-
2
-
-
0035215722
-
Selected novel anticancer treatments targeting cell signaling proteins
-
Elsayed Y.A., Sausville E.A. Selected novel anticancer treatments targeting cell signaling proteins. Oncologist. 6:2001;517-537
-
(2001)
Oncologist
, vol.6
, pp. 517-537
-
-
Elsayed, Y.A.1
Sausville, E.A.2
-
3
-
-
0036359548
-
Hypoxia - A key regulatory factor in tumour growth
-
Harris A.L. Hypoxia - a key regulatory factor in tumour growth. Nat. Rev. Cancer. 2:2002;38-47
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 38-47
-
-
Harris, A.L.1
-
4
-
-
0036216692
-
HIF-1 and tumor progression: Pathophysiology and therapeutics
-
Semenza G.L. HIF-1 and tumor progression: pathophysiology and therapeutics. Trends Mol. Med. 8:2002;S62-67
-
(2002)
Trends Mol. Med.
, vol.8
, pp. 62-67
-
-
Semenza, G.L.1
-
5
-
-
0031823016
-
The molecular basis of the hypoxia response pathway: Tumour hypoxia as a therapy target
-
Blancher C., Harris A.L. The molecular basis of the hypoxia response pathway: tumour hypoxia as a therapy target. Cancer Metastasis Rev. 17:1998;187-194
-
(1998)
Cancer Metastasis Rev.
, vol.17
, pp. 187-194
-
-
Blancher, C.1
Harris, A.L.2
-
6
-
-
0030690459
-
Molecular aspects of oxygen sensing in physiological adaptation to hypoxia
-
Czyzyk-Krzeska M.F. Molecular aspects of oxygen sensing in physiological adaptation to hypoxia. Respir. Physiol. 110:1997;99-111
-
(1997)
Respir. Physiol.
, vol.110
, pp. 99-111
-
-
Czyzyk-Krzeska, M.F.1
-
7
-
-
0029842459
-
Oxygen sensing and molecular adaptation to hypoxia
-
Bunn H.F., Poyton R.O. Oxygen sensing and molecular adaptation to hypoxia. Physiol. Rev. 76:1996;839-885
-
(1996)
Physiol. Rev.
, vol.76
, pp. 839-885
-
-
Bunn, H.F.1
Poyton, R.O.2
-
8
-
-
8044253996
-
Structural and functional analysis of hypoxia-inducible factor 1
-
Semenza G.L., Agani F., Booth G., Forsythe J., Iyer N., Jiang B.H., et al. Structural and functional analysis of hypoxia-inducible factor 1. Kidney Int. 51:1997;553-555
-
(1997)
Kidney Int.
, vol.51
, pp. 553-555
-
-
Semenza, G.L.1
Agani, F.2
Booth, G.3
Forsythe, J.4
Iyer, N.5
Jiang, B.H.6
-
9
-
-
0028816847
-
Purification and characterization of hypoxia-inducible factor 1
-
Wang G.L., Semenza G.L. Purification and characterization of hypoxia-inducible factor 1. J. Biol. Chem. 270:1995;1230-1237
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 1230-1237
-
-
Wang, G.L.1
Semenza, G.L.2
-
10
-
-
0029944965
-
Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1
-
Jiang B.H., Rue E., Wang G.L., Roe R., Semenza G.L. Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. J. Biol. Chem. 271:1996;17771-17778
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 17771-17778
-
-
Jiang, B.H.1
Rue, E.2
Wang, G.L.3
Roe, R.4
Semenza, G.L.5
-
11
-
-
0030787469
-
Transactivation and inhibitory domains of hypoxia-inducible factor 1 alpha. Modulation of transcriptional activity by oxygen tension
-
Jiang B.H., Zheng J.Z., Leung S.W., Roe R., Semenza G.L. Transactivation and inhibitory domains of hypoxia-inducible factor 1 alpha. Modulation of transcriptional activity by oxygen tension. J. Biol. Chem. 272:1997;19253-19260
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 19253-19260
-
-
Jiang, B.H.1
Zheng, J.Z.2
Leung, S.W.3
Roe, R.4
Semenza, G.L.5
-
13
-
-
0035834409
-
A conserved family of prolyl-4-hydroxylases that modify HIF
-
Bruick R.K., McKnight S.L. A conserved family of prolyl-4-hydroxylases that modify HIF. Science. 294:2001;1337-1340
-
(2001)
Science
, vol.294
, pp. 1337-1340
-
-
Bruick, R.K.1
McKnight, S.L.2
-
14
-
-
17944375360
-
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
-
Epstein A.C., Gleadle J.M., McNeill L.A., Hewitson K.S., O'Rourke J., Mole D.R., et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell. 107:2001;43-54
-
(2001)
Cell
, vol.107
, pp. 43-54
-
-
Epstein, A.C.1
Gleadle, J.M.2
McNeill, L.A.3
Hewitson, K.S.4
O'Rourke, J.5
Mole, D.R.6
-
17
-
-
0035903468
-
Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation
-
Masson N., Willam C., Maxwell P.H., Pugh C.W., Ratcliffe P.J. Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation. EMBO J. 20:2001;5197-5206
-
(2001)
EMBO J.
