-
1
-
-
0036359548
-
Hypoxia - A key regulatory factor in tumour growth
-
Harris AL. Hypoxia - a key regulatory factor in tumour growth. Nat Rev 2002;2:38-47.
-
(2002)
Nat. Rev.
, vol.2
, pp. 38-47
-
-
Harris, A.L.1
-
2
-
-
0036216692
-
HIF-1 and tumor progression: Pathophysiology and therapeutics
-
Semenza GL. HIF-1 and tumor progression: pathophysiology and therapeutics. Trends Mol Med 2002;8:S62-7.
-
(2002)
Trends Mol. Med.
, vol.8
-
-
Semenza, G.L.1
-
4
-
-
0033954247
-
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α
-
Ravi R, Mookerjee B, Bhujwalla Z, et al. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α. Genes Dev 2000;14:34-44.
-
(2000)
Genes Dev.
, vol.14
, pp. 34-44
-
-
Ravi, R.1
Mookerjee, B.2
Bhujwalla, Z.3
-
5
-
-
0029789568
-
Functional interference between hypoxia and dioxin signal transduction pathways: Competition for recruitment of the Arnt transcription factor
-
Gradin K, McGuire J, Wenger RH, et al. Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor. Mol Cell Biol 1996;16: 5221-31.
-
(1996)
Mol. Cell Biol.
, vol.16
, pp. 5221-5231
-
-
Gradin, K.1
McGuire, J.2
Wenger, R.H.3
-
6
-
-
0037119415
-
Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1α-degradative pathway
-
Isaacs JS, Jung YJ, Mimnaugh EG, Martinez A, Cuttitta F, Neckers LM. Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1α-degradative pathway. J Biol Chem 2002;277:29936-44.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 29936-29944
-
-
Isaacs, J.S.1
Jung, Y.J.2
Mimnaugh, E.G.3
Martinez, A.4
Cuttitta, F.5
Neckers, L.M.6
-
7
-
-
0034925041
-
Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1
-
Jiang BH, Jiang G, Zheng JZ, Hunter T, Vogt PK. Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1. Cell Growth & Differ 2001;12:363-9.
-
(2001)
Cell Growth & Differ.
, vol.12
, pp. 363-369
-
-
Jiang, B.H.1
Jiang, G.2
Zheng, J.Z.3
Hunter, T.4
Vogt, P.K.5
-
8
-
-
0036789574
-
Regulation of hypoxia-inducible factor 1α expression and function by the mammalian target of rapamycin
-
Hudson CC, Liu M, Chiang GG, et al. Regulation of hypoxia-inducible factor 1α expression and function by the mammalian target of rapamycin. Mol Cell Biol 2002;22:7004-14.
-
(2002)
Mol. Cell Biol.
, vol.22
, pp. 7004-7014
-
-
Hudson, C.C.1
Liu, M.2
Chiang, G.G.3
-
9
-
-
0035933726
-
Hypoxia induces the activation of the phosphatidylinositol-3-kinase/AKT cell survival pathway in PC12 cells. Protective role in apoptosis
-
Alvarez-Tejado M, Naranjo-Suarez S, Jimenez C, Carrara AC, Landzuri MO, del Peso L. Hypoxia induces the activation of the phosphatidylinositol-3-kinase/AKT cell survival pathway in PC12 cells. Protective role in apoptosis. J Biol Chem 2001;276:22368-74.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 22368-22374
-
-
Alvarez-Tejado, M.1
Naranjo-Suarez, S.2
Jimenez, C.3
Carrara, A.C.4
Landzuri, M.O.5
del Peso, L.6
-
10
-
-
0032538797
-
Signal transduction in hypoxic cells: Inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia inducible factor-1α
-
Kallio PJ, Okamoto K, O'Brian S, et al. Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia inducible factor-1α. EMBO J 1998;17: 6573-86.
-
(1998)
EMBO J.
