Natural product-based inhibitors of hypoxia-inducible factor-1 (HIF-1)

Current Drug Targets

Volumn 7, Issue 3, 2006, Pages 355-369

  Nagle, Dale G ^a   Zhou, Yu Dong ^a  

^a UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

HIF 1; Hypoxia selective; Molecular targeted drug discovery; Natural product; Small molecule HIF 1 inhibitor; Tumor hypoxia

Indexed keywords

17 ALLYLAMINO 17 DEMETHOXYGELDANAMYCIN; 2 METHOXYESTRADIOL; 2 MORPHOLINO 8 PHENYLCHROMONE; APIGENIN; CAMPTOTHECIN DERIVATIVE; CYCLOHEXIMIDE; CYCLOSPORIN A; DACTINOMYCIN; GELDANAMYCIN; GL 331; HEAT SHOCK PROTEIN 90; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; KUTKIN; KUTKOSIDE; MAMMALIAN TARGET OF RAPAMYCIN; NOVOBIOCIN; PACLITAXEL; PICROSIDE I; PODOPHYLLOTOXIN DERIVATIVE; PROTEIN INHIBITOR; PROTEIN KINASE B; PSEUDOLARIC ACID B; RADICICOL; RESVERATROL; TOPOTECAN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINCRISTINE; WORTMANNIN; BIOLOGICAL PRODUCT;

ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CELL HYPOXIA; CLINICAL TRIAL; CONCENTRATION RESPONSE; CYTOTOXICITY; DRUG EFFICACY; DRUG ISOLATION; DRUG MECHANISM; DRUG POTENCY; DRUG RESEARCH; DRUG SCREENING; DRUG TARGETING; HIGH THROUGHPUT SCREENING; HUMAN; LIVER TOXICITY; MOLECULAR WEIGHT; NONHUMAN; PROTEIN FUNCTION; PROTEIN SYNTHESIS INHIBITION; PROTEIN TARGETING; REVIEW; SOLID TUMOR; TRANSCRIPTION REGULATION; ANIMAL; BIOTRANSFORMATION; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM;

ANIMALS; BIOLOGICAL PRODUCTS; BIOTRANSFORMATION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1;

EID: 33645822306     PISSN: 13894501     EISSN: None     Source Type: Journal    
DOI: 10.2174/138945006776054979     Document Type: Review

References (168)

1. Moody, E.J.; Simon, B.A. and Johns, R.A. (2001) in The Pharmacological Basis of Therapeutics, (Hardman, J.G., Limbird, L.E. and Gilman, A.G., Ed.), McGraw-Hill Medical Publishing Division, New York, pp. 385-397.
2. Brown, J.M. (1999) Cancer Res., 59(23), 5863-5870.
3. Harris, A.L. (2002) Nat. Rev. Cancer, 2(1), 38-47.
4. Subarsky, P. and Hill, R.P. (2003) Clin. Exp. Metastasis, 20(3), 237-250.
5. Brown, J.M. and Wilson, W.R. (2004) Nat. Rev. Cancer, 4(6), 437-447.
6. Sutphin, P.D.; Chan, D.A. and Giaccia, A.J. (2004) Cell Cycle, 3(2), 160-163.
7. Graeber, T.G.; Osmanian, C.; Jacks, T.; Housman, D.E.; Koch, C.J.; Lowe, S.W. and Giaccia, A.J. (1996) Nature, 379(6560), 88-91.
8. Semenza, G.L. and Wang, G.L. (1992) Mol. Cell. Biol., 12(12), 5447-5454.
9. Wang, G.L. and Semenza, G.L. (1995) J. Biol. Chem., 270(3), 1230-1237.
10. Wang, G.L.; Jiang, B.H.; Rue, E.A. and Semenza, G.L. (1995) Proc. Natl. Acad. Sci. U. S. A., 92(12), 5510-5514.
11. Semenza, G.L. (1999) Annu. Rev. Cell Dev. Biol., 15, 551-578.
12. Huang, L.E. and Bunn, H.F. (2003) J. Biol. Chem., 278(22), 19575-19578.
13. Poellinger, L. and Johnson, R.S. (2004) Curr. Opin. Genet. Dev., 14, 81-85.
14. Mazure, N.M.; Brahimi-Horn, M.C.; Berta, M.A.; Benizri, E.; Bilton, R.L.; Dayan, F.; Ginouves, A.; Berra, E. and Pouyssegur, J. (2004) Biochem. Pharmacol., 68(6), 971-980.