, vol.20
, pp. 5197-5206
-
-
Masson, N.1
Willam, C.2
Maxwell, P.H.3
Pugh, C.W.4
Ratcliffe, P.J.5
-
18
-
-
0034641615
-
Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex
-
Kamura T., Sato S., Iwai K., Czyzyk-Krzeska M., Conaway R.C., Conaway J.W. Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. Proc. Natl. Acad. Sci. U.S.A. 97:2000;10430-10435
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 10430-10435
-
-
Kamura, T.1
Sato, S.2
Iwai, K.3
Czyzyk-Krzeska, M.4
Conaway, R.C.5
Conaway, J.W.6
-
19
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell P.H., Wiesener M.S., Chang G.W., Clifford S.C., Vaux E.C., Cockman M.E., et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature. 399:1999;271-275
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
-
20
-
-
0041885339
-
HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels
-
Masson N., Ratcliffe P.J. HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels. J. Cell Sci. 116:2003;3041-3049
-
(2003)
J. Cell Sci.
, vol.116
, pp. 3041-3049
-
-
Masson, N.1
Ratcliffe, P.J.2
-
21
-
-
18744375998
-
Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation
-
Jeong J.W., Bae M.K., Ahn M.Y., Kim S.H., Sohn T.K., Bae M.H., et al. Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation. Cell. 111:2002;709-720
-
(2002)
Cell
, vol.111
, pp. 709-720
-
-
Jeong, J.W.1
Bae, M.K.2
Ahn, M.Y.3
Kim, S.H.4
Sohn, T.K.5
Bae, M.H.6
-
22
-
-
0031020884
-
Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
-
Tian H., McKnight S.L., Russell D.W. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev. 11:1997;72-82
-
(1997)
Genes Dev.
, vol.11
, pp. 72-82
-
-
Tian, H.1
McKnight, S.L.2
Russell, D.W.3
-
23
-
-
0031000736
-
A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development
-
Ema M., Taya S., Yokotani N., Sogawa K., Matsuda Y., Fujii-Kuriyama Y. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc. Natl. Acad. Sci. U.S.A. 94:1997;4273-4278
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, pp. 4273-4278
-
-
Ema, M.1
Taya, S.2
Yokotani, N.3
Sogawa, K.4
Matsuda, Y.5
Fujii-Kuriyama, Y.6
-
24
-
-
0031733828
-
Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit. HIF3alpha
-
Gu Y.Z., Moran S.M., Hogenesch J.B., Wartman L., Bradfield C.A. Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit. HIF3alpha. Gene Exp. 7:1998;205-213
-
(1998)
Gene Exp.
, vol.7
, pp. 205-213
-
-
Gu, Y.Z.1
Moran, S.M.2
Hogenesch, J.B.3
Wartman, L.4
Bradfield, C.A.5
-
25
-
-
0032189844
-
Induction of endothelial PAS domain protein-1 by hypoxia: Characterization and comparison with hypoxia-inducible factor-1alpha
-
Wiesener M.S., Turley H., Allen W.E., Willam C., Eckardt K.U., Talks K.L., et al. Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha. Blood. 92:1998;2260-2268
-
(1998)
Blood
, vol.92
, pp. 2260-2268
-
-
Wiesener, M.S.1
Turley, H.2
Allen, W.E.3
Willam, C.4
Eckardt, K.U.5
Talks, K.L.6
-
26
-
-
0035812789
-
Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: Suppression of HIF-mediated gene expression by HIF-3alpha
-
Hara S., Hamada J., Kobayashi C., Kondo Y., Imura N. Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: suppression of HIF-mediated gene expression by HIF-3alpha. Biochem. Biophys. Res. Commun. 287:2001;808-813
-
(2001)
Biochem. Biophys. Res. Commun.
