The interaction of histone deacetylase inhibitors and DNA methyltransferase inhibitors in the treatment of human cancer cells

Current Medicinal Chemistry - Anti-Cancer Agents

Volumn 3, Issue 3, 2003, Pages 187-199

  Zhu, Wei Guo ^a   Otterson, Gregory A ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

5 aza 2 deoxycytidine; DNA methyltransferase; Histone acetylation; Histone deacetylase; Transcriptional repression

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; 5 METHYLCYTOSINE; ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; APICIDIN; AZACITIDINE; BUTYRIC ACID; CARBOPLATIN; CISPLATIN; CYTOSINE; DEPSIPEPTIDE; DNA; FLAVOPIRIDOL; FLUOROURACIL; FR 901228; HISTONE; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; METHYLTRANSFERASE INHIBITOR; MG 98; N (2 AMINOPHENYL) 4 (3 PYRIDINYLMETHOXYCARBONYLAMINOMETHYL)BENZAMIDE; OXAMFLATIN; RETINOIC ACID; TEMOZOLOMIDE; TRAPOXIN; TRICHOSTATIN A; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALPROIC ACID; VORINOSTAT;

ACETYLATION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; BREAST CANCER; CANCER CELL; CELL DIFFERENTIATION; CELL GROWTH; CELL METABOLISM; CELL STRUCTURE; CLINICAL TRIAL; COLON CANCER; DNA METHYLATION; DRUG EFFICACY; DRUG HALF LIFE; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REACTIVATION; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; IN VITRO STUDY; LEUKEMIA; LUNG CANCER; MOUSE; NONHUMAN; REVIEW; SIDE EFFECT; STRUCTURE ACTIVITY RELATION; TUMOR SUPPRESSOR GENE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL DIFFERENTIATION; DNA METHYLATION; DNA MODIFICATION METHYLASES; DRUG SYNERGISM; GENE SILENCING; HISTONE DEACETYLASES; HUMANS; MOLECULAR STRUCTURE; NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 0037276902     PISSN: 15680118     EISSN: None     Source Type: Journal    
DOI: 10.2174/1568011033482440     Document Type: Review

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