Adenosine as a neuromodulator and as a homeostatic regulator in the nervous system: Different roles, different sources and different receptors

Neurochemistry International

Volumn 38, Issue 2, 2001, Pages 107-125

  Cunha, R A ^a,b  

^a INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

^b UNIVERSITY OF LISBON   (Portugal)

Author keywords

A1 receptors; A2A receptors; Adenosine; Adenosine release; Adenosine transporters; Ecto nucleotidases; Neuromodulation

Indexed keywords

ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A2 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE RECEPTOR; ECTO 5' NUCLEOTIDASE; RECEPTOR SUBTYPE;

AGING; BRAIN METABOLISM; BRAIN PROTECTION; ENZYME INHIBITION; HOMEOSTASIS; HUMAN; NERVE CELL PLASTICITY; NERVE ENDING; NERVOUS SYSTEM; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; REVIEW; SYNAPSE;

ADENOSINE; AGING; ANIMALS; HOMEOSTASIS; NERVE ENDINGS; NERVOUS SYSTEM PHYSIOLOGY; NEURONAL PLASTICITY; NEUROTRANSMITTER AGENTS; RECEPTORS, CELL SURFACE; RECEPTORS, PURINERGIC P1;

EID: 0035255227     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(00)00034-6     Document Type: Review

References (252)