, vol.287
, pp. 808-813
-
-
Hara, S.1
Hamada, J.2
Kobayashi, C.3
Kondo, Y.4
Imura, N.5
-
27
-
-
0026846928
-
The role of angiogenesis in tumor growth
-
Folkman J. The role of angiogenesis in tumor growth. Semin. Cancer Biol. 3:1992;65-71
-
(1992)
Semin. Cancer Biol.
, vol.3
, pp. 65-71
-
-
Folkman, J.1
-
28
-
-
0036216692
-
HIF-1 and tumor progression: Pathophysiology and therapeutics
-
Semenza G.L. HIF-1 and tumor progression: pathophysiology and therapeutics. Trends Mol. Med. 8:2002;S62-67
-
(2002)
Trends Mol. Med.
, vol.8
, pp. 62-67
-
-
Semenza, G.L.1
-
29
-
-
0034654174
-
Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
-
Zhong H., Chiles K., Feldser D., Laughner E., Hanrahan C., Georgescu M.M., et al. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res. 60:2000;1541-1545
-
(2000)
Cancer Res.
, vol.60
, pp. 1541-1545
-
-
Zhong, H.1
Chiles, K.2
Feldser, D.3
Laughner, E.4
Hanrahan, C.5
Georgescu, M.M.6
-
30
-
-
0035012605
-
HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
-
Laughner E., Taghavi P., Chiles K., Mahon P.C., Semenza G.L. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol. Cell. Biol. 21:2001;3995-4004
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 3995-4004
-
-
Laughner, E.1
Taghavi, P.2
Chiles, K.3
Mahon, P.C.4
Semenza, G.L.5
-
31
-
-
0037008770
-
Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway
-
Treins C., Giorgetti-Peraldi S., Murdaca J., Semenza G.L., Van Obberghen E. Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway. Biol. Chem. 277:2002;27975-27981
-
(2002)
Biol. Chem.
, vol.277
, pp. 27975-27981
-
-
Treins, C.1
Giorgetti-Peraldi, S.2
Murdaca, J.3
Semenza, G.L.4
Van Obberghen, E.5
-
32
-
-
12244267687
-
Gastric epithelial reactive oxygen species prevent normoxic degradation of hypoxia-inducible factor-1alpha in gastric cancer cells
-
Park J.H., Kim T.Y., Jong H.S., Kim T.Y., Chun Y.S., Park J.W., et al. Gastric epithelial reactive oxygen species prevent normoxic degradation of hypoxia-inducible factor-1alpha in gastric cancer cells. Clin. Cancer Res. 9:2003;433-440
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 433-440
-
-
Park, J.H.1
Kim, T.Y.2
Jong, H.S.3
Kim, T.Y.4
Chun, Y.S.5
Park, J.W.6
-
33
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
-
Zhong H., De Marzo A.M., Laughner E., Lim M., Hilton D.A., Zagzag D., et al. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res. 59:1999;5830-5835
-
(1999)
Cancer Res.
, vol.59
, pp. 5830-5835
-
-
Zhong, H.1
De Marzo, A.M.2
Laughner, E.3
Lim, M.4
Hilton, D.A.5
Zagzag, D.6
-
34
-
-
0034213146
-
Expression of hypoxia-inducible factor 1alpha in brain tumors: Association with angiogenesis, invasion, and progression
-
Zagzag D., Zhong H., Scalzitti J.M., Laughner E., Simons J.W., Semenza G.L. Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression. Cancer. 88:2000;2606-2618
-
(2000)
Cancer
, vol.88
, pp. 2606-2618
-
-
Zagzag, D.1
Zhong, H.2
Scalzitti, J.M.3
Laughner, E.4
Simons, J.W.5
Semenza, G.L.6
-
35
-
-
0034282518
-
Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer
-
Birner P., Schindl M., Obermair A., Plank C., Breitenecker G., Oberhuber G. Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res. 60:2000;4693-4696
-
(2000)
Cancer Res.
