A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease

Lancet

Volumn 365, Issue 9457, 2005, Pages 412-415

  Di Fonzo, Alessio ^a,b   Rohé, Christan F ^a   Ferreira, Joaquim ^c   Chien, Hsin F ^d   Vacca, Laura ^e   Stocchi, Fabrizio ^e   Guedes, Leonor ^c   Fabrizio, Edito ^e   Manfredi, Mario ^e   Vanacore, Nicola ^f   Goldwurm, Stefano ^g   Breedveld, Guido ^a   Sampaio, Cristina ^c   Meco, Giuseppe ^e   Barbosa, Egberto ^d   Oostra, Ben A ^a   Bonifati, Vincenzo ^a,e  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF MILAN   (Italy)

^c Institute de Molecular Medicine   (Portugal)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

^e SAPIENZA UNIVERSITY OF ROME   (Italy)

^f ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^g PARKINSON INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA;

ADULT; AGED; ARTICLE; AUTOSOMAL DISORDER; AUTOSOMAL INHERITANCE; BRAZIL; GENE AMPLIFICATION; GENE IDENTIFICATION; GENE MUTATION; GENE SEQUENCE; HETEROZYGOSITY; HUMAN; ITALY; MOUSE; NERVE DEGENERATION; NONHUMAN; NUCLEOTIDE SEQUENCE; ONSET AGE; PARKINSON DISEASE; PARKINSONISM; PHENOTYPE; POLYMERASE CHAIN REACTION; PORTUGAL; PRIORITY JOURNAL; RAT;

EID: 19944431081     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(05)17829-5     Document Type: Article

References (5)

1. Bonifati V, Oostra BA, Heutink P. Unraveling the pathogenesis of Parkinson's disease - the contribution of monogenic forms. Cell Mol Life Sci. 61:2004;1729-1750
2. Funayama M, Hasegawa K, Kowa H, Saito M, Tsuji S, Obata F. A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2-q13.1. Ann Neurol. 51:2002;296-301
3. Paisan-Ruiz C, Jain S, Evans EW, et al. Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. Neuron. 44:2004;595-600
4. Zimprich A, Biskup S, Leitner P, et al. Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron. 44:2004;601-607
5. Hughes AJ, Ben-Shlomo Y, Daniel SE, Lees AJ. What features improve the accuracy of clinical diagnosis in Parkinson's disease: a clinicopathologic study. Neurology. 42:1992;1142-1146