Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease

Science

Volumn 290, Issue 5492, 2000, Pages 767-773

  Kordower, J H ^a   Emborg, M E ^a   Bloch, J ^a   Ma, S Y ^a   Chu, Y ^a   Leventhal, L ^a   McBride, J ^a   Chen, E Y ^a   Palfi, S ^a   Roitberg, B Z ^a   Brown, W D ^a   Holden, J E ^a   Pyzalski, R ^a   Taylor, M D ^a   Carvey, P ^a   Ling, Z ^a   Trono, D ^a   Hantraye, P ^a   Deglon, N ^a   Aebischer, P ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; VIRUS VECTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; DRUG DELIVERY SYSTEM; DRUG EFFICACY; IMMUNOREACTIVITY; LENTIVIRINAE; NERVE CELL DEGENERATION; NONHUMAN; PARKINSON DISEASE; PRIMATE; PRIORITY JOURNAL;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; AGING; ANIMALS; ANTIGENS, CD; DIHYDROXYPHENYLALANINE; DISEASE MODELS, ANIMAL; DOPAMINE; FEMALE; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; LENTIVIRUS; MACACA MULATTA; NEOSTRIATUM; NERVE DEGENERATION; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; NEURONS; PARKINSON DISEASE; PARKINSONIAN DISORDERS; PSYCHOMOTOR PERFORMANCE; SUBSTANTIA NIGRA; TYROSINE 3-MONOOXYGENASE;

EID: 0034721690     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.290.5492.767     Document Type: Article

References (34)