, vol.17
, pp. 6573-6586
-
-
Kallio, P.J.1
Okamoto, K.2
O'Brian, S.3
-
11
-
-
0029944965
-
Dimerization, DNA binding and transactivation properties of hypoxia-inducible factor-1
-
Jiang BH, Rue E, Wang GI, Roe R, Semenza GL. Dimerization, DNA binding and transactivation properties of hypoxia-inducible factor-1 . J Biol Chem 1996;271:17771-8.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 17771-17778
-
-
Jiang, B.H.1
Rue, E.2
Wang, G.I.3
Roe, R.4
Semenza, G.L.5
-
12
-
-
0030937718
-
Activation of hypoxia-inducible factor-1; definition of regulatory domains within the α subunit
-
Pugh CW, O'Rourke JF, Nagao M, Gleadle J, Ratcliffe PJ. Activation of hypoxia-inducible factor-1; definition of regulatory domains within the α subunit. J Biol Chem 1997;272:11205-14.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 11205-11214
-
-
Pugh, C.W.1
O'Rourke, J.F.2
Nagao, M.3
Gleadle, J.4
Ratcliffe, P.J.5
-
13
-
-
0037515549
-
MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300
-
Sang N, Stiehl DP, Bohensky J, Leshchinsky I, Srivnas V, Caro J. MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300. J Biol Chem 2003;278:14013-9.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 14013-14019
-
-
Sang, N.1
Stiehl, D.P.2
Bohensky, J.3
Leshchinsky, I.4
Srivnas, V.5
Caro, J.6
-
14
-
-
0034050050
-
Loss of PTEN facilitates HIF-1-mediated gene expression
-
Zundel W, Schindler C, Haas-Kogan D, et al. Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev 2000;14:391-6.
-
(2000)
Genes Dev.
, vol.14
, pp. 391-396
-
-
Zundel, W.1
Schindler, C.2
Haas-Kogan, D.3
-
15
-
-
0032540956
-
Hypoxia-inducible factor 1α (HIF-1α) is a non-hemeiron protein. Implications for oxygen sensing
-
Srinivas V, Zhu X, Salceda S, Nakamura R, Caro J. Hypoxia-inducible factor 1α (HIF-1α) is a non-hemeiron protein. Implications for oxygen sensing. J Biol Chem 1998;273:18019-22.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 18019-18022
-
-
Srinivas, V.1
Zhu, X.2
Salceda, S.3
Nakamura, R.4
Caro, J.5
-
16
-
-
0036735392
-
The redox protein thioredoxin-1 (Trx-1) increases hypoxia-inducible factor 1α protein expression: Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis
-
Welsh SJ, Bellamy WT, Briehl MM, Powis G. The redox protein thioredoxin-1 (Trx-1) increases hypoxia-inducible factor 1α protein expression: Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis. Cancer Res 2002;62:5089-95.
-
(2002)
Cancer Res.
, vol.62
, pp. 5089-5095
-
-
Welsh, S.J.1
Bellamy, W.T.2
Briehl, M.M.3
Powis, G.4
-
17
-
-
0033118983
-
Molecular mechanisms of transcription activation by HLF and HIF1α in response to hypoxia: Their stabilization and redox signal-induced interaction with CBP/p300
-
Ema M, Hirota K, Mimura J, et al. Molecular mechanisms of transcription activation by HLF and HIF1α in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300. EMBO J 1999;18:1905-14.
-
(1999)
EMBO J.
, vol.18
, pp. 1905-1914
-
-
Ema, M.1
Hirota, K.2
Mimura, J.3
-
18
-
-
0033870281
-
The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages
-
Talks KL, Turley H, Gatter KC, et al. The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 2000;157: 411-21.
-
(2000)
Am. J. Pathol.
, vol.157
, pp. 411-421
-
-
Talks, K.L.1
Turley, H.2
Gatter, K.C.3
-
19
-
-
0033571682
-
Over-expression of hypoxia-inducible factor 1α in common human cancers and metastases
-
Zhong H, De Marco A, Laughner E, et al. Over-expression of hypoxia-inducible factor 1α in common human cancers and metastases. Cancer Res 1999;59:5830-5.
-
(1999)
Cancer Res.
