-
1
-
-
0029929046
-
Strong expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in ovarian borderline and malignant neoplasms
-
Abu-Jawdeh GM, Faix JD, Niloff J, Tognazzi K, Manseau E, Dvorak HF, and Brown LF (1996) Strong expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in ovarian borderline and malignant neoplasms. Lab Investig 74:1105-1115.
-
(1996)
Lab Investig
, vol.74
, pp. 1105-1115
-
-
Abu-Jawdeh, G.M.1
Faix, J.D.2
Niloff, J.3
Tognazzi, K.4
Manseau, E.5
Dvorak, H.F.6
Brown, L.F.7
-
2
-
-
0030973344
-
Fludarabine. An update of its pharmacology and use in the treatment of haematological malignancies
-
Adkins JC, Peters DH, and Markham A (1997) Fludarabine. An update of its pharmacology and use in the treatment of haematological malignancies. Drugs 53:1005-1037.
-
(1997)
Drugs
, vol.53
, pp. 1005-1037
-
-
Adkins, J.C.1
Peters, D.H.2
Markham, A.3
-
3
-
-
0030890933
-
Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase
-
Akmed NN, Grimes HL, Bellacosa A, Chan TO, and Tsichlis PN (1997) Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase. Proc Natl Acad Sci USA 94:3627-3632.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 3627-3632
-
-
Akmed, N.N.1
Grimes, H.L.2
Bellacosa, A.3
Chan, T.O.4
Tsichlis, P.N.5
-
4
-
-
0037177867
-
Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilizatian of HIF-1α nor sufficient for HIF-1-dependent target gene transcription
-
Arsham AM, Plas DR, Thompson CB, and Simon MC (2002) Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilizatian of HIF-1α nor sufficient for HIF-1-dependent target gene transcription. J Biol Chem 277:15162-15170.
-
(2002)
J Biol Chem
, vol.277
, pp. 15162-15170
-
-
Arsham, A.M.1
Plas, D.R.2
Thompson, C.B.3
Simon, M.C.4
-
5
-
-
0036901350
-
Angiogenesis in epithelian ovarian cancer
-
Bamberger ES and Perrett CW (2002) Angiogenesis in epithelian ovarian cancer. Mol Pathol 55:348-359.
-
(2002)
Mol Pathol
, vol.55
, pp. 348-359
-
-
Bamberger, E.S.1
Perrett, C.W.2
-
6
-
-
0027369120
-
Increased accumulation of p53 protein in cisplatin-resistant ovarian cell lines
-
Brown R, Clugston C, Burns P, Edlin A, Vasey P, Vojtesek B, and Kaye SB (1993) Increased accumulation of p53 protein in cisplatin-resistant ovarian cell lines. Int J Cancer 55:678-684.
-
(1993)
Int J Cancer
, vol.55
, pp. 678-684
-
-
Brown, R.1
Clugston, C.2
Burns, P.3
Edlin, A.4
Vasey, P.5
Vojtesek, B.6
Kaye, S.B.7
-
7
-
-
0345060442
-
Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites and causes dramatic vascular remodeling in an ovarian cancer model
-
Byrne AT, Ross L, Holash J, Nakanishi M, Hu L, Hofmann JI, Yancopoulos GD, and Jaffe RB (2003) Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites and causes dramatic vascular remodeling in an ovarian cancer model. Clin Cancer Res 9:5721-5728.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 5721-5728
-
-
Byrne, A.T.1
Ross, L.2
Holash, J.3
Nakanishi, M.4
Hu, L.5
Hofmann, J.I.6
Yancopoulos, G.D.7
Jaffe, R.B.8
-
8
-
-
0034648765
-
Angiogenesis in cancer and other diseases
-
Carmeliet P and Jain RK (2000) Angiogenesis in cancer and other diseases. Nature (Lond) 407:249-257.
-
(2000)
Nature (Lond)
, vol.407
, pp. 249-257
-
-
Carmeliet, P.1
Jain, R.K.2
-
9
-
-
0036782278
-
VEGF and the quest for tumour angiogenesis factors
-
Ferrara N (2002) VEGF and the quest for tumour angiogenesis factors. Nat Rev Cancer 2:795-803.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 795-803
-
-
Ferrara, N.1
-
10
-
-
0036984640
-
Role of angiogenesis in tumor growth and metastasis
-
Folkman J (2002) Role of angiogenesis in tumor growth and metastasis. Semin Oncol 29:15-18.
