuropharmacology. 4/5:1997;689-696.
210. 7 receptor antagonist. J. Med. Chem. 41:1998;655-657.
211. 4 receptor. Med. Res. Rev. 13:1993;633-662.
212. 1A antagonists BMY 7378, NAN 190 and (-)-propranolol on serotonergic dorsal raphe unit activity in behaving cats. J. Pharmacol. Exp. Ther. 270:1994;1359-1366.
213. 1A antagonist, increases serotonergic neuronal activity in behaving cats: comparison with (S)-WAY-100135. J. Pharmacol. Exp. Ther. 278:1996;752-762.
214. 2 receptors are enriched on neocortical pyramidal neurones destroyed by intrastriatal volkensin. J. Pharmacol. Exp. Ther. 261:1992;1273-1281.
215. Francken, B.J.B., Jurzak, M., Luyten, W.H.M.L., et al., 1998. h5-HT5A receptor in stably transfected HEK293 cells couples to G-proteins and receptor activation inhibits adenylate cyclase. Fourth IUPHAR Satellite meeting on Serotonin, Rotterdam, pp. 66.
216. Froehner S.C., Luetje C.W., Scotland P.B. et al. The postsynaptic 43K protein clusters muscle nicotinic acetylcholine receptors in Xenopus oocytes. Neuron. 5:1990;403-410.
217. Fuller R.W. Serotonin receptors involved in the regulation of pituitary-adrenocrtical function in rats. Behav. Brain Res. 73:1996;215-219.
218. Gaddum J.H., Picarelli Z.P. Two kinds of tryptamine receptor. Br. J. Pharmacol. 12:1957;323-328.
219. 4 receptor. Br. J. Pharmacol. 111:1994;332-338.
220. Galeotti N., Ghelardini C., Teodori E. et al. Antiamnesic activity of metoclopramide, cisapride and SR-17 in the mouse passive avoidance test. Pharmacol. Res. 36:1997;59-67.
221. 4 receptors in the mouse passive avoidance test. J. Pharmacol. Exp. Ther. 286:1998;1115-1121.
222. 3H]hydroxytryptamine in slices of the human neocortex. J. Neurochem. 59:1992;1293-1301.
223. 1A receptor function in the rat in vivo. Eur. J. Pharmacol. 191:1990;391-400.
224. 1A receptor antagonist and an SSRI in vivo: effects on 5-HT cell firing and extracellular 5-HT. Br. J. Pharmacol. 115:1995;1064-1070.
225. Gartside S.E., McQuade R., Sharp T. Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on 5-HT cell firing and release: comparison between dorsal and median raphe 5-HT systems. Neuropharmacology. 36:1997;1697-1703.
226. 1-adrenoceptors. Psychopharmacology. 130:1997;261-268.
227. 4 receptor mediated modulation of 5-HT release in the rate hippocampus in vivo. Br. J. Pharmacol. 117:1996;1474-1980.
228. 7 receptor gene (HTR7) to chromosome 10q and exclusion of genetic linkage with Tourette syndrome. Genomics. 26:1995;207-209.
229. 4 receptor: molecular cloning and pharmacological characterisation of two splice variants. EMBO J. 14:1995;2806-2815.
230. 6 receptor mRNA in the central nervous system of control or 5,5-dihydroxytryptamine-treated rats. Synapse. 23:1996;164-173.
231. 6 receptor-like material in the rat central nervous system. Brain Res. 746:1997;207-219.
232. Gerfen C.R. The neostriatal mosaic: multiple levels of compartmental organization. Trends Neurosci. 15:1992;133-139.
233. Geyer M.A. Serotonergic functions in arousal and motor activity. Behav. Brain Res. 73:1996;31-36.
234. 1A receptor subtype increases rat plasma ACTH concentration. Eur. J. Pharmacol. 147:1988;431-439.
235. 6serotonin receptors may reflect psychoactive profile. Mol. Med. 1, 398-406.
236. 2 agonists or antagonists? Neuropsychopharmacology. 3:1990;509-517.
237. Glennon R.A., Lucki I. Behavioural models of serotonin receptor activation. Sanders-Bush E. The Serotonin Receptors. 1988;253-293 The Humana, Clifton, NJ.
238. 1nonA-nonB receptors in rat hypothalamus? Mol. Pharmacol. 49:1996;556-559.
239. 2 function after 5,7-dihydroxytryptamine lesioning or repeated antidepressant treatments. J. Neurochem. 50:1988;730-738.
240. 2 receptor antagonist, RP 62203, selectively blocks serotoninergic but not dopaminergic induced inhibition in the rat prefrontal cortex. Eur. J. Pharmacol. 204:1991;97-100.
241. 1 function. Neuropharmacology. 24:1985;1187-1194.
242. 2 receptors: involvement of the prepositus hypoglossal nucleus. Neuropharmacology. 30:1991;1309-1318.
243. 3H]PAT. Nature. 305:1983;140-142.
244. Green A.R., Grahame-Smith D.G. Effects of drugs on the processes regulating the functional activity of brain 5-hydroxytryptamine. Nature. 260:1976;487-491.
245. Green A.R., Heal D.J. The effects of drugs on serotonin-mediated behavioural models. Green A.R. Neuropharmacology of Serotonin. 1985;326-365 Oxford University, Oxford.
246. 3 receptor antagonists - a critical update on therapeutic potential. Trends Pharmacol. Sci. 14:1993;265-270.
247. Grailhe R., Waeber C., Brunner D. et al. The 5-HT5A receptors: localization in the CNS and increased exploratory activity in 5-HT5A knockout mice. Soc. Neurosci. Abstr. 23:1997;482.19.
248. 1A receptor antagonists NAN-190 and BMY 7378 are partial agonists in the rat dorsal raphe nucleus in vitro. Eur. J. Pharmacol. 211:1992;211-219.
249. 4 receptors in guinea-pig and rat brain. Br. J. Pharmacol. 109:1993;618-624.
250. 2A receptors in heterologous expession systems. J. Neurochem. 63:1994;1255-1260.
251. 2A receptors expressed in fibroblasts. J. Pharm. Exp. Ther. 271:1994;1122-1126.
252. 1A receptors. Mol. Pharmacol. 41:1992;695-698.
253. 1A receptors. Neuropharmacology. 25:1986;1307-1313.
254. 1E-like serotonin receptor. Mol. Pharmacol. 43:1993;412-418.
255. 7 receptor in rat brain. Br. J. Pharmacol. 117:1996;657-666.
256. 3 receptor mutant mice. Soc. Neurosci. Abstr. 23:1997;116.7.
257. 1A receptors in mediating 5-hydroxytryptophan induced myoclonic jerks in guinea pigs. Eur. J. Pharmacol. 294:1995;743-751.
258. Haigler H.J., Aghajanian G.K. Lysergic acid diethylamide and serotonin: a comparison of the effects on serotoninergic neurons and neurons receiving a serotonergic input. J. Pharmacol. Exp. Ther. 188:1974;688-699.
259. Hajós M., Gartside S.E., Sharp T. Inhibition of median and dorsal raphe neurones following administration of the selective serotonin reuptake inhibitor paroxetine. Naunyn-Schmiedeberg's Arch. Pharmacol. 351:1995;624-629.
260. 1A receptor-mediated modulation of neuronal activity of the medial prefrontal cortex, Forum Eur. Neurosic. Abstr.
261. 1A receptor-induced inhibition o 5-HT neuronal activity in the rat. Br. J. Pharmacol. (in press).