15. Brahimi-Horn, C.; Mazure, N. and Pouyssegur, J. (2005) Cell. Signal., 17(1), 1-9.
16. Ivan, M.; Kondo, K.; Yang, H.; Kim, W.; Valiando, J.; Ohh, M.; Salic, A.; Asara, J.M.; Lane, W.S. and Kaelin, W.G. Jr. (2001) Science, 292(5516), 464-468.
17. Jaakkola, P.; Mole, D.R.; Tian, Y.M.; Wilson, M.I.; Gielbert, J.; Gaskell, S.J.; Kriegsheim, A.V.; Hebestreit, H.F.; Mukherji, M.; Schofield, C.J.; Maxwell, P.H.; Pugh, C.W. and Ratcliffe, P.J. (2001) Science, 292(5516), 468-472.
18. Lando, D.; Peet, D.J.; Whelan, D.A.; Gorman, J.J. and Whitelaw, M.L. (2002) Science, 295(5556), 858-861.
19. Semenza, G.L. (2003) Nat. Rev. Cancer, 3, 721-732.
20. Giaccia, A.; Siim, B.G. and Johnson, R.S. (2003) Nat. Rev. Drug Discov., 2(10), 803-811.
21. Welsh, S.J. and Powis, G. (2003) Curr. Cancer Drug Targets, 3(6), 391-405.
22. Powis, G. and Kirkpatrick, L. (2004) Mol. Cancer Ther., 3(5), 647-654.
23. Yeo, E.J.; Chun, Y.S. and Park, J.W. (2004) Biochem. Pharmacol., 68(6), 1061-1069.
24. Paul, S.A.; Simons, J.W. and Mabjeesh, N.J. (2004) J. Cell Physiol., 200(1), 20-30.
25. Hopfl, G.; Ogunshola, O. and Gassmann, M. (2004) Am. J. Physiol. Regul. Integr. Comp. Physiol., 286(4), R608-R623.
26. Zhong, H.; De Marzo, A.M.; Laughner, E.; Lim, M.; Hilton, D.A.; Zagzag, D.; Buechler, P.; Isaacs, W.B.; Semenza, G.L. and Simons, J.W. (1999) Cancer Res., 59(22), 5830-5835.
27. Bos, R.; Zhong, H.; Hanrahan, C.F.; Mommers, E.C.; Semenza, G.L.; Pinedo, H.M.; Abeloff, M.D.; Simons, J.W.; van Diest, P.J. and van der Wall, E. (2001) J. Natl. Cancer Inst., 93(4), 309-314.
28. Bos, R.; van der Groep, P.; Greijer, A.E.; Shvarts, A.; Meijer, S.; Pinedo, H.M.; Semenza, G.L.; van Diest, P.J. and van der Wall, E. (2003) Cancer, 97(6), 1573-1581.
29. Vleugel, M.M.; Greijer, A.E.; Shvarts, A.; van der Groep, P.; van Berkel, M.; Aarbodem, Y.; van Tinteren, H.; Harris, A.L.; van Diest, P.J. and van der Wall, E. (2005) J. Clin. Pathol., 58(2), 172-177.
30. Takahashi, R.; Tanaka, S.; Hiyama, T.; Ito, M.; Kitadai, Y.; Sumii, M.; Haruma, K. and Chayama, K. (2003) Oncol. Rep., 10(4), 797-802.
31. Sohda, M.; Ishikawa, H.; Masuda, N.; Kato, H.; Miyazaki, T.; Nakajima, M.; Fukuchi, M.; Manda, R.; Fukai, Y.; Sakurai, H. and Kuwano, H. (2004) Int. J. Cancer, 110(6), 838-844.
32. Theodoropoulos, V.E.; Lazaris, A.C.; Sofras, F.; Gerzelis, I.; Tsoukala, V.; Ghikonti, I.; Manikas, K. and Kastriotis, I. (2004) Eur. Urol., 46(2), 200-208.
33. Zhong, H.; Semenza, G.L.; Simons, J.W. and De Marzo, A.M. (2004) Cancer Detect. Prev., 28(2), 88-93.
34. Jiang, B.H.; Agani, F.; Passaniti, A. and Semenza, G.L. (1997) Cancer Res., 57(23), 5328-5335.
35. Maxwell, P.H.; Dachs, G.U.; Gleadle, J.M.; Nicholls, L.G.; Harris, A.L.; Stratford, I.J.; Hankinson, O.; Pugh, C.W. and Ratcliffe, P.J. (1997) Proc. Natl. Acad. Sci. U. S. A., 94(15), 8104-8109.
36. Ryan, H.E.; Lo, J. and Johnson, R.S. (1998) EMBO J., 17(11), 3005-3015.
37. Ryan, H.E.; Poloni, M.; McNulty, W.; Elson, D.; Gassmann, M.; Arbeit, J.M. and Johnson, R.S. (2000) Cancer Res., 60(15), 4010-4015.
