Molecular-targeted antitumor agents: The Saururus cernuus dineolignans manassantin B and 4-O-demethylmanassantin B are potent inhibitors of hypoxia-activated HIF-1

Journal of Natural Products

Volumn 67, Issue 5, 2004, Pages 767-771

  Hodges, Tyler W ^a   Hossain, Chowdhury Faiz ^a   Kim, Yong Pil ^a   Zhou, Yu Dong ^a   Nagle, Dale G ^a  

^a UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 O NORMANASSANTIN B; DINEOLIGNAN; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LIGNAN; MANASSANTIN B; OXYGEN; TIRAPAZAMINE; UNCLASSIFIED DRUG; VASCULOTROPIN;

ADAPTATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOASSAY; CELL SURVIVAL; CHEMICAL STRUCTURE; CHIRALITY; CONTROLLED STUDY; DRUG INHIBITION; HUMAN; HUMAN CELL; HYPOXIA; IC 50; IRON CHELATION; PLANT; PROTON NUCLEAR MAGNETIC RESONANCE; SAURURUS CERNUUS; SPECTROSCOPY; STRUCTURE ANALYSIS;

ANOXIA; ANTINEOPLASTIC AGENTS, PHYTOGENIC; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; FURANS; HYPOXIA-INDUCIBLE FACTOR 1; INHIBITORY CONCENTRATION 50; LIGNANS; NUCLEAR PROTEINS; PLANTS, MEDICINAL; SAURURACEAE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

SAURURUS; SAURURUS CERNUUS;

EID: 2542560545     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np030514m     Document Type: Article

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