-
(2002)
Semin Oncol
, vol.29
, pp. 15-18
-
-
Folkman, J.1
-
11
-
-
0029761644
-
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
-
Forsythe JA, Jiang BH, Iyer NV, Agani F, Leung SW, Koos RD, and Semenza GL (1996) Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 16:4604-4613.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4604-4613
-
-
Forsythe, J.A.1
Jiang, B.H.2
Iyer, N.V.3
Agani, F.4
Leung, S.W.5
Koos, R.D.6
Semenza, G.L.7
-
12
-
-
0029563795
-
Molecular genetic analysis of the Von Hippel-Lindau Disease (VHL) tumour suppressor gene in gonadal tumours
-
Foster K, Osborne RJ, Huddart RA, Affara NA, Ferguson-Smith MA, and Maher ER (1995) Molecular genetic analysis of the Von Hippel-Lindau Disease (VHL) tumour suppressor gene in gonadal tumours. Eur J Cancer 31A:2392-2395.
-
(1995)
Eur J Cancer
, vol.31 A
, pp. 2392-2395
-
-
Foster, K.1
Osborne, R.J.2
Huddart, R.A.3
Affara, N.A.4
Ferguson-Smith, M.A.5
Maher, E.R.6
-
13
-
-
0037064010
-
Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
-
Fukuda R, Hirota K, Fan F, Jung YD, Ellis LM, and Semenza GL (2002) Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem 277:38205-38211.
-
(2002)
J Biol Chem
, vol.277
, pp. 38205-38211
-
-
Fukuda, R.1
Hirota, K.2
Fan, F.3
Jung, Y.D.4
Ellis, L.M.5
Semenza, G.L.6
-
14
-
-
0037200012
-
Vanadate-induced expression of hypoxia-inducible factor 1α and vascular endothelial growth factor through phosphatidylinositol 3-kinase/Akt pathway and reactive oxygen species
-
Gao N, Ding M, Zheng JZ, Zhang Z, Leonard SS, Liu KJ, Shi X, and Jiang BH (2002) Vanadate-induced expression of hypoxia-inducible factor 1α and vascular endothelial growth factor through phosphatidylinositol 3-kinase/Akt pathway and reactive oxygen species. J Biol Chem 277:31963-31971.
-
(2002)
J Biol Chem
, vol.277
, pp. 31963-31971
-
-
Gao, N.1
Ding, M.2
Zheng, J.Z.3
Zhang, Z.4
Leonard, S.S.5
Liu, K.J.6
Shi, X.7
Jiang, B.H.8
-
15
-
-
0029060757
-
Fludarabine- and gemcitabine-induced apoptosis: Incorporation of analogs into DNA is a critical event
-
Huang P and Plunkett W (1995) Fludarabine- and gemcitabine-induced apoptosis: incorporation of analogs into DNA is a critical event. Cancer Chemother Pharmacol 36:181-188.
-
(1995)
Cancer Chemother Pharmacol
, vol.36
, pp. 181-188
-
-
Huang, P.1
Plunkett, W.2
-
16
-
-
0036789574
-
Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin
-
Hudson CC, Liu M, Chiang GG, Otterness DM, Loomis DC, Kaper F, Giaccia AJ, and Abraham RT (2002) Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Mol Cell Biol 22:7004-7014.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 7004-7014
-
-
Hudson, C.C.1
Liu, M.2
Chiang, G.G.3
Otterness, D.M.4
Loomis, D.C.5
Kaper, F.6
Giaccia, A.J.7
Abraham, R.T.8
-
17
-
-
0035917313
-
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for 02 sensing
-
Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, Salic A, Asara JM, Lane WS, and Kaelin WG Jr (2001) HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for 02 sensing. Science (Wash DC) 292:464-468.
-
(2001)
Science (Wash DC)
, vol.292
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
Kim, W.4
Valiando, J.5
Ohh, M.6
Salic, A.7
Asara, J.M.8
Lane, W.S.9
Kaelin Jr., W.G.10
-
18
-
-
0035917808
-
2-regulated prolyl hydroxylation
-
2-regulated prolyl hydroxylation. Science (Wash DC) 292:468-472.
-
(2001)
Science (Wash DC)
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.M.3
Wilson, M.I.4
Gielbert, J.5
Gaskell, S.J.6
Kriegsheim, A.7
Hebestreit, H.F.8
Mukherji, M.9
Schofield, C.J.10
-
19
-
-
0030659531
-
V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: Involvement of HIF-1 in tumor progression
-
Jiang BH, Agani F, Passaniti A, and Semenza GL (1997) V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression. Cancer Res 57:5328-5335.
-
(1997)
Cancer Res
, vol.57
, pp. 5328-5335
-
-
Jiang, B.H.1
Agani, F.2
Passaniti, A.3
Semenza, G.L.4
-
20
-
-
0034925041
-
Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1
-
Jiang BH, Jiang G, Zheng JZ, Lu Z, Hunter T, and Vogt PK (2001) Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1. Cell Growth Differ 12:363-369.
