Inhibitors of mitochondrial complex I attenuate the accumulation of hypoxia-inducible factor-1 during hypoxia in Hep3B cells

Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology

Volumn 132, Issue 1, 2002, Pages 107-109

  Agani, Faton H ^a   Pichiule, Paola ^a   Carlos Chavez, Juan ^a   LaManna, Joseph C ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Hep3B cells; Hypoxia; Mitochondrial complex I; MPP+; Oxygen sensing; Rotenone

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; HYPOXIA INDUCIBLE FACTOR 1ALPHA; ROTENONE; HIF1A PROTEIN, HUMAN; OXYGEN; TRANSCRIPTION FACTOR; UNCOUPLING PROTEIN;

ARTICLE; CONTROLLED STUDY; DRUG EFFECT; GENE ACTIVATION; HEPATOMA CELL; HUMAN; HUMAN CELL; HYPOXIA; MITOCHONDRIAL RESPIRATION; RESPIRATORY CHAIN; ANOXIA; CELL CULTURE; DOSE RESPONSE; ELECTRON TRANSPORT; METABOLISM; MITOCHONDRION;

1-METHYL-4-PHENYLPYRIDINIUM; ANOXIA; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON TRANSPORT; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MITOCHONDRIA; OXYGEN; ROTENONE; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; UNCOUPLING AGENTS;

EID: 0036010219     PISSN: 10956433     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1095-6433(01)00535-9     Document Type: Article

References (8)

1. The role of mitochondria in the regulation of hypoxia-inducible factor 1 expression during hypoxia
2. Oxygen sensing and molecular adaptation to hypoxia
3. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
4. 2-dependent degradation domain via the ubiquitin-proteasome pathway
5. Oxygen radicals as messengers in oxygen-dependent gene expression
6. Hypoxia-inducible factor 1 alpha (HIF-1 alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions - Its stabilization by hypoxia depends on redox-induced changes
7. 2 homeostasis by hypoxia-inducible factor 1
8. Expression of hypoxia-inducible factor 1: Mechanisms and consequences