A radicicol derivative, KF58333, inhibits expression of hypoxia-inducible factor-1α and vascular endothelial growth factor, angiogenesis and growth of human breast cancer xenografts

Japanese Journal of Cancer Research

Volumn 92, Issue 12, 2001, Pages 1342-1351

  Kurebayashi, Junichi ^a   Otsuki, Takemi ^b   Kurosumi, Masafumi ^c   Soga, Shiro ^d   Akinaga, Shiro ^d   Sonoo, Hiroshi ^a  

^a Department of Breast and Thyroid Surgery ^*  (Japan)

^b KAWASAKI MEDICAL SCHOOL   (Japan)

^c SAITAMA CANCER CENTER   (Japan)

^d KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Angiogenesis; Breast cancer; Hypoxia inducible factor 1; Radicicol; Vascular endothelial growth factor

Indexed keywords

ANGIOGENESIS INHIBITOR; HEAT SHOCK PROTEIN 90; HYPOXIA INDUCIBLE FACTOR 1ALPHA; KF 58333; KI 67 ANTIGEN; MESSENGER RNA; OXIME DERIVATIVE; RADICICOL; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANTIBODY LABELING; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECT; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LABELING INDEX; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN SECRETION; TISSUE NECROSIS; TUMOR CELL; TUMOR VASCULARIZATION; TUMOR XENOGRAFT;

ANIMALS; ANOXIA; APOPTOSIS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL DIVISION; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL GROWTH FACTORS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KI-67 ANTIGEN; LACTONES; LYMPHOKINES; MACROLIDES; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; NUCLEAR PROTEINS; RNA, MESSENGER; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0035676830     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2001.tb02159.x     Document Type: Article

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