-
(2001)
Cell Growth Differ
, vol.12
, pp. 363-369
-
-
Jiang, B.H.1
Jiang, G.2
Zheng, J.Z.3
Lu, Z.4
Hunter, T.5
Vogt, P.K.6
-
21
-
-
0034652392
-
Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells
-
Jiang BH, Zheng JZ, Aoki M, and Vogt PK (2000) Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells. Proc Natl Acad Sci USA 97:1749-1753.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 1749-1753
-
-
Jiang, B.H.1
Zheng, J.Z.2
Aoki, M.3
Vogt, P.K.4
-
22
-
-
0033525830
-
Regulation of the hypoxia-inducible transcription factor 1α by the ubiquitin-proteasome pathway
-
Kallio PJ, Wilson WJ, O'Brien S, Makino Y, and Poellinger L (1999) Regulation of the hypoxia-inducible transcription factor 1α by the ubiquitin-proteasome pathway. J Biol Chem 274:6519-6525.
-
(1999)
J Biol Chem
, vol.274
, pp. 6519-6525
-
-
Kallio, P.J.1
Wilson, W.J.2
O'Brien, S.3
Makino, Y.4
Poellinger, L.5
-
23
-
-
0037446983
-
Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells
-
Knowles HJ, Raval RR, Harris AL, and Ratcliffe PJ (2003) Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells. Cancer Res 63:1764-1768.
-
(2003)
Cancer Res
, vol.63
, pp. 1764-1768
-
-
Knowles, H.J.1
Raval, R.R.2
Harris, A.L.3
Ratcliffe, P.J.4
-
24
-
-
0035885932
-
Vascular endothelial growth factor (VEGF) is an autocrine growth factor for VEGF receptor-positive human tumors
-
Masood R, Cai J, Zheng T, Smith DL, Hinton DR, and Gill PS (2001) Vascular endothelial growth factor (VEGF) is an autocrine growth factor for VEGF receptor-positive human tumors. Blood 98:1904-1913.
-
(2001)
Blood
, vol.98
, pp. 1904-1913
-
-
Masood, R.1
Cai, J.2
Zheng, T.3
Smith, D.L.4
Hinton, D.R.5
Gill, P.S.6
-
25
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, and Ratcliffe PJ (1999) The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature (Lond) 399:271-275.
-
(1999)
Nature (Lond)
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
Wykoff, C.C.7
Pugh, C.W.8
Maher, E.R.9
Ratcliffe, P.J.10
-
26
-
-
0029681850
-
Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression
-
Mazure NM, Chen EY, Yeh P, Laderoute KR, and Giaccia AJ (1996) Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression. Cancer Res 58:3436-3440.
-
(1996)
Cancer Res
, vol.58
, pp. 3436-3440
-
-
Mazure, N.M.1
Chen, E.Y.2
Yeh, P.3
Laderoute, K.R.4
Giaccia, A.J.5
-
27
-
-
0031719516
-
Role of vascular endothelial growth factor in ovarian cancer: Inhibition of ascites formation by immunoneutralization
-
Mesiano S, Ferrara N, and Jaffe RB (1998) Role of vascular endothelial growth factor in ovarian cancer: inhibition of ascites formation by immunoneutralization. Am J Pathol 153:1249-1256.
-
(1998)
Am J Pathol
, vol.153
, pp. 1249-1256
-
-
Mesiano, S.1
Ferrara, N.2
Jaffe, R.B.3
-
28
-
-
0028153737
-
Vascular permeability factor gene expression in normal and neoplastic human ovaries
-
Olson TA, Mohanraj D, Carson LF, and Ramakrishnan S (1994) Vascular permeability factor gene expression in normal and neoplastic human ovaries. Cancer Res 54:276-280.
-
(1994)
Cancer Res
, vol.54
, pp. 276-280
-
-
Olson, T.A.1
Mohanraj, D.2
Carson, L.F.3
Ramakrishnan, S.4
-
29
-
-
0037073695
-
Induction of hypoxia-inducible factor-1α by transcriptional and translational mechanisms
-
Page EL, Robitaille GA, Pouyssegur J, and Richard DE (2002) Induction of hypoxia-inducible factor-1α by transcriptional and translational mechanisms. J Biol Chem 277:48403-48409.
-
(2002)
J Biol Chem
, vol.277
, pp. 48403-48409
-
-
Page, E.L.1
Robitaille, G.A.2
Pouyssegur, J.3
Richard, D.E.4
-
30
-
-
0033954247
-
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha
-
Ravi R, Mookerjee B, Bhujwalla ZM, Sutter CH, Artemov D, Zeng Q, Dillehay LE, Madan A, Semenza GL, and Bedi A (2000) Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. Genes Dev 14:34-44.
