The μ switch region tandem repeats are important, but not required, for antibody class switch recombination

Journal of Experimental Medicine

Volumn 193, Issue 2, 2001, Pages 159-168

  Luby, Thomas M ^a   Schrader, Carol E ^b   Stavnezer, Janet ^b   Selsing, Erik ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

B lymphocyte; Class switching; Gene rearrangement; Heavy chain; Immunoglobulin isotype

Indexed keywords

ANTIBODY; IMMUNOGLOBULIN CLASS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAIN;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; GENE DELETION; GENE LOCUS; GENE REARRANGEMENT; GENETIC RECOMBINATION; HYBRIDOMA; IMMUNOGLOBULIN PRODUCTION; INTRON; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ANALYSIS; TANDEM REPEAT;

ANIMALS; B-LYMPHOCYTES; BASE SEQUENCE; CELLS, CULTURED; DNA; DNA PRIMERS; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; HYBRIDOMAS; IMMUNOGLOBULIN SWITCH REGION; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; RECOMBINATION, GENETIC; SEQUENCE DELETION; SEQUENCE HOMOLOGY, NUCLEIC ACID; TANDEM REPEAT SEQUENCES;

EID: 0035862327     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.193.2.159     Document Type: Article

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15. Switch recombination in a transfected plasmid occurs preferentially in a B cell line that undergoes switch recombination of its chromosomal Ig heavy chain genes
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27. Regulatory regions 3′ of the immunoglobulin heavy chain intronic enhancer differentially affect expression of a heavy chain transgene in resting and activated B cells
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