Proteasomal Inhibition by α-Synuclein Filaments and Oligomers

Journal of Biological Chemistry

Volumn 279, Issue 13, 2004, Pages 12924-12934

  Lindersson, Evo ^a   Beedholm, Rasmus ^a   Højrup, Peter ^b   Moos, Torben ^c   Gai, WeiPing ^d   Hendil, Klavs B ^e   Jensen, Poul H ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d FLINDERS MEDICAL CENTRE   (Australia)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITION; ENZYMES; HYDROLYSIS; NEUROLOGY; OLIGOMERS;

NEURODEGENERATIVE DISORDERS; PROTEASOMES;

BIOCHEMISTRY;

ALPHA SYNUCLEIN; AMYLOID A PROTEIN; AMYLOID BETA PROTEIN; CHAPERONE; CHYMOTRYPSIN INHIBITOR; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; LIGAND; POLYUBIQUITIN; PROTEASOME;

ACTIN FILAMENT; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; COVALENT BOND; DEGENERATIVE DISEASE; DOPAMINERGIC NERVE CELL; DYSTROPHY; HUMAN; HUMAN CELL; NERVE DEGENERATION; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN LOCALIZATION;

ALPHA-SYNUCLEIN; CHYMOTRYPSIN; CYSTEINE ENDOPEPTIDASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; HSP70 HEAT-SHOCK PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; LEWY BODIES; LIGANDS; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON; MULTIENZYME COMPLEXES; NERVE TISSUE PROTEINS; NEURODEGENERATIVE DISEASES; NEURONS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; RECOMBINANT PROTEINS; SYNUCLEINS; TIME FACTORS;

EID: 1842424791     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M306390200     Document Type: Article

References (58)