262. 1 receptors. Eur. J. Pharmacol. 314:1996;285-291.
263. 1A receptor ligands on Fos-like immunoreactivity in rat brain: evidence for activation of noradrenergic transmission. Synapse (in press).
264. Hajós-Korcsok E., McQuade R., Sharp T. Influence of 5-HT1A receptors on central noradrenergic activity: microdialysis studies using (±)-MDL 73(005EF and its enantiomers. Neuropharmacology. 38:1999;299-306.
265. 1D-type serotonin receptor. Mol. Pharmacol. 40:1991;143-148.
266. 1D-like pharmacological specificity. Biochem. Biophys. Res. Comm. 184:1992;752-759.
267. 1D receptors in rat: structural and pharmacological comparison of the two cloned receptors. Mol. Cell. Neurosci. 3:1992;578-587.
268. Handley S.L. 5-Hydroxytryptamine pathways in anxiety and its treatment. Pharmacol. Ther. 66:1995;103-148.
269. Handley S.L., McBlane J.W. 5-HT drugs in animal models of anxiety. Psychopharmacology. 112:1993;13-20.
270. 1A antagonist, WAY 100635, ameliorates the cognitive impairment induced by fornix transection in the marmoset. Psychopharmacology. 127:1996;245-254.
271. 1 receptor distinct from 1A, 1B and 1C subtypes. J. Neurochem. 56:1991;221-227.
272. Harro J., Vasar E., Bradwejn J. CCK in animal and human research on anxiety. Trends Pharmacol. Sci. 14:1993;244-249.
273. 1D receptor genes. Trends Pharmacol. Sci. 13:1992;152-159.
274. 1D receptor subtypes. Trends Pharmacol. Sci. 17:1996;103-105.
275. 7) receptor isoforms in human and rat produced by alternative splicing: species differences due to altered intron-exon organization. J. Neurochem. 68:1997;1372-1381.
276. 7) receptor isoforms produced by alternative splicing. Neuropharmacology. 37:1998;1621-1632.
277. Heinemann S., Boulter J., Connolly J. et al. The nicotinic receptor genes. Clin. Neuropharmacol. 14:1991;S45-S61.
278. Hen R. Of mice and flies - commonalities among 5-HT receptors. Trends Pharmacol. Sci. 13:1992;160-165.
279. Hen R., Rocha B.A., Grailhe R. et al. The role of serotonin 1A, 1B and 5A receptor subtypes in self-administration and locomotor responses to drugs of abuse. Soc. Neurosci. Abstr. 24:1998;567.8.
280. 3H]-5-hydroxytryptamine binding site subtype in bovine brain membranes. J. Neurosci. 7:1987;894-903.
281. 1-like and GABA receptors in the dorsal raphe nucleus of the rat. Neuropharmacology. 27:1988;993-1001.
282. 1D receptors in the substantia nigra of the guinea-pig elicits contralateral rotation. Br. J. Pharmacol. 102:1991;305-310.
283. 3-receptor antagonists. Psychopharmacology. 104:1991;545-551.
284. Hillegaart V. Effects of local application of 5-HT and 8-OH-DPAT into the dorsal and median raphe nuclei on core temperature in the rat. Psychopharmacology. 103:1991;291-296.
285. 1A-receptor antagonist. J. Med. Chem. 33:1990;1541-1544.
286. Hirst W.D., Price G.W., Rattray M. et al. Identification of 5-hydroxytryptamine receptors positively coupled to adenylyl cyclase in rat cultured astrocytes. Br. J. Pharmacol. 120:1997;509-515.
287. 1A autoreceptor blockade potentiates the ability of the 5-HT reuptake inhibitor citalopram to increase nerve terminal output of 5-HT in vivo: a microdialysis study. J. Neurochem. 60:1993;776-779.
288. 1-adrenoceptors in the inhibition of 5-HT release I. BMY7378 and prazosin. Neuropharmacology. 34:1995;615-620.
289. Hjorth S., Carlsson A., Lindberg P. et al. 8-Hydroxy-2-(di-n-propylamino)tetralin, 8-OH-DPAT, a potent and selective simplifies ergot congener with central 5-HT receptor stimulating activity. J. Neural. Transm. 55:1982;169-188.
290. 1A receptors: behavioural and in vivo brain microdialysis studies. Life Sci. 46:1990;955-963.
291. 1B autoreceptor blocking properties of the beta adrenoceptor antagonist (-)penbutolol. J. Pharmacol. Exp. Ther. 265:1993;707-712.
292. 1B receptor agonist CP-93129 suppresses rat hippocampal 5-HT release in vivo: comparison with RU 24969. Eur. J. Pharmacol. 209:1991;249-252.
293. 1C receptor mRNA in adult rat brain. FEBS Lett. 247:1989;453-462.
294. 3 receptor A subunit. Eur. J. Pharmacol. 245:1993;187-192.
295. 3 receptor purified from mammalian cells. J. Neurochem. 70:1998;824-834.
296. Hoyer D., Boddeke H.W.G.M. Partial agonists, full agonists, antagonists: dilemmas of definition. Trends Pharmacol. Sci. 14:1993;270-275.
297. Hoyer D., Martin G. 5-HT receptor-classification and nomenclature: towards harmonization with the human genome. Neuropharmacology. 36:1997;419-428.
298. Hoyer D., Middlemiss D.N. The pharmacology of the terminal 5-HT autoreceptors in mammalian brain: evidence for species differences. Trends Pharmacol. Sci. 10:1989;130-132.
299. 1B recognition sites. Brain Res. 376:1986;85-96.
300. 125I]iodocyanopindolol. Eur. J. Pharmacol. 118:1985;1-12.
301. 3H]ketanserin. Eur. J. Pharmacol. 118:1985;13-23.
302. Hoyer D., Clarke D.E., Fozard J.R. et al. International union of pharmacological classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol. Rev. 46:1994;157-193.
303. Humphrey P.P.A., Hartig P., Hoyer D. A proposed new nomenclature for 5-HT receptors. Trends Pharmacol. Sci. 14:1993;233-236.
304. Hussy N., Lukas W., Jones K.A. Functional properties of a cloned 5-hydroxytryptamine ionotropic receptor subunit: comparison with native mouse receptors. J. Physiol. 481:1994;311-323.
305. 1D receptor antagonist, on brain 5-HT metabolism, extracellular 5-HT concentration and behaviour in the guinea pig. Neuropharmacology, 34, 383-392.
306. 3 receptors control dopamine release in the nucleus accumbens of freely moving rats. Neurosci. Lett. 101:1989;214-217.
307. Invernizzi R., Belli S., Samanin R. Citalopram's ability to increase the extracellular concentrations of serotonin in the dorsal raphe prevents the drug's effect in the frontal cortex. Brain Res. 584:1992;322-324.
308. 3 receptor subunit. NeuroReport. 5:1993;121-124.
309. 2A receptors with carbon-11-MDL 100 907. J. Nucl. Med. 39:1998;208-214.
310. Iversen S.D. 5-HT and anxiety. Neuropharmacology. 23:1984;1553-1560.
311. 1A receptor enhances acetylcholine release in conscious rats. J. Neurochem. 62:1994;1804-1808.
312. 3 receptor channel. Ann. Rev. Physiol. 57:1995;447-468.
313. 3H]BIMU-1. Neuropharmacology. 33:1994;1027-1038.
314. 7(b)). Br. J. Pharmacol. 122:1997;126-132.
315. 1C receptors in the antiserotonergic properties of some antidepressant drugs. Eur. J. Pharmacol. 231:1993;223-229.