, vol.59
, pp. 5830-5835
-
-
Zhong, H.1
De Marco, A.2
Laughner, E.3
-
20
-
-
0035860147
-
Relation of hypoxia inducible factor 1α and 2α in operable non-small cell lung cancer to angiogenic molecular profile of tumors and survival
-
Giatromanolaki A, Koukourakis M, Sivridis E, Turley H, Talks K. Relation of hypoxia inducible factor 1α and 2α in operable non-small cell lung cancer to angiogenic molecular profile of tumors and survival. Br J Cancer 2001;85:881-90.
-
(2001)
Br. J. Cancer
, vol.85
, pp. 881-890
-
-
Giatromanolaki, A.1
Koukourakis, M.2
Sivridis, E.3
Turley, H.4
Talks, K.5
-
21
-
-
0034896068
-
Expression of hypoxia-inducible factor-1α in epithelial ovarian tumors: Its impact on prognosis and on response to chemotherapy
-
Birner P, Schindl M, Obermair A, Breitenecker G, Oberhuber G. Expression of hypoxia-inducible factor-1α in epithelial ovarian tumors: its impact on prognosis and on response to chemotherapy. Clin Cancer Res 2001;7:1661-8.
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 1661-1668
-
-
Birner, P.1
Schindl, M.2
Obermair, A.3
Breitenecker, G.4
Oberhuber, G.5
-
22
-
-
0037443587
-
Levels of hypoxia-inducible factor-1α independently predict prognosis in patients with lymph node negative breast carcinoma
-
Bos R, van der Groep P, Greijer AE, et al. Levels of hypoxia-inducible factor-1α independently predict prognosis in patients with lymph node negative breast carcinoma. Cancer 2003; 97:1573-81.
-
(2003)
Cancer
, vol.97
, pp. 1573-1581
-
-
Bos, R.1
van der Groep, P.2
Greijer, A.E.3
-
23
-
-
0035300410
-
Expression of hypoxia-inducible factor-1α: A novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer
-
Aebersold DM, Burri P, Beer KT, et al. Expression of hypoxia-inducible factor-1α: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res 2001; 61:2911-6.
-
(2001)
Cancer Res.
, vol.61
, pp. 2911-2916
-
-
Aebersold, D.M.1
Burri, P.2
Beer, K.T.3
-
24
-
-
0035925072
-
Levels of hypoxia-inducible factor-1α during breast carcinogenesis
-
Bos R, Zhong H, Hanrahan C, et al. Levels of hypoxia-inducible factor-1α during breast carcinogenesis. J Natl Cancer Inst 2001;91:309-14.
-
(2001)
J. Natl. Cancer Inst.
, vol.91
, pp. 309-314
-
-
Bos, R.1
Zhong, H.2
Hanrahan, C.3
-
25
-
-
0034213146
-
Expression of hypoxia-inducible factor-1α in brain tumors: Association with angiogenesis, invasion and progression
-
Zagzag D, Zhong H, Scalzetti J, Laughner E, Simons J, Semenza G. Expression of hypoxia-inducible factor-1α in brain tumors: association with angiogenesis, invasion and progression. Cancer 2000;88:2606-18.
-
(2000)
Cancer
, vol.88
, pp. 2606-2618
-
-
Zagzag, D.1
Zhong, H.2
Scalzetti, J.3
Laughner, E.4
Simons, J.5
Semenza, G.6
-
26
-
-
0035023084
-
The contribution of proangiogenic factors to the progression of malignant disease: Role of vascular endothelial growth factor and its receptors
-
Neufeld G, Kessler O, Vadasz Z, Gluzman-Poltorak Z. The contribution of proangiogenic factors to the progression of malignant disease: role of vascular endothelial growth factor and its receptors. Surg Oncol Clin N Am 2001;10:339-56.
-
(2001)
Surg. Oncol. Clin. N. Am.
, vol.10
, pp. 339-356
-
-
Neufeld, G.1
Kessler, O.2
Vadasz, Z.3
Gluzman-Poltorak, Z.4
-
27
-
-
0031035753
-
Expression and distribution of vascular endothelial growth factor protein in human brain tumors
-
Pietsch T, Valter MM, Wolf HK, et al. Expression and distribution of vascular endothelial growth factor protein in human brain tumors. Acta Neuropathol 1997;93:109-17.