38. Kung, A.L.; Wang, S.; Klco, J.M.; Kaelin, W.G. and Livingston, D.M. (2000) Nat. Med., 6(12), 1335-1340.
39. Hopfl, G.; Wenger, R.H.; Ziegler, U.; Stallmach, T.; Gardelle, O.; Achermann, R.; Wergin, M.; Kaser-Hotz, B.; Saunders, H.M.; Williams, K.J.; Stratford, I.J.; Gassmann, M. and Desbaillets, I. (2002) Cancer Res., 62(10), 2962-2970.
40. Unruh, A.; Ressel, A.; Mohamed, H.G.; Johnson, R.S.; Nadrowitz, R.; Richter, E.; Katschinski, D.M. and Wenger, R.H. (2003) Oncogene, 22(21), 3213-3220.
41. Majumder, P.K.; Febbo, P.G.; Bikoff, R.; Berger, R.; Xue, Q.; McMahon, L.M.; Manola, J.; Brugarolas, J.; McDonnell, T.J.; Golub, T.R.; Loda, M.; Lane, H.A. and Sellers, W.R. (2004) Nat. Med., 10(6), 594-601.
42. Moeller, B.J.; Cao, Y.; Li, C.Y. and Dewhirst, M.W. (2004) Cancer Cell, 5(5):429-441.
43. Rapisarda, A.; Zalek, J.; Hollingshead, M.; Braunschweig, T.; Uranchimeg, B.; Bonomi, C.A.; Borgel, S.D.; Carter, J.P.; Hewitt, S.M.; Shoemaker, R.H. and Melillo, G. (2004) Cancer Res., 64(19), 6845-6848.
44. Carmeliet, P.; Dor, Y.; Herbert, J.M.; Fukumura, D.; Brusselmans, K.; Dewerchin, M.; Neeman, M.; Bono, F.; Abramovitch, R.; Maxwell, P.; Koch, C.J.; Ratcliffe, P.; Moons, L.; Jain, R.K.; Collen, D. and Keshert, E. (1998) Nature, 394(6692), 485-490.
45. Blouw, B.; Song, H.; Tihan, T.; Bosze, J.; Ferrara, N.; Gerber, H.P.; Johnson, R.S. and Bergers, G. (2003) Cancer Cell, 4(2), 133-146.
46. Newman, D.J.; Cragg, G.M. and Snader, K.M. (2003) J. Nat. Prod., 66(7), 1022-1037.
47. Wang, G.L. and Semenza, G.L. (1993) J. Biol. Chem., 268(29), 21513-21518.
48. Page, E.L.; Robitaille, G.A.; Pouyssegur, J. and Richard, D.E. (2002) J. Biol. Chem., 277(50), 48403-48409.
49. Huang, T.S.; Shu, C.H.; Shih, Y.L.; Huang, H.C.; Su, Y.C.; Chao, Y.; Yang, W.K. and Whang-Peng, J. (1996) Cancer Lett., 110(1-2), 77-85.
50. Chang, H.; Shyu, K.G.; Lee, C.C.; Tsai, S.C.; Wang, B.W.; Lee, Y.H. and Lin, S. (2003) Biochem. Biophys. Res. Commun., 302(1), 95-100.
51. Lin, S.; Huang, H.C.; Chen, L.L.; Lee, C.C. and Huang, T.S. (2001) Mol. Pharmacol., 60(4), 768-775.
52. Liu JM, Chen LT, Chao Y, Li AF, Wu CW, Liu TS, Shiah HS, Chang JY, Chen JD, Wu HW, Lin, W.C.; Lan, C. and Whang-Peng, J. (2002) Cancer Chemother. Pharmacol., 49(5), 425-428.
53. Gaddipati, J.P.; Madhavan, S.; Sidhu, G.S.; Singh, A.K.; Seth. P. and Maheshwari, R.K. (1999) Mol. Cell Biochem., 194(1-2), 271-281.
54. Chander, R.; Kapoor, N.K. and Dhawan, B.N. (1992) Biochem. Pharmacol., 44(1), 180-183.
55. Symolon, H.; Schmelz, E.M.; Dillehay, D.L. and Merrill, A.H. Jr. (2004) J. Nutr., 134(5), 1157-1161.
56. Rapisarda, A.; Uranchimeg, B.; Scudiero, D.A.; Selby, M.; Sausville, E.A.; Shoemaker, R.H. and Melillo, G. (2002) Cancer Res., 62(15), 4316-4324.