316. 1B receptor. J. Biol. Chem. 267:1992;5735-5738.
317. 1A receptor antagonist, NAD-299. J. Pharmacol. Exp. Ther. 283:1997;216-225.
318. 3 receptor reveals species-specific sensitivity to curare antagonism. Soc. Neurosci. Abstr. 18:1992;249.
319. 3 receptor ligands lack modulatory influence on acetylcholine release in rat entorhinal cortex. Naunyn-Schmiedberg's Arch. Pharmacol. 347:1993;241-247.
320. B synaptic potential in rat dopamine neurons. J. Neurosci. 12:1992;2000-2006.
321. 1F receptor agonists inhibit neurogenic dural inflammation in guinea pigs. NeuroReport. 8:1997;2237-2240.
322. 1A receptor agonists and in their inhibitory effects on the firing of serotonergic neurons in the rat? J. Pharmacol. Exp. Ther. 272:1995;920-929.
323. 3 receptor antagonist. Br. J. Pharmacol. 93:1988;985-993.
324. 3 subtype of serotonin receptor in primary cultures of rodent hippocampus. Neurosci. Lett. 174:1994;133-136.
325. 2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors. Proc. Natl. Acad. Sci. USA. 87:1990;928-932.
326. 1C receptor. Science. 244:1988;558-564.
327. 1A receptors. Naunyn-Schmiedeberg's Arch. Pharmacol. 352:1995;583-584.
328. 2C receptor stimulates cyclic GMP formation in choroid plexus. J. Neurochem. 64:1995;199-205.
329. 2 receptors in serotonin-induced contraction of human isolated coronary arteries. Circulation. 90:1994;1141-1153.
330. 3 receptors in the rat hippocampal dentate gyrus: a patch-clamp study. J. Neurophysiol. 71:1994;1935-1947.
331. Kawaguchi Y., Wilson C.J., Augood S.J. et al. Striatal interneurones: chemical, physiological and morphological characterisation. Trends Neurosci. 18:1995;527-535.
332. 2A antagonist with a favorable CNS safety profile. J. Pharmacol. Exp. Ther. 277:1996;968-981.
333. i. Br. J. Pharmacol. 100:1990;223-230.
334. 1C receptors mediate 1-3(chlorophenyl)piperazine-induced hypophagia. Br. J. Pharmacol. 103:1991;2016-2020.
335. 2B receptor antgonist. Br. J. Pharmacol. 111:1994;797-802.
336. 2B receptor agonist, BW 723C86, on three rat models of anxiety. Br. J. Pharmacol. 117:1996;1443-1448.
337. 2B receptor antagonist with anxiolytic-like properties. Br. J. Pharmacol. 117:1996;427-434.
338. 2C receptor antagonist. Neuropharmacology. 36:1997;609-620.
339. 4 receptor antagonists, SB204070A and SB207266A in rats. Neuropharmacology. 4/5:1997;707-712.
340. 1A receptor antagonist. Brain Res. 673:1995;217-225.
341. 1A receptors expressed by a subpopulation of cholinergic neurons in the rat medial septum and diagonal band of Broca - a double immunocytochemical study. Neuroscience. 74:1996;143-154.
342. 1A receptors in rat brain. J. Neurosci. Res. 46:1996;697-708.
343. 4 receptors. Naunyn-Schmiedeberg's Arch. Pharmacol. 351:1995;229-236.
344. 3 receptor binding sites in rabbit ileum: comparison with those in rat ileum and rat brain. Neurochem. Int. 19:1991;389-396.
345. 3 receptor. Biochem. Soc. Trans. 20:1992;118-121.
346. Kirsch J., Langosch D., Prior P. et al. The 93-kDa glycine receptor-associated protein binds to tubulin. J. Biol. Chem. 266:1991;22242-22245.
347. Kobilka B.K., Frielle T., Collins S. et al. An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins. Nature. 329:1987;75-77.
348. 1C receptors. Neurosci. Biobehav. Rev. 16:1992;95-105.
349. 6 serotonin receptor. J. Neurochem. 66:1996;47-56.
350. 3 receptor antagonist on dopamine and serotonin metabolism in mesolimbic and nigrostriatal dopaminergic neurons. Eur. J. Pharmacol. 169:1989;321.
351. 1A sites in rat brain: in vitro binding and autoradiographic studies. J. Pharmacol. Exp. Ther. 272:1995;429-437.
352. 2B receptor. Mol. Pharmacol. 46:1994;227-234.
353. 2f) from rat stomach fundus. Mol. Pharmacol. 42:1992;549-557.
354. Labrecque J., Fargin A., Bouvier M. et al. Serotonergic antagonists differentially inhibit spontaneous activity and decrease ligand binding capacity of the rat 5-hydroxytryptamine type 2C receptor in Sf9 cells. Mol. Pharmacol. 48:1995;150-159.
355. A receptor complex: electrophysiological studies. Chadwick D., Widdows K. Steroids and Neuronal Activity. 1990;56-82 Wiley, New York.
356. 1A receptor ligands (+)-WAY 100135 and SDZ 216525. Eur. J. Pharmacol. 249:1993;25-35.
357. 3 receptor cDNA and its splice variants from guinea pig. Mol. Pharmacol. 53:1998;202-212.
358. 3H]WAY 100 635 in the mouse. Eur. J. Pharmacol. 271:1994;505-514.
359. Larkman P.M., Kelly J.S. Pharmacological characterization of the receptor mediating 5-HT evoked motoneuronal depolarization in vitro. Fozard J.R., Saxena P.R. Serotonin, Molecular Biology, Receptors and Functional Effects. 1991;310-321 Birkhauser Verlag, Basel, Switzerland.
360. Lawrence A.J., Marsden C.A. Terminal autoreceptor control of 5-hydroxytryptamine release as measured by in vivo microdialysis in the conscious guinea-pig. J. Neurochem. 58:1992;142-146.
361. 1A (serotonin-1A) receptor mRNA expression in rat hippocampus after adrenalectomy. Psychopharmacology. 130:1997;368-374.
362. 1E) in human brain: interaction with a GTP-binding protein. J. Neurochem. 53:1989;465-471.
363. 4 receptors improve social olfactory memory in rat. Neuropharmacology. 4/5:1997;681-688.
364. Levy F.O., Gudermann T., Birnbaumer M. et al. Molecular cloning of a human gene (S31) encoding a novel serotonin receptor mediating inhibition of adenylyl cyclase. FEBS Lett. 296:1992;201-206.
365. 1D subtype. J. Biol. Chem. 267:1992;7553-7562.
366. Leysen J.E., Niemegeers C.J.E., Tollenare J.P. et al. Serotonergic component of neuroleptic receptors. Nature. 272:1978;168-171.
367. 2 receptors. Psychopharmacology. 112:1993;S40-S54.
368. 1D in the rabbit and guinea-pig brain cortex. Naunyn-Schmiedeberg's Arch. Pharmacol. 343:1991;353-364.
369. 3H]MDL 100 907. Naunyn-Schmeideberg's Arch. Pharmacol. 356:1997;446-454.
370. 2-like receptor: expression in brain, heart and intestine. FEBS Lett. 312:1992;203-207.
371. Lovinger D.M., White G., Weight F.F. Ethanol inhibits NMDA-activated ion current in hippocampal neurons. Science. 243:1989;1721-1724.
372. 7) implicated in the regulation of mammalian circadian rhythms. Neuron. 11:1993;449-458.