1. 3 receptor. Pathophysiological significance and therapeutic implications for neurodegenerative disorders
2. Changes in adenosine receptors in the neonatal brain following hypoxic ischemia
3. 3H]aspartate release in cultured retina cells exposed to oxidative stress
4. Phosphorylation of an α1-like subunit of an ω-conotoxin-sensitive brain calcium channel by cAMP-dependent protein kinase A and protein kinase C
5. 1 receptor expressed in chinese hamster ovary cells not only inhibits cAMP accumulation but also stimulates phospholipase C and arachidonate release
6. Facilitation by arachidonic acid of acetylcholine release from the rat hippocampus
7. 1 receptor
8. Release of neurotransmitter amino acids from rat brain synaptosomes and its regulation in aging
9. The control of the metabolism and the hormonal role of adenosine
10. 1 adenosine receptors
11. Inhibition by adenosine receptor agonists of synaptic transmission in rat periaqueductal gray neurons
12. Exogenous creatine delays anoxic depolarization and protects from hypoxic damage: Dose-effect relationship
13. Apoptosis by 2-chloro-2′-deoxy-adenosine and 2-chloro-adenosine in human peripheral blood mononuclear cells
14. Supply-to-demand ratio for oxygen determines formation of adenosine by the heart
15. Normal aging: Regionally specific changes in hippocampal synaptic transmission
16. 1 receptor inhibition of glutamate exocytosis and protein kinase C-mediated decoupling
17. 1 adenosine receptor antagonism in rat hippocampal slices
18. Probabilistic secretion of quanta from nerve terminals in avian ciliary ganglia modulated by adenosine
19. 1 receptors by phosphorylation in Zucker rats
20. Release of adenosine from ischaemic brain
21. The local regulation of cerebral blood flow
22. 1 receptor agonists as clinically viable agents for treatment of ischemic brain damage
23. Prevention of cycloheximide-induced apoptosis in hepatocytes by adenosine and by caspase inhibitors
24. Inhibitory avoidance learning inhibits ectonucleotidases activities in hippocampal synaptosomes of adult rats
25. Adenosine-stimulated astroglial swelling in cat cerebral cortex in vivo with total inhibition by a non-diuretic acylaryloxyacid derivative
26. Upregulation of the enzymes chain hydrolysing extracellular ATP after transient forebrain ischemia in the rat
27. Activation of NO-cGMP signalling pathway depresses hippocampal synaptic transmission through an adenosine receptor-dependent mechanism
28. Modulation of excitatory synaptic transmission by adenosine released from single hippocampal pyramidal neurons
29. 1 receptor by a facilitatory metabotropic glutamate receptor
30. Regulation of glutamate and aspartate release from slices of the hippocampal CA1 area: Effects of adenosine and baclofen
31. 2+-channels to release adenosine from spinal cord synaptosomes
32. Presynaptic enhancement of inhibitory synaptic transmission by protein kinases A and C in the rat hippocampus
33. Presynaptic inhibition of calcium-dependent and calcium-independent release elicited with ionomycin, gadolinium, and α-latrotoxin in the hippocampus
34. 1 receptor activation inhibits basal accumulation of inositol phosphates in rat hippocampus
35. Adenosine modulation of calcium currents and presynaptic inhibition of GABA release in suprachiasmatic and arcuate nucleus neurons
36. 2A adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice
37. Purines and their roles in apoptosis
38. 1 adenosine receptors
39. 2a-adenosine receptor of the motor nerve endings is positively coupled to adenylate cyclase
40. 3H]-ACh release from rat motor nerve endings
41. 2A receptor activation modulates nicotinic autoreceptor function at the rat neuromuscular junction
42. 3H]-ACh release from the motor nerve terminals
43. 2A facilitatory adenosine receptor activation balance depends on motor nerve stimulation paradigm at the rat hemidiaphragm
44. Response to prejunctional adenosine receptors is dependent on stimulus frequency
45. Release of ATP and adenosine and formation of extracellular adenosine in the hippocampus
46. 2A receptors in the CNS
47. On slices, synaptosomes and dissociated neurones to study in vitro ageing physiology
48. Age-dependent modification of adenosine modulation by arachidonic acid in the rat hippocampus
49. Facilitation of GABA release by arachidonic acid in rat hippocampal synaptosomes
50. 3H]GABA release from rat hippocampal nerve terminals
51. 2A receptor facilitation of synaptic transmission in the CA1 area of the rat hippocampus requires protein kinase C but not protein kinase A activation
52. Extracellular metabolism of adenine nucleotides and adenosine in the innervated skeletal muscle of the frog
53. Adenosine and adenine nucleotides are independently released from both the nerve terminals and the muscle fibres upon electrical stimulation of the innervated skeletal muscle of the frog
54. 2a receptors in the rat hippocampus
55. 2A receptors stimulate acetylcholine release from nerve terminals of the rat hippocampus
56. 2A adenosine receptor binding in aged striatum, hippocampus and cortex of the rat
57. Preferential release of ATP and its extracellular catabolism as a source of adenosine upon high- but not low-frequency stimulation of rat hippocampal slices
58. Preferential activation of excitatory adenosine receptors at rat hippocampal and neuromuscular synapses by adenosine formed from released adenine nucleotides
59. 2A receptors
60. Modification upon aging of extracellular adenosine metabolism in rat hippocampal slices
61. 1 receptors
62. 3H]acetylcholine release from the rat hippocampus
63. 2A receptors