-
(1997)
Acta Neuropathol.
, vol.93
, pp. 109-117
-
-
Pietsch, T.1
Valter, M.M.2
Wolf, H.K.3
-
28
-
-
0034676331
-
Up-regulation of hypoxia-inducible factors HIF-1α and HIF-2α under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function
-
Krieg M, Haas R, Brauch H, Acker T, Flamme I, Plate K. Up-regulation of hypoxia-inducible factors HIF-1α and HIF-2α under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function. Oncogene 2000;19:5435-43.
-
(2000)
Oncogene
, vol.19
, pp. 5435-5443
-
-
Krieg, M.1
Haas, R.2
Brauch, H.3
Acker, T.4
Flamme, I.5
Plate, K.6
-
29
-
-
0342433777
-
Hypoxia-inducible factor (HIF-1) and its relationship to apoptosis and proliferation in lung cancer
-
Volm M, Koomagi R. Hypoxia-inducible factor (HIF-1) and its relationship to apoptosis and proliferation in lung cancer. Anticancer Res 2000;20:1527-33.
-
(2000)
Anticancer Res.
, vol.20
, pp. 1527-1533
-
-
Volm, M.1
Koomagi, R.2
-
30
-
-
0032581277
-
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
-
Carmeliet P, Dor Y, Herbert JM, et al. Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 1998;394:485-90.
-
(1998)
Nature
, vol.394
, pp. 485-490
-
-
Carmeliet, P.1
Dor, Y.2
Herbert, J.M.3
-
31
-
-
0034255036
-
Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
-
Bruick RK. Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. Proc Natl Acad Sci USA 2000;97:9082-7.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 9082-9087
-
-
Bruick, R.K.1
-
32
-
-
0035266307
-
Hypoxia inducible factor (HIF-1α and HIF-2α) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy
-
Koukourakis M, Giatromanolaki A, Skarlatos J, et al. Hypoxia inducible factor (HIF-1α and HIF-2α) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy. Cancer Res 2001;61:1830-2.
-
(2001)
Cancer Res.
, vol.61
, pp. 1830-1832
-
-
Koukourakis, M.1
Giatromanolaki, A.2
Skarlatos, J.3
-
33
-
-
0035884701
-
HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors
-
Sowter HM, Ratcliffe PJ, Watson P, Greenberg AH, Harris AL. HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Cancer Res 2001;61:6669-73.
-
(2001)
Cancer Res.
, vol.61
, pp. 6669-6673
-
-
Sowter, H.M.1
Ratcliffe, P.J.2
Watson, P.3
Greenberg, A.H.4
Harris, A.L.5
-
34
-
-
0037093238
-
Expression of hypoxia-inducible factors in human renal cancer: Relationship to angiogenesis and to the von Hippel-Lindau gene mutation
-
Turner KJ, Moore JW, Jones A, et al. Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation. Cancer Res 2002;62:2957-61.
-
(2002)
Cancer Res.
, vol.62
, pp. 2957-2961
-
-
Turner, K.J.1
Moore, J.W.2
Jones, A.3
-
35
-
-
0038788826
-
Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1α (HIF-1α): Role of cytoplasmic trapping of HIF-2α
-
Park S, Dadak AM, Haase VH, Fontana L, Giaccia AJ, Johnson RS. Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1α (HIF-1α): role of cytoplasmic trapping of HIF-2α. Mol Cell Biol 2003;23:4959-71.
-
(2003)
Mol. Cell Biol.
, vol.23
, pp. 4959-4971
-
-
Park, S.1
Dadak, A.M.2
Haase, V.H.3
Fontana, L.4
Giaccia, A.J.5
Johnson, R.S.6
-
36
-
-
0035914436
-
Hypoxia-inducible factor-2α (HIF-2α) is involved in the apoptotic response to hypoglycemia but not to hypoxia
-
Brusselmans K, Bono F, Maxwell Y, et al. Hypoxia-inducible factor-2α (HIF-2α) is involved in the apoptotic response to hypoglycemia but not to hypoxia. J Biol Chem 2001;276:39192-6.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 39192-39196
-
-
Brusselmans, K.1
Bono, F.2
Maxwell, Y.3
-
37
-
-
0035003528
-
Gene transfer of antisense hypoxia inducible factor-1α enhances the therapeutic efficacy of cancer immunotherapy
-
Sun X, Kanwar JR, Leung E, Lehnert K, Wang D, Krissansen GW. Gene transfer of antisense hypoxia inducible factor-1α enhances the therapeutic efficacy of cancer immunotherapy. Gene Ther 2001;8:638-45.