373. 1E-like rat and human 5-hydroxytryptamine receptor genes. Proc. Natl. Acad. Sci. 90:1993;2184-2188.
374. 3 receptor-mediated ion current in nodose ganglion neurons from the adult rat. J. Pharm. Exp. Ther. 265:1993;771-776.
375. 1C receptor by electrophysiological assays of mRNA-injected Xenopus oocytes. Proc. Natl. Acad. Sci. USA. 84:1987;4332-4336.
376. 1F receptor radioligand. Soc. Neurosci. Abstr. 22:1996;528.
377. 1 receptors and behaviour. Neurosci. Biobehav. Rev. 16:1992;83-93.
378. (2A) receptors with positron emission tomography. Life Sci. 158:1996;187-192.
379. Lyer R.N., Bradberry C.W. Serotonin-mediated increase in prefrontal cortex dopamine release: pharmacological characterization. J. Pharm. Exp. Ther. 277:1996;40-47.
380. 3 receptors in the induction of LTP in mossy fibre-CA3 system of guinea-pig hippocampal slices. Neurosci. Res. 18:1994;277-282.
381. 4 receptors. Neuropharmacology. 4/5:1997;697-706.
382. 2A receptor antagonist. Eur. J. Pharmacol. 259:1994;137-141.
383. 2A receptors on interneurons in rat piriform cortex. J. Pharmacol. Exp. Ther. 278:1996;1373-1382.
384. 3 receptor, a serotonin-gated ion channel. Science. 254:1991;432-437.
385. 1A-receptors mediate stimulation of adenylate cyclase in rat hippocampus. Naunyn-Schmiedeberg's Arch. Pharmacol. 333:1986;335-341.
386. 1B serotonin receptor: cloning, functional expression, and localization in motor control centers. Proc. Natl. Acad. Sci. 89:1992;3020-3024.
387. 3 receptors in the control of 5-HT release in rat hippocampus in vivo. Br. J. Pharmacol. 106:1992;139-142.
388. (3) receptors sited on cholinergic axon terminals of human cerebral cortex mediate inhibition of acetylcholine release. J. Neurochem. 58:1992;2334-2337.
389. 1D receptors. Br. J. Pharmacol. 123:1998;45-50.
390. 1B receptors mediating inhibition of acetylcholine release. Eur. J. Pharmacol. 129:1986;333-337.
391. 1A receptors respectively mediate inhibition of glutamate release and inhibition of cyclic GMP production in rat cerebellum in vitro. J. Neurochem. 66:1996;203-209.
392. 1D autoreceptors in human cerebral cortex. J. Neurochem. 60:1993;1179-1182.
393. 5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization. Mol. Pharmacol. 43:1993;313-319.
394. 1-like subtype. Proc. Natl. Acad. Sci. USA. 89:1992;5517-5521.
395. McAskill R., Mir S., Taylor D. Pindolol augmentation of antidepressant therapy. Br. J. Psychiatry. 173:1998;203-208.
396. McCallum R.W., Parkash, C., Campoli-Richards, D.M., Goa, K.L. (1988) Cisapride: a preliminary review ofits pharmacodynamic and pharmcokinetic properties, and therapeutic use as a prokinetic agent in gastrointestinal disorders. Drugs, 36, 652-681.
397. McQuade R., Sharp T., 1996. Effect of 8-OH-DPAT on 5-HT release in dorsal and median raphe innervated brain regions of the rat. In: Gonzalez, J.L., Borges, R., Mas, M. (Eds.), Monitoring molecules in neuroscience, Proceedings of the 7th International Conference on In vivo Methods. University of Laguna, Tenerife, pp.133-134.
398. Medanic M., Gillette M.U. Serotonin regulates the phase of the rat suprachiasmatic circadian pacemaker in vitro only during the subjective day. J. Physiol. 450:1992;629-642.
399. 1A agonists. Mol. Pharmacol. 37:1990;231-237.
400. 1A agonists. Mol. Pharmacol. 37:1990;231-237.
401. 2A receptor induced release of glutamate from C6 glioma cells. The Pharmacologist. 39:1997;61.
402. 4 receptor agonists and antagonists in learning. Pharmacol. Biochem. Behav. 56:1997;347-351.
403. 2 receptor by in situ hybridization histochemistry. Correlation with the distribution of receptor sites. Brain Res. 524:1990;139-143.
404. 1C receptor mRNA in the rodent brain examined by in situ hybridization histochemistry. Comparison with receptor binding distribution. Neuroscience. 35:1990;577-591.
405. Mengod G., Vilaró M.T., Raurich A. et al. 5-HT receptors in mammalian brain: receptor autoradiography and in situ hybridisation studies of new ligands and newly identified receptors. Histochem. J. 28:1996;747-758.
406. 1B ligand-binding phenotype by Thr355Asn site directed mutagenesis. Biochem. Pharmacol. 44:1992;1917-1920.
407. Meyerhof W., Obermüller F., Fehr S. et al. A novel serotonin receptor: primary structure, pharmacology, and expression pattern in distinct brain regions. DNA Cell Biol. 12:1993;401-409.
408. 3H]5-HT binding sites and at the 5-HT autoreceptor by propranool. Eur. J. Pharmacol. 101:1984;289-293.
409. 1 recognition site. Eur. J. Pharmacol. 90:1983;151-153.
410. 1B receptors. Ann. N.Y. Acad. Sci. 600:1990;132-147.
411. Middlemiss D.N., Tricklebank M.D. Centrally active 5-HT receptor agonists and antagonists. Neurosci. Biobehav. Rev. 16:1992;75-82.
412. 1A receptor-mediated activity. J. Pharmacol. Exp. Ther. 256:1991;973-982.
413. 2C receptors tonically inhibit dopamine (DA) and noradrenaline (NA), but not 5-HT, release in the frontal cortex invivo. Neuropharmacology. 37:1998;953-955.
414. 2C receptor antagonist SB 206 553. Neuropharmacology. 36:1997;743-745.
415. 1A receptor-mediated activity in the rat: a pharmacological characterization of the actions of novel agonists and antagonists. J. Pharmacol. Exp. Ther. 264:1993;1364-1376.
416. Miller J.D., Morin L.P., Schwartz W.J. et al. New insights into the mammalian circadian clock. Sleep. 19:1996;641-667.
417. 1E) serotonin receptors in human brain. Neurosci. Lett. 136:1992;223-226.
418. Milligan G., Marshall F., Rees S. G16 as a universal G-protein adapter: implications for agonist screening strategies. Trends Pharmacol. Sci. 17:1996;235-237.
419. 3 receptor antagonists LY 277 359 and granisetron potentiate the suppressant action of apomorphine on the basal firing rate of ventral tegmental dopamine cells. Eur. J. Pharmacol. 209:1991;143-150.
420. 1A receptors: respective distributions of encoding mRNA, receptor protein and binding sites by in situ hybridisation histochemistry, radioimmunohistochemistry and autoradiographic mapping in the rat brain. Neurochem. Int. 19:1991;453-465.
421. 1A receptor mRNA in the rat brain. Brain Res. Mol. Brain Res. 14:1992;357-362.
422. 3 receptor: heterogeneity in distribution and function among species. Mol. Pharmacol. 48:1995;407-416.
423. 1C receptor is a prominent serotonin receptor subtype in the central nervous system. Proc. Natl. Acad. Sci. 86:1989;6793-6797.
424. Monsma F.J., Shen Y., Ward R.P. et al. Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol. Pharmacol. 43:1993;320-327.