64. Immunologically distinct isoforms of ecto-5′-nucleotidase in nerve terminals of different areas of the rat hippocampus
65. 3H]-GABA release from rat hippocampal synaptosomes
66. 1 receptor ligands on energy metabolism and macromolecular biosynthesis in cultured central neurons
67. Extracellular ATP and adenosine cause apoptosis of pulmonary artery endothelial cells
68. 2, and energy status in working guinea pig hearts
69. Hypoxia-induced inhibition of adenosine kinase potentiates cardiac adenosine release
70. Endogenous adenosine modulates long-term potentiation in the hippocampus
71. 1 receptor activation in the rat hippocampus
72. 1 adenosine and class II metabotropic glutamate receptors in the regulation of purine and glutamate release from rat hippocampal slices
73. 2A receptor in the rat striatum
74. An adenosine agonist inhibits and a cyclic AMP analogue enhances the release of glutamate but not GABA from slices of rat dentate gyrus
75. Mechanism of adenosine accumulation in the hippocampal slice during energy deprivation
76. 2A adenosine receptor characteristics following repeated seizures in developing rats
77. The physiological activity of adenine compounds with special reference to their action upon the mammalian heart
78. The physiological role of adenosine in the central nervous system
79. Extracellular adenosine concentrations in hippocampal brain slices and the tonic inhibitory modulation of evoked excitatory responses
80. Effects of protein kinase C activation on the sensitivity of pre- and post-synaptic adenosine receptors
81. 1 receptors inhibit adenylate cyclase activity and neurotransmitter release and hyperpolarize pyramidal neurons in rat hippocampus
82. Adenosine increases synaptic facilitation in the in vitro rat hippocampus: Evidence for a presynaptic site of action
83. Adenine nucleotides undergo rapid, quantitative conversion to adenosine in the extracellular space in rat hippocampus
84. 1 receptor-mediated responses in the rat hippocampus
85. Release of adenosine from rat hippocampal slices by nitric oxide donors
86. Metabolic control and its analysis. Additional relationships between elasticities and control coefficients
87. 2B receptors
88. Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal ganglia
89. 2b receptors mediate an increase in interleukin (IL)-6 mRNA and IL-6 protein synthesis in human astroglioma
90. + flux and the anoxic depolarization to adenosine 5′-triphosphate levels in hypoxic/hypoglycemic rat hippocampal slices
91. 1 receptor-mediated actions in rat hippocampus
92. 1 receptor stimulation
93. Adenosine and neuroprotection
94. The xanthine derivative 1-(5′-oxohexyl)-3-methyl-7-propylxanthine (HWA 285) enhances actions of adenosine
95. Propentofylline and other adenosine transport inhibitors increase the efflux of adenosine following electrical or metabolic stimulation of rat hippocampal slices
96. iα-3
97. Effects of adenosine receptors on the synaptic and EPSP-spike components of long-term potentiation and depotentiation in the guinea-pig hippocampus
98. 2 receptor antagonist, reduces cerebral ischemic injury in the mongolian gerbil
99. Characterization of inhibition mediated by adenosine in the hippocampus of the rat in vitro
100. The effect of adenosine on the release of transmitter from the phrenic nerve of the rat
101. Purinergic modulation of cortical acetylcholine release is decreased in aging rats
102. 2 receptors are modified during seizure: Effect of cyclopentyladenosine administration
103. 2+ uptake through class A calcium channels in rat hippocampal CA3 but not CA1 synaptosomes
104. Facilitatory and inhibitory modulation by endogenous adenosine of noradrenaline release in the epididymal portion of rat vas deferens
105. The electrophysiology of adenosine in the mammalian central nervous system
106. Endogenous adenosine contributes to hypoxic synaptic depression in hippocampus from young and aged rats
107. 2a receptor involves activation of both N- and P-type calcium channels by different G proteins and protein kinases in the same nerve terminals
108. 13C NMR spectroscopy
109. Modulatory effects of adenosine on inhibitory post-synaptic potentials in the lateral amygdala of the rat
110. 1 AR mRNA expression or G protein α-subunit content
111. + channels in cerebral ischemic preconditioning
112. N-methyl-D-aspartate, kainate and quisqualate release endogenous adenosine from rat cortical slices
113. Inhibition of lipolysis by adenosine is potentiated with age
114. Adenosine receptor ligands: Differences with acute versus chronic treatment
115. Production of adenosine from extracellular ATP at the striatal cholinergic synapse
116. 2A receptor stimulation increases release of acetylcholine from rat hippocampus but not striatum, and does not affect catecholamine release
117. Age-dependent change in the inhibitory effect of an adenosine agonist on hippocampal acetylcholine release in rats
118. 1-adenosine receptor
119. 3H]CGS 21680 to rat brain using autoradiography
120. 2A receptor antagonist
121. 2 receptor activation attenuates reperfusion injury by inhibiting neutrophil accumulation, superoxide generation, and coronary endothelial adherence
122. 3H]purine outflow evoked by short-term hypoxia and hypoglycemia in rat hippocampal slices
123. Adenosine receptors of cerebral microvessels and choroid plexus
124. Anoxic depolarization determines ischemic brain injury
125. Protein kinase C phosphorylates the inhibitory guanine-nucleotide-binding regulatory component and apparently supresses its function in hormonal inhibition of adenylate cyclase