-
(2001)
Gene Ther.
, vol.8
, pp. 638-645
-
-
Sun, X.1
Kanwar, J.R.2
Leung, E.3
Lehnert, K.4
Wang, D.5
Krissansen, G.W.6
-
38
-
-
0347512126
-
Hypoxia inducible factor as a cancer drug target
-
Welsh SJ, Powis G. Hypoxia inducible factor as a cancer drug target. Curr Cancer Drug Targets 2003;3:391-405.
-
(2003)
Curr. Cancer Drug Targets
, vol.3
, pp. 391-405
-
-
Welsh, S.J.1
Powis, G.2
-
39
-
-
0036841843
-
Reduction of hypoxia-induced transcription through the repression of hypoxia-inducible factor-1α/Aryl hydrocarbon receptor nuclear translocator DNA binding by the 90-kDa heat-shock protein inhibitor radicicol
-
Hur E, Kim HH, Chol SM, et al. Reduction of hypoxia-induced transcription through the repression of hypoxia-inducible factor-1α /Aryl hydrocarbon receptor nuclear translocator DNA binding by the 90-kDa heat-shock protein inhibitor radicicol. Mol Pharmacol 2002;62:975-82.
-
(2002)
Mol. Pharmacol.
, vol.62
, pp. 975-982
-
-
Hur, E.1
Kim, H.H.2
Chol, S.M.3
-
40
-
-
0035676830
-
A radicicol derivative, KF58333, inhibits expression of hypoxia-inducible factor-1α and vascular endothelial growth factor, angiogenesis and growth of human breast cancer xenografts
-
Kurebayashi J, Otsuki T, Kurosumi M, Soga S, Akinaga S, Sonoo H. A radicicol derivative, KF58333, inhibits expression of hypoxia-inducible factor-1α and vascular endothelial growth factor, angiogenesis and growth of human breast cancer xenografts. Jpn J Cancer Res 2001; 92:1342-51.
-
(2001)
Jpn. J. Cancer Res.
, vol.92
, pp. 1342-1351
-
-
Kurebayashi, J.1
Otsuki, T.2
Kurosumi, M.3
Soga, S.4
Akinaga, S.5
Sonoo, H.6
-
41
-
-
0036569704
-
Geldanamycin induces degradation of hypoxia-inducible factor 1α protein via the proteosome pathway in prostate cancer cells
-
Mabjeesh NJ, Post DE, Willard MT, et al. Geldanamycin induces degradation of hypoxia-inducible factor 1α protein via the proteosome pathway in prostate cancer cells. Cancer Res 2002;62:2478-82.
-
(2002)
Cancer Res.
, vol.62
, pp. 2478-2482
-
-
Mabjeesh, N.J.1
Post, D.E.2
Willard, M.T.3
-
42
-
-
10744231706
-
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF
-
Mabjeesh NJ, Escuin D, LaVallee TM, et al. 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell 2003;3:363-75.
-
(2003)
Cancer Cell
, vol.3
, pp. 363-375
-
-
Mabjeesh, N.J.1
Escuin, D.2
LaVallee, T.M.3
-
43
-
-
0037470172
-
Microtubule disruption utilizes an NF-κB-dependent pathway to stabilize HIF-1α protein
-
Jung YJ, Isaacs JS, Lee S, Trepel J, Neckers L. Microtubule disruption utilizes an NF-κB-dependent pathway to stabilize HIF-1α protein. J Biol Chem 2003;278:7445-52.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 7445-7452
-
-
Jung, Y.J.1
Isaacs, J.S.2
Lee, S.3
Trepel, J.4
Neckers, L.5
-
44
-
-
0036682284
-
Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway
-
Rapisarda A, Uranchimeg B, Scudiero DA, et al. Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway. Cancer Res 2002;62:4316-24.