, vol.60
, pp. 4693-4696
-
-
Birner, P.1
Schindl, M.2
Obermair, A.3
Plank, C.4
Breitenecker, G.5
Oberhuber, G.6
-
36
-
-
0035925072
-
Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis
-
Bos R., Zhong H., Hanrahan C.F., Mommers E.C., Semenza G.L., Pinedo H.M., et al. Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis. J. Natl. Cancer Inst. 93:2001;309-314
-
(2001)
J. Natl. Cancer Inst.
, vol.93
, pp. 309-314
-
-
Bos, R.1
Zhong, H.2
Hanrahan, C.F.3
Mommers, E.C.4
Semenza, G.L.5
Pinedo, H.M.6
-
37
-
-
0035300410
-
Expression of hypoxia-inducible factor-1alpha: A novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer
-
Aebersold D.M., Burri P., Beer K.T., Laissue J., Djonov V., Greiner R.H., et al. Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res. 61:2001;2911-2916
-
(2001)
Cancer Res.
, vol.61
, pp. 2911-2916
-
-
Aebersold, D.M.1
Burri, P.2
Beer, K.T.3
Laissue, J.4
Djonov, V.5
Greiner, R.H.6
-
38
-
-
0030816109
-
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
-
Maxwell P.H., Dachs G.U., Gleadle J.M., Nicholls L.G., Harris A.L., Stratford I.J., et al. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc. Natl. Acad. Sci. U.S.A. 94:1997;8104-8109
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, pp. 8104-8109
-
-
Maxwell, P.H.1
Dachs, G.U.2
Gleadle, J.M.3
Nicholls, L.G.4
Harris, A.L.5
Stratford, I.J.6
-
39
-
-
0033870727
-
Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth
-
Ryan H.E., Poloni M., McNulty W., Elson D., Gassmann M., Arbeit J.M., et al. Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth. Cancer Res. 60:2000;4010-4015
-
(2000)
Cancer Res.
, vol.60
, pp. 4010-4015
-
-
Ryan, H.E.1
Poloni, M.2
McNulty, W.3
Elson, D.4
Gassmann, M.5
Arbeit, J.M.6
-
40
-
-
0141988698
-
Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia
-
Sowter H.M., Raval R.R., Moore J.W., Ratcliffe P.J., Harris A.L. Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia. Cancer Res. 63:2003;6130-6134
-
(2003)
Cancer Res.
, vol.63
, pp. 6130-6134
-
-
Sowter, H.M.1
Raval, R.R.2
Moore, J.W.3
Ratcliffe, P.J.4
Harris, A.L.5
-
41
-
-
0036528246
-
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
-
Kondo K., Klco J., Nakamura E., Lechpammer M., Kaelin W.G. Jr. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell. 1:2002;237-246
-
(2002)
Cancer Cell
, vol.1
, pp. 237-246
-
-
Kondo, K.1
Klco, J.2
Nakamura, E.3
Lechpammer, M.4
Kaelin Jr., W.G.5
-
42
-
-
2342597973
-
Inhibition of HIF2alpha Is Sufficient to Suppress pVHL-defective tumor growth
-
Kondo K., Kim W.Y., Lechpammer M., Kaelin W.G. Jr. Inhibition of HIF2alpha Is Sufficient to Suppress pVHL-defective tumor growth. PLoS Biol. 1:2003;439-444
-
(2003)
PLoS Biol.
, vol.1
, pp. 439-444
-
-
Kondo, K.1
Kim, W.Y.2
Lechpammer, M.3
Kaelin Jr., W.G.4
-
43
-
-
0035003528
-
Gene transfer of antisense hypoxia inducible factor-1 alpha enhances the therapeutic efficacy of cancer immunotherapy
-
Sun X., Kanwar J.R., Leung E., Lehnert K., Wang D., Krissansen G.W. Gene transfer of antisense hypoxia inducible factor-1 alpha enhances the therapeutic efficacy of cancer immunotherapy. Gene Ther. 8:2001;638-645
-
(2001)
Gene Ther.