57. Rapisarda, A.; Uranchimeg, B.; Sordet, O.; Pommier, Y.; Shoemaker, R.H. and Melillo, G. (2004) Cancer Res., 64(4), 1475-1482.
58. Cushman, M.; Jayaraman, M.; Vroman, J.A.; Fukunaga, A.K.; Fox, B.M.; Kohlhagen, G.; Strumberg, D. and Pommier, Y. (2000) J. Med. Chem., 43(20), 3688-3698.
59. Rapisarda, A.; Shoemaker, R.H. and Melillo, G. (2004) Cell Cycle, 3(2), 172-175.
60. Mabjeesh N.J.; Escuin, D.; LaVallee, T.M.; Pribluda, V.S.; Swartz, G.M.; Johnson, M.S.; Willard, M.T.; Zhong, H.; Simons, J.W. and Giannakakou, P. (2003) Cancer Cell, 3(4), 363-375.
61. Jung, Y.J.; Isaacs, J.S.; Lee, S.; Trepel, J. and Neckers, L. (2003) J. Biol. Chem., 278(9), 7445-7452.
62. Hagen, T.; D'Amico, G.; Quintero, M.; Palacios-Callender, M.; Hollis, V.; Lam, F. and Moncada, S. (2004) Biochem. Biophys. Res. Commun., 322(3), 923-929.
63. Pribluda, V.S.; Gubish, E.R. Jr.; Lavallee, T.M.; Treston, A.; Swartz, G.M. and Green, S.J. (2000) Cancer Metastasis Rev., 19(1-2), 173-179.
64. Ricker, J.L.; Chen, Z.; Yang, X.P.; Pribluda, V.S.; Swartz, G.M. and van Waes, C. (2004) Clin. Cancer Res., 10(24), 8665-8673.
65. Mazure, N.M.; Brahimi-Horn, M.C. and Pouyssegur, J. (2003) Curr. Pharm. Des., 9(7), 531-541.
66. Liu, L. and Simon, M.C. (2004) Cancer Biol. Ther., 3(6), 492-497.
67. Arsham, A.M.; Plas, D.R.; Thompson, C.B. and Simon, M.C. (2002) J. Biol. Chem., 277(17), 15162-15170.
68. Alvarez-Tejado, M.; Alfranca, A.; Aragones, J.; Vara, A.; Landazuri, M.O. and del Peso, L. (2002) J. Biol. Chem., 277(16), 13508-13517.
69. Laughner, E.; Taghavi, P.; Chiles, K.; Mahon, P.C. and Semenza, G.L. (2001) Mol. Cell. Biol., 21(12), 3995-4004.
70. Hudson, C.C.; Liu, M.; Chiang, G.G.; Otterness, D.M.; Loomis, D.C.; Kaper, F.; Giaccia, A.J. and Abraham, R.T. (2002) Mol. Cell. Biol., 22(20), 7004-7014.
71. Tan, C.; de Noronha, R.G.; Roecker, A.J.; Pyrzynska, B.; Khwaja, F.; Zhang, Z.; Zhang, H.; Teng, Q.; Nicholson, A.C.; Giannakakou, P.; Zhou, W.; Olson, J.J.; Pereira, M.M.; Nicolaou, K.C. and Van Meir, E.G. (2005) Cancer Res., 65(2), 605-612.
72. Gradin, K.; McGuire, J.; Wenger, R.H.; Kvietikova, I.; Whitelaw, M.L.; Toftgard, R.; Tora, L.; Gassmann, M. and Poellinger, L. (1996) Mol. Cell. Biol., 16(10), 5221-5231.
73. Minet, E.; Mottet, D.; Michel, G.; Roland, I.; Raes, M.; Remacle, J. and Michiels, C. (1999) FEBS Lett., 460(2), 251-256.
74. Mabjeesh, N.J.; Post, D.E.; Willard, M.T.; Kaur, B.; Van Meir, E.G.; Simons, J.W. and Zhong, H. (2002) Cancer Res., 62(9), 2478-2482.
75. Isaacs, J.S.; Jung, Y.J.; Mimnaugh, E.G.; Martinez, A.; Cuttitta, F. and Neckers, L.M. (2002) J. Biol. Chem., 277(33), 29936-29944.
76. Katschinski, D.M.; Le, L.; Heinrich, D.; Wagner, K.F.; Hofer, T.; Schindler, S.G. and Wenger, R.H. (2002) J. Biol. Chem., 277(11), 9262-9267.
77. Hur, E.; Kim, H.H.; Choi, S.M.; Kim, J.H.; Yim, S.; Kwon, H.J.; Choi Y, Kim, D.K.; Lee, M.O. and Park, H. (2002) Mol. Pharmacol., 62(5), 975-982.