425. Morales M., Battenberg E., de Lecea L. et al. The type 3 serotonin receptor is expressed in a subpopulation of GABAergic neurons in the rat neocortex and hippocampus. Brain Res. 731:1996;199-202.
426. Morales M., Battenberg E., de Lecea L. et al. Cellular and subcellular immunolocalization of the type 3 serotonin receptor in the rat central nervous system. Mol. Brain Res. 36:1996;251-260.
427. 3 receptor is present in different subpopulations of GABAergic neurons in the rat telencephalon. J. Neurosci. 17:1997;3157-3167.
428. 2 receptors in the rat brain. Neuroscience. 54:1993;701-717.
429. 2 receptors in the rat brain: neurochemical identification of cell types by immunocytochemistry. Neuropsychopharmacology. 11:1994;157-166.
430. 3 receptor antagonists GR38032F and BRL24924, on anxiety in socially isolated rats. Br. J. Pharmacol., 97, 457p.
431. Mork A., Geisler A. 5-Hydroxytryptamine receptor agonists influence calcium-stimulated adenylate cyclase activity in the cerebral cortex and hippocampus of the rat. Eur. J. Pharmacol. 175:1990;237-244.
432. 3 receptors by functional epitope tagging. J. Neurochem. 66:1996;1027-1032.
433. 1A antagonists WAY 100 135 and SDZ 216-525 on 5-HT neuronal firing in the guinea-pig dorsal raphe nucleus. Neuropharmacology. 33:1994;61-66.
434. 1A antagonists WAY 100 135 and WAY 100 635, on guinea-pig behaviour and dorsal raphe 5-HT neurone firing. Br. J. Pharmacol. 117:1996;750-756.
435. 2B receptors mediates serotonin embryonic functions. 4th IUPHAR Satellite Meeting of the Serotonin Club, Rotterdam, Abstract S2.3.
436. Needleman S.B., Wunsch C.D. A general method applicable to the search for similarities in the amino acid sequence of two proteins. J. Mol. Biol. 48:1970;443-453.
437. 7 receptor from Xenopus laevis. Recept. Channel. 3:1995;61-70.
438. Nicoll R.A., Malenka R.C., Kauer J.A. Functional comparison of neurotransmitter receptor subtypes in mammalian central nervous system. Physiol. Rev. 70:1990;513-565.
439. 3 receptor-induced increases in calcium levels in individual brain nerve terminals. J. Neurochem. 67:1996;581-592.
440. 3 receptor stably expressed in HEK-293 cells. Br. J. Pharmacol. (Suppl.). 119:1996;P261.
441. 1A receptor antagonist (S)-UH-301 prevents (R)-8-OH-DPAT-induced decrease in interstitial concentrations of serotonin in the rat hippocampus. Eur. J. Pharmacol. 216:1992;373-378.
442. 2 receptors to decrease potassium conductance in rat nucleus accumbens neurones. J. Physiol. 417:1989;1-12.
443. Oberlander C. Effects of a potent 5-HT agonist, RU 24 969, on the mesocortico-limbic and nigrostriatal dopamine systems. Br. J. Pharmacol. 80:1983;675P.
444. Oberlander C., Hunt P.F., Dumont C., Boissier J.R. Dopamine-independent rotational response to unilateral injection of serotonin. Life Sci. 28:1981;2595-2601.
445. 7 receptor: importance of the third intracellular loop for receptor-G-protein interaction. FEBS Lett. 412:1997;321-324.
446. 1A receptor activation. Br. J. Pharmacol. 106:1992;603-609.
447. Olivier B., Mos J., van Oorschot R., Hen R. Serotonin receptors and animal models of aggressive behavior. Pharmacopsychiatry. 28(2):1995;80-90.
448. Olsen R.W. Drug interactions at the GABA receptor-ionophore complex. Ann. Rev. Pharmacol. Toxicol. 22:1982;245-277.
449. Ortells M.O., Lunt G.G. Evolutionary history of the ligand-gated ion-channel superfamily of receptors. Trends Neurosci. 18:1995;121-127.
450. 1B receptors. Nature. 360:1992;161-163.
451. 1F receptor. Soc. Neurosci. Abstr. 22:1996;528.12.
452. 1A receptor. Proc. Natl. Acad. Sci. 95:1998;10734-10739.
453. Patel S., Roberts J., Moorman J. et al. Localization of serotonin-4 receptors in the striatonigral pathway in rat brain. Neuroscience. 69:1995;1159-1167.
454. Palacios J.M., Waeber C., Mengod G. et al. Autoradiography of 5-HT receptors: a critical appraisal. Neurochem. Int. 18:1991;17-25.
455. 3 receptors in human brain. J. Neurolog. Sci. 144:1996;119-127.
456. 1B receptors. J. Neurochem. 60:1993;380-383.
457. 3 receptors: focus on alcohols and anaesthetic agents. Trends Pharmacol. Sci. 17:1996;95-99.
458. 1F receptors. Eur. J. Pharmacol. 295:1996;271-274.
459. 3) antagonist on electrophysiological properties of the rat hippocampus. Br. J. Pharmacol. 112:1994;695-703.
460. 3 receptors in rat cerebral cortex and nucleus accumbens. Br. J. Pharmacol. 103:1991;1790-1794.
461. 1B receptor-mediated responses in stably transfected C6-glial cells by ketanserin and GR 127935. Eur. J. Pharmacol. 300:1996;141-145.
462. 1B receptors. Naunyn-Schmiedeberg's Arch. Pharmacol. 353:1996;144-156.
463. 1B/D receptor ligands: an answer from GTPgS binding studies with stably transfected C6-glial cell lines. Neuropharmacology. 4/5:1997;499-512.
464. Pazos A., Cortes R., Palacios J.M. Quantitative autoradiographic mapping of serotonin receptors in the rat brain. II. Serotonin-2 receptors. Brain Res. 346:1985;231-249.
465. Pazos A., Palacios J.M. Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors. Brain Res. 346:1985;205-230.
466. Pazos A., Probst A., Palacios J.M. Serotonin receptors in the human brain-IV. Autoradiographic mapping of serotonin-2 receptors. Neuroscience. 21:1987;123-139.
467. Pazos A., Hoyer D., Palacios J.M. The binding of serotonergic ligands to the porcine choroid plexus: characterisation of a new type of serotonin recognition site. Eur. J. Pharmacol. 106:1984;539-546.
468. 3H]5-hydroxytrytamine binding sites by the neuroleptic spiperone in the rat brain. J. Neurochem. 36:1981;205-230.
469. 3H]spiroperidol. Mol. Pharmacol. 16:1979;687-699.
470. 3 receptors. Trends Pharmacol. Sci. 13:1992;391-397.
471. 1F receptors: binding affinities, brain penetration and activity in the neurogenic inflammation model of migraine. Life Sci. 61:1997;2117-2126.
472. Piguet P., Galvan M. Transient and long-lasting actions of 5-HT on rat dentate gyrus neurones in vitro. J. Physiol. Lond. 481:1994;629-639.
473. 11C]WAY-100635. Eur. J. Pharmacol. 283:1995;R1-R3.
474. 1B knock-out mice. NeuroReport. 7:1995;353-359.
475. 1D receptors regulate 5-HT release in the rat raphe nuclei. In vivo voltammetry and in vitro superfusion studies. Neuropsychopharmacology. 13:1995;249-260.
476. 1D receptors in the rat brain. Synapse. 22:1996;54-62.