, vol.8
, pp. 638-645
-
-
Sun, X.1
Kanwar, J.R.2
Leung, E.3
Lehnert, K.4
Wang, D.5
Krissansen, G.W.6
-
44
-
-
0035205085
-
A new HIF-1 alpha variant induced by zinc ion suppresses HIF-1-mediated hypoxic responses
-
Chun Y.S., Choi E., Yeo E.J., Lee J.H., Kim M.S., Park J.W. A new HIF-1 alpha variant induced by zinc ion suppresses HIF-1-mediated hypoxic responses. J. Cell Sci. 114:2001;4051-4061
-
(2001)
J. Cell Sci.
, vol.114
, pp. 4051-4061
-
-
Chun, Y.S.1
Choi, E.2
Yeo, E.J.3
Lee, J.H.4
Kim, M.S.5
Park, J.W.6
-
45
-
-
0037083845
-
A dominant-negative isoform lacking exons 11 and 12 of the human hypoxia-inducible factor-1alpha gene
-
Chun Y.S., Choi E., Kim T.Y., Kim M.S., Park J.W. A dominant-negative isoform lacking exons 11 and 12 of the human hypoxia-inducible factor-1alpha gene. Biochem. J. 362:2002;71-79
-
(2002)
Biochem. J.
, vol.362
, pp. 71-79
-
-
Chun, Y.S.1
Choi, E.2
Kim, T.Y.3
Kim, M.S.4
Park, J.W.5
-
46
-
-
0035969508
-
Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression
-
Makino Y., Cao R., Svensson K., Bertilsson G., Asman M., Tanaka H., et al. Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature. 414:2001;550-554
-
(2001)
Nature
, vol.414
, pp. 550-554
-
-
Makino, Y.1
Cao, R.2
Svensson, K.3
Bertilsson, G.4
Asman, M.5
Tanaka, H.6
-
47
-
-
0037031808
-
Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus
-
Makino Y., Kanopka A., Wilson W.J., Tanaka H., Poellinger L. Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus. J. Biol. Chem. 277:2002;32405-32408
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 32405-32408
-
-
Makino, Y.1
Kanopka, A.2
Wilson, W.J.3
Tanaka, H.4
Poellinger, L.5
-
48
-
-
0032749463
-
Hypoxia-induced activation of HIF-1: Role of HIF-1alpha-Hsp90 interaction
-
Minet E., Mottet D., Michel G., Roland I., Raes M., Remacle J., et al. Hypoxia-induced activation of HIF-1: role of HIF-1alpha-Hsp90 interaction. FEBS Lett. 460:1999;251-256
-
(1999)
FEBS Lett.
, vol.460
, pp. 251-256
-
-
Minet, E.1
Mottet, D.2
Michel, G.3
Roland, I.4
Raes, M.5
Remacle, J.6
-
49
-
-
0037119415
-
Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway
-
Isaacs J.S., Jung Y.J., Mimnaugh E.G., Martinez A., Cuttitta F., Neckers L.M. Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway. J. Biol. Chem. 277:2002;29936-29944
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 29936-29944
-
-
Isaacs, J.S.1
Jung, Y.J.2
Mimnaugh, E.G.3
Martinez, A.4
Cuttitta, F.5
Neckers, L.M.6
-
50
-
-
0036569704
-
Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells
-
Mabjeesh N.J., Post D.E., Willard M.T., Kaur B., Van Meir E.G., Simons J.W., et al. Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells. Cancer Res. 62:2002;2478-2482
-
(2002)
Cancer Res.
, vol.62
, pp. 2478-2482
-
-
Mabjeesh, N.J.1
Post, D.E.2
Willard, M.T.3
Kaur, B.4
Van Meir, E.G.5
Simons, J.W.6
-
51
-
-
0035937715
-
Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia
-
Chen C., Pore N., Behrooz A., Ismail-Beigi F., Maity A. Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia. J. Biol. Chem. 276:2001;9519-9525
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 9519-9525
-
-
Chen, C.1
Pore, N.2
Behrooz, A.3
Ismail-Beigi, F.4
Maity, A.5
-
52
-
-
0030659531
-
V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: Involvement of HIF-1 in tumor progression
-
Jiang B.H., Agani F., Passaniti A., Semenza G.L. V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression. Cancer Res. 57:1997;5328-5335
-
(1997)
Cancer Res.
