Selective growth-inhibitory, cell-cycle deregulatory and apoptotic response of apigenin in normal versus human prostate carcinoma cells

Biochemical and Biophysical Research Communications

Volumn 287, Issue 4, 2001, Pages 914-920

  Gupta, Sanjay ^a   Afaq, Farrukh ^a   Mukhtar, Hasan ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apigenin; Apoptosis; Cell cycle arrest; Chemoprevention; Prostate cancer

Indexed keywords

APIGENIN; FLAVONOID;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE G2 PHASE; CELL DEATH; CELL GROWTH; CELL VIABILITY; CONTROLLED STUDY; DNA DETERMINATION; DOSE RESPONSE; DRUG EFFECT; EPITHELIUM CELL; FLUORESCENCE MICROSCOPY; FRUIT; GROWTH INHIBITION; HUMAN; HUMAN CELL; KERATINOCYTE; MITOSIS INHIBITION; NICK END LABELING; PRIORITY JOURNAL; PROSTATE CANCER; VEGETABLE;

EID: 0035812747     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.5672     Document Type: Article

References (22)

1. Diet and its preventive role in prostatic disease
2. Plant phenolics
3. Effects of naturally-occurring flavonoids and biflavonoids on epidermal cyclooxygenase and lipooxygenase from guinea-pigs
4. Flavonoids (apigenin, tangeretin) counteract tumor promoter-induced inhibition of intercellular communication of rat liver epithelial cells
5. Anti-mutagenesis and anti-promotion by apigenin, robinetin and indole-3-carbinol
6. Reversion of v-H-ras-transformed NIH 3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes
7. Flavonoids, dietary-derived inhibitors of cell proliferation and in vitro angiogenesis
8. Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice
9. Suppression of inducible cyclooxy-genase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages
10. Cell-cycle arrest at G2/M and growth inhibition by apigenin in human colon carcinoma cell lines
11. Apigenin inhibits growth and induces G2/M arrest by modulating cyclin-CDK regulators and ERK MAP kinase activation in breast carcinoma cells
12. Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells
13. Signal pathways involved in apigenin inhibition of growth and induction of apoptosis of human anaplastic thyroid cancer cells (ARO)
14. Prostate cancer chemoprevention by green tea
15. Inhibition of ultraviolet light induced skin carcinogenesis in SKH-1 mice by apigenin, a plant flavonoid
16. Fruit and vegetable intakes and prostate cancer risk
17. Health effects and bioavailability of dietary flavonols
18. Flavonoids suppress androgen-independent human prostate tumor proliferation
19. Induction of p21/WAF1 and G1 cell-cycle arrest by the chemopreventive agent apigenin
20. Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer
21. Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells
22. Target to apoptosis: A hopeful weapon for prostate cancer