78. Isaacs, J.S.; Jung, Y.J. and Neckers, L. (2004) J. Biol. Chem., 279(16), 16128-16135.
79. Katschinski, D.M.; Le, L.; Schindler, S.G.; Thomas, T.; Voss, A.K. and Wenger, R.H. (2004) Cell. Physiol. Biochem., 14(4-6), 351-360.
80. Grenert, J.P.; Sullivan, W.P.; Fadden, P.; Haystead, T.A.; Clark, J.; Mimnaugh, E.; Krutzsch, H.; Ochel, H.J.; Schulte, T.W.; Sausville, E.; Neckers, L.M. and Toft, D.O. (1997) J. Biol. Chem., 272(38), 23843-23850.
81. Stebbins, C.E.; Russo, A.A.; Schneider, C.; Rosen, N.; Hartl, F.U. and Pavletich, N.P. (1997) Cell, 89(2), 239-250.
82. Prodromou, C.; Roe, S.M.; O'Brien, R.; Ladbury, J.E.; Piper, P.W. and Pearl, LH. (1997) Cell, 90(1), 65-75.
83. Schulte, T.W.; Akinaga, S.; Murakata, T.; Agatsuma, T.; Sugimoto, S.; Nakano, H.; Lee, Y.S.; Simen, B.B.; Argon, Y.; Felts, S.; Toft, D.O.; Neckers, L.M. and Sharma, S.V. (1999) Mol. Endocrinol., 13(9), 1435-1448.
84. Kurebayashi, J.; Otsuki, T.; Kurosumi, M.; Soga, S.; Akinaga, S. and Sonoo, H. (2001) Jpn. J. Cancer Res., 92(12), 1342-1351.
85. Neckers, L. (2002) Trends Mol. Med., 8(4 Suppl), S55-S61.
86. Bisht, K.S.; Bradbury, C.M.; Mattson, D.; Kaushal, A.; Sowers, A.; Markovina, S.; Ortiz, K.L.; Sieck, L.K.; Isaacs, J.S.; Brechbiel, M.W.; Mitchell, J.B.; Neckers, L.M. and Gius, D. (2003) Cancer Res., 63(24), 8984-8995.
87. Grem, J.L.; Morrison, G.; Guo, X.D.; Agnew, E.; Takimoto, C.H.; Thomas, R.; Szabo, E.; Grochow, L.; Grollman, F.; Hamilton, J.M.; Neckers, L. and Wilson, R.H. (2005) J. Clin. Oncol., 23(9), 1885-1893.
88. Birt, D.F.; Walker, B.; Tibbels, M.G. and Bresnick, E. (1986) Carcinogenesis, 7(6), 959-963.
89. Wei, H.; Tye, L.; Bresnick, E. and Birt, D.F. (1990) Cancer Res., 50(3), 499-502.
90. Caltagirone, S.; Rossi, C.; Poggi, A.; Ranelletti, F.O.; Natali, P.G.; Brunetti, M.; Aiello, F.B. and Piantelli, M. (2000) Int. J. Cancer, 87(4), 595-600.
91. Tatsuta, A.; Iishi, H.; Baba, M.; Yano, H.; Murata, K.; Mukai, M. and Akedo, H. (2000) Clin. Exp. Metastasis, 18(8), 657-662.
92. Gupta, S.; Afaq, F. and Mukhtar, H. (2001) Biochem. Biophys. Res. Commun., 287(4), 914-920.
93. Way, T.D.; Kao, M.C. and Lin, J.K. (2004) J. Biol. Chem., 279(6), 4479-4489.
94. Shukla, S. and Gupta, S. (2004) Clin. Cancer Res., 10(9), 3169-3178.
95. Czyz, J.; Madeja, Z.; Irmer, U.; Korohoda, W. and Hulser, D.F. (2005) Int. J. Cancer, 114(1), 12-18.
96. Osada, M.; Imaoka, S. and Funae, Y. (2004) FEBS Lett., 575(1-3), 59-63.
97. Fang, J.; Xia, C.; Cao, Z.; Zheng, J.Z.; Reed, E. and Jiang, B.H. (2005) FASEB J., 19(3), 342-353.
98. Jang, M.; Cai, L.; Udeani, G.O.; Slowing, K.V.; Thomas, C.F.; Beecher, C.W.; Fong, H.H.; Farnsworth, N.R.; Kinghorn, A.D.; Mehta, R.G.; Moon, R.C. and Pezzuto, J.M. (1997) Science, 275(5297), 218-220.