, vol.57
, pp. 5328-5335
-
-
Jiang, B.H.1
Agani, F.2
Passaniti, A.3
Semenza, G.L.4
-
53
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell P.H., Wiesener M.S., Chang G.W., Clifford S.C., Vaux E.C., Cockman M.E., et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature. 399:1999;271-275
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
-
54
-
-
0034050050
-
Loss of PTEN facilitates HIF-1-mediated gene expression
-
Zundel W., Schindler C., Haas-Kogan D., Koong A., Kaper F., Chen E., et al. Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev. 14:2003;391-396
-
(2003)
Genes Dev.
, vol.14
, pp. 391-396
-
-
Zundel, W.1
Schindler, C.2
Haas-Kogan, D.3
Koong, A.4
Kaper, F.5
Chen, E.6
-
55
-
-
0033954247
-
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha
-
Ravi R., Mookerjee B., Bhujwalla Z.M., Sutter C.H., Artemov D., Zeng Q., et al. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. Genes Dev. 14:2000;34-44
-
(2000)
Genes Dev.
, vol.14
, pp. 34-44
-
-
Ravi, R.1
Mookerjee, B.2
Bhujwalla, Z.M.3
Sutter, C.H.4
Artemov, D.5
Zeng, Q.6
-
56
-
-
0037064010
-
Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
-
Fukuda R., Hirota K., Fan F., Jung Y.D., Ellis L.M., Semenza G.L. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J. Biol. Chem. 277:2002;38205-38211
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 38205-38211
-
-
Fukuda, R.1
Hirota, K.2
Fan, F.3
Jung, Y.D.4
Ellis, L.M.5
Semenza, G.L.6
-
57
-
-
0037070223
-
Normoxic induction of the hypoxia-inducible factor 1alpha by insulin and interleukin-1beta involves the phosphatidylinositol 3-kinase pathway
-
Stiehl D.P., Jelkmann W., Wenger R.H., Hellwig-Burgel T. Normoxic induction of the hypoxia-inducible factor 1alpha by insulin and interleukin-1beta involves the phosphatidylinositol 3-kinase pathway. FEBS Lett. 512:2002;157-162
-
(2002)
FEBS Lett.
, vol.512
, pp. 157-162
-
-
Stiehl, D.P.1
Jelkmann, W.2
Wenger, R.H.3
Hellwig-Burgel, T.4
-
58
-
-
10744231706
-
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF
-
Mabjeesh N.J., Escuin D., LaVallee T.M., Pribluda V.S., Swartz G.M., Johnson M.S., et al. 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell. 3:2003;363-375
-
(2003)
Cancer Cell
, vol.3
, pp. 363-375
-
-
Mabjeesh, N.J.1
Escuin, D.2
Lavallee, T.M.3
Pribluda, V.S.4
Swartz, G.M.5
Johnson, M.S.6
-
59
-
-
0036682284
-
Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway
-
Rapisarda A., Uranchimeg B., Scudiero D.A., Selby M., Sausville E.A., Shoemaker R.H., et al. Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway. Cancer Res. 62:2002;4316-4324
-
(2002)
Cancer Res.
, vol.62
, pp. 4316-4324
-
-
Rapisarda, A.1
Uranchimeg, B.2
Scudiero, D.A.3
Selby, M.4
Sausville, E.A.5
Shoemaker, R.H.6
-
60
-
-
0028109332
-
YC-1, a novel activator of platelet guanylate cyclase
-
Ko F.N., Wu C.C., Kuo S.C., Lee F.Y., Teng C.M. YC-1, a novel activator of platelet guanylate cyclase. Blood. 84:1994;4226-4233
-
(1994)
Blood
, vol.84
, pp. 4226-4233
-
-
Ko, F.N.1
Wu, C.C.2
Kuo, S.C.3
Lee, F.Y.4
Teng, C.M.5
-
61
-
-
0031046943
-
Effect of YC-1, an NO-independent, superoxide-sensitive stimulator of soluble guanylyl cyclase, on smooth muscle responsiveness to nitrovasodilators
-
Mulsch A., Bauersachs J., Schafer A., Stasch J.P., Kast R., Busse R. Effect of YC-1, an NO-independent, superoxide-sensitive stimulator of soluble guanylyl cyclase, on smooth muscle responsiveness to nitrovasodilators. Br. J. Pharmacol. 120:1997;681-689
-
(1997)
Br. J. Pharmacol.
