A common LRRK2 mutation in idiopathic Parkinson's disease

Lancet

Volumn 365, Issue 9457, 2005, Pages 415-416

  Gilks, William P ^a   Abou Sleiman, Patrick M ^a   Gandhi, Sonia ^a   Jain, Shushant ^a,b   Singleton, Andrew ^b   Lees, Andrew J ^a,d   Shaw, Karen ^a   Bhatia, Kailash P ^a   Bonifati, Vincenzo ^c   Quinn, Niall P ^a   Lynch, John ^a   Healy, Daniel G ^a   Holton, Janice L ^a   Revesz, Tamas ^a   Wood, Nicholas W ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID DERIVATIVE; GLYCINE; SERINE;

ADULT; AGED; ARTICLE; CODON; CONTROLLED STUDY; EXON; GENE IDENTIFICATION; GENE MUTATION; GENE SEQUENCE; GENETIC COUNSELING; HETEROZYGOSITY; HUMAN; IDIOPATHIC DISEASE; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; PARKINSON DISEASE; PATHOLOGY; PRIORITY JOURNAL;

EID: 19944432921     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(05)17830-1     Document Type: Article

References (5)

1. Vila M, Przedborski S. Genetic clues to the pathogenesis of Parkinson's. Nat Med. 10:(suppl):2004;S58-S62
2. Paisan-Ruiz C, Jain S, Evans EW, et al. Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. Neuron. 44:2004;595-600
3. Zimprich A, Biskup S, Leitner P, et al. Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron. 44:2004;601-607
4. Hughes AJ, Daniel SE, Kilford L, Lees AJ. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry. 55:1992;181-184
5. Healy DG, Abou-Sleiman PM, Wood NW. PINK, PANK, or PARK? A clinicians' guide to familial parkinsonism. Lancet Neurol. 3:2004;652-662