99. Gescher, A.J. and Steward, W.P. (2003) Cancer Epidemiol. Biomarkers Prev., 12(10), 953-957.
100. Aggarwal, B.B.; Bhardwaj, A.; Aggarwal, R.S.; Seeram, N.P.; Shishodia, S. and Takada, Y. (2004) Anticancer Res., 24(5A), 2783-2840.
101. Cao, Z.; Fang, J.; Xia, C.; Shi, X. and Jiang, B.H. (2004) Clin. Cancer Res., 10(15), 5253-5263.
102. Erez, N.; Milyavsky, M.; Eilam, R.; Shats, I.; Goldfinger, N. and Rotter, V. (2003) Cancer Res., 63(24), 8777-8783.
103. Anonymous (2004) in AHFS Drug Information 2004, (McEvoy, G.K., Ed.), American Society of Health-System Pharmacists, Inc./American Hospital Formulary Service, Bethesda, pp. 3625-3638.
104. D'Angelo, G.; Duplan, E.; Vigne, P. and Frelin, C. (2003) J. Biol. Chem., 278(17), 15406-15411.
105. Chandel, N.S.; Maltepe, E.; Goldwasser, E.; Mathieu, C.E.; Simon, M.C. and Schumacker, P.T. (1998) Proc. Natl. Acad. Sci. USA, 95(20), 11715-11720.
106. Chandel, N.S.; McClintock, D.S.; Feliciano, C.E.; Wood, T.M.; Melendez, J.A.; Rodriguez, A.M. and Schumacker, P.T. (2000) J. Biol. Chem., 275(33), 25130-25138.
107. Agani, F.H.; Pichiule, P.; Chavez, C.J. and LaManna, J.C. (2002) Comp. Biochem. Physiol. Part A, 132(1), 107-109.
108. Hagen, T.; Taylor, C.T.; Lam, F. and Moncada, S. (2003) Science, 302(5652), 1975-1978.
109. Mateo, J.; Garcia-Lecea, M.; Cadenas, S.; Hernandez, C. and Moncada, S. (2003) Biochem. J., 376(Pt 2), 537-544.
110. Hodges, T.W.; Hossain, C.F.; Kim, Y.P.; Zhou, Y.D. and Nagle, D.G. (2004) J. Nat. Prod., 67(5), 767-771.
111. Mohammed, K.A.; Hossain, C.F.; Zhang, L.; Bruick, R.K.; Zhou, Y.D. and Nagle, D.G. (2004) J. Nat. Prod., 67(12), 2002-2007.
112. Kim, M.S.; Kwon, H.J.; Lee, Y.M.; Baek, J.H.; Jang, J.E.; Lee, S.W.; Moon, E.J.; Kim, H.S.; Lee, S.K.; Chung, H.Y.; Kim, C.W. and Kim, K.W. (2001) Nat. Med., 7(4), 437-443.
113. Tsuji, N.; Kobayashi, M.; Nagashima, K.; Wakisaka, Y. and Koizumi, K. (1976) J. Antibiot. (Tokyo), 29(1), 1-6.
114. Yoshida, M.; Kijima, M.; Akita, M. and Beppu, T. (1990) J. Biol. Chem., 265(28), 17174-17179.
115. Lee, Y.M.; Kim, S.H.; Kim, H.S.; Son, M.J.; Nakajima, H.; Kwon, J.H. and Kim, K.W. (2003) Biochem. Biophys. Res. Commun., 300(1), 241-246.
116. Ueda, H.; Nakajima, H.; Hori, Y.; Fujita, T.; Nishimura, M.; Goto, T. and Okuhara, M. (1994) J. Antibiot. (Tokyo), 47(3), 301-310.
117. Shigematsu, N.; Ueda, H.; Takase, S.; Tanaka, H.; Yamamoto, K. and Tada, T. (1994) J. Antibiot. (Tokyo), 47(3), 311-314.
118. Ueda, H.; Manda, T.; Matsumoto, S.; Mukumoto, S.; Nishigaki, F.; Kawamura, I. and Shimomura, K. (1994) J. Antibiot. (Tokyo), 47(3), 315-323.