, vol.120
, pp. 681-689
-
-
Mulsch, A.1
Bauersachs, J.2
Schafer, A.3
Stasch, J.P.4
Kast, R.5
Busse, R.6
-
62
-
-
0030943456
-
Differential effects of isoliquiritigenin and YC-1 in rat aortic smooth muscle
-
Wegener J.W., Nawrath H. Differential effects of isoliquiritigenin and YC-1 in rat aortic smooth muscle. Eur. J. Pharmacol. 323:1997;89-91
-
(1997)
Eur. J. Pharmacol.
, vol.323
, pp. 89-91
-
-
Wegener, J.W.1
Nawrath, H.2
-
63
-
-
0036227586
-
Nitric oxide independent activation of guanylate cyclase by YC-1 causes erectile responses in the rat
-
Mizusawa H., Hedlund P., Brioni J.D., Sullivan J.P., Andersson K.E. Nitric oxide independent activation of guanylate cyclase by YC-1 causes erectile responses in the rat. J. Urol. 167:2002;2276-2281
-
(2002)
J. Urol.
, vol.167
, pp. 2276-2281
-
-
Mizusawa, H.1
Hedlund, P.2
Brioni, J.D.3
Sullivan, J.P.4
Andersson, K.E.5
-
64
-
-
0037223315
-
YC-1 potentiates the nitric oxide/cyclic GMP pathway in corpus cavernosum and facilitates penile erection in rats
-
Hsieh G.C., O'Neill A.B., Moreland R.B., Sullivan J.P., Brioni J.D. YC-1 potentiates the nitric oxide/cyclic GMP pathway in corpus cavernosum and facilitates penile erection in rats. Eur. J. Pharmacol. 458:2003;183-189
-
(2003)
Eur. J. Pharmacol.
, vol.458
, pp. 183-189
-
-
Hsieh, G.C.1
O'Neill, A.B.2
Moreland, R.B.3
Sullivan, J.P.4
Brioni, J.D.5
-
65
-
-
0034718509
-
Human recombinant soluble guanylyl cyclase: Expression, purification, and regulation
-
Lee Y.C., Martin E., Murad F. Human recombinant soluble guanylyl cyclase: expression, purification, and regulation. Proc. Natl. Acad. Sci. U.S.A. 97:2000;10763-10768
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 10763-10768
-
-
Lee, Y.C.1
Martin, E.2
Murad, F.3
-
66
-
-
0031890057
-
Mechanism of YC-1-induced activation of soluble guanylyl cyclase
-
Friebe A., Koesling D. Mechanism of YC-1-induced activation of soluble guanylyl cyclase. Mol. Pharmacol. 53:1998;123-127
-
(1998)
Mol. Pharmacol.
, vol.53
, pp. 123-127
-
-
Friebe, A.1
Koesling, D.2
-
67
-
-
0035871942
-
Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor in Hep3B cells
-
Chun Y.S., Yeo E.J., Choi E., Teng C.M., Bae J.M., Kim M.S., et al. Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor in Hep3B cells. Biochem. Pharmacol. 61:2001;947-954
-
(2001)
Biochem. Pharmacol.
, vol.61
, pp. 947-954
-
-
Chun, Y.S.1
Yeo, E.J.2
Choi, E.3
Teng, C.M.4
Bae, J.M.5
Kim, M.S.6
-
68
-
-
0037414180
-
YC-1: A potential anticancer drug targeting hypoxia-inducible factor 1
-
Yeo E.J., Chun Y.S., Cho Y.S., Kim J., Lee J.C., Kim M.S., et al. YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1. J. Natl. Cancer Inst. 95:2003;516-525
-
(2003)
J. Natl. Cancer Inst.
, vol.95
, pp. 516-525
-
-
Yeo, E.J.1
Chun, Y.S.2
Cho, Y.S.3
Kim, J.4
Lee, J.C.5
Kim, M.S.6
-
70
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza G.L. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer. 3:2003;721-732
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
|