126. 2a receptor is not mediated by increases in cyclic AMP
127. Clinical trials in dementia with propentofylline
128. 2 receptor antagonists
129. Rapid turnover of the AMP-adenosine metabolic cycle in the guinea pig heart
130. Biochemico-pharmacological mechanisms and the relation between anticalorigenic, hypothermic, and antihypoxic effects of adenosine
131. Adenosine depresses excitatory but not fast inhibitory synaptic transmission in area CA1 of the rat hippocampus
132. Extracellular adenosine concentrations during in vitro ischaemia in rat hippocampal slices
133. 2A adenosine receptor gene function as negative translational regulator
134. Inhibition of human monocyte TNF production by adenosine receptor agonists
135. 1 neurones
136. Intracellular formation and release of adenosine from rat hippocampal slices evoked by electrical stimulation or energy depletion
137. 2a adenosine receptors in the hippocampus and cortex of young and old rats
138. 1 receptor responses
139. 2A receptors in the limbic cortex, but not striatum, of aged rats
140. Presynaptic inhibition of excitatory synaptic transmission by adenosine in rat hippocampus: Analysis of unitary EPSP variance by whole-cell recording
141. Adenosine stimulates glycogenolysis in mouse cerebral cortex: A possible coupling mechanism between neuronal activity and energy metabolism
142. 2-terminal kinase
143. Release of adenosine by activation of NMDA receptors in the hippocampus
144. 2-adenosine receptor to stimulatory guanine nucleotide-binding protein in bovine brain striatum
145. Acute peroxide treatment of rat hippocampal slices induces adenosine-mediated inhibition of excitatory transmission in area CA1
146. Adenosine and its mononucleotides as regulatory and adaptative signals in the brain
147. Adenosine production and metabolism
148. Adenosine formation and release by embryonic chick neurons and glia in cell culture
149. Activity-dependent release of endogenous adenosine modulates synaptic responses in the rat hippocampus
150. 2+ current in hippocampal CA3 neurons
151. 2A receptors by SCH 58261 results in neuroprotective effects in cerebral ischaemia in rats
152. 2a receptors in regulating GABAergic synaptic transmission in striatal medium spiny neurons
153. Ageing is associated with changes in glutamate release, protein tyrosine kinase and Ca2+/calmodulin-dependent protein kinase II in rat hippocampus
154. 1 receptor binding in the post-ischaemic rat brain
155. Synaptosomal ATPase activities in temporal cortex and hippocampal formation of humans with focal epilepsy
156. 5′-Nucleotidase from rat heart membranes. Inhibition by adenine nucleotides and related compounds
157. 2 receptors supplants ischemic preconditioning in providing ischemic tolerance in rat livers
158. 1 adenosine receptor/G protein coupling: Identification of a membrane protein that stabilizes the association of the receptor/G protein complex
159. Trophic actions of extracellular nucleotides and nucleosides on glial and neuronal cells
160. 2 receptor agonists and antagonists on local rates of energy metabolism in the rat brain
161. Adenosine and the concept of retaliatory metabolites
162. 2A adenosine receptor in PC12 cells
163. Adenosine in rat cerebral cortex: Its determination, normal values, and correlation to AMP and cyclic AMP during shortlasting ischemia
164. 2A receptors inhibit the conductance of NMDA receptor channels in rat neostriatal neurons
165. 2 adenosine receptor cooperation
166. 2A adenosine receptor activation reduces ischemia-reperfussion injury in rat kidney
167. s
168. Adenosine-induced presynaptic inhibition of IPSCs and EPSCs in rat hypothalamic supraoptic nucleus neurones
169. 1 adenosine receptors in cortex, hippocampus and cerebellum in ageing mouse brain
170. 2A adenosine receptor in PC12 cells
171. Investigations into the adenosine outflow from hippocampal slices by ischemia-like conditions
172. Role of adenosine in channel arrest in the anoxic turtle brain
173. Tonic adenosine neuromodulation is unaltered in motor nerve endings of aged rats
174. Anoxic preconditioning in hippocampal slices: Role of adenosine
175. 2a adenosine receptor antagonists on cerebral ischemic injury in the gerbil
176. Inhibitory action of CGS 21680 on cerebral cortical neurons is antagonized by bicuculline and picrotoxin - Is GABA involved?
177. Depression of corticospinal cells by various purines and pyrimidines
178. Nucleoside transport in cultured mammalian cells. Multiple forms with different sensitivity to inhibition by nitrobenzylthioinosine or hypoxanthine
179. Adenosine decreases neurotransmitter release at central synapses
180. Pre- and post-synaptic actions of adenosine in the in vitro hippocampus
181. Adenine nucleotides as neurohumoral agents in the brain. The quantities liberated on excitation of superfused cerebral tissues
182. A simple apparatus for studying the release of neurotransmitters from synaptosomes
183. 2-adenosine receptors in DDT1 MF-2 cells
184. Adenosine, antioxidant enzymes and cytoprotection
185. 2 receptor antagonist prevents frontal cortex EEG abnormalities in a rat model of Huntington's disease
186. Purinergic inhibition of neurotransmitter release in the central nervous system
187. 2A receptor interactions with receptors for other neurotransmitters and neuromodulators
188. Adenosine receptors and calcium: Basis for proposing a third (A3) adenosine receptor
189. Action of adenosine triphosphate on endplate potentials recorded from muscle fibres of the rat diaphragm and frog sartorius
190. The effects of adenosine triphosphate and adenosine diphosphate on transmission at the rat and frog neuromuscular junctions