119. Nakajima, H.; Kim, Y.B.; Terano, H.; Yoshida, M. and Horinouchi, S. (1998) Exp. Cell Res., 241(1), 126-133.
120. Pellizzaro, C.; Coradini, D. and Daidone, M.G. (2002) Carcinogenesis, 23(5), 735-740.
121. Zgouras, D.; Wachtershauser, A.; Frings, D. and Stein, J. (2003) Biochem. Biophys. Res. Commun., 300(4), 832-838.
122. Miki, K.; Unno, N.; Nagata, T.; Uchijima, M.; Konno, H.; Koide, Y. and Nakamura, S. (2004) Shock, 22(5), 446-452.
123. Zhang, Y.; Adach, M.; Zhao, X.; Kawamura, R. and Imai, K. (2004) Int. J. Cancer, 110(2), 301-308.
124. Zhang, Y.; Jung, M.; Dritschilo, A. and Jung, M. (2004) Radiat. Res., 161(6), 667-674.
125. Monneret C (2005) Eur. J. Med. Chem., 40(1), 1-13.
126. Piekarz, R. and Bates, S. (2004) Curr. Pharm. Des., 10(19), 2289-2298.
127. Yoshida, M.; Matsuyama, A.; Komatsu, Y. and Nishino, N. (2003) Curr. Med. Chem., 10(22), 2351-2358.
128. Zhu, W.G. and Otterson, G.A. (2003) Curr. Med. Chem. Anti-Canc. Agents, 3(3), 187-19.
129. Byrd, J.C.; Marcucci, G.; Parthun, M.R.; Xiao, J.J.; Klisovic, R.B.; Moran, M.; Lin, T.S.; Liu, S.; Sklenar, A.R.; Davis, M.E.; Lucas, D.M.; Fischer, B.; Shank, R.; Tejaswi, S.L.; Binkley, P.; Wright, J.; Chan, K.K. and Grever, M.R. (2005) Blood, 105(3), 959-967.
130. Marshall, J.L.; Rizvi, N.; Kauh, J.; Dahut, W.; Figuera, M.; Kang, M.H.; Figg, W.D.; Wainer, I.; Chaissang, C.; Li, M.Z. and Hawkins, M.J. (2002) J. Exp. Ther. Oncol., 2(6), 325-332.
131. Sandor, V.; Bakke, S.; Robey, R.W.; Kang, M.H.; Blagosklonny, M.V.; Bender, J.; Brooks, R.; Piekarz, R.L.; Tucker, E.; Figg, W.D.; Chan, K.K.; Goldspiel, B.; Fojo, A.T.; Balcerzak, S.P. and Bates, S.E. (2002) Clin. Cancer Res., 8(3), 718-728.
132. Piekarz, R.L.; Robey, R.; Sandor, V.; Bakke, S.; Wilson, W.H.; Dahmoush, L.; Kingma, D.M.; Turner, M.L.; Altemus, R. and Bates, S.E. (2001) Blood, 98(9), 2865-2868.
133. Jeong, J.W.; Bae, M.K.; Ahn, M.Y.; Kim, S.H.; Sohn, T.K.; Bae, M.H.; Yoo, M.A.; Song, E.J.; Lee, K.J. and Kim, K.W. (2002) Cell, 111(5), 709-720.
134. Lin, S.; Tsai, S.C.; Lee, C.C.; Wang, B.W.; Liou, J.Y. and Shyu, K.G. (2004) Mol. Pharmacol., 66(3), 612-619.
135. Fukuda, K.; Hibiya, Y.; Mutoh, M.; Koshiji, M.; Akao, S. and Fujiwara, H. (1999) Planta Med., 65(4), 381-383.
136. Pan, D.J.; Li, Z.L.; Hu, C.Q.; Chen, K.; Chang, J.J. and Lee, K.H. (1990) Planta Med., 56(4), 383-385.
137. Li, M.H.; Miao, Z.H.; Tan, W.F.; Yue, J.M.; Zhang, C.; Lin, L.P.; Zhang, X.W. and Ding, J. (2004) Clin. Cancer Res., 10(24), 8266-8274.
138. Tan, W.F.; Zhang, X.W.; Li, M.H.; Yue, J.M.; Chen, Y.; Lin, L.P. and Ding. J. (2004) Eur. J. Pharmacol., 499(3), 219-228.
139. Blum, R.; Jacob-Hirsch, J.; Amariglio, N.; Rechavi, G. and Kloog, Y. (2005) Cancer Res., 65(3), 999-1006.
140. Wang, G.L.; Jiang, B.H. and Semenza, G.L. (1995) Biochem. Biophys. Res. Commun., 212(2), 550-556.
141. Huang, L.E.; Arany, Z.; Livingston, D.M. and Bunn, H.F. (1996) J. Biol. Chem., 271(50), 32253-32259.
142. Ema, M.; Hirota, K.; Mimura, J.; Abe, H.; Yodoi, J.; Sogawa, K.; Poellinger, L. and Fujii-Kuriyama, Y. (1999) EMBO J., 18(7), 1905-1914.
143. Carrero, P.; Okamoto, K.; Coumailleau, P.; O'Brien. S.; Tanaka, H. and Poellinger, L. (2000) Mol. Cell. Biol., 20(1), 402-415.