477. 1D receptor family. EMBO J. 11:1992;4779-4786.
478. 1D receptor family. EMBO J. 11:1992;4779-4786.
479. Plassat J.-L., Amlaiky N., Hen R. Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase. Mol. Pharmacol. 44:1993;229-236.
480. 1A receptor in rat brain: correlation with receptor binding. J. Neurosci. 12:1992;440-453.
481. 2C receptors. Mol. Brain Res. 23:1994;163-178.
482. 1D receptors. Naunyn-Schmeideberg's Arch. Pharmacol. 356:1997;312-320.
483. 1A) receptor antagonist in rat brain. J. Pharmacol. Exp. Ther. 265:1993;739-744.
484. Prosser R.A., Dean R.R., Edgar D.M. et al. Serotonin and the mammalian circadian system: I. In vitro phase shifts by serotonergic agonists and antagonists. J. Biol. Rhythms. 8:1993;1-16.
485. 3 receptors in mammalian hindbrain - a consensus. Trends Pharmacol. Sci. 11:1990;135-137.
486. Price D.L., Whitehouse P.J., Struble R.G. et al. Transmitter systems in selected types of dementia. Riederer P., Kopp N., Pearson J. An Introduction to Neurotransmission in Health and Disease. 1990;Oxford Medical, Oxford.
487. Prisco S., Pessia M., Ceci A. et al. Chronic treatment with DAU 6215, a new 5-HT3 receptor antagonist, causes a selective decrease in the number of spontaneously active dopaminergic neurons in the ventral tegmental area. Eur. J. Pharmacol. 214:1992;13-19.
488. Pritchett D.B., Bach A.W.J., Wozny M. et al. Structure and functional expression of a cloned rat serotonin 5-HT-2 receptor. EMBO J. 7:1988;4135-4140.
489. 2 receptor. EMBO J. 7:1988;4135-4140.
490. Prosser R.A., Gillette M.U. The mammalian circadian clock in the suprachiasmatic nuclei is reset in vitro by cAMP. J. Neurosci. 9:1989;1073-1081.
491. Radja F., Laporte A.-M., Daval G. et al. Autoradiography of serotonin receptor subtypes in the central nervous system. Neurochem. Int. 18:1991;1-15.
492. 3 receptor antagonists of release of cholecystokinin-like immunoreactivity from the frontal cortex of freely moving rats. Naunyn-Schmiedeberg's Arch. Pharmacol. 347:1993;111-114.
493. 3 receptor blockade in slices from rat entorhinal cortex. Brain Res. 712:1996;274-280.
494. 4 receptor antagonism does not affect motor and reward mechanisms in the rat. Eur. J. Pharmacol. 357:1998;115-120.
495. 5A serotonin receptor. FEBS Lett. 355:1994;242-246.
496. 4 receptors in post mortem human brain tissue: Distribution, pharmacology and effects of neurodegenerative diseases. Br. J. Pharmacol. 114:1995;993-998.
497. 1A receptor agonists on septal cholinergic neurons in culture. Brain Res. Dev. Brain Res. 82:1994;245-258.
498. 2C receptors. Neuroscience. 69:1995;903-913.
499. Riekkinen P., Sirvio J., Riekkinen P. Non-reversal of scopolamine- or age-related EEG changes by ondansetron, methysergide or alaproclate.
500. 1B receptor selectivity for 5-HT terminal autoreceptor activity: an in vivo microdialysis study in the freely moving guinea pig. Neuropharmacology. 4/5:1997;549-558.
501. Roberts, C., Belenguer, A., Middlemiss, D.N., et al., 1997b. Comparison of 5-HT autoreceptor control in guinea pig dorsal and median raphe innervated brain regions. Br. J. Pharmacol. (in press).
502. 1A agonists in depression: a composite analysis of buspirone in the treatment of depression. J. Clin. Psychopharmacol. 10:1990;67S-76S.
503. 1D antagonist and a 5-HT reuptake inhibitor synergistically increases 5-HT release in guinea pig hypothalamus in vivo. J. Neurochem. 67:1996;2204-2207.
504. 1A antagonist, WAY-100 635 selectively potentiates the presynaptic effects of serotonergic antidepressants in rat brain. Neurosci. Lett. 219:1996;123-126.
505. 4 receptors in rat esophagus: functional and second messenger studies. J. Pharm. Exp. Ther. 272:1995;977-983.
506. 3 receptors on presynaptic nerve terminals from rat striatum. J. Neurochem. 70:1998;1094-1103.
507. Ropert N., Guy N. Serotonin facilitates GABAergic transmission in the CA1 region of rat hippocampus in vitro. J. Physiol. 441:1991;121-136.
508. 2 receptor mRNA levels. Eur. J. Pharmacol. 207:1991;169-172.
509. 1C receptors. J. Pharmacol. Exp. Ther. 260:1992;1361-1365.
510. Roth B.L., Craigo S.C., Choudhary M.S. et al. Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J. Pharm. Exp. Ther. 268:1994;1403-1410.
511. 1A receptor antagonist WAY 100135: an in vivo microdialysis study. Eur. J. Pharmacol. 239:1993;195-202.
512. 4 receptor colocalization on hippocampal pyramidal cells. Neuropharmacology. 33:1994;551-557.
513. 6) receptor: molecular cloning, localization and stimulation of cAMP accumulation. Biochem. Biophys. Res. Comm. 193:1993;268-276.
514. 7) activating cAMP formation. Proc. Natl. Acad. Sci. 90:1993;8547-8551.
515. 1B receptor. Science. 265:1994;1875-1878.
516. Saudou F., Hen R. 5-Hydroxytryptamine receptor subtypes in vertebrates and invertebrates. Neurochem. Int. 25:1994;503-532.
517. 1C receptor subtypes. Biochem. Biophys. Res. Comm. 181:1991;1469-1478.
518. 1A receptor ligands by means of in vivo animal models. Eur. J. Pharmacol. 315:1996;245-254.
519. Sanders-Bush E. Adaptive regulation of central serotonin receptors linked to phosphoinositide hydrolysis. Neuropsychopharmacology. 3:1990;411-416.
520. Sanders-Bush E., Burris K.D., Knoth K. Lysergic acid diethylamide and 2,5-dimethoxy-4-methylamphetamine are partial agonists at serotonin receptors linked to phosphoinositide hydrolysis. J. Pharmacol. Exp. Ther. 246:1988;924-928.
521. Sanders-Bush E., Canton H. Serotonin receptors: signal transduction pathways. Bloom F.E., Kupfer D.J. Psychopharmacology, The Fourth Generation of Progress. 1995;431-442 Raven, New York.
522. 4 recognition sites in the porcine caudate nucleus by radioligand binding. Neuropharmacology. 33:1994;543-549.
523. 1D (BRL 15572) receptor ligands on guinea-pig and human 5-HT auto- and heteroceptors. Naunyn-Schmeideberg's Arch. Pharmacol. 356:1997;321-327.
524. 3H]dopamine. Eur. J. Pharmacol. 167:1989;309-310.
525. 2B serotonin receptor. FEBS Lett. 342:1994;85-90.
526. 1A receptors: considerations on receptor effector coupling across systems. Neuropharmacology. 36:1997;429-437.
527. 1A binding sites inhibit forskolin-stimulated adenylate cyclase activity in calf hippocampus. Br. J. Pharmacol. 95:1988;975-985.
528. 1D receptors mediating inhibition of adenylate cyclase activity. Pharmacological comparison with special reference to the effects of yohimbine, rauwolscine and some beta-adrenoceptor antagonists. Naunyn-Schmiedeberg's Arch. Pharmacol. 340:1989;285-292.
