Reversible inhibition of α-synuclein fibrillization by dopaminochrome-mediated conformational alterations

Journal of Biological Chemistry

Volumn 280, Issue 22, 2005, Pages 21212-21219

  Norris, Erin H ^a   Giasson, Benoit I ^a   Hodara, Roberto ^a,b   Xu, Shaohua ^a   Trojanowski, John Q ^a   Ischiropoulos, Harry ^a,b   Lee, Virginia M Y ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGLOMERATION; AMINES; CONFORMATIONS; DISEASE CONTROL; MOLECULAR BIOLOGY; MUTAGENESIS; NEUROLOGY; OLIGOMERS; POLYPEPTIDES;

DENATURATION; DOPAMINE; FIBRILLIZATION; RENATURATION;

ENZYME INHIBITION;

ALPHA SYNUCLEIN; COMPLEMENTARY DNA; DOPAMINE; SYNTHETIC PEPTIDE;

ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; DEGENERATIVE DISEASE; DOPAMINERGIC SYSTEM; FOURIER TRANSFORM MASS SPECTROMETRY; HUMAN; NERVE CELL; NEUROLOGIC DISEASE; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN MOTIF; SITE DIRECTED MUTAGENESIS; SUBSTANTIA NIGRA;

ALPHA-SYNUCLEIN; AMINO ACID MOTIFS; CIRCULAR DICHROISM; DNA, COMPLEMENTARY; DOPAMINE; HISTIDINE; HUMANS; INDOLEQUINONES; METHIONINE; MICROSCOPY, ATOMIC FORCE; MICROSCOPY, ELECTRON; MUTAGENESIS; MUTATION; NERVE TISSUE PROTEINS; OXIDATIVE STRESS; OXYGEN; PARKINSON DISEASE; PEPTIDES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SYNUCLEINS; TIME FACTORS; TYROSINE;

EID: 20444401187     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M412621200     Document Type: Article

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