1. Ellison, D. & Love, S. (1998) in Neuropathology (Ellison, D. & Love, S., eds) pp. 28.1-28.6, Mosby International Ltd., London, UK
2. Glickman, M. H. & Ciechanover, A. (2001) Physiol. Rev. 82, 373-428
3. Goedert, M., Spillantini, M. G. & Davies, S. W. (1998) Curr. Opin. Neurobiol. 8, 619-632
4. Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., Stenroos, E. S., Chandrasekharappa, S., Athanassiadou, A., Papapetropoulos, T., Johnson, W. G., Lazzarini, A. M., Duvoisin, R. C., Di Iorio, G., Golbe, L. I. & Nussbaum, R. L. (1997) Science 276, 2045-2047
5. Krüger, R., Kuhn, W., Muller, T., Woitalla, D., Graeber, M., Kosel, S., Przuntek, H., Epplen, J. T., Schols, L. & Riess, O. (1998) Nat. Genet. 18, 106-108
6. Narhi, L., Wood, S. J., Steavenson, S., Jiang, Y., Wu, G. M., Anafi, D., Kaufman, S. A., Martin, F., Sitney, K., Denis, P., Louis, J. C., Wypych, J., Biere, A. L. & Citron, M. (1999) J. Biol. Chem. 274, 9843-9846
7. Conway, K. A., Harper, J. D. & Lansbury, P. T. (1998) Nat. Med. 4, 1318-1320
8. Baba, M., Nakajo, S., Tu, P. H., Tomita, T., Nakaya, K., Lee, V. M., Trojanowski, J. Q. & Iwatsubo, T. (1998) Am. J. Pathol. 152, 879-884
9. Dickson, D. W., Liu, W., Hardy, J., Farrer, M., Mehta, N., Uitti, R., Mark, M., Zimmerman, T., Golbe, L., Sage, J., Sima, A., D'Amato, C., Albin, R., Gilman, S. & Yen, S. H. (1999) Am. J. Pathol. 155, 1241-1251
10. Kahle, P. J., Neumann, M., Ozmen, L., Muller, V., Odoy, S., Okamoto, N., Jacobsen, H., Iwatsubo, T., Trojanowski, J. Q., Takahashi, H., Wakabayashi, K., Bogdanovic, N., Riederer, P., Kretzschmar, H. A. & Haass, C. (2001) Am. J. Pathol. 159, 2215-2225
11. Serpell, L. C., Berriman, J., Jakes, R., Goedert, M. & Crowther, R. A. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 4897-4902
12. Spillantini, M. G., Crowther, R. A., Jakes, R., Hasegawa, M. & Goedert, M. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 6469-6473
13. Conway, K. A., Harper, J. D. & Lansbury, P. T., Jr. (2000) Biochemistry 39, 2552-2563
14. Masliah, E., Rockenstein, E., Veinbergs, I., Mallory, M., Hashimoto, M., Takeda, A., Sagara, Y., Sisk, A. & Mucke, L. (2000) Science 287, 1265-1269
15. Feany, M. B. & Bender, W. W. (2000) Nature 404, 394-398
16. McNaught, K. S. & Jenner, P. (2001) Neurosci. Lett. 297, 191-194
17. McNaught, K. S., Olanow, C. W., Halliwell, B., Isacson, O. & Jenner, P. (2001) Nat. Rev. Neurosci. 2, 589-594
18. McNaught, K. S., Belizaire, R., Jenner, P., Olanow, C. W. & Isacson, O. (2002) Neurosci. Lett. 326, 155-158
19. McNaught, K. S., Belizaire, R., Isacson, O., Jenner, P. & Olanow, C. W. (2003) Exp. Neurol. 179, 38-46
20. Tofaris, G. K., Razzaq, A., Ghetti, B., Lilley, K. & Spillantini, M. G. (2003) J. Biol. Chem. 278, 44405-44411
21. Stefanis, L., Larsen, K. E., Rideout, H. J., Sulzer, D. & Greene, L. A. (2001) J. Neurosci. 21, 9549-9560
22. Tanaka, Y., Engelender, S., Igarashi, S., Rao, R. K., Wanner, T., Tanzi, R. E., Sawa, A. L., Dawson, V., Dawson, T. M. & Ross, C. A. (2001) Hum. Mol. Genet. 10, 919-926
23. Petrucelli, L., O'Farrell, C., Lockhart, P. J., Baptista, M., Kehoe, K., Vink, L., Choi, P., Wolozin, B., Farrer, M., Hardy, J. & Cookson, M. R. (2002) Neuron 36, 1007-1019
24. Snyder, H., Mensah, K., Theisler, C., Lee, J., Matouschek, A. & Wolozin, B. (2003) J. Biol. Chem. 278, 11753-11759
25. Auluck, P. K., Chan, H. Y., Trojanowski, J. Q., Lee, V. M. & Bonini, N. M. (2002) Science 295, 865-868
26. Hendil, K. B. & Uerkvitz, W. (1991) J. Biochem. Biophys. Methods 22, 155-165
27. Jensen, P. H., Højrup, P., Hager, H., Nielsen, M. S., Jakobsen, L., Olesen, O. F., Gliemann, J. & Jakes, R. (1997) Biochem. J. 323, 539-546
28. Jensen, P. H., Islam, K., Kenney, J., Nielsen, M. S., Power, J. & Gai, W. P. (2000). J. Biol. Chem. 275, 21500-21507