-
(2000)
Genes Dev
, vol.14
, pp. 34-44
-
-
Ravi, R.1
Mookerjee, B.2
Bhujwalla, Z.M.3
Sutter, C.H.4
Artemov, D.5
Zeng, Q.6
Dillehay, L.E.7
Madan, A.8
Semenza, G.L.9
Bedi, A.10
-
31
-
-
0032725554
-
P42/P44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1
-
Richard DE, Berra E, Gothie E, Roux D, and Pouyssegur J (1999) P42/P44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1. J Biol Chem 274:32631-32637.
-
(1999)
J Biol Chem
, vol.274
, pp. 32631-32637
-
-
Richard, D.E.1
Berra, E.2
Gothie, E.3
Roux, D.4
Pouyssegur, J.5
-
32
-
-
0030961006
-
Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
-
Salceda S and Caro J (1997) Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem 272:22642-22647.
-
(1997)
J Biol Chem
, vol.272
, pp. 22642-22647
-
-
Salceda, S.1
Caro, J.2
-
33
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL (2003) Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3:721-732.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
34
-
-
0032590011
-
PIK3CA is implicated as an oncogene in ovarian cancer
-
Shayesteh L, Lu Y, Kuo WL, Baldocchi R, Godfrey T, Collins C, Pinkel D, Powell B, Mills GB, and Gray JW (1999) PIK3CA is implicated as an oncogene in ovarian cancer. Nat Genet 21:99-102.
-
(1999)
Nat Genet
, vol.21
, pp. 99-102
-
-
Shayesteh, L.1
Lu, Y.2
Kuo, W.L.3
Baldocchi, R.4
Godfrey, T.5
Collins, C.6
Pinkel, D.7
Powell, B.8
Mills, G.B.9
Gray, J.W.10
-
35
-
-
0034145605
-
Inhibition of malignant ascites and growth of human ovarian carcinoma by oral administration of a potent inhibitor of the vascular endothelial growth factor receptor tyrosine kinases
-
Xu L, Yoneda J, Herrera C, Wood J, Killion JJ, and Fidler IJ (2000) Inhibition of malignant ascites and growth of human ovarian carcinoma by oral administration of a potent inhibitor of the vascular endothelial growth factor receptor tyrosine kinases. Int J Oncol 16:445-454.
-
(2000)
Int J Oncol
, vol.16
, pp. 445-454
-
-
Xu, L.1
Yoneda, J.2
Herrera, C.3
Wood, J.4
Killion, J.J.5
Fidler, I.J.6
-
36
-
-
0026760566
-
Abnormal structure and expression of the p53 gene in human ovarian carcinoma cell lines
-
Yaginuma Y and Westphal H (1992) Abnormal structure and expression of the p53 gene in human ovarian carcinoma cell lines. Cancer Res 52:4196-4199.
-
(1992)
Cancer Res
, vol.52
, pp. 4196-4199
-
-
Yaginuma, Y.1
Westphal, H.2
-
37
-
-
0041672301
-
The oncegene phosphatidylinositol 3′-kinase catalytic subunit alpha promotes angiogenesis via vascular endothelial growth factor in ovarian carcinoma
-
Zhang L, Yang N, Katsaros D, Huang W, Park JW, Fracchioli S, Vezzani C, Rigault de la Longrais IA, Yao W, Rubin SC, et al. (2003) The oncegene phosphatidylinositol 3′-kinase catalytic subunit alpha promotes angiogenesis via vascular endothelial growth factor in ovarian carcinoma. Cancer Res 63:4225-4231.
-
(2003)
Cancer Res
, vol.63
, pp. 4225-4231
-
-
Zhang, L.1
Yang, N.2
Katsaros, D.3
Huang, W.4
Park, J.W.5
Fracchioli, S.6
Vezzani, C.7
Rigault De La Longrais, I.A.8
Yao, W.9
Rubin, S.C.10
-
38
-
-
0034654174
-
Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/ AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
-
Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C, Georgescu MM, Simons JW, and Semenza GL (2000) Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/ AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 60:1541-1545.
-
(2000)
Cancer Res
, vol.60
, pp. 1541-1545
-
-
Zhong, H.1
Chiles, K.2
Feldser, D.3
Laughner, E.4
Hanrahan, C.5
Georgescu, M.M.6
Simons, J.W.7
Semenza, G.L.8
-
39
-
-
0034050050
-
Loss of PTEN facilitates HIF-1-mediated gene expression
-
Zundel W, Schindler C, Haas-Kogan D, Koong A, Kaper F, Chen E, Gottschalk AR, Ryan HE, Johnson RS, Jefferson AB, et al. (2000) Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev 14:391-396.
-
(2000)
Genes Dev
, vol.14
, pp. 391-396
-
-
Zundel, W.1
Schindler, C.2
Haas-Kogan, D.3
Koong, A.4
Kaper, F.5
Chen, E.6
Gottschalk, A.R.7
Ryan, H.E.8
Johnson, R.S.9
Jefferson, A.B.10
|