Inhibition of mitochondrial respiration by the anticancer agent 2-methoxyestradiol

Biochemical and Biophysical Research Communications

Volumn 322, Issue 3, 2004, Pages 923-929

  Hagen, Thilo ^a   D'Amico, Gabriela ^a   Quintero, Marisol ^a   Palacios Callender, Miriam ^a   Hollis, Veronica ^a   Lam, Francis ^a   Moncada, Salvador ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

2 Methoxyestradiol; Apoptosis; Hypoxia inducible factor; Mitochondria; Reactive oxygen species

Indexed keywords

2 METHOXYESTRADIOL; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; HYPOXIA INDUCIBLE FACTOR 1ALPHA; OXYGEN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; REACTIVE OXYGEN METABOLITE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPATHOLOGY; DOWN REGULATION; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; EMBRYO; ENZYME ACTIVATION; ENZYME MECHANISM; ENZYME REACTIVATION; FIBROBLAST; HUMAN; HUMAN CELL; HYPOXIA; KIDNEY CELL; MITOCHONDRIAL RESPIRATION; MITOSIS INHIBITION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STABILITY; PROTEIN SYNTHESIS INHIBITION; RESPIRATORY CHAIN; SUBMITOCHONDRIAL PARTICLE; TUMOR CELL DESTRUCTION;

ANTICARCINOGENIC AGENTS; APOPTOSIS; CELL DIVISION; CELL LINE; ELECTRON TRANSPORT; ESTRADIOL; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KIDNEY; KINETICS; MITOCHONDRIA; OXYGEN CONSUMPTION; REACTIVE OXYGEN SPECIES; TRANSCRIPTION FACTORS;

EID: 4444229716     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.07.204     Document Type: Article

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