Synthesis of new indeno[1,2-c]isoquinolines: Cytotoxic non-camptothecin topoisomerase I inhibitors

Journal of Medicinal Chemistry

Volumn 43, Issue 20, 2000, Pages 3688-3698

  Cushman, M ^a   Jayaraman, M ^a   Vroman, J A ^a   Fukunaga, A K ^a   Fox, B M ^a   Kohlhagen, G ^b   Strumberg, D ^b   Pommier, Y ^b  

^a PURDUE UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 ARYL 4 CARBOXYISOQUINOLONE DERIVATIVE; ACID ANHYDRIDE; CAMPTOTHECIN; DNA; DNA TOPOISOMERASE INHIBITOR; INDENO[1,2 C]ISOQUINOLINE DERIVATIVE; ISOQUINOLINE DERIVATIVE; NITROGEN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CONTROLLED STUDY; CYTOTOXICITY; DNA CLEAVAGE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; INTERCALATION COMPLEX;

EID: 0034609859     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000029d     Document Type: Article

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