-
(2002)
Cancer Res.
, vol.62
, pp. 4316-4324
-
-
Rapisarda, A.1
Uranchimeg, B.2
Scudiero, D.A.3
-
45
-
-
1242271198
-
Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: Mechanism and therapeutic implications
-
Rapisarda A, Uranchimerg B, Sordet O, Pommier Y, Shoemaker RH, Melillo G. Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications. Cancer Res 2004;64: 1475-82.
-
(2004)
Cancer Res.
, vol.64
, pp. 1475-1482
-
-
Rapisarda, A.1
Uranchimerg, B.2
Sordet, O.3
Pommier, Y.4
Shoemaker, R.H.5
Melillo, G.6
-
47
-
-
0037225763
-
Inhibition of hypoxia-induced angiogenesis by FK228, a specific histone deacetylase inhibitor, via suppression of HIF-1α activity
-
Lee YM, Kim SH, Kim HS, et al. Inhibition of hypoxia-induced angiogenesis by FK228, a specific histone deacetylase inhibitor, via suppression of HIF-1α activity. Biochem Biophys Res Commun 2003; 300:241-6.
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.300
, pp. 241-246
-
-
Lee, Y.M.1
Kim, S.H.2
Kim, H.S.3
-
48
-
-
0034654174
-
Modulation of hypoxia-inducible factor 1α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
-
Zhong H, Chiles K, Feldser D, et al. Modulation of hypoxia-inducible factor 1α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 2000; 60:1541-5.
-
(2000)
Cancer Res.
, vol.60
, pp. 1541-1545
-
-
Zhong, H.1
Chiles, K.2
Feldser, D.3
-
49
-
-
0035012605
-
HER2(neu) signaling increases the rate of hypoxia-inducible factor 1α(HIF-1α) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
-
Laughner E, Taghavi P, Chiles K, Mahon PC, Semenza GL. HER2(neu) signaling increases the rate of hypoxia-inducible factor 1α(HIF-1α) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol 2001; 21:3995-4004.
-
(2001)
Mol. Cell Biol.
, vol.21
, pp. 3995-4004
-
-
Laughner, E.1
Taghavi, P.2
Chiles, K.3
Mahon, P.C.4
Semenza, G.L.5
-
50
-
-
0031754373
-
Mersalyl is a novel inducer of vascular endothelial growth factor gene expression and hypoxia-inducible factor 1 activity
-
Agani F, Semenza GL. Mersalyl is a novel inducer of vascular endothelial growth factor gene expression and hypoxia-inducible factor 1 activity. Mol Pharmacol 1998;54:749-54.
-
(1998)
Mol. Pharmacol.
, vol.54
, pp. 749-754
-
-
Agani, F.1
Semenza, G.L.2
-
52
-
-
0035871942
-
Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor in Hep3B cells
-
Chun YS, Yeo EJ, Choi E, et al. Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor in Hep3B cells. Biochem Pharmacol 2000;61:947-54.
-
(2000)
Biochem. Pharmacol.
, vol.61
, pp. 947-954
-
-
Chun, Y.S.1
Yeo, E.J.2
Choi, E.3
-
53
-
-
0037414180
-
YC-1: A potential anticancer drug targeting hypoxia-inducible factor 1
-
Yeo EJ, Chun YS, Cho YS, et al. YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1. J Natl Cancer Inst 2003;95: 516-25.
-
(2003)
J. Natl. Cancer Inst.
, vol.95
, pp. 516-525
-
-
Yeo, E.J.1
Chun, Y.S.2
Cho, Y.S.3
-
54
-
-
0142144338
-
The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1α and vascular endothelial growth factor formation
-
Welsh SJ, Williams RR, Birmingham A, Newman DJ, Kirkpatrick DL, Powis G. The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1α and vascular endothelial growth factor formation. Mol Cancer Ther 2003; 2:235-43.
-
(2003)
Mol. Cancer Ther.