529. 6 receptor-like profile stimulating adenylyl cyclase activity in pig caudate membranes. Naunyn-Schmiedeberg's Arch. Pharmacol. 350:1994;356-360.
530. 1A agonists. J. Pharmacol. Exp. Ther. 273:1995;101-112.
531. 1A receptor agonists in the rat. J. Pharmacol. Exp. Ther. 265:1993;572-579.
532. 6 receptors positively coupled to adenylyl cyclase in striatal neurones in culture. NeuroReport. 5:1994;2553-2557.
533. Segal M. Physiological and pharmacological evidence for a serotonergic projection to the hippocampus. Brain. Res. 94:1975;115-131.
534. 1A autoreceptor. J. Neurosci. Methods. 34:1990;83-90.
535. 1 agonists reduce 5-hydroxytryptamine release in rat hippocampus in vivo as determined by brain microdialysis. Br. J. Pharmacol. 96:1989;283-290.
536. 1A antagonist, BMY 7378. Eur. J. Pharmacol. 176:1990;331-340.
537. 1A receptor antagonist, SDZ 216-525, decreases 5-HT release in rat hippocampus in vivo. Br. J. Pharmacol. 109:1993;699-702.
538. 1A autoreceptors and alpha1-adrenoceptors in the inhibition of 5-HT release-II NAN-190 and SDZ 216-525. Neuropharmacology. 35:1996;735-741.
539. 1A receptor antagonist on 5-HT neuronal activity and release. Eur J. Pharmacol. 320:1997;15-19.
540. 2C receptors. Neuropharmacology. 33:1994;467-471.
541. 2 receptors in interneurons. Synapse. 9:1991;208-218.
542. 7 serotonin receptor subtype. J. Biol. Chem. 268:1993;18200-18204.
543. 7 receptor-mediated cyclic adenosine monophosphate accumulation in rat frontocortical astrocytes. J. Pharm. Exp. Ther. 279:1996;1551-1558.
544. Shenker A., Maayani S., Weinstein H. et al. Enhanced serotonin-stimulated adenylate cyclase activity in membranes from adult guinea pig hippocampus. Life Sci. 32:1983;2335-2342.
545. 7 receptors in rat frontocortical astrocytes. Brain Res. 784:1998;57-62.
546. - ion channels modulated by multiple drug-binding sites. Trends Pharmacol. Sci. 13:1992;446-450.
547. 4 receptor antagonists on rat behaviour in the elevated plus-maze test. Eur. J. Pharmacol. 309:1996;219-222.
548. Simansky K.J. Serotonergic control of the organization of feeding and satiety. Behav. Brain Res. 73:1996;37-42.
549. 1 receptor. Eur. J. Pharmacol. 157:1988;173-181.
550. 1D receptor antagonist. Behav. Brain Res. 73:1996;157-161.
551. 1D receptor antagonist GR127935 on extracellular levels of 5-HT in the guinea-pig frontal cortex as measured by microdialysis. Neuropharmacology. 34:1995;377-382.
552. 6 receptors. Br. J. Pharmacol. 124:1998;556-562.
553. 7 receptor binding sites in rat hypothalamus: sensitivity to chronic antidepressant treatment. Mol. Pharmacol. 47:1995;99-103.
554. 7 receptors: molecular biology, functional correlates and possible therapeutic indications. Drug News and Perspectives. 10:1997;214-224.
555. 3 receptor antagonist, on A9 and A10 dopamine neurons. Eur. J. Pharmacol. 163:1989;115-118.
556. 2 receptor antagonist MDL 100 907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies. J. Pharmacol. Exp. Ther. 266:1993;684-691.
557. 1A receptor ligand. Eur. J. Pharmacol. 201:1991;163-169.
558. 1B agonists: a comparative study with dorsal raphe neurons. Neuropharmacology. 27:1988;707-715.
559. 7 receptor: cloning and pharmacological characterisation of two receptor variants. FEBS Lett. 413:1997;489-494.
560. 1A receptor genes. Eur. J. Pharmacol. 227:1992;153-162.
561. 1A autoreceptors modulate 5-HT release in the guinea-pig dorsal raphe nucleus. Neuropharmacology. 33:1994;393-402.
562. 3 receptor antagonism on hippocampal theta-rhythm, memory and LTP induction in the freely moving rat. J. Neurosci. 15:1995;2445-2452.
563. 3 receptor recognition sites in the putamen of patients with Huntington's disease. Eur. J. Pharmacol. 242:1993;137-143.
564. 4 receptor ligands to modulate rat striatal dopamine release in vitro and in vivo. Br. J. Pharmacol. 117:1996;55-62.
565. 3H]meta-chlorophenylbiguanide. Eur. J. Pharmacol. 243:1993;13-18.
566. 3H]5-carboxamidotryptamine. Neuropharmacology 37, 1611-1619.
567. 7 receptor mRNA in rat brain. Br. J. Pharmacol. 123:1998;229P.
568. 3 receptors in rat amygdala. Neuron. 8:1992;199-203.
569. 1A receptor activation. Br. J. Pharmacol. 115:1995;703-711.
570. Tanaka E., North R.A. Actions of 5-hydroxytryptamine on neurons of the rat cingulate cortex. J. Neurophysiol. 69:1993;1749-1757.
571. 6 receptor null mice. Fourth IUPHAR Satellite meeting on Serotonin, Rotterdam, S1.2.
572. 3 receptor messenger RNA. Proc. Natl. Acad. Sci. 90:1993;1430-1434.
573. 2C serotonin receptors. Nature. 374:1995;542-546.
574. 4 receptor agonist, RS17017. Psychopharmacology. 135:1998;407-415.
575. 4 receptor involvement in the serotonin-enhanced dopamine efflux from the substantia nigra of the freely moving rat: a microdialysis study. Brain Res. 796:1998;117-124.
576. 7 receptors in guinea pig brain. Br. J. Pharmacol. 115:1995;107-116.
577. Tonini M., Galligan J.J., North R.A. Effects of cisapride on cholinergic neurotransmission and propulsive motility in the guinea-pig ileum. Gastroenterology. 96:1989;1257-1264.
578. 4 receptor agonists facilitate cholinergic transmission in the circular muscle of guinea-pig ileum: antagonism by tropisetron and DAU6285. Life Sci. 50:1992;173-178.
579. 1A-related anxiolytics. Trends Pharmacol. Sci. 8:1987;432-437.
580. 1 receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-propylamino)tetralin in the rat. Eur. J. Pharmacol. 106:1984;271-282.
581. 1 receptor agonist, RU 24 969, in the rat. Neuropharmacology. 25:1986;877-886.
582. 1B receptors: in vivo microdialysis studies. J. Neurochem. 69:1997;2019-2025.
583. 7 receptor positively coupled to adenylyl cyclase. J. Neurochem. 63:1994;456-464.
584. Turek F.W. Circadian neural rhythms in mammals. Ann. Rev. Physiol. 47:1985;49-64.
585. 3 receptor gene and assignment to human chromosome 11. FEBS Lett. 339:1994;302-306.
586. 4 receptor mRNA in the rat brain. Naunyn-Schmiedeberg's Arch. Pharmacol. 354:1996;210-212.
587. Unsworth C.D., Molinoff P.B. Characterisation of a 5-hydroxytryptamine receptor in mouse neuroblastoma N18TG2 cells. J. Pharm. Exp. Ther. 269:1993;246-255.
