Hsp90 inhibitors as novel cancer chemotherapeutic agents

Trends in Molecular Medicine

Volumn 8, Issue 4 SUPPL., 2002, Pages

  Neckers, Len ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

17 ALLYLAMINOGELDANAMYCIN; ANDROGEN RECEPTOR; ANSAMYCIN DERIVATIVE; BCR ABL PROTEIN; CHAPERONE; CHIMERIC PROTEIN; CISPLATIN; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; DOXORUBICIN; ESTROGEN RECEPTOR; ETOPOSIDE; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; HELIX LOOP HELIX PROTEIN; HYPOXIA INDUCIBLE FACTOR 1; IMATINIB; MUTANT PROTEIN; NOVOBIOCIN; PACLITAXEL; PROTEIN INHIBITOR; PROTEIN KINASE B; PROTEIN KINASE P60; PROTEIN P53; PROTEIN SERINE THREONINE KINASE; RADICICOL; RAF PROTEIN; TRANSCRIPTION FACTOR; TUMOR ANTIGEN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER; CANCER CELL; CANCER CHEMOTHERAPY; CANCER GROWTH; CELL SURVIVAL; CLINICAL TRIAL; DRUG EFFECT; DRUG EFFICACY; DRUG PROTEIN BINDING; DRUG TARGETING; DRUG TOLERABILITY; GENE MUTATION; HUMAN; LIVER TOXICITY; NONHUMAN; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION;

ANTIBIOTICS, ANTINEOPLASTIC; BENZOQUINONES; CLINICAL TRIALS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; NEOPLASMS; PROTEIN-TYROSINE KINASES; QUINONES; TRANSCRIPTION FACTORS;

EID: 0036219609     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4914(02)02316-X     Document Type: Review

References (60)

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51. Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin
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