144. Welsh, S.J.; Bellamy, W.T.; Briehl, M.M. and Powis, G. (2002) Cancer Res., 62(17), 5089-5095.
145. Welsh, S.J.; Williams, R.R.; Birmingham, A.; Newman, D.J.; Kirkpatrick, D.L. and Powis, G. (2003) Mol. Cancer Ther., 2(3), 235-243.
146. Wang, G.L.; Jiang, B.H. and Semenza, G.L. (1995) Biochem. Biophys. Res. Commun., 216(2), 669-675.
147. Hur, E.; Chang, K.Y.; Lee, E.; Lee, S.K. and Park, H. (2001) Mol. Pharmacol., 59(5), 1216-1224.
148. Hasebe, Y.; Egawa, K.; Yamazaki, Y.; Kunimoto, S.; Hirai, Y.; Ida, Y. and Nose, K. (2003) Biol. Pharm. Bull., 26(10), 1379-1383.
149. Fang, J.; Cao, Z.; Chen, Y.C.; Reed, E. and Jiang, B.H. (2004) Mol. Pharmacol., 66(1), 178-186.
150. Ciccolini, J.; Evrard, A. and Cuq, P. (2004) Curr. Med. Chem. Anti-Canc. Agents, 4(2), 71-81.
151. Ikeda, R.; Furukawa, T.; Kitazono, M.; Ishitsuka, K.; Okumura, H.; Tani, A.; Sumizawa, T.; Haraguchi, M.; Komatsu, M.; Uchimiya, H.; Ren, X.Q.; Motoya, T.; Yamada, K. and Akiyama, S. (2002) Biochem. Biophys. Res. Commun., 291(4), 806-812.
152. Roy, S.; Balasubramanian, S.; Wang, J.; Chandrashekhar, Y.; Charboneau, R. and Barke, R. (2003) Surgery, 134(2), 336-344.
153. Phares, D.L. (1867) Am. J. Pharm., 39, 468.
154. Hartwell, J.L. (1971) Lloydia, 34(2), 204-255.
155. Salceda, S.; Beck, I.; Srinivas, V. and Caro, J. (1997) Kidney Int., 51(2), 556-559.
156. Dudley, D.T.; Pang, L.; Decker, S.J.; Bridges, A.J. and Saltiel, A.R. (1995) Proc. Natl. Acad. Sci. USA, 92(17), 7686-7689.
157. Alessi, D.R.; Cuenda, A.; Cohen, P.; Dudley, D.T. and Saltiel, A.R. (1995) J. Biol. Chem., 270(46), 27489-27494.
158. Richard, D.E.; Berra, E.; Gothie, E.; Roux, D. and Pouyssegur, J. (1999) J. Biol. Chem., 274(46), 32631-32637.
159. Lee, E.; Yim, S.; Lee, S.K. and Park, H. (2002) Mol. Cells, 14(1), 9-15.
160. Sang, N.; Stiehl, D.P.; Bohensky, J.; Leshchinsky, I.; Srinivas, V. and Caro, J. (2003) J. Biol. Chem., 278(16), 14013-14019.
161. Kung, A.L.; Zabludoff, S.D.; France, D.S.; Freedman, S.J.; Tanner, E.A.; Vieira, A.; Cornell-Kennon, S.; Lee, J.; Wang, B.; Wang, J.; Memmert, K.; Naegeli, H.U.; Petersen, F.; Eck, M.J.; Bair, K.W.; Wood, A.W. and Livingston, D.M. (2004) Cancer Cell, 6(1), 33-43.
162. Waksman S.A. and Bugie, E. (1944) J. Bacteriol., 48, 527-530.
163. Geiger, W.A.; Conn, J.E. and Waksman S.A. (1944) J. Bacteriol., 48, 531-536.
164. McInnes, A.G.; Taylor, A. and Walter, J.A. (1976) J. Am. Chem. Soc., 98(21), 6741.
165. Fujimoto, H.; Sumino, M.; Okuyama, E. and Ishibashi, M. (2004) J. Nat. Prod., 67(1), 98-102.
166. Takahashi, I.; Kobayashi, E.; Asano, K.; Yoshida, M. and Nakano, H. (1987) J. Antibiot. (Tokyo), 40(12), 1782-1784.
167. Kruger, E.A.; Blagosklonny, M.V.; Dixon, S.C. and Figg, W.D. (1998-99) Invasion Metastasis, 18(4), 209-218.
168. Nagle, D.G.; Zhou, Y.-D.; Mora, F.D.; Mohammed, K.A. and Kim, Y.-P. (2004) Curr. Med. Chem., 11(13), 1725-1756.