29. Gai, W. P., Power, J. H. T., Blumbergs, P. C. & Jensen, P. H. (1999) J. Neurochem. 73, 2093-2100
30. Kristensen, P., Johnsen, A. H., Uerkvitz, W., Tanaka, K. & Hendil, K. B. (1995) Biochem. Biophys. Res. Commun. 207, 1059
31. Hendil, K. B., Hartmann-Petersen, R. & Tanaka, K. (2002) J. Mol. Biol. 315, 627-636
32. Mirza, B., Hadberg, H., Thomsen, P. & Moos, T. (2000) Neuroscience 95, 425-432
33. Leveugle, B., Faucheux, B. A., Bouras, C., Nillesse, N., Spik, G., Hirsch, E. C., Agid, Y. & Hof, P. R. (1996) Acta Neuropathol. 91, 566-572
34. Gai, W. P., Yuan, H. X., Li, X. Q., Power, J. T. H., Blumbergs, P. C. & Jensen, P. H. (2000) Exp. Neurol. 166, 324-333
35. Rattan, S. I. (1998) Biochem. Mol. Biol. Int. 45, 753-759
36. Jensen, P. H., Nielsen, M. S., Jakes, R., Dotti, C. G. & Goedert, M. (1998) J. Biol. Chem. 273, 26292-26294
37. Fonager, J., Beedholm, R., Clark, B. F. & Rattan, S. I. (2002) Exp. Gerontol. 37, 1223-1228
38. McKeith, I. G., Galasko, D., Kosaka, K., Perry, E. K., Dickson, D. W., Hansen, L. A., Salmon, D. P., Lowe, J., Mirra, S. S., Byrne, E. J., Lennox, G., Quinn, N. P., Edwardson, J. A., Ince, P. G., Bergeron, C., Burns, A., Miller, B. L., Lovestone, S., Collerton, D., Jansen, E. N., Ballard, C., de Vos, R. A., Wilcock, G. K., Jellinger, K. A. & Perry, R. H. (1996) Neurology 5, 1113-1124
39. Spillantini, M. G., Schmidt, M. L., Lee, V. M., Trojanowski, J. Q., Jakes, R. & Goedert, M. (1997) Nature 388, 839-840
40. Glickman, M. H., Rubin, D. M., Coux, O., Wefes, I., Pfeifer, G., Cjeka, Z., Baumeister, W., Fried, V. A. & Finley, D. (1998) Cell 94, 615-623
41. Gai, W. P., Pountney, D. L., Power, J. H., Li, Q. X., Culvenor, J. G., McLean, C. A., Jensen, P. H. & Blumbergs, P. C. (2003) Exp. Neurol. 181, 68-78
42. Conway, K. A., Rochet, J. C., Bieganski, R. M. & Lansbury, P. T., Jr. (2001) Science 294, 1346-1349
43. Sanchez, I., Mahlke, C. & Yuan, J. (2003) Nature 421, 373-379
44. Giasson, B. I., Murray, I. V., Trojanowski, J. Q. & Lee, V. M. (2001) J. Biol. Chem. 276, 2380-2386
45. Conway, K. A., Lee, S. J., Rochet, J. C., Ding, T. T., Williamson, R. E. & Lansbury, P. T., Jr. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 571-576
46. Chan, H. Y., Warrick, J. M., Gray-Board, G. L., Paulson, H. L. & Bonini, N. M. (2000) Hum. Mol. Genet. 9, 2811-2820
47. Tatton, W. G., Chalmers-Redman, R. M., Elstner, M., Leesch, W., Jagodzinski, F. B., Stupak, D. P., Sugrue, M. M. & Tatton, N. A. (2000) J. Neural. Transm. 60, (suppl.) 77-100
48. Kisselev, A. F. & Goldberg, A. L. (2001) Chem. Biol. 8, 739-758
49. Tsubuki, S., Saito, Y. & Kawashima, S. (1994) FEBS Lett. 344, 229-233
50. Conconi, M., Djavadi-Ohaniance, L., Uerkvitz, W., Hendil, K. B. & Friguet, B. (1999) Arch. Biochem. Biophys. 362, 325-328
51. Tanahashi, N., Murakami, Y., Minami, Y., Shimbara, N., Hendil, K. B. & Tanaka, K. (2000) J. Biol. Chem. 275, 14336-14345
52. Lashuel, H. A., Petre, B. M., Wall, J., Simon, M., Nowak, R. J., Walz, T. & Lansbury, P. T., Jr. (2002) J. Mol. Biol. 322, 1089-1102
53. Volles, M. J., Lee, S. J., Rochet, J. C., Shtilerman, M. D., Ding, T. T., Kessler, J. C. & Lansbury, P. T., Jr. (2001) Biochemistry 40, 7812-7819
54. Tatton, N. A. (2000) Exp. Neurol. 166, 29-43
55. Hashimoto, M., Rockenstein, E., Mante, M., Mallory, M. & Masliah, E. (2001) Neuron 32, 213-223
56. Bence, N. F., Sampat, R. M. & Kopito, R. R. (2001) Science 292, 552-555
57. Lee, M. K., Stirling, W., Xu, Y., Xu, X., Qui, D., Mandir, A. S., Dawson, T. M., Copeland, N. G., Jenkins, N. A. & Price, D. L. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 8968-8973
58. Davies, S. W., Turmaine, M., Cozens, B. A., DiFiglia, M., Sharp, A. H., Ross, C. A., Scherzinger, E., Wanker, E. E., Mangiarini, L. & Bates, G. P. (1997) Cell 90, 537-548