588. Unwin N. Nicotinic acetylcholine receptor at 9A resolution. J. Mol. Biol. 229:1993;1101-1124.
589. Unwin N. Acetylcholine receptor channel imaged in the open state. Nature. 373:1995;37-43.
590. 2A receptor-mediated regulation of brain-derived neurotrophic factor mRNA in the hippocampus and the neocortex. J. Neurosci. 17:1997;2785-2795.
591. Van de Kar L.D., Rittenhouse P.A., Li Q. et al. Serotonergic regulation of renin and prolactin secretion. Behav. Brain Res. 73:1996;203-208.
592. 1A ligand MDL 73005EF in the rat hippocampal slice. Eur. J. Pharmacol. 196:1991;291-298.
593. 1A receptor ligands on rat dorso-lateral septal neurones in vitro. Br. J. Pharmacol. 106:1992;893-899.
594. 4 receptor cDNA. J. Neurochem. 69:1997;1810-1819.
595. VanderMaelen, C.P., Braselton, J.P., 1990. Intravenously administered buspirone inhibits dorsal and median raphe 5-HT neurones with about equal potency. 2nd IUPHAR Satellite Meeting on Serotonin, Basel, Switzerland.
596. Vane J.R. The relative activities of some tryptamine analogues on the isolated rat stomach strip preparation. Br. J. Pharmacol. Chemother. 14:1959;87-98.
597. 2+ permeable ion channels. Proc. Natl. Acad. Sci. 95:1998;11456-11461.
598. 3 receptor ligand-gated ion channels. Recept. Channel. 3:1995;7-12.
599. Vanhoutte P.M., Humphrey P.P.A., Spedding M. Recommendations for nomenclature of new receptor subtypes. Pharmacol. Rev. 48:1996;1-2.
600. 1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats. J. Neurosci. 6:1986;3473-3482.
601. Verlinden M., Reyntjens A., Schuermans V. Safety profile of cisapride. Johnson A.G., Lux G. Progress in the Treatment of Gastrointestrial Mofilit Disorders: The Role of Cispride. 1988;130-136 Excerpta Medica, Amsterdam.
602. 4 receptor mRNA in rat brain by in situ hybridisation histochemistry. Mol. Brain Res. 43:1996;356-360.
603. 1B receptor. EMBO J. 10:1991;4017-4023.
604. von Hungren K., Roberts S., Hill D.F. Serotonin-sensitive adenylate cyclase activity in immature rat brain. Brain Res. 84:1975;257-267.
605. 3H]ICS205-930. Neuroscience. 31:1989;393-400.
606. 3H]5-carboxamidotryptamine binding sites in the guinea pig and rat brain. Eur. J. Pharmacol. 283:1995;31-46.
607. 1F receptor binding sites in the guinea pig brain: an autoradiographic study. Naunyn-Schmiedeberg's Arch. Pharmacol. 352:1995;263-275.
608. 1D recognition sites: radioligand binding studies in human, pig and calf brain membranes. Naunyn-Schmiedeberg's Arch. Pharmacol. 337:1988;595-601.
609. 1D receptor: a progress review. Neurochem. Res. 15:1990;567-582.
610. 1D receptors in the guinea pig brain: pre- and postsynaptic localizations in the striatonigral pathway. Brain Res. 528:1990;197-206.
611. 3H]GR113 808 labels 5-HT(4) receptors in the human and guinea pig brain. NeuroReport. 4:1993;1239-1242.
612. 2F receptor. Mol. Pharmacol. 43:1993;419-426.
613. 2C receptors in neuropeptide containing neurons of the rat striatum. Soc. Neurosci. Abstr. 21:1995;728.7.
614. Ward R.P., Hamblin M.W., Lachowicz J.E. et al. Localization of serotonin subtype 6 receptor messenger RNA in the rat brain by in situ hybridisation histochemistry. Neuroscience. 64:1995;1105-1111.
615. 1Dβ. Proc. Natl. Acad. Sci. USA. 89:1992;3630-3634.
616. 5A 5-hydroxytryptamine receptor and the human β2-adrenergic receptor produced in the methylotropic yeast Pichia pastoris. Biochem. J. 330:1998;1137-1147.
617. 1A binding sites on serotonin containing neurones in the raphe dorsalis and raphe centralis nuclei of the rat brain. Neurochem. Int. 7:1985;1061-1072.
618. 3 receptor gene and functional expression of two splice variants. Mol. Brain Res. 26:1994;233-241.
619. 1A receptor activation increases hippocampal acetylcholine efflux and motor activity in the guinea pig: agonist efficacy influences functional activity in vivo. J. Pharmacol. Exp. Ther. 270:1994;656-664.
620. 3H-5-HT from spinal cord synaptosomes of rat. Neuropharmacology. 31:1992;725-733.
621. 5B receptor couples to a G-protein in mammalian cell membranes. FEBS lett. 333:1993;25-31.
622. Witz P., Amlaiky N., Plassat J.-L. et al. Cloning and characterization of a Drosophila serotonin receptor that activates adenylate cyclase. Proc. Natl. Acad. Sci. 87:1990;8940-8944.
623. Wright D.E., Seroogy K.B., Lundgren K.H. et al. Comparative localization of serotonin1A, 1C, and 2 receptor subtype mRNAs in rat brain. J. Comp. Neurol. 351:1995;357-373.
624. 2C receptor gene: complete cDNA, genomic structure, and alternatively spliced variant. EMBL accession number U49516.
625. Yakel J.L., Lagrutta A., Adelman J.P. et al. Single amino acid substitution affects desensitization of the 5-hydroxytryptamine-3 receptor expressed in Xenopus oocytes. Proc. Natl. Acad. Sci. 90:1993;5030-5033.
626. 4 receptor involvement in the enhancement of acetylcholine release by p-chloroamphetamine. Brain Res. 772:1997;95-101.
627. 4 receptors. Naunyn-Schmiedeberg's Arch. Pharmacol. 356:1997;712-720.
628. Yan W., Wilson C.C., Haring J.H. Effects of neonatal serotonin depletion on the development of rat dentate granule cells. Dev. Brain Res. 98:1997;177-184.
629. 3 receptor channels in dissociated rat superior cervical ganglion neurons. J. Physiol. 448:1992;237-256.
630. 7 receptor gene expression in the rat hippocampus. Mol. Brain Res. 45:1997;182-186.
631. 7 receptors mediate serotonergic effects on light-sensitive suprachiasmatic nucleus neurons. Brain Res. 755:1997;246-254.
632. 1A receptors negtively coupled to adenylyl cyclase activity in rat hippocampal membranes. Mol. Pharmacol. 41:1992;1066-1072.
633. 6 receptor subtype in the rat brain. Life Sci. 62:1998;1473-1477.
634. 1C receptor contains eight hydrophobic domains and is X-linked. Mol. Brain Res. 11:1991;143-149.
635. Yu X.M., Askalan R., Keil G.J. et al. NMDA channel regulation by channel-associated protein tyrosine kinase Src. Science. 275:1997;674-678.
636. 3 receptor agonist 2-methyl-5-HT reduces postsynaptic potentials in rat CA1 pyramidal neurons of the hippocampus in vitro. Brain Res. 651:1994;337-341.
637. 4 antagonists inhibits potassium-stimulated GABA efflux from rat substantia nigra in vivo. Br. J. Pharmacol. 119:1996;347P.
638. 1E receptor. Mol. Pharmacol. 42:1992;180-185.