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Volumn 62, Issue 2, 2004, Pages 330-332

The safety and tolerability of a mixed lineage kinase inhibitor (CEP-1347) in PD

Author keywords

[No Author keywords available]

Indexed keywords

CEP 1347; LEVODOPA; PLACEBO;

EID: 0842324952     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/01.wnl.0000103882.56507.20     Document Type: Article
Times cited : (58)

References (8)
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    • Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease
    • Hartmann A, Hunot S, Michel PP, et al. Caspase-3: a vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease. Proc Natl Acad Sci USA 2000;97:2875-2880.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 2875-2880
    • Hartmann, A.1    Hunot, S.2    Michel, P.P.3
  • 4
    • 0032692497 scopus 로고    scopus 로고
    • CEP1347 (KT 7515) and inhibitor of JNK activation, rescues sympathetic neurons and neuronally differentiated PC12 cells from death evoked by 3 distinct insults
    • Maroney AC, Finn JP, Bozyczko-Coyne D, et al. CEP1347 (KT 7515) and inhibitor of JNK activation, rescues sympathetic neurons and neuronally differentiated PC12 cells from death evoked by 3 distinct insults. J Neurochem 1999;73:1901-1912.
    • (1999) J Neurochem , vol.73 , pp. 1901-1912
    • Maroney, A.C.1    Finn, J.P.2    Bozyczko-Coyne, D.3
  • 5
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    • CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons in vivo
    • Saporito MS, Brown EM, Miller MS, Carswell S. CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons in vivo. J Pharmacol Exp Ther 1999;288:421-427.
    • (1999) J Pharmacol Exp Ther , vol.288 , pp. 421-427
    • Saporito, M.S.1    Brown, E.M.2    Miller, M.S.3    Carswell, S.4
  • 6
    • 0033840581 scopus 로고    scopus 로고
    • MPTP activates c-Jun NH(2)-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo
    • Saporito MS, Thomas BA, Scott RW. MPTP activates c-Jun NH(2)-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo. J Neurochem 2000;75:1200-1208.
    • (2000) J Neurochem , vol.75 , pp. 1200-1208
    • Saporito, M.S.1    Thomas, B.A.2    Scott, R.W.3
  • 7
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    • Unified Parkinson's Disease Rating Scale
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    • Fahn S, Elton RL, members of the UPDRS Development Committee. Unified Parkinson's Disease Rating Scale. In: Fahn S, Marsden CO, Calne DB, Goldstein M, eds. Recent development in Parkinson's disease, vol. 2. Florham Park: Macmillan Health Care Information, 1987:153-164.
    • (1987) Recent Development in Parkinson's Disease , vol.2 , pp. 153-164
    • Fahn, S.1    Elton, R.L.2
  • 8
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    • Effect of peripheral catechol-O-methyltransferase inhibition on the pharmacokinetics and pharmacodynamics of levodopa in parkinsonian patients
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    • (1994) Neurology , vol.44 , pp. 913-919
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.