191. ATP release from affinity-purified rat cholinergic nerve terminals
192. Ectoenzymes control adenosine modulation of immunoisolated cholinergic synapses
193. ATP and glutamate are released from separate neurones in the rat medial habenula nucleus: Frequency dependence and adenosine-mediated inhibition of release
194. 2A activation reduces lung reperfussion injury following transplantation
195. Adenosine and brain ischemia
196. 1 receptors in rat brain by in vivo treatment with R-PIA: Involvement of coated vesicles
197. 1 receptors
198. The effect of adenosine and adenine nucleotides on the cyclic adenosine 3′,5′-phosphate content of guinea pig cerebral cortex slices
199. Presynaptic inhibition of miniature excitatory synaptic currents by baclofen and adenosine in the hippocampus
200. ATP diphosphohydrolase and 5′-nucleotidase activities from hippocampal synaptosomes after brain ischemia
201. 5′-Nucleotidase activity of mossy fibers in the dentate gyrus of normal and epileptic rats
202. Inhibition of quantal transmitter release in the absence of calcium influx by a G protein-linked adenosine receptor at hippocampal synapses
203. 2+ currents and synaptic transmission in cultured rat hippocampal pyramidal neurones
204. Differential effect of adenosine on pre- and post-synaptic calcium fluxes
205. Models for the regulation of purine metabolism in rat hepatocytes: Evaluation of tracer kinetic experiments
206. Interactions between adenosine and phorbol esters or lithium at the frog neuromuscular junction
207. 2 receptor-mediated excitatory actions on the nervous system
208. Modulation of synaptic transmission in the hippocampus of aged rats by inhibitory and excitatory adenosine receptors
209. Adenine nucleotides as inhibitors of synaptic transmission: Role of localised ectonucleotidases
210. 1 receptors prevents, a facilitatory action of calcitonin gene-related peptide in the rat hippocampus
211. Intracellular analysis of a post-synaptic action of adenosine in the rat hippocampus
212. 3H]γ-aminobutyric acid in rat hippocampal synaptosomes
213. 2A-adenosine receptor in primary human endothelial cells
214. On the mechanism by which adenosine receptor activation inhibits the release of acetylcholine from motor nerve endings
215. Adenosine derived fron neurally released ATP is the physiologic cause of skeletal neuromuscular depression
216. Modulation of purinergic neurotransmission
217. 1-adenosine receptors in rat hippocampal slices
218. 2 in stimulated rat cardiomyocytes
219. 1 receptors are located predominantly on axons in the rat hippocampus
220. 2+ channels by protein kinase C in rat central and peripheral neurons: Disruption of G protein-mediated inhibition
221. ATP release, adenosine formation, and modulation of dynorphin and glutamic acid release by adenosine analogues in rat hippocampal mossy fiber synaptosomes
222. Adenosine modulates cell growth in human epidermoid carcinoma (A431) cells
223. Comparison of the actions of adenosine at pre- and post-synaptic receptors in the rat hippocampus in vitro
224. Presynaptic inhibition in the hippocampus
225. ATP channels
226. 1-receptor agonists on ischemia-induced decrease in 2-deoxyglucose uptake in rat hippocampal slices
227. Purinergic inhibition of GABA and glutamate release in the thalamus: Implications for thalamic network activity
228. 2 receptors differentially modulates calcium channels and glycinergic synaptic transmission in rat brainstem
229. Increase in cerebral interstitial fluid adenosine concentration during hypoxia, local potassium infusion, and ischaemia
230. Cytosolic phosphorylation potential
231. Adenosine and cerebral ischemia: Therapeutic future or death of a brave concept?
232. 3 receptor stimulation and cerebral ischemia
233. 2A receptor agonist and antagonists
234. Adenosine-induced apoptosis in chick embryonic sympathetic neurons: A new physiological role for adenosine
235. Adenosine protects chick embryonic sympathetic neurons from apoptotic death by 2′-deoxyadenosine - Importance of ATP in apoptosis
236. Decrease in cold tolerance of aged rats caused by the enhanced endogenous adenosine activity
237. Neural release of ATP and adenosine
238. Stimulation-dependent release of adenosine triphosphate from hippocampal slices
239. Activation of metabotropic glutamate receptors increases cAMP accumulation in hippocampus by potentiating responses to endogenous adenosine
240. Cholinergic phosphatidylinositol modulation of inhibitory, G protein-linked neurotransmitter actions: Electrophysiological studies in the rat hippocampus
241. B-mediated synaptic current by adenosine recorded in vitro in midbrain dopamine neurons
242. Adenosine inhibits evoked synaptic transmission primarily by reducing presynaptic calcium influx in area CA1 of hippocampus
243. 2+ channels by adenosine autoreceptors
244. Adenosine inhibits excitatory but not inhibitory synaptic transmission in the hippocampus
245. Whole-cell recording of anoxic effects on hippocampal neurons in slices
246. 1 receptors mediate retinotectal presynaptic inhibition: Uncoupling by C-kinase and role in LTP during regeneration
247. 1 and class II metabotropic glutamate receptors mediate shared presynaptic inhibition of retinotectal transmission
248. The effects of adenosine on the energy metabolism of the reperfused intestine in rats
249. 2 receptor through a protein kinase C signaling pathway
250. Adenosine release mediates cyanide-induced suppresion of CA1 neuronal activity
251. Biochemistry, localization and functional roles of ecto-nucleotidases in the nervous system