, vol.2
, pp. 235-243
-
-
Welsh, S.J.1
Williams, R.R.2
Birmingham, A.3
Newman, D.J.4
Kirkpatrick, D.L.5
Powis, G.6
-
55
-
-
4444369682
-
Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia inducible factor-1α
-
Welsh SJ, Williams R, Kirkpatrick L, Paine-Murrieta G, Powis G. Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia inducible factor-1α. Mol Cancer Ther 2004;3: 233-44.
-
(2004)
Mol. Cancer Ther.
, vol.3
, pp. 233-244
-
-
Welsh, S.J.1
Williams, R.2
Kirkpatrick, L.3
Paine-Murrieta, G.4
Powis, G.5
-
56
-
-
0028785860
-
Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1
-
Wang GL, Jiang BH, Semenza GL. Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1. Biochem Biophys Res Commun 1995;216:669-75.
-
(1995)
Biochem. Biophys. Res. Commun.
, vol.216
, pp. 669-675
-
-
Wang, G.L.1
Jiang, B.H.2
Semenza, G.L.3
-
57
-
-
0035037527
-
Mitogen-activated protein kinase kinase inhibitor PD98059 blocks the trans-activation but not the stabilization or DNA binding ability of hypoxia-inducible factor-1α
-
Hur E, Chang KY, Lee E, Lee SK, Park H. Mitogen-activated protein kinase kinase inhibitor PD98059 blocks the trans-activation but not the stabilization or DNA binding ability of hypoxia-inducible factor-1α. Mol Pharmacol 2001;59:1216-24.
-
(2001)
Mol. Pharmacol.
, vol.59
, pp. 1216-1224
-
-
Hur, E.1
Chang, K.Y.2
Lee, E.3
Lee, S.K.4
Park, H.5
-
58
-
-
0035477438
-
Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1α, HIF-2α, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3′-kinase/Akt signaling pathway
-
Blancher C, Moore JW, Robertson N, Harris AL. Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1α, HIF-2α, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3′ -kinase/Akt signaling pathway. Cancer Res 2001;61:7349-55.
-
(2001)
Cancer Res.
, vol.61
, pp. 7349-7355
-
-
Blancher, C.1
Moore, J.W.2
Robertson, N.3
Harris, A.L.4
-
59
-
-
0032240610
-
UCN-01, a protein kinase C inhibitor, inhibits endothelial cell proliferation and angiogenic hypoxic response
-
Kruger EA, Blagoskionny MV, Dixon SC, Figg WD. UCN-01, a protein kinase C inhibitor, inhibits endothelial cell proliferation and angiogenic hypoxic response. Invasion Metastasis 1999;18:209-18.
-
(1999)
Invasion Metastasis
, vol.18
, pp. 209-218
-
-
Kruger, E.A.1
Blagoskionny, M.V.2
Dixon, S.C.3
Figg, W.D.4
-
60
-
-
0028844810
-
Diphenylene iodonium inhibits the induction of erythropoietin and other mammalian genes by hypoxia. Implications for the mechanism of oxygen sensing
-
Gleadle JM, Ebert BL, Ratcliffe PJ. Diphenylene iodonium inhibits the induction of erythropoietin and other mammalian genes by hypoxia. Implications for the mechanism of oxygen sensing. Eur J Biochem 1995; 234:92-9.
-
(1995)
Eur. J. Biochem.
, vol.234
, pp. 92-99
-
-
Gleadle, J.M.1
Ebert, B.L.2
Ratcliffe, P.J.3
-
61
-
-
0141483520
-
Regulation of the pro-angiogenic microenvironment by carboxyamidotriazole
-
Oliver VK, Patton AM, Desai S, Lorang D, Libutti SK, Kohn EC. Regulation of the pro-angiogenic microenvironment by carboxyamidotriazole. J Cell Physiol 2003;197:139-48.
-
(2003)
J. Cell Physiol.
, vol.197
, pp. 139-148
-
-
Oliver, V.K.1
Patton, A.M.2
Desai, S.3
Lorang, D.4
Libutti, S.K.5